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81. 发明授权

US5858714A Human metaxin protein 失效
标题翻译：人类metaxin蛋白
公开(公告)号：US5858714A
公开(公告)日：1999-01-12
申请号：US864799
申请日：1997-05-29
申请人： Jennifer L. Hillman , Neil C. Corley , Purvi Shah
发明人： Jennifer L. Hillman , Neil C. Corley , Purvi Shah
IPC分类号： A61K38/00 , C07K14/47 , C12N1/21 , C12N15/12 , C12N15/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The invention provides a human metaxin protein and polynucleotides which identify and encode MTXP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MTXP-1.
摘要翻译：本发明提供鉴定和编码MTXP-1的人类metaxin蛋白和多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与MTXP-1表达相关的疾病的方法。

82. 发明授权

US5858712A CDNA encoding a LEA-motif developmental protein homologous to avian px19 失效
标题翻译： CDNA编码与禽类px19同源的LEA基序发育蛋白
公开(公告)号：US5858712A
公开(公告)日：1999-01-12
申请号：US796676
申请日：1997-02-06
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K14/435
CPC分类号： C07K14/4702 , A61K38/00
摘要： px19 is an avian gene recently identified as a bromodexoyuridine (BrdU)-sensitive transcript associated with hematopoiesis in early chick development. Its translation product contains an "LEA" (late embryogenesis abundant) motif which had previously been observed only in plant seed proteins. The present invention provides nucleic acids encoding a human LEA motif protein (HuLEAP) homologous to the avian px19 gene product. Also provided are expression vectors, transformed host cells, and methods of using them to produce recombinant HuLEAP polypeptides.
摘要翻译： px19是一种禽类基因，最近被鉴定为与早期小鸡发育中造血作用相关的溴代维甲酸（BrdU）敏感转录物。其翻译产品含有以前仅在植物种子蛋白中观察到的“LEA”（晚期胚胎发生丰富）基序。本发明提供编码与禽类px19基因产物同源的人LEA基序蛋白（HuLEAP）的核酸。还提供了表达载体，转化的宿主细胞和使用它们产生重组HuLEAP多肽的方法。

83. 发明授权

US5856139A Proline-rich acidic protein 失效
标题翻译：脯氨酸丰富的酸性蛋白
公开(公告)号：US5856139A
公开(公告)日：1999-01-05
申请号：US815175
申请日：1997-03-11
申请人： Preeti Lal , Jennifer L. Hillman , Surya K. Goli
发明人： Preeti Lal , Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K14/47 , C12N15/12 , C12N15/00 , C07H21/04 , C12N1/20 , C12P21/02
CPC分类号： C07K14/47
摘要： The present invention provides a human proline-rich acidic protein (PRAP) and polynucleotides which identify and encode PRAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, or antagonists. This invention also provides methods for preventing or treating disorders associated with the expression of PRAP.
摘要翻译：本发明提供了富含脯氨酸的酸性蛋白（PRAP）和识别和编码PRAP的多核苷酸。此外，本发明提供表达载体和宿主细胞，激动剂，抗体或拮抗剂。本发明还提供了预防或治疗与PRAP表达相关的疾病的方法。

84. 发明授权

US5856131A Human selenoprotein 失效
公开(公告)号：US5856131A
公开(公告)日：1999-01-05
申请号：US807043
申请日：1997-02-24
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： A61K38/00 , C07K14/47 , C12P21/06 , C07H21/04 , C12N1/21 , C12N15/63
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human selenoprotein (HSEL) and polynucleotides which identify and encode HSEL. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HSEL and a method for producing HSEL. The invention also provides for agonists, antibodies, or antagonists specifically binding HSEL, and their use, in the prevention and treatment of diseases associated with expression of HSEL. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HSEL for the treatment of diseases associated with the expression of HSEL. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HSEL.

85. 发明授权

US5847093A Human apoptosis regulator 失效
标题翻译：人类凋亡调节因子
公开(公告)号：US5847093A
公开(公告)日：1998-12-08
申请号：US773910
申请日：1996-12-27
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P7/06 , A61P9/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译：本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。

86. 发明授权

US5843665A Human pyrophosphatase 失效
公开(公告)号：US5843665A
公开(公告)日：1998-12-01
申请号：US741437
申请日：1996-10-31
申请人： Phillip R. Hawkins , Jennifer L. Hillman
发明人： Phillip R. Hawkins , Jennifer L. Hillman
IPC分类号： A61P29/00 , A61P35/00 , C12N9/14 , C12Q1/68 , C07H21/04 , C12P19/34
CPC分类号： C12N9/14
摘要： The present invention provides a human pyrophosphatase (HPYP) and polynucleotides which identify and encode HPYP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPYP and a method for producing HPYP. The invention also provides for use of HPYP and agonists, antibodies, or antagonists specifically binding HPYP, in the prevention and treatment of cancer and inflammatory diseases. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPYP for the treatment of diseases associated with the expression of HPYP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPYP.

87. 发明授权

US5840559A Human spermidine/spermine N1-acetyltransferase 失效
公开(公告)号：US5840559A
公开(公告)日：1998-11-24
申请号：US742009
申请日：1996-10-30
申请人： Jennifer L. Hillman
发明人： Jennifer L. Hillman
IPC分类号： A61K38/00 , A61P35/00 , C12N9/10 , C12N15/54 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1029 , A61K38/00
摘要： The present invention provides a human spermidine/spermine N1-acetyltransferase (S-ACTR) and polynucleotides which identify and encode S-ACTR. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding S-ACTR and a method for producing S-ACTR. The invention also provides for use of S-ACTR and agonists, antibodies, or antagonists specifically binding S-ACTR, in the prevention and treatment of cancers. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding S-ACTR for the treatment of diseases associated with the expression of S-ACTR. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, or antibodies specifically binding S-ACTR.

88. 发明授权

US5814451A Subunits of NADH dehydrogenase 失效
公开(公告)号：US5814451A
公开(公告)日：1998-09-29
申请号：US785065
申请日：1997-01-17
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： A61K38/00 , C12N9/02 , C12N15/53 , C12P21/08 , C12Q1/68 , C12N9/06
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

89. 发明授权

US5795724A Human N-acetyl transferase 失效
公开(公告)号：US5795724A
公开(公告)日：1998-08-18
申请号：US928443
申请日：1997-09-12
申请人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
发明人： Jennifer L. Hillman , Y. Tom Tang , Neil C. Corley
IPC分类号： A61K38/00 , C12N9/10 , C12N15/54 , C12Q1/68
CPC分类号： C12N9/104 , C12Q1/6883 , A61K38/00 , C12Q2600/158
摘要： The invention provides a human N-acetyl transferase (NACTH) and polynucleotides which identify and encode NACTH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of NACTH.

90. 发明授权

US5763589A Human membrane protein 失效
标题翻译：人膜蛋白
公开(公告)号：US5763589A
公开(公告)日：1998-06-09
申请号：US781562
申请日：1997-01-09
申请人： Jennifer L. Hillman , Surya K. Goli
发明人： Jennifer L. Hillman , Surya K. Goli
IPC分类号： C07K14/705 , C12N1/21 , C12N15/12 , C07H21/04 , C12N15/63
CPC分类号： C07K14/705
摘要： The present invention provides a novel human integral membrane (IMP) and polynucleotides which identify and encode IMP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding IMP and a method for producing IMP. The invention also provides for agonists, antibodies, or antagonists specifically binding IMP, and their use, in the prevention and treatment of diseases associated with expression of IMP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding IMP for the treatment of diseases associated with the expression of IMP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding IMP.
摘要翻译：本发明提供了一种新型人体内膜（IMP）和识别和编码IMP的多核苷酸。本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码IMP的核酸序列和产生IMP的方法。本发明还提供特异性结合IMP的激动剂，抗体或拮抗剂及其在预防和治疗与IMP表达有关的疾病中的用途。另外，本发明提供了反义分子用于编码IMP的多核苷酸用于治疗与IMP表达相关的疾病。本发明还提供利用多核苷酸或其片段或其互补体和特异性结合IMP的抗体的诊断测定法。

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