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81. 发明申请

US20060183901A1 Crystalline form of an indazole-carboxamide compound 审中-公开
标题翻译：吲唑 - 甲酰胺化合物的结晶形式
公开(公告)号：US20060183901A1
公开(公告)日：2006-08-17
申请号：US11355323
申请日：2006-02-16
申请人： Paul Fatheree , S. Turner , Robert Chao , Jyanwei Liu , Hao Zhang , Daniel Genov , Junning Lee
发明人： Paul Fatheree , S. Turner , Robert Chao , Jyanwei Liu , Hao Zhang , Daniel Genov , Junning Lee
IPC分类号： C07D403/14
CPC分类号： C07D451/04
摘要： The invention provides crystalline halide salts of 1-isopropyl-1H-indazole-3-carboxylic acid {(1S,3R,5R)-8-[2-(4-acetylpiperazin-1-yl)ethyl]-8-azabicyclo[3.2.1]oct-3-yl}amide and solvates thereof. The invention also provides pharmaceutical compositions comprising such salts, methods of using such crystalline salts to treat diseases associated with 5-HT4 receptor activity, and processes useful for preparing such crystalline salts.
摘要翻译：本发明提供1-异丙基-1H-吲唑-3-羧酸{（1S，3R，5R）-8- [2-（4-乙酰基哌嗪-1-基）乙基] -8-氮杂双环[3.2 .1]辛-3-基}酰胺及其溶剂合物。本发明还提供包含这些盐的药物组合物，使用这种结晶盐治疗与5-HT 4受体活性有关的疾病的方法，以及可用于制备此类结晶盐的方法。

82. 发明授权

US06453648B1 Method for manufacturing a heat generating apparatus 有权
标题翻译：制造发热装置的方法
公开(公告)号：US06453648B1
公开(公告)日：2002-09-24
申请号：US09347963
申请日：1999-07-06
申请人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
发明人： Jie Zhang , Hao Zhang , Larry Rigby , Wade A. Hull
IPC分类号： A61F700
CPC分类号： A61F7/034 , A61F2007/0226 , A61F2007/0249
摘要： The present invention relates to a method for manufacturing a heating device which is capable of generating heat when exposed to oxygen. The heat generating element comprises activated carbon and iron is used to generate an exothermic oxidation reaction within the heating device. Introducing an oxidation inhibitor during the manufacturing process allows the manufacturing of the device to take place in ambient atmospheric conditions. The present invention also includes a loading facilitator which allows the heat generating medium to be more easily and efficiently loaded into the heat generating device. When appropriate, the oxidation inhibitor and loading facilitator can be removed.
摘要翻译：本发明涉及一种能够在暴露于氧气时产生热量的加热装置的制造方法。发热元件包括活性炭和铁，用于在加热装置内产生放热氧化反应。在制造过程中引入氧化抑制剂可使装置的制造在环境大气条件下进行。本发明还包括能够使发热介质更容易且有效地装载到发热装置中的负载辅助装置。适当时，可以除去氧化抑制剂和负载促进剂。

83. 发明授权

US06284266B1 Methods and apparatus for improved administration of fentanyl and sufentanil 失效
标题翻译：改善氟芬太尼和舒芬太尼治疗的方法和装置
公开(公告)号：US06284266B1
公开(公告)日：2001-09-04
申请号：US09162587
申请日：1998-09-29
申请人： Jie Zhang , Hao Zhang
发明人： Jie Zhang , Hao Zhang
IPC分类号： A61K970
CPC分类号： A61F7/02 , A61B2017/00765 , A61F7/032 , A61F7/034 , A61F2013/00187 , A61F2013/00204 , A61F2013/00906 , A61F2013/0091 , A61K9/0009 , A61K9/0024 , A61K9/7023 , A61K31/4468 , A61K31/4535 , A61M31/002 , A61M37/00 , A61M2037/0007 , A61N1/30
摘要： Methods and apparatus for improving administration of analgesics through the use of heat. The present invention relates to the use of heat in conjunction with specially designed transdermal analgesic delivery systems and conventional commercial transdermal analgesic delivery systems to alter, mainly increase, the analgesic release rate from the transdermal analgesic delivery systems or the depot sites to accommodate certain clinical needs.
摘要翻译：通过使用热量来改善镇痛药的施用方法和装置。本发明涉及加热与特别设计的透皮止痛递送系统和常规商业经皮止痛递送系统的用途，以改变，主要增加经皮止痛剂递送系统或贮库部位的镇痛释放速率以适应某些临床需要。

84. 发明授权

US06264981B1 Oral transmucosal drug dosage using solid solution 有权
标题翻译：口服透粘膜用药剂量使用固体溶液
公开(公告)号：US06264981B1
公开(公告)日：2001-07-24
申请号：US09428071
申请日：1999-10-27
申请人： Hao Zhang , Jed Croft
发明人： Hao Zhang , Jed Croft
IPC分类号： A61K948
CPC分类号： A61K9/0056 , A61K9/006 , A61K9/1694 , A61K9/2009 , A61K9/2013
摘要： The present invention is directed toward formulation and method for oral transmucosal delivery of a pharmaceutical. The invention provides a drug formulation comprising a solid pharmaceutical agent in solid solution with a dissolution agent. The formulation is administered into a patient's oral cavity, delivering the pharmaceutical agent by absorption through a patient's oral mucosal tissue. The formulation and method provide for improved oral mucosal delivery of the pharmaceutical agent.
摘要翻译：本发明涉及口服经粘膜递送药物的制剂和方法。本发明提供一种药物制剂，其包含固体溶剂中的固体药剂与溶解剂。该制剂被施用到患者的口腔中，通过患者的口腔粘膜组织吸收来递送药剂。制剂和方法提供改进的药物的口腔粘膜递送。

85. 发明授权

US06193821B1 Fine grain tantalum sputtering target and fabrication process 有权
标题翻译：细粒钽溅射靶和制造工艺
公开(公告)号：US06193821B1
公开(公告)日：2001-02-27
申请号：US09353700
申请日：1999-07-14
申请人： Hao Zhang
发明人： Hao Zhang
IPC分类号： C22F118
CPC分类号： C23C14/3414 , C22F1/18 , Y10S148/158
摘要： A process for treating substantially pure tantalum includes plastically deformed a billet, such as by side-forging or side-rolling, to reduce a first dimension of the billet transverse to the centerline, preferably by about 70% to about 85%. The billet is then upset, such as by upset forging or upset rolling, to reduce a second dimension of the billet transverse to the first dimension (for example, a second dimension lying parallel to the centerline), preferably by about 90% to about 99%. In accordance with an especially preferred process, the upsetting of the billet is followed by rolling along a plane normal to the second dimension. It has been found that billets prepared in accordance with the invention have grain sizes no greater than about 25 &mgr;m and predominantly textures relative to their rolling planes, so that targets machined from such billets in such a way that their sputtering surfaces correspond with these rolling planes will have the same predominant textures.
摘要翻译：用于处理基本上纯的钽的方法包括例如通过侧锻或侧面轧制来塑性变形坯料，以减少横向于中心线的坯料的第一尺寸，优选地减小约70％至约85％。然后，坯料例如通过镦锻或镦粗轧制而变形，以减小横向于第一尺寸（例如，平行于中心线的第二尺寸）的坯料的第二尺寸，优选地为约90％至约99 ％。根据特别优选的方法，坯料的镦锻随后沿着垂直于第二尺寸的平面滚动。已经发现，根据本发明制备的坯料相对于其轧制平面具有不大于约25μm的颗粒尺寸和主要<222>的纹理，使得从这些坯料加工的靶材使得它们的溅射表面对应于这些滚动平面将具有相同的主要<222>纹理。

86. 发明授权

US11727583B2 Core-level high resolution petrophysical characterization method 有权
公开(公告)号：US11727583B2
公开(公告)日：2023-08-15
申请号：US17010372
申请日：2020-09-02
申请人： Hao Zhang , Stephen Dymmock , Nora Patricia Alarcon , Fei Le
发明人： Hao Zhang , Stephen Dymmock , Nora Patricia Alarcon , Fei Le
IPC分类号： G06T7/50 , E21B47/002 , G06T3/40 , E21B47/12
CPC分类号： G06T7/50 , E21B47/0025 , G06T3/4053 , E21B47/12
摘要： A method for characterizing a subsurface formation includes receiving image data of the subsurface formation obtained by a sensor tool and receiving a plurality of non-image data logs, each non-image data log being obtained by a different type of sensor tool. The method also includes performing an electrofacies analysis on the plurality of non-image data logs where the electrofacies analysis includes defining clusters wherein each cluster has a similar property to provide a plurality of electrofacies blocks with each electrofacies block representing a depth interval. The method further includes partitioning the image data into multiple high-resolution depth segments that share a similar property, feature, and/or pattern for each electrofacies block and assigning data from the plurality of non-image data logs into a corresponding high-resolution depth segment to provide a high-resolution data log that characterizes the subsurface formation.

87. 发明授权

US11499686B1 X-axis curvable LED lighting system and method of use 有权
公开(公告)号：US11499686B1
公开(公告)日：2022-11-15
申请号：US17479736
申请日：2021-09-20
申请人： Daniel Machlis , Eva Lu , Hao Zhang
发明人： Daniel Machlis , Eva Lu , Hao Zhang
IPC分类号： F21S4/28 , F21V5/04 , F21Y103/10 , F21Y115/10
摘要： An x-axis curvable LED lighting system includes an elongated notched x-axis curved channel enclosed in a casing which can be freely bent without a machine having a bottom portion and one or more walls extending therefrom; an elongated lens to secure over a top of the elongated curved channel; and a flexible light strip, having a mounting strip to secure to one of the one or more walls of the elongated curved channel; LED lights attached to the mounting strip by an extension such that the LED lights are positioned within the elongated curved channel along the bottom portion; the LED lights emit light through the elongated lens.

88. 发明申请

US20220017886A1 Linoleic Acid Isomerase and its Application in Production of Conjugated Linoleic Acid 有权
公开(公告)号：US20220017886A1
公开(公告)日：2022-01-20
申请号：US17497963
申请日：2021-10-10
申请人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
发明人： Haiqin Chen , Bo Yang , He Gao , Jianxin Zhao , Yongquan Chen , Hao Zhang , Wei Chen
IPC分类号： C12N9/90 , C12P7/64
摘要： Disclosed is linoleic acid isomerases and their application in production of conjugated linoleic acid, which belongs to the technical fields of protein engineering and microbial engineering. The linoleic acid isomerase derived from Bifidobacterium is used to produce the conjugated linoleic acid. The recombinant E. coli containing the linoleic acid isomerase of the invention is added into a reaction system containing linoleic acid and react for 3 h to produce conjugated linoleic acids. The conversion rate of the conjugated linoleic acid of the invented method ranges from 12.1% to 42.1%, and the percentage of cis9, trans11-CLA in the conjugated linoleic acid can reach 84.3% to 89.1%. The invention provides a method for using microorganisms to produce conjugated linoleic acids with high safety and yield where cis9, trans11-CLA isomer is the major form in the conjugated linoleic acid products.

89. 发明申请

US20210403884A1 Diacylglycerol Acyltransferase 1 and Application Thereof in Production of Triacylglycerol 有权
公开(公告)号：US20210403884A1
公开(公告)日：2021-12-30
申请号：US17469899
申请日：2021-09-09
申请人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
发明人： Haiqin Chen , Wei Chen , Xin Tang , Jun Cao , Jianxin Zhao , Yongquan Chen , Hao Zhang
IPC分类号： C12N9/10 , C12P7/64
摘要： Disclosed is a diacylglycerol acyltransferase 1, a recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1, and application thereof in production of triacylglycerol. The diacylglycerol acyltransferase 1 of the invention has a function of catalyzing synthesis of triacylglycerol. After the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 of the invention is subjected to induction culture for 48 h, the content of total fatty acid and triacylglycerol in the recombinant Saccharomyces cerevisiae containing the diacylglycerol acyltransferase 1 can be respectively increased by 1.94 folds and 12.09 folds as compared with those of Saccharomyces cerevisiae without the recombinant diacylglycerol acyltransferase 1. The instant invention provides a method for improving the ability of microorganisms to produce polyunsaturated fatty acids (PUFAs) by means of genetic engineering.

90. 发明申请

US20190235109A1 GENERATING A HIGH-RESOLUTION LITHOLOGY MODEL FOR SUBSURFACE FORMATION EVALUATION 审中-公开
公开(公告)号：US20190235109A1
公开(公告)日：2019-08-01
申请号：US15883817
申请日：2018-01-30
申请人： Hao Zhang , Alberto Mezzatesta
发明人： Hao Zhang , Alberto Mezzatesta
IPC分类号： G01V1/30 , E21B7/06 , G01V1/50 , C09K8/62 , E21B49/00 , G01V1/28 , G01V5/10 , G01V3/08 , G01V99/00
摘要： Examples of techniques for generating a high-resolution lithology model for subsurface formation evaluation are disclosed. In one example implementation according to aspects of the present disclosure, a computer-implemented method includes determining, by a processing device, a low-resolution lithology volumetric model. The method further includes comparing, by the processing device, the low-resolution lithology volumetric model to a high-resolution imaging log. The method further includes calculating, by the processing device, a dynamic boundary curve for each of a plurality of moving windows. The method further includes generating, by the processing device, the high-resolution lithology model based at least in part on the calculated dynamic boundary curve for each of the plurality of moving windows. The method further includes controlling a drilling operation based at least in part on the high-resolution lithology model.

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