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81. 发明授权

US06590109B2 Method for isolating terpene trilactones (ginkgolides, bilobalide) from leaves and pharmaceutical powders of ginkgo biloba 失效
标题翻译：从叶片和银杏叶药物粉末中分离萜内三聚物（银杏内酯，银杏内酯）的方法
公开(公告)号：US06590109B2
公开(公告)日：2003-07-08
申请号：US10194089
申请日：2002-07-11
申请人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
发明人： Dirk Lichtblau , Nina Berova , John Berger , Koji Nakanishi
IPC分类号： C07D30793
CPC分类号： C07D307/77 , A61K31/365 , A61K36/16
摘要： A method of isolating terpene trilactones from Ginkgo biloba plant material or extract comprising the steps of suspending the plant material or extract in either water or an aqueous solution of an oxidation reagent; extracting the terpene trilactones using an acceptable extraction agent; separating the organic layer from the aqueous layer; washing the organic layer with an acceptable aqueous salt or hydroxide solution, which may be an alkaline solution; and drying the organic layer to form a dried extract containing terpene trilactones. Further purification by treatment with or filtration over activated charcoal, by treatment with or filtration over alumina and by recrystallization with an acceptable solvent or solvent mixture leads to extracts with a content of terpene trilactones higher than 50%. Unwanted levels of ginkgolic acids are reduced to acceptable levels by reversed phase chromatography.
摘要翻译：从银杏植物材料或提取物中分离萜品三内酯的方法，包括将植物材料或提取物悬浮在水或氧化试剂的水溶液中的步骤; 使用可接受的提取剂萃取萜烯三内酯; 从水层分离有机层; 用可接受的盐或氢氧化物溶液洗涤有机层，其可以是碱性溶液; 并干燥有机层以形成含有萜烯三内酯的干燥提取物。通过用活性炭处理或过滤进一步纯化，通过在氧化铝上处理或过滤，并用可接受的溶剂或溶剂混合物重结晶，得到萜烯三内酯的含量高于50％的提取物。不需要的银杏酸水平通过反相色谱法降至可接受的水平。

82. 发明授权

US06362288B1 Thermoplastic silicone elastomers from compatibilized polyamide resins 有权
标题翻译：来自相容聚酰胺树脂的热塑性硅橡胶
公开(公告)号：US06362288B1
公开(公告)日：2002-03-26
申请号：US09616625
申请日：2000-07-26
申请人： Christopher Michael Brewer , Igor Chorvath , Michael K. Lee , Yongjun Lee , Dawei Li , Koji Nakanishi , Robert Leo Oldinski , Lenin James Petroff , Richard L. Rabe , David Joseph Romenesko
发明人： Christopher Michael Brewer , Igor Chorvath , Michael K. Lee , Yongjun Lee , Dawei Li , Koji Nakanishi , Robert Leo Oldinski , Lenin James Petroff , Richard L. Rabe , David Joseph Romenesko
IPC分类号： G08G7708
CPC分类号： C08L77/02 , C08G77/12 , C08G77/14 , C08G77/16 , C08G77/18 , C08G77/20 , C08G77/26 , C08G77/44 , C08G77/445 , C08G77/448 , C08G77/455 , C08G77/458 , C08G77/46 , C08L77/00 , C08L77/06 , C08L83/04 , Y10S525/903 , C08L83/00 , C08L2666/14
摘要： A method for preparing a thermoplastic elastomer is disclosed, said method comprising (I) mixing (A) a rheologically stable polyamide resin having a melting point or glass transition temperature of 25° C. to 275° C., (B) a silicone base comprising (B′) 100 parts by weight of a diorganopolysiloxane gum having a plasticity of at least 30 and having an average of at least 2 alkenyl groups in its molecule and (B″) 5 to 200 parts by weight of a reinforcing filler, the weight ratio of said silicone base to said polyamide resin being greater than 35:65 to 85:15, (C) a compatibilizer selected from (i) a coupling agent, (ii) a functional diorganopolysiloxane or (iii) a copolymer comprising at least one diorganopolysiloxane block and at least one block selected from polyamide, polyether, polyurethane, polyurea, polycarbonate or polyacrylate, (D) an organohydrido silicon compound which contains an average of at least 2 silicon-bonded hydrogen groups in its molecule and (E) a hydrosilation catalyst, components (D) and (E) being present in an amount sufficient to cure said diorganopolysiloxane (B′); and (II) dynamically curing said diorganopolysiloxane (B′).
摘要翻译：公开了一种制备热塑性弹性体的方法，所述方法包括（I）混合（A）熔点或玻璃化转变温度为25℃至275℃的流变学稳定的聚酰胺树脂，（B）硅氧烷基包含（B'）100重量份的可塑性为至少30且在其分子中平均具有至少2个烯基的二有机聚硅氧烷胶，（B“）为（B”）5〜200重量份的增强填料，所述硅氧烷基与所述聚酰胺树脂的重量比大于35:65至85:15，（C）选自（i）偶联剂，（ii）官能二有机聚硅氧烷或（iii）共聚物的增容剂，至少一个二有机聚硅氧烷嵌段和至少一个选自聚酰胺，聚醚，聚氨酯，聚脲，聚碳酸酯或聚丙烯酸酯的嵌段;（D）在其分子中平均含有至少2个与硅键合的氢基团的有机氢化硅化合物，（E）硅氢化催化剂部分（D）和（E）以足以固化所述二有机聚硅氧烷（B'）的量存在; 和（II）动态固化所述二有机聚硅氧烷（B'）。

83. 发明授权

US06362287B1 Thermoplastic silicone elastomers formed from nylon resins 有权
标题翻译：由尼龙树脂形成的热塑性硅橡胶
公开(公告)号：US06362287B1
公开(公告)日：2002-03-26
申请号：US09535556
申请日：2000-03-27
申请人： Igor Chorvath , Michael K. Lee , Yongjun Lee , Dawei Li , Koji Nakanishi , Robert Leo Oldinski , Richard L. Rabe , David Joseph Romenesko , Jeffrey Paul Sage
发明人： Igor Chorvath , Michael K. Lee , Yongjun Lee , Dawei Li , Koji Nakanishi , Robert Leo Oldinski , Richard L. Rabe , David Joseph Romenesko , Jeffrey Paul Sage
IPC分类号： C08G7708
CPC分类号： C08L83/04 , C08G77/12 , C08G77/20 , C08G77/44 , Y10S525/903 , C08L2666/14 , C08L2666/28
摘要： A method for preparing a thermoplastic elastomer is disclosed, said method comprising (I) mixing (A) a rheologically stable polyamide resin having a melting point or glass transition temperature of 25° C. to 275° C., (B) a silicone base comprising (B′) 100 parts by weight of a diorganopolysiloxane gum having a plasticity of at least 30 and having an average of at least 2 alkenyl radicals in its molecule and (B″) 5 to 200 parts by weight of a reinforcing filler, the weight ratio of said silicone base to said polyamide resin being greater than 35:65 to 85:15, (C) 0.1 to 5 parts by weight of a hindered phenol compound for each 100 parts by weight of said polyamide and said silicone base, (D) an organohydrido silicon compound which contains an average of at least 2 silicon-bonded hydrogen groups in its molecule and (E) a hydrosilation catalyst, components (D) and (E) being present in an amount sufficient to cure said diorganopolysiloxane (B′); and (II) dynamically curing said diorganopolysiloxane (B′), wherein at least one property of the thermoplastic elastomer selected from tensile strength or elongation is at least 25% greater than the respective property for a corresponding simple blend wherein said diorganopolysiloxane is not cured and said thermoplastic elastomer has an elongation of at least 25%.
摘要翻译：公开了一种制备热塑性弹性体的方法，所述方法包括（I）混合（A）熔点或玻璃化转变温度为25℃至275℃的流变学稳定的聚酰胺树脂，（B）硅氧烷基包含（B'）100重量份的塑性为至少30的二有机聚硅氧烷胶，其分子中平均具有至少2个烯基，（B“）为5〜200重量份的增强填料，所述硅氧烷基与所述聚酰胺树脂的重量比大于35:65至85:15，（C）每100重量份所述聚酰胺和所述有机硅基料为0.1至5重量份的受阻酚化合物，（D）在其分子中平均含有至少2个与硅键合的氢基团的有机氢化硅化合物，（E）硅氢化催化剂，组分（D）和（E）以足以固化所述二有机聚硅氧烷的量存在 B'）; 和（II）动态固化所述二有机聚硅氧烷（B'），其中选自拉伸强度或伸长率的热塑性弹性体的至少一种性能比相应的简单混合物的相应性能大至少25％，其中所述二有机聚硅氧烷不固化，所述热塑性弹性体的伸长率至少为25％。

84. 发明授权

US6068703A Gas mixing apparatus and method 失效
标题翻译：气体混合装置及方法
公开(公告)号：US6068703A
公开(公告)日：2000-05-30
申请号：US893414
申请日：1997-07-11
申请人： Chen-An Chen , Koji Nakanishi , Aihua Chen
发明人： Chen-An Chen , Koji Nakanishi , Aihua Chen
IPC分类号： B01F3/02 , B01F5/06 , C23C16/44 , C23C16/455 , C23C16/511 , H01J37/32 , H01L21/285 , C23C16/00
CPC分类号： C23C16/45512 , B01F5/064 , B01F5/0656 , B01F5/0665 , C23C16/455 , H01J37/3244 , B01F3/02
摘要： The present invention provides apparatus, systems, and methods related to the manufacture of integrated circuits. Specifically, embodiments of the present invention include apparatus designed to provide thorough and reliable fluid mixture for gases used in a semiconductor processing system. In one embodiment of the invention, the gas mixing apparatus comprises a gas mixer housing having a gas inlet, a fluid flow channel, and a gas outlet. The fluid flow channel is fluidly coupled to a plurality of gas sources. The majority of the gas mixture occurs in the fluid flow channel which comprises one or more fluid separators for separating the gas into two or more gas portions and one or more fluid collectors for allowing the gas portions to collide with each other to mix the gas portions. This separation and collection of the gas portions results in a thoroughly mixed gas.
摘要翻译：本发明提供了与集成电路的制造相关的装置，系统和方法。具体地，本发明的实施例包括设计成为半导体处理系统中使用的气体提供彻底且可靠的流体混合物的装置。在本发明的一个实施例中，气体混合装置包括具有气体入口，流体流动通道和气体出口的气体混合器壳体。流体流动通道流体耦合到多个气体源。大部分气体混合物发生在流体流动通道中，流体流动通道包括一个或多个流体分离器，用于将气体分离成两个或更多个气体部分和一个或多个流体收集器，用于允许气体部分相互碰撞以混合气体部分。气体部分的分离和收集导致充分混合的气体。

85. 发明授权

US6001824A Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same 失效
标题翻译：丁酰基 - 酪氨酰基精胺，其类似物及其制备和使用方法
公开(公告)号：US6001824A
公开(公告)日：1999-12-14
申请号：US376924
申请日：1995-01-23
申请人： Koji Nakanishi , Danwen Huang , Seok-Ki Choi , Aristotle Kalivretenos , Robert Goodnow
发明人： Koji Nakanishi , Danwen Huang , Seok-Ki Choi , Aristotle Kalivretenos , Robert Goodnow
IPC分类号： C07C237/22 , C07C245/18 , C07C247/16 , C07C247/18 , C07C279/14 , A61K31/655
CPC分类号： C07C279/14 , C07C237/22 , C07C245/18 , C07C247/16 , C07C247/18
摘要： The present invention provides a compound having the structure: ##STR1## wherein R.sub.1 is a saturated or unsaturated linear or branched chain alkyl group, or a cholestanyl group; wherein R.sub.2 is a 2-indolyl, 3-indolyl, 4-indolyl, 5-indolyl, 4-hydroxyphenyl, 4-(arylalkyloxy)phenyl, 3,4-dihalophenyl, 4-hydroxy-3,5-dihalophenyl, 4-azidophenyl or 4-halophenyl group; wherein R.sub.3 is H, a linear or branched chain alkyl or alkenyl group, or a phenyl, 2-azidophenyl, 3-azidophenyl, 4-azidophenyl group, or an a alkenylacyl, 3-amino-3-butylpropyl, N-[N-(N-{4-azidobenzoyl}aminopropyl) aminopropyl], cis- or trans-cinnamyl, 2-amino-2-[(4'-azidophenyl)acetyl, (trifluoromethyl)aminoacetyl or D- or L-arginyl group bonded through the .alpha.-carbonyl moiety thereof; R.sub.4 is H, or a linear or branched chain alkyl group; wherein R.sub.5, R.sub.6 and R.sub.7 are independently the same or different and are H, a linear or branched chain alkyl group, an aryl group or an arylalkyl group; wherein n, j and t are each 0 or 1; wherein m, o, p, q, r and s are independently the same or different and are 0, 1 or 2; wherein r+s and m+o are each equal to 2; wherein, if j is 0, p+q is 2; wherein, if j is 1, then p is 1, q is 0 and R.sub.6 is H; and wherein * denotes a D or L configuration. The invention also provides a method of synthesizing the compound. Another aspect of the invention concerns a method of treating a subject afflicted by a disorder associated with binding of an etiological agent to a glutamate receptor.
摘要翻译：本发明提供具有以下结构的化合物：其中R1是饱和或不饱和的直链或支链烷基或胆甾烷基; 其中R2是2-吲哚基，3-吲哚基，4-吲哚基，5-吲哚基，4-羟基苯基，4-（芳基烷氧基）苯基，3,4-二卤代苯基，4-羟基-3,5-二卤代苯基，4-叠氮基苯基或4-卤代苯基; 其中R 3为H，直链或支链烷基或烯基，或苯基，2-叠氮基苯基，3-叠氮基苯基，4-叠氮基苯基或链烯基酰基，3-氨基-3-丁基丙基，N- [N- （N- {4-叠氮基苯甲酰基}氨基丙基）氨基丙基]，顺式或反式肉桂基，2-氨基-2 - [（4'-叠氮基苯基）乙酰基，（三氟甲基）氨基乙酰基或D-或L-精氨酰基其α-羰基部分; R4是H或直链或支链烷基; 其中R5，R6和R7独立地相同或不同，为H，直链或支链烷基，芳基或芳基烷基; 其中n，j和t各自为0或1; 其中m，o，p，q，r和s独立地相同或不同，为0,1或2; 其中r + s和m + o各自等于2; 其中，如果j是0，p + q是2; 其中，如果j为1，则p为1，q为0且R6为H; 并且其中*表示D或L构型。本发明还提供了一种合成化合物的方法。本发明的另一方面涉及一种治疗受病原体与谷氨酸受体的结合相关疾病的受试者的治疗方法。

86. 发明授权

US5945475A Silicone release coating compositions 失效
标题翻译：硅酮脱模涂料组合物
公开(公告)号：US5945475A
公开(公告)日：1999-08-31
申请号：US978078
申请日：1997-11-25
申请人： Takateru Yamada , Taku Koyama , Koji Nakanishi
发明人： Takateru Yamada , Taku Koyama , Koji Nakanishi
IPC分类号： C08L83/07 , C08K5/05 , C08K5/5419 , C09D5/20 , C09D183/04 , C09D183/07 , C08K5/54
CPC分类号： C08K5/5419 , C08K5/05 , C09D183/04
摘要： This invention relates to a silicone release coating composition comprising (A) a diorganopolysiloxane having at least two alkenyl groups in each molecule, (B) an organohydrogenpolysiloxane having at least three silicon-bonded hydrogen atoms in each molecule, (C) a mixture of an alkynyl alcohol and an organosiloxane having at least one aliphatic triple bond-containing alkoxy group, and (D) a platinum group metal catalyst. The silicone release coating compositions of this invention have superior curability and storage stability at room temperature, and produce a uniform coating when used in thin film form on applicator rolls.
摘要翻译：本发明涉及有机硅剥离涂料组合物，其包含（A）在每个分子中具有至少两个烯基的二有机聚硅氧烷，（B）每个分子中具有至少三个与硅键合的氢原子的有机氢聚硅氧烷，（C）炔基醇和具有至少一个含脂肪族三键的烷氧基的有机硅氧烷，（D）铂族金属催化剂。本发明的有机硅剥离涂料组合物在室温下具有优异的固化性和储存稳定性，并且当在涂布辊上以薄膜形式使用时产生均匀的涂层。

87. 发明授权

US5786391A Regulating gene expression using retinoids with Ch.sub.2 OH or related groups at the side chain terminal position 失效
标题翻译：调节基因表达，使用类视黄醇与Ch2OH或相关基团在侧链末端位置
公开(公告)号：US5786391A
公开(公告)日：1998-07-28
申请号：US371535
申请日：1995-01-11
申请人： Lorraine J. Gudas , Charles Achkar , Jochen Buck , Alexander W. Langston , Fadila Derguini , Koji Nakanishi
发明人： Lorraine J. Gudas , Charles Achkar , Jochen Buck , Alexander W. Langston , Fadila Derguini , Koji Nakanishi
IPC分类号： A61K31/07 , A61K31/075 , A61K31/122 , A61K31/203 , A61K31/232 , A61K31/115 , A61K31/045 , A61K31/08
CPC分类号： A61K31/07 , A61K31/075 , A61K31/122 , A61K31/203 , A61K31/232
摘要： For the first time, certain retinoids with a side chain terminal CH.sub.2 OH group or ester or ether thereof or aldehyde rather than a side chain terminal COOH group and substitution at the 4-position have been indicated to bind to nuclear receptors and to be biologically active in inducing cell differentiation of normal and tumor cells. These compounds activate gene expression through binding to nuclear receptor proteins. These compounds induce differentiation in normal and cancer cells and are useful for treating leukemias, and lymphomas, squamous cell carcinomas, deep (cystic) acne, psoriasis and photodamaged or aging skin. These compounds have stability and in vitro half-life advantages over and solubility differences from all-trans-retinoic acid and activity advantages over 13-cis retinoic acid.
摘要翻译：具有侧链末端CH 2 OH基团或其酯或醚或具有侧链末端COOH基团的某些类维生素A和第4位的取代已被表明与核受体结合并具有生物学活性诱导正常和肿瘤细胞的细胞分化。这些化合物通过结合核受体蛋白激活基因表达。这些化合物在正常和癌细胞中诱导分化，并且可用于治疗白血病，淋巴瘤，鳞状细胞癌，深（囊性）痤疮，牛皮癣和光损伤或衰老皮肤。与13-顺式视黄酸相比，这些化合物具有超过全反式视黄酸的稳定性和体外半衰期优点和与全反式视黄酸的溶解度差异和活性优势。

88. 发明授权

US4339588A Plant growth regulators comprising 4-hydroxyisoxazole and related compounds 失效
标题翻译：包含4-羟基异恶唑和相关化合物的植物生长调节剂
公开(公告)号：US4339588A
公开(公告)日：1982-07-13
申请号：US277593
申请日：1981-06-26
申请人： Takenori Kusumi , Koji Nakanishi
发明人： Takenori Kusumi , Koji Nakanishi
IPC分类号： A01N43/80 , C07D261/08 , C07D261/12
CPC分类号： A01N43/80 , C07D261/08 , C07D261/12
摘要： The compound 4-hydroxyisoxazole and its lower alkyl and acyl derivatives are useful as plant growth regulators, particularly as herbicides.
摘要翻译：化合物4-羟基异恶唑及其低级烷基和酰基衍生物可用作植物生长调节剂，特别是作为除草剂。

89. 发明授权

US08881362B2 Stator manufacturing method and stator 有权
标题翻译：定子制造方法和定子
公开(公告)号：US08881362B2
公开(公告)日：2014-11-11
申请号：US13673651
申请日：2012-11-09
申请人： Joji Yoshimura , Koji Nakanishi , Yasuhiro Ueno
发明人： Joji Yoshimura , Koji Nakanishi , Yasuhiro Ueno
IPC分类号： H02K15/02 , H02K15/12 , H02K1/18
CPC分类号： H02K15/02 , H02K1/185 , H02K15/022 , H02K15/12 , Y10T29/49801 , Y10T156/10
摘要： In a stator manufacturing method to manufacture a stator in which divided-core assemblies are arranged in a cylindrical shape, each of which includes a divided-core member having a teeth portion on which a coil is wound. In this method, the divided-core assemblies are inserted in the cylindrical shape into a fixed mold, resin sheets containing glass fibers or carbon fibers are disposed on coil-end portions of the cylindrically-arranged divided-core assemblies, and a slide part of a movable mold applies pressure to and molds the resin sheets, thereby combining the divided core assemblies into a single unit. The movable mold is operated to position the divided-core assemblies in place by a cylindrical part and then apply pressure to and mold the resin sheets by the slide part.
摘要翻译：在制造定子的定子制造方法中，其中分割芯组件布置成圆柱形，每个定子制造方法包括具有缠绕线圈的齿部的分离芯构件。在该方法中，分割芯组件以圆柱形插入固定模具中，将包含玻璃纤维或碳纤维的树脂片设置在圆柱形分割芯组件的线圈端部上，并且将滑动部分可移动模具对树脂片材施加压力并成型，从而将分割的芯部组件组合成单个单元。操作可动模具以通过圆柱形部件将分离芯组件定位在适当位置，然后通过滑动部件施加压力并使树脂片模制。

90. 发明申请

US20120141093A1 CONTENT TRANSMISSION/RECEPTION SYSTEM 有权
标题翻译：内容传输/接收系统
公开(公告)号：US20120141093A1
公开(公告)日：2012-06-07
申请号：US13390556
申请日：2011-05-31
申请人： Katsuhisa Yamaguchi , Koji Nakanishi
发明人： Katsuhisa Yamaguchi , Koji Nakanishi
IPC分类号： H04N9/80
CPC分类号： H04N21/4405 , G06F21/10 , G11B20/00086 , G11B20/00492 , G11B2020/10537 , G11B2020/10842 , H04L9/0869 , H04L63/0428 , H04L2209/601 , H04N5/765 , H04N21/432 , H04N21/433 , H04N21/4367 , H04N21/4408 , H04N21/442
摘要： To provide a device that easily judges that content that has been edited and moved back differs from original content. A content transmission device 60 divides edited content composed of partial original content and partial edited content to generate transfer data pieces, generates a nonce value of each piece, encrypts the piece based on the nonce value, and transmits the encrypted transfer data pieces and nonce values. When switch occurs between the partial contents, the device 60 generates nonce value such that discontinuity exists between the generated nonce value and immediately previously generated nonce value. A content reception device 70 receives the encrypted transfer data pieces and nonce values, decrypts the pieces based on the nonce values, writes the transfer data pieces into recording medium. When discontinuity exists between currently received nonce value and immediately previously received nonce value, the device 70 detects reception of partial edited content.
摘要翻译：提供容易判断已编辑和移回的内容与原始内容不同的设备。内容发送装置60将由部分原始内容和部分编辑内容构成的编辑内容分割，生成传送数据，生成每个片段的随机数值，并根据随机数值进行加密，并发送加密的传送数据和随机数值。当在部分内容之间发生切换时，设备60产生随机值，使得在所生成的随机数值和紧接的先前生成的随机值之间存在不连续性。内容接收装置70接收加密的传送数据片段和随机数值，根据随机数值解密片段，将传送数据片段写入记录介质。当在当前接收到的随机数值和紧接在先接收的随机值之间存在不连续性时，设备70检测部分编辑内容的接收。

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