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81. 发明申请

US20130096567A1 DYNAMIC KNEE BALANCER WITH FORCE OR PRESSURE SENSING 有权
标题翻译：动态KNEE平衡器，具有强力或压力感应功能
公开(公告)号：US20130096567A1
公开(公告)日：2013-04-18
申请号：US13709506
申请日：2012-12-10
申请人： Michael Fisher , Anthony K Hedley , Michael Howard , Kevin M Cordes , Toshinobu Katsuya
发明人： Michael Fisher , Anthony K Hedley , Michael Howard , Kevin M Cordes , Toshinobu Katsuya
IPC分类号： A61B17/16
CPC分类号： A61F2/4657 , A61B17/1626 , A61B17/1675 , A61B34/30 , A61F2/38 , A61F2/3859 , A61F2/4684 , A61F2002/4666
摘要： A device for performing a surgical procedure on a knee includes an adjustable femoral portion, a tibial portion and at least one sensor coupled with the femoral and/or tibial portions to sense pressure exerted by the femoral and tibial portions against one another. The femoral portion is adapted for removably coupling with a distal end of a femur to adjust tension in soft tissue adjacent the knee and has at least one positioning feature adapted to move relative to the distal end of the femur as the femoral portion is adjusted, thus helping position a femoral prosthetic on the distal end of the femur. The sensor(s) may be adapted to sense pressure at medial and lateral sides of the knee, and relative pressures may be displayed as data on a visual display. Adjustments to the femoral member may be made to balance pressure at flexion and extension of the knee.
摘要翻译：用于在膝盖上执行外科手术的装置包括可调整的股骨部分，胫骨部分和与股骨和/或胫骨部分联接的至少一个传感器，以感测由股骨和胫骨部分彼此抵抗的压力。股骨部分适于与股骨的远端可移动地联接以调节邻近膝盖的软组织中的张力，并且具有适于在调节股骨部分时相对于股骨的远端移动的至少一个定位特征，因此帮助股骨假体位于股骨远端。传感器可以适于感测膝盖的内侧和外侧的压力，并且相对压力可以作为数据显示在视觉显示器上。可以对股骨构件进行调整，以平衡膝盖弯曲和伸展时的压力。

82. 发明授权

US08402114B2 Systems and methods for selecting advertisements for display over a communications network 有权
公开(公告)号：US08402114B2
公开(公告)日：2013-03-19
申请号：US11646637
申请日：2006-12-28
申请人： Martin Abbott , Michael Fisher , Michael Yavonditte , Yaron Galai
发明人： Martin Abbott , Michael Fisher , Michael Yavonditte , Yaron Galai
IPC分类号： G06F15/16
CPC分类号： G06Q30/0251 , G06Q30/02 , G06Q30/0244 , G06Q30/0269 , G06Q30/0277 , G06Q30/08
摘要： Systems and methods are provided for selecting advertisements for display over a communications network and, more particularly, to systems and methods for selecting video advertisements for display within internet web pages based on relevance, bid price, past performance, or a combination thereof.

83. 发明申请

US20120260671A1 DISPOSABLE BIOREACTOR CONDENSER BAG AND FILTER HEATER 有权
标题翻译：可处理的生物反应器冷凝器袋和过滤器加热器
公开(公告)号：US20120260671A1
公开(公告)日：2012-10-18
申请号：US13434345
申请日：2012-03-29
申请人： Richard L. DAMREN , Colin Tuohey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
发明人： Richard L. DAMREN , Colin Tuohey , Thomas Erdenberger , Michael Fisher , Geoffrey L. Hodge , Patrick M. Guertin , Parrish M. Galliher
IPC分类号： F28D15/00 , F24F7/00 , F25B21/02
CPC分类号： C12M29/26 , B01D5/0042 , B01D5/0093 , B01D46/4263 , B01D53/265 , C12M23/28 , C12M29/04 , C12M41/12
摘要： Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioretractor, forming a dry gas stream for entering or leaving the bioreactor.
摘要翻译：本文公开了一种系统和方法，用于冷凝进入生物反应器或留下生物减馏器的湿气流中的水分，形成用于进入或离开生物反应器的干燥气流。

84. 外观设计

USD654590S1 Surgical saw blade hub 有权
标题翻译：手术锯片毂
公开(公告)号：USD654590S1
公开(公告)日：2012-02-21
申请号：US29337758
申请日：2009-05-28
申请人： Michael Fisher , Barjinder Chana
设计人： Michael Fisher , Barjinder Chana

85. 发明申请

US20080213874A1 WEIGHT MEASUREMENTS OF LIQUIDS IN FLEXIBLE CONTAINERS 审中-公开
标题翻译：液体在柔性容器中的重量测量
公开(公告)号：US20080213874A1
公开(公告)日：2008-09-04
申请号：US12039052
申请日：2008-02-28
申请人： Peter A. Mitchell , Michael Fisher
发明人： Peter A. Mitchell , Michael Fisher
IPC分类号： C12M1/34 , G01F22/00
CPC分类号： G01F23/14 , G01F23/18 , G01F23/20 , G01G17/04
摘要： Articles and methods for measuring weight of a liquid in a disposable bag bioreactor are presented. In certain embodiments, bioreactor systems described herein include a supported container (e.g., a flexible bag in a reusable housing) for containing a liquid, and at least two pressure indicating sensors operatively associated with the container. A first pressure indicating sensor can be placed near the bottom of the container to measure the total downward force within the container, including the liquid head in the container and the gas pressure above the liquid. The second pressure indicating sensor can be placed near the top of the container to measure only the pressure at the top of or above the liquid. Signals from the pressure indicating sensors can be directed to a control system that receives the signals and calculates a difference between the signals. This difference can be used to determine a volume or a weight of the liquid in the container. Advantageously, real-time weight measurements can be obtained while the system is in operation and continuous flow processes can be monitored. Moreover, in some embodiments, the pressure indicating sensors are isolated from contact with any fluid (e.g., liquid) in the container and, therefore, do not require cleaning after processing of each batch of reactants. Contamination of the process fluid by contact with the pressure indicating sensors can also be avoided.
摘要翻译：提出了一次性袋式生物反应器中液体重量测量的物品和方法。在某些实施方案中，本文所述的生物反应器系统包括用于容纳液体的支撑容器（例如，可重复使用的壳体中的柔性袋）和与容器可操作地相关联的至少两个压力指示传感器。第一压力指示传感器可以放置在容器的底部附近，以测量容器内的总的向下的力，包括容器中的液体头和液体上方的气体压力。第二压力指示传感器可以放置在容器顶部附近，以仅测量液体顶部或上方的压力。来自压力指示传感器的信号可以被引导到接收信号并计算信号之间的差异的控制系统。该差异可用于确定容器中液体的体积或重量。有利的是，可以在系统运行时获得实时重量测量，并且可以监视连续的流程。此外，在一些实施例中，压力指示传感器与容器中的任何流体（例如液体）接触隔离，因此在处理每批反应物之后不需要清洁。也可以避免通过与压力指示传感器的接触对工艺流体的污染。

86. 发明申请

US20080139865A1 Environmental containment systems 有权
标题翻译：环境遏制系统
公开(公告)号：US20080139865A1
公开(公告)日：2008-06-12
申请号：US11879033
申请日：2007-07-13
申请人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher
发明人： Parrish M. Galliher , Geoffrey L. Hodge , Michael Fisher
IPC分类号： B09B5/00
CPC分类号： C12M41/14 , B08B15/02 , C12M23/52 , C12M37/02 , C12M41/00 , C12M41/40 , Y10S55/18
摘要： Environmental containment systems, and in certain embodiments, systems and methods involving vessels and unit operations or components of cell culture, cell containment, bioreactor, chemical manufacturing, or pharmaceutical manufacturing systems provided with environmental containment are provided. Certain vessels, unit operations, devices, and components may be used to perform all or part of biological, chemical, and/or pharmaceutical manufacturing processes therein. In some embodiments, an environmental containment system includes a multi-level containment apparatus. For instance, a first substantially closed environmental containment enclosure may be contained within a second substantially closed environmental containment enclosure; the first and second enclosures may be contained in a third substantially closed environmental containment enclosure, etc. Each of the environments within the substantially closed environmental containment enclosures may be controlled independently, and leakage of any materials from an inner system may be contained by an outer system.
摘要翻译：提供环境容纳系统，并且在某些实施方案中，提供了涉及容器和单元操作的系统和方法或细胞培养物，细胞容纳物，生物反应器，化学制造或具有环境容纳物的药物制造系统。某些容器，单元操作，装置和部件可用于执行其中的生物，化学和/或药物制造过程的全部或部分。在一些实施例中，环境容纳系统包括多级容纳装置。例如，第一基本封闭的环境容纳外壳可以包含在第二基本封闭的环境容纳外壳内; 第一和第二外壳可以包含在第三基本封闭的环境容纳外壳等中。基本封闭的环境容纳外壳内的每个环境可以独立地被控制，并且任何材料从内部系统的泄漏可以被外部系统。

87. 发明申请

US20080052328A1 ABSTRACTED AND OPTIMIZED ONLINE BACKUP AND DIGITAL ASSET MANAGEMENT SERVICE 审中-公开
标题翻译：摘要和优化的在线备份和数字资产管理服务
公开(公告)号：US20080052328A1
公开(公告)日：2008-02-28
申请号：US11775809
申请日：2007-07-10
申请人： Benjamin Widhelm , Michael Fisher
发明人： Benjamin Widhelm , Michael Fisher
IPC分类号： G06F17/30 , H04L9/32
CPC分类号： H04L63/0428 , G06F16/188 , H04L63/1408
摘要： A system and method for providing online storage and security. Digital assets are sent from client applications to server applications. The server implements an algorithm that optimizes the storage of digital assets. The server extracts the meta-data from digital assets and stores the meta-data in a relational database. The storage of digital assets will depend on analyzing the meta-data; factors such as file type, frequency of usage, and frequency of access are considered by the storage destination optimizing algorithm. The server also implements an algorithm that protects the digital assets from unauthorized network access. Upon detection of network intrusion by the security algorithm, the digital assets of the compromised users will be frozen, then either be destroyed or render unreadable by the unauthorized user. The security algorithm may then send an instance of the digitals assets to the compromised user to ensure that the digital assets remain accessible.
摘要翻译：一种用于提供在线存储和安全性的系统和方法。数字资产从客户端应用程序发送到服务器应用程序。服务器实现了优化数字资产存储的算法。服务器从数字资产提取元数据，并将元数据存储在关系数据库中。数字资产的存储将取决于元数据的分析; 存储目的地优化算法考虑文件类型，使用频率和访问频率等因素。服务器还实现了保护数字资产免受未经授权的网络访问的算法。在通过安全算法检测到网络入侵时，受到攻击的用户的数字资产将被冻结，然后被未经授权的用户销毁或使其无法读取。然后，安全算法可以将数字资产的实例发送给受感染的用户，以确保数字资产保持可访问。

88. 发明申请

US20070247818A1 Adjustable attachment for electronic assemblies 失效
标题翻译：电子组件的可调附件
公开(公告)号：US20070247818A1
公开(公告)日：2007-10-25
申请号：US11407021
申请日：2006-04-19
申请人： Shawn Canfield , Joseph Corrado , Michael Fisher , Udo Jourdan , Budy Notohardjono
发明人： Shawn Canfield , Joseph Corrado , Michael Fisher , Udo Jourdan , Budy Notohardjono
IPC分类号： H05K7/00
CPC分类号： H05K7/1411 , H05K7/1424
摘要： An apparatus and method used for connecting surfaces to one another is provided. In one embodiment, the apparatus comprises of a mounting body with a front and a back portion. The front portion includes an opening that is aligned with another opening of a block, fixably attached to this front portion. The openings of the block and/or front section can include internal threading. A threaded insert is then placed inside the block such that the insert can move from a first position to a second position using threading movement.
摘要翻译：提供了用于将表面彼此连接的装置和方法。在一个实施例中，该装置包括具有前部和后部的安装体。前部包括与块的另一开口对准的开口，该开口可固定地附接到该前部。块和/或前部的开口可以包括内部螺纹。然后将螺纹插入件放置在块内，使得插入件可以使用螺纹移动从第一位置移动到第二位置。

89. 发明申请

US20060293303A1 Antiprotozoal imidazopyridine compounds 有权
标题翻译：抗原虫咪唑并吡啶化合物
公开(公告)号：US20060293303A1
公开(公告)日：2006-12-28
申请号：US10573363
申请日：2004-12-06
申请人： Tesfaye Biftu , Matthew Wyvratt , Michael Fisher
发明人： Tesfaye Biftu , Matthew Wyvratt , Michael Fisher
IPC分类号： A61K31/506 , C07D471/04
CPC分类号： C07D471/04
摘要： Compounds described by the Formula (I) or (II): or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidieal agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria. African typanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).
摘要翻译：由式（I）或（II）表示的化合物：或其药学上可接受的盐或N-氧化物。该化合物可用于治疗和预防哺乳动物和鸟类中的原生动物疾病。用于控制家禽中球虫病的方法包括单独施用有效量的化合物，或与一种或多种抗球虫剂组合施用。用于控制家禽中球虫病的组合物包含单独的化合物，或与一种或多种抗球虫剂组合。用于治疗和预防哺乳动物原生动物疾病的方法，例如弓形体病，疟疾。非洲typanosomias，恰加斯病和机会性感染包括单独施用化合物，或与一种或多种抗原虫剂组合施用。

90. 发明申请

US20060178358A1 Antiprotozoal imidazopyridine compounds 有权
公开(公告)号：US20060178358A1
公开(公告)日：2006-08-10
申请号：US10548154
申请日：2004-03-02
申请人： Matthew Wyvratt , Tesfaye Biftu , Michael Fisher , Dennis Schmatz
发明人： Matthew Wyvratt , Tesfaye Biftu , Michael Fisher , Dennis Schmatz
IPC分类号： A61K31/506 , C07D471/04
CPC分类号： C07D471/04 , C07D519/00
摘要： Compounds described by the Formula (I): (I) or pharmaceutically acceptable salts, or N-oxides thereof. The compounds are useful for the treatment and prevention of protozoal diseases in mammals and birds. A method for controlling coccidiosis in poultry comprises administering an effective amount of the compound alone, or in combination with one or more anticoccidial agent(s). A composition for controlling coccidiosis in poultry comprises the compound alone, or in combination with one or more anticoccidial agent(s). Methods for the treatment and prevention of mammalian protozoal diseases, such as, for example, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, and opportunistic infections comprise administering the compound alone, or in combination with one or more antiprotozoal agent(s).

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