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81. 发明授权

US07399823B1 Antimicrobial theta defensins and methods of using same 有权
标题翻译：抗微生物θ防御素及其使用方法
公开(公告)号：US07399823B1
公开(公告)日：2008-07-15
申请号：US10009317
申请日：2000-05-10
申请人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
发明人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/12 , C07K14/4723 , C12P21/00 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also provides nucleic acids encoding theta defensins and antibodies that specifically bind a theta defensin. In addition, the invention relates to methods of using theta defensin to reduce or inhibit microbial growth or survival.
摘要翻译：本发明涉及具有抗微生物活性的分离的环肽，θ防御素，以及θ防御素类似物。 θ防御素可以具有氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8，其中Xaa1至Xaa8是定义其中Xaa1可通过肽键与Xaa8连接; 并且其中可以在Xaa3和Xaa3之间，Xaa5和Xaa5之间以及Xaa7和Xaa7之间形成交联。例如，本发明提供具有氨基酸序列Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg的θ防御素 SEQ ID NO：1），其中位置1处的Gly（Gly-1）通过肽键与Arg-18连接，并且其中二硫键存在于Cys-3和Cys-16之间，Cys-5和Cys之间 -14，以及Cys-7和Cys-12之间。本发明还提供编码θ防御素和特异性结合θ防御素的抗体的核酸。此外，本发明涉及使用θ防御素来减少或抑制微生物生长或存活的方法。

82. 发明申请

US20070022107A1 Methods and apparatus for generic semantic access to information systems 有权
标题翻译：通用语义访问信息系统的方法和设备
公开(公告)号：US20070022107A1
公开(公告)日：2007-01-25
申请号：US11186253
申请日：2005-07-21
申请人： Jun Yuan , Babak Hamidzadeh
发明人： Jun Yuan , Babak Hamidzadeh
IPC分类号： G06F17/30
CPC分类号： G06F17/30684 , G06F17/30731 , G06F17/30734
摘要： A method of providing information from at least one information resource. A semantic query is received that includes one or more generic constructs referencing an ontology relating to a domain of the information resource(s). A representation of the semantic query in an ontology representation language is inferred from the constructs. The query representation is used to access the information resource(s). This method allows a user to formulate database queries semantically without knowledge as to underlying data structures.
摘要翻译：一种从至少一个信息资源提供信息的方法。接收到语义查询，其包括引用与信息资源的域相关的本体的一个或多个通用构造。本体表示语言中的语义查询的表示从结构中推断出来。查询表示用于访问信息资源。这种方法允许用户在语义上制定数据库查询，而不需要基础数据结构的知识。

83. 发明授权

US07122080B2 Integrated process for simultaneous beneficiation, leaching, and dewatering of kaolin clay suspension 有权
公开(公告)号：US07122080B2
公开(公告)日：2006-10-17
申请号：US10214359
申请日：2002-08-08
申请人： Robert J. Pruett , Jun Yuan , Christopher R. L. Golley , Michael J. Garska
发明人： Robert J. Pruett , Jun Yuan , Christopher R. L. Golley , Michael J. Garska
IPC分类号： C04B14/04
CPC分类号： C09C1/42 , B03D3/06 , C01P2004/61 , C01P2004/62 , C01P2006/22 , C01P2006/40 , C01P2006/60 , C01P2006/80 , Y02P20/125
摘要： The present invention provides an improved method of beneficiating and dewatering kaolin clays. The product of the improved process is a brightened, dewatered kaolin, suitable for use in pigments and paper coating compositions. The improved beneficiation process provides refined kaolin for pigments and other purposes of the same or better quality as prior art processes, but with the use of fewer steps and materials, at significant cost and environmental savings.

84. 发明申请

US20060124033A1 Fine platy kaolin composition 有权
标题翻译：精细高岭土组成
公开(公告)号：US20060124033A1
公开(公告)日：2006-06-15
申请号：US10531257
申请日：2003-12-15
申请人： Robert Pruett , Jun Yuan , Bomi Bilimoria , Roger Wygant , Anthony Lyons
发明人： Robert Pruett , Jun Yuan , Bomi Bilimoria , Roger Wygant , Anthony Lyons
IPC分类号： C04B14/04
CPC分类号： C09C1/42 , C01P2004/20 , C01P2004/54 , C01P2004/60 , C01P2006/22 , D21H19/40 , D21H21/52
摘要： The present invention relates to a kaolin composition having improved physical properties, for example, for use in the production of paper products. The composition can comprise kaolin having a shape factor of at least about 20. The kaolin can have a particle size distribution such that at least about 94% by weight of the kaolin can have an esd of less than about 2 μm and/or at least about 80% by weight of the kaolin can have an esd of less than 1 μm. The amount of the kaolin having an esd of less than about 0.25 μm can range from about 25% to about 60% by weight. The Hercules viscosity of the kaolin product is less than 4000 rpm at 18 dynes at 63% solids and less than 1500 rpm at 18 dynes at 69% solids when measured using the “A” bob. The present invention also relates to an improved method for making the kaolin product from sedimentary kaolin.
摘要翻译：本发明涉及具有改善的物理性能的高岭土组合物，例如用于生产纸制品。该组合物可以包含具有至少约20的形状因子的高岭土。高岭土可以具有使得高岭土的至少约94重量％的esd可以具有小于约2μm的esd和/或至少约80重量％的高岭土可以具有小于1m的esd。具有小于约0.25μm的esd的高岭土的量可以为约25重量％至约60重量％。高岭土产品的Hercules粘度在18达因数时为63％固体，小于1500转/分钟，18达因时为69％固体，当使用“A”鲍伯测量时。本发明还涉及一种由沉淀高岭土制备高岭土产品的改进方法。

85. 发明申请

US20050277654A1 4,5-Disubstituted-2-aryl pyrimidines 失效
标题翻译： 4,5-二取代-2-芳基嘧啶
公开(公告)号：US20050277654A1
公开(公告)日：2005-12-15
申请号：US11123755
申请日：2005-05-06
申请人： George Maynard , Manuka Ghosh , Jun Yuan , Kevin Currie , Scott Mitchell , Qin Guo , He Zhao
发明人： George Maynard , Manuka Ghosh , Jun Yuan , Kevin Currie , Scott Mitchell , Qin Guo , He Zhao
IPC分类号： A61K31/505 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/04 , C07D471/04 , C07D498/04
CPC分类号： A61K31/505 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/04 , C07D405/12 , C07D417/04 , C07D471/04 , C07D498/04
摘要： 4,5-disubstituted-2-arylpyrimidines of Formula I and Formula II are provided: wherein R1, R2, R3, R8, R9, A and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred compounds of Formula I and II bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled 4,5-disubstituted-2-arylpyrimidines, which are useful as probes for the localization of C5a receptors.
摘要翻译：提供式I和式II的4,5-二取代-2-芳基嘧啶：其中R 1，R 2，R 3，R 本文定义了R 8，R 9，A和Ar。这些化合物是C5a受体的配体。优选的式I和II化合物以高亲和力结合C5a受体，并在C5a受体上呈现中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。此外，本发明提供标记的4,5-二取代-2-芳基嘧啶，其可用作C5a受体定位的探针。

86. 发明授权

US06936617B2 Heteroaryl substituted fused bicyclic heteroaryl compound as GABAA receptor ligands 失效
标题翻译：杂芳基取代的稠合双环杂芳基化合物作为GABA A受体配体
公开(公告)号：US06936617B2
公开(公告)日：2005-08-30
申请号：US10194852
申请日：2002-07-12
申请人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
发明人： Alan Hutchison , George Maynard , Pamela Albaugh , Linghong Xie , Jun Yuan , Scott Mitchell , Vinod Singh , Manuka Ghosh , Guiying Li , Nian Liu
IPC分类号： G01N33/48 , A61K31/4355 , A61K31/4439 , A61K31/444 , A61K31/4985 , A61K31/5025 , A61K31/506 , A61K31/519 , A61P25/00 , A61P25/14 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D471/04 , C07D487/04 , C07D513/04 , C12N15/09 , C12Q1/02 , G01N33/58 , G01N33/60 , A61K31/437
CPC分类号： C07D487/04 , C07D471/04 , C07D513/04
摘要： This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及可以由式I或式II描述的杂芳基取代的稠合双环杂芳基化合物，例如杂芳基取代的咪唑并吡啶，咪唑并吡嗪，咪唑并吡啶，咪唑并嘧啶和咪唑并噻唑。本发明特别涉及以高选择性结合的这些化合物并且对GABA A A受体的苯并二氮杂位点具有高亲和力。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I和式II化合物的方法。本发明还涉及式I或式II的苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

87. 发明授权

US06916827B2 Substituted ring-fused imidazole derivative: GABAA receptors ligands 失效
标题翻译：取代的环稠合咪唑衍生物：GABA A受体配体
公开(公告)号：US06916827B2
公开(公告)日：2005-07-12
申请号：US10438496
申请日：2003-05-15
申请人： George D. Maynard , Jun Yuan , George P. Luke , Kevin Currie
发明人： George D. Maynard , Jun Yuan , George P. Luke , Kevin Currie
IPC分类号： A61P25/00 , C07D471/04 , A61K31/437 , A61K31/4184 , A61K31/506 , C07D403/06
CPC分类号： C07D471/04
摘要： Substituted ring-fused imidazole derivatives that bind to GABAA receptors are provided. Such compounds may be used to modulate ligand binding to GABAA receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of central nervous system (CNS) disorders in humans, domesticated companion animals and livestock animals. Compounds provided herein may be administered alone or in combination with one or more other CNS agents to potentiate the effects of the other CNS agent(s). Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting GABAA receptors (e.g., receptor localization studies).
摘要翻译：提供了与GABA A A受体结合的取代的环稠合咪唑衍生物。这样的化合物可用于在体内或体外调节配体与GABA A A受体的结合，并且特别可用于治疗人类中的各种中枢神经系统（CNS）紊乱，驯养伴侣动物和牲畜。本文提供的化合物可以单独施用或与一种或多种其它CNS剂组合施用，以增强其它CNS剂的作用。还提供了用于治疗这种病症的药物组合物和方法，以及使用这种配体检测GABA A受体的方法（例如，受体定位研究）。

88. 发明授权

US06916819B2 Benzimidazole and pyridylimidazole derivatives 失效
标题翻译：苯并咪唑和吡啶基咪唑衍生物
公开(公告)号：US06916819B2
公开(公告)日：2005-07-12
申请号：US10038069
申请日：2001-12-21
申请人： Guiying Li , John M. Peterson , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , Vinod Singh , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu
发明人： Guiying Li , John M. Peterson , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , Vinod Singh , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/4245 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , C07D233/20 , C07D233/54 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10 , C07D491/113 , C07D403/12
CPC分类号： C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I化合物的新方法。本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

89. 发明申请

US20050015496A1 Virtual connnectivity with local connection translation 有权
标题翻译：虚拟连接与本地连接转换
公开(公告)号：US20050015496A1
公开(公告)日：2005-01-20
申请号：US10619330
申请日：2003-07-14
申请人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
发明人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
IPC分类号： G06F15/00 , H04L12/28 , H04L12/56 , H04L29/06 , H04L29/08 , H04L29/12 , G06F15/16
CPC分类号： H04L63/12 , H04L29/06 , H04L29/12009 , H04L29/12518 , H04L61/2571 , H04L69/32 , H04W8/14 , H04W36/0011 , H04W80/04
摘要： A middle layer network protocol enhancement, virtual connectivity (VC) makes the network attachment point changes of local and remote peers transparent to applications that use network services. A virtual connectivity module local to each peer translates communication connection parameters from apparent to real and vice versa, as well as sending and receiving secure connection updates directly to and from peers. Unlike Mobile IP, no routing infrastructure modifications are required. A subscribe-notify service provides connection update notifications when direct peer-to-peer connection updates are not possible, for example, when two communicating peers move simultaneously or when the moving peer is communicating with a peer behind network address translation (NAT). Methods for detecting these conditions are disclosed, as is a virtual connectivity protocol and virtual connectivity module architecture.
摘要翻译：中间层网络协议增强，虚拟连接（VC）使本地和远程对等体的网络连接点更改对使用网络服务的应用程序透明化。每个对等体本地的虚拟连接模块将通信连接参数从明显转换为实际，反之亦然，以及直接向对方发送和接收安全连接更新。与移动IP不同，不需要进行路由基础架构修改。当直接对等连接更新不可行时，例如当两个通信对等体同时移动或当移动对等体与网络地址转换（NAT）之后的对等体通信时，订阅通知服务提供连接更新通知。公开了用于检测这些条件的方法，以及虚拟连接协议和虚拟连接模块架构。

90. 发明授权

US06820073B1 System and method for multiple pass cooperative processing 有权
标题翻译：多通道协同处理系统和方法
公开(公告)号：US06820073B1
公开(公告)日：2004-11-16
申请号：US10101488
申请日：2002-03-20
申请人： Jeffrey A. Bedell , William Hurwood , Benjamin Z. Li , Sadanand Sahasrabudhe , Xinyi Wang , Jun Yuan
发明人： Jeffrey A. Bedell , William Hurwood , Benjamin Z. Li , Sadanand Sahasrabudhe , Xinyi Wang , Jun Yuan
IPC分类号： G06F1730
CPC分类号： G06F17/30286 , Y10S707/954 , Y10S707/99932 , Y10S707/99933 , Y10S707/99934
摘要： A system for collaborative processing, comprising a controlling module with access to at least one relational database capable of performing a first set of functions on the data in the database and at least one external analytical engine, the external analytical engine being external to the relational database and being capable of a second set of functions on the data in the database. The controlling module is capable of iteratively processing a multi-step calculation including generating SQL statements to the relational database, passing preliminary results to an external analytical engine and saving data back into the relational database for further processing until the multi-step calculation is performed.
摘要翻译：一种用于协同处理的系统，包括控制模块，该控制模块可访问至少一个能够对数据库中的数据执行第一组功能的关系数据库和至少一个外部分析引擎，所述外部分析引擎在关系数据库外部并且能够对数据库中的数据进行第二组功能。控制模块能够迭代处理多步计算，包括生成SQL语句到关系数据库，将初步结果传递给外部分析引擎，并将数据保存回关系数据库进行进一步处理，直到执行多步计算。

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