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81. 发明授权

US06961616B2 Trending of conduction time for optimization of cardiac resynchronization therapy in cardiac rhythm management system 有权
标题翻译：心脏再同步治疗心脏节律管理系统优化传导时间的趋势
公开(公告)号：US06961616B2
公开(公告)日：2005-11-01
申请号：US09964972
申请日：2001-09-27
申请人： Andrew P. Kramer , Jeffrey Stahmann , Veerichetty A. Kadhiresan
发明人： Andrew P. Kramer , Jeffrey Stahmann , Veerichetty A. Kadhiresan
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/36542 , A61N1/3682 , A61N1/3684
摘要： A method of optimizing cardiac resynchronization therapy delay over a patient's full range of activity for use in operating an implantable cardiac pacing device and such a device are disclosed. The method includes measuring selected conduction time between selected sites in the heart for a plurality of beats and logging the values on a periodic repeating programmable basis to produce cumulative data and constructing a current template of conduction time in relation to one or more other sensed parameters of interest over a desired range of patient activity levels. The current template is used to derive suggested optimum pacing timing.
摘要翻译：公开了一种优化患者用于操作可植入心脏起搏装置和这种装置的全部活动范围的心脏再同步治疗延迟的方法。该方法包括测量心脏中多个节拍之间的选定位点之间的选定导通时间，并且以周期性重复可编程为基础记录该值，以产生累积数据并构建相对于一个或多个其它感测参数的传导时间的当前模板对所需范围的患者活动水平感兴趣。当前模板用于推导最佳起搏时间。

82. 发明授权

US5983138A Device and method for ventricular tracking and pacing 失效
标题翻译：心室跟踪和起搏的装置和方法
公开(公告)号：US5983138A
公开(公告)日：1999-11-09
申请号：US833281
申请日：1997-04-04
申请人： Andrew P. Kramer
发明人： Andrew P. Kramer
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/368
摘要： A device and method for multi chamber pacing a patient's heart having heart failure and intrinsic conduction, wherein ventricular tracking is used to pace the ventricle when the sinus rate exceeds a preset atrial maximum tracking rate. The ventricular tracking pacemaker increases the range of pacing the ventricle. The ventricular tracking minimizes the loss of ventricular pacing caused by intrinsic conduction when the sinus rate is below an atrial maximum tracking rate, and it induces a new ventricular pacing behavior for sinus rates above the atrial maximum tracking rate without any pacing hysteresis as the sinus rate returns towards the lower rate limit.
摘要翻译：一种用于多室起搏具有心力衰竭和内在传导的患者心脏的装置和方法，其中当窦速率超过预设的心房最大跟踪率时，使用心室跟踪来调节心室。心室跟踪起搏器增加心室起搏的范围。当窦速度低于心房最大跟踪率时，心室跟踪使由内在传导引起的心室起搏损失最小化，并且对于心房最大跟踪率以上的窦速率引起新的心室起搏行为，而没有起搏滞后作为窦速率返回到较低的汇率限制。

83. 发明授权

US08909337B2 System to treat AV-conducted ventricular tachyarrhythmia 有权
标题翻译：系统治疗AV进行性室性快速性心律失常
公开(公告)号：US08909337B2
公开(公告)日：2014-12-09
申请号：US13473774
申请日：2012-05-17
申请人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
发明人： Julia Moffitt , Andrew P. Kramer , Imad Libbus
IPC分类号： A61N1/365 , A61N1/368 , A61N1/362 , A61N1/36 , A61N1/39 , A61B5/0464 , A61N1/05
CPC分类号： A61N1/36114 , A61B5/0464 , A61N1/0587 , A61N1/3622 , A61N1/3627 , A61N1/368 , A61N1/3684 , A61N1/3962 , A61N2001/0585
摘要： Various aspects of the present subject matter provide devices and methods to treat AV-conducted ventricular tachyarrhythmia (AVCVT). According to various embodiments of the method, an AVCVT is sensed, an IVC-LA fat pad is stimulated when the AVCVT is sensed to block AV conduction, and bradycardia support pacing is provided while the IVC-LA fat pad is stimulated. Other aspects and embodiments are provided herein.
摘要翻译：本主题的各个方面提供了治疗AV进行性室性快速性心律失常（AVCVT）的装置和方法。根据该方法的各种实施例，感测到AVCVT，当检测到AVCVT以阻止AV传导时刺激IVC-LA脂肪垫，并且在IVC-LA脂肪垫被刺激的同时提供心动过缓支持起搏。本文提供了其它方面和实施例。

84. 发明授权

US08874211B2 Hypertension therapy based on activity and circadian rhythm 有权
标题翻译：基于活动和昼夜节律的高血压治疗
公开(公告)号：US08874211B2
公开(公告)日：2014-10-28
申请号：US12968797
申请日：2010-12-15
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/08 , A61N1/36 , A61N1/365 , A61N1/362
CPC分类号： A61N1/36139 , A61N1/3601 , A61N1/3611 , A61N1/36114 , A61N1/36117 , A61N1/36135 , A61N1/3627 , A61N1/36535 , A61N1/36542 , A61N1/3655 , A61N1/36564 , A61N1/36571 , A61N1/37288
摘要： According to an embodiment of a method for using an implantable device to deliver a hypertension therapy to a patient, an activity level is sensed using the implantable medical device. The implantable device may be programmed with a mapping of the sensed activity level to intensity levels for the hypertension therapy. The method may determine a desired intensity for the hypertension therapy as a function of both a circadian rhythm template and the sensed activity level, and use the implantable device to deliver the hypertension therapy using the desired intensity.
摘要翻译：根据使用可植入装置将高血压治疗递送给患者的方法的实施例，使用可植入医疗装置感测活动水平。可植入装置可以用感测的活动水平与高血压治疗的强度水平的映射进行编程。该方法可以根据昼夜节律模板和所感测的活动水平来确定高血压治疗的期望强度，并且使用可植入装置使用期望的强度递送高血压治疗。

85. 发明授权

US08634930B2 System for providing diabetic therapy 有权
标题翻译：糖尿病治疗系统
公开(公告)号：US08634930B2
公开(公告)日：2014-01-21
申请号：US11428070
申请日：2006-06-30
申请人： Yousufali Dalal , Andrew P. Kramer , Lizbeth M. Mino
发明人： Yousufali Dalal , Andrew P. Kramer , Lizbeth M. Mino
IPC分类号： A61N1/36
CPC分类号： A61N1/37288 , A61N1/36007 , A61N1/36014 , A61N1/36053 , A61N1/36114 , A61N1/36135 , A61N1/3621 , A61N1/36557 , A61N1/36585 , A61N1/37282
摘要： Various system embodiments include a glucose control input, a low physical activity input, and a diabetic therapy delivery system adapted to respond to the glucose control input and the low physical activity input to deliver diabetic therapy. According to various embodiments, the diabetic therapy includes an anti-arrhythmia therapy, a hypertension therapy, a neural stimulation therapy adapted to reduce a risk of myocardial infarction, a neural stimulation therapy adapted to be applied after a myocardial infarction to reduce an infarct area, a neural stimulation therapy adapted to reduce a risk of sudden cardiac death, a therapy adapted to secrete insulin, or a therapy to reduce a workload of a diabetic heart. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施方案包括葡萄糖控制输入，低体力活动输入和适于响应于葡萄糖控制输入和低体力活动输入以递送糖尿病治疗的糖尿病治疗递送系统。根据各种实施方案，糖尿病治疗包括抗心律失常治疗，高血压治疗，适于降低心肌梗死风险的神经刺激疗法，适于在心肌梗死后应用以减少梗死面积的神经刺激疗法，适于减少心源性猝死的风险的神经刺激疗法，适于分泌胰岛素的治疗剂或减少糖尿病心脏的工作量的治疗方法。本文提供了其它方面和实施例。

86. 发明授权

US08565875B2 Cardiac rhythm management system with maximum tracking rate (MTR) hysteresis 有权
标题翻译：具有最大跟踪率（MTR）滞后的心律管理系统
公开(公告)号：US08565875B2
公开(公告)日：2013-10-22
申请号：US12966601
申请日：2010-12-13
申请人： Andrew P. Kramer
发明人： Andrew P. Kramer
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/3684
摘要： A cardiac rhythm management system provides both a safe maximum pacing rate limit and a physiological maximum pacing rate limit. In one embodiment, a normal maximum tracking rate (MTR) and a hysteresis MTR are provided. The hysteresis MTR is set higher than the normal MTR and functions as a maximum pacing rate. When an atrial rate exceeds the hysteresis MTR limit, the maximum pacing rate limit is set to the normal MTR. Once the atrial rate falls below a predetermined threshold, the maximum pacing rate limit is set to the hysteresis MTR. This provides for a more rapid and natural maximum pacing rate limit for a patient, while still protecting the patient from being paced at abnormally high rates.
摘要翻译：心律管理系统提供安全的最大起搏速率限制和生理最大起搏速率限制。在一个实施例中，提供正常的最大跟踪率（MTR）和滞后MTR。滞后MTR设置为高于正常MTR，并作为最大起搏速率。当心房率超过滞后MTR限制时，最高起搏速率限制设置为正常MTR。一旦心房率下降到预定阈值以下，最大起搏速率限制被设定为迟滞MTR。这为患者提供了更快速和自然的最大起搏速率限制，同时仍然保护患者不会以异常高的速率起搏。

87. 发明申请

US20130190840A1 SYSTEMS AND METHODS FOR AVOIDING NEURAL STIMULATION HABITUATION 有权
标题翻译：用于避免神经刺激症状的系统和方法
公开(公告)号：US20130190840A1
公开(公告)日：2013-07-25
申请号：US13793702
申请日：2013-03-11
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36057 , A61N1/36114 , A61N1/36167 , A61N1/37235
摘要： An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.
摘要翻译：一个实施方案涉及一种用于将迷走神经刺激治疗递送至迷走神经的方法，包括递送神经刺激信号以根据迷走神经刺激治疗的预定时间表非迷走神经中的输入轴突和传出轴突两者非选择性地刺激，以及选择用于迷走神经刺激治疗的预定时间表的至少一个参数的值以控制神经刺激疗法以避免迷走神经刺激治疗的生理习惯。该参数包括从由用于预定治疗期间的预定治疗持续时间参数组成的参数组中选择的至少一个参数以及与用于间歇神经刺激参数的开启/关闭定时相关联的预定间歇神经刺激参数。

88. 发明授权

US08369948B2 Apparatus for reversal of myocardial remodeling with pre-excitation 有权
标题翻译：用于预激发反转心肌重塑的装置
公开(公告)号：US08369948B2
公开(公告)日：2013-02-05
申请号：US13279493
申请日：2011-10-24
申请人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Andrew P. Kramer , Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/365 , A61N1/36542 , A61N1/36585 , A61N1/368
摘要： An apparatus for reversing ventricular remodeling with electro-stimulatory therapy. A ventricle is paced by delivering one or more stimulatory pulses in a manner such that a stressed region of the myocardium is pre-excited relative to other regions in order to subject the stressed region to a lessened preload and afterload during systole. The unloading of the stressed myocardium over time effects reversal of undesirable ventricular remodeling.
摘要翻译：用电刺激治疗逆转心室重构的装置。通过递送一个或多个刺激脉冲以使得相对于其它区域预激励心肌的应激区域以使受压区域在收缩期间减轻预负荷和后负荷来起搏心室。随着时间的推移，应力心肌的卸载会影响不良心室重构的逆转。

89. 发明申请

US20120310295A1 SYSTEMS AND METHODS FOR AVOIDING NEURAL STIMULATION HABITUATION 有权
标题翻译：用于避免神经刺激症状的系统和方法
公开(公告)号：US20120310295A1
公开(公告)日：2012-12-06
申请号：US13585466
申请日：2012-08-14
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/36117 , A61N1/36053 , A61N1/36057 , A61N1/36114 , A61N1/36167 , A61N1/37235
摘要： An embodiment relates to a method for delivering a vagal stimulation therapy to a vagus nerve, including delivering a neural stimulation signal to non-selectively stimulate both afferent axons and efferent axons in the vagus nerve according to a predetermined schedule for the vagal stimulation therapy, and selecting a value for at least one parameter for the predetermined schedule for the vagal stimulation therapy to control the neural stimulation therapy to avoid physiological habituation to the vagal stimulation therapy. The parameter(s) include at least one parameter selected from the group of parameters consisting of a predetermined therapy duration parameter for a predetermined therapy period, and a predetermined intermittent neural stimulation parameter associated with on/off timing for the intermittent neural stimulation parameter.
摘要翻译：一个实施方案涉及一种用于将迷走神经刺激治疗递送至迷走神经的方法，包括递送神经刺激信号以根据迷走神经刺激治疗的预定时间表非迷走神经中的输入轴突和传出轴突两者非选择性地刺激，以及选择用于迷走神经刺激治疗的预定时间表的至少一个参数的值以控制神经刺激疗法以避免迷走神经刺激治疗的生理习惯。该参数包括从由用于预定治疗期间的预定治疗持续时间参数组成的参数组中选择的至少一个参数以及与用于间歇神经刺激参数的开启/关闭定时相关联的预定间歇神经刺激参数。

90. 发明申请

US20120215276A1 SYSTEMS, DEVICES AND METHODS USED IN VERIFYING NEURAL STIMULATION CAPTURE 有权
标题翻译：用于验证神经刺激捕获的系统，设备和方法
公开(公告)号：US20120215276A1
公开(公告)日：2012-08-23
申请号：US13460949
申请日：2012-05-01
申请人： Imad Libbus , Andrew P. Kramer
发明人： Imad Libbus , Andrew P. Kramer
IPC分类号： A61N1/37
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Various system embodiments comprise a neural stimulator, a premature ventricular contraction (PVC) event detector, a heart rate detector, an analyzer, and a controller. The neural stimulator is adapted to generate a stimulation signal adapted to stimulate an autonomic neural target. The analyzer is adapted to, in response to a PVC event signal from the PVC event detector, generate an autonomic balance indicator (ABI) as a function of pre-PVC heart rate data and post-PVC heart rate data. Other aspects and embodiments are provided herein.
摘要翻译：各种系统实施例包括神经刺激器，早产性心室收缩（PVC）事件检测器，心率检测器，分析器和控制器。神经刺激器适于产生适于刺激自主神经靶标的刺激信号。分析器适于响应来自PVC事件检测器的PVC事件信号，产生作为PVC前心率数据和PVC后心率数据的函数的自主平衡指示器（ABI）。本文提供了其它方面和实施例。

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