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81. 发明授权

US4452768A Process for removing heavy metal ions from wet-processed phosphoric acid 失效
标题翻译：从湿法磷酸中去除重金属离子的方法
公开(公告)号：US4452768A
公开(公告)日：1984-06-05
申请号：US455252
申请日：1983-01-03
申请人： Reinhard Gradl , Gunther Schimmel , Werner Krause , Gero Heymer
发明人： Reinhard Gradl , Gunther Schimmel , Werner Krause , Gero Heymer
IPC分类号： C01B25/238 , B01D11/04 , C01B25/237 , C01B25/46 , C01G1/00 , C01B25/16 , B01D11/00 , B03C1/00 , C01G17/00
CPC分类号： C01B25/237 , C22B3/24 , Y02P10/234
摘要： The disclosure relates to process for removing heavy metal ions, especially cadmium, copper, lead and mercury ions from wet-processed phosphoric acid. To this end, the crude acid is contacted with a mixture consisting of an adsorbent and a diorganyldithiophosphoric acid ester or, after treatment with the ester, the acid is contacted with the adsorbent alone, and the purified phosphoric acid is ultimately separated from the ester and adsorbent.
摘要翻译：本公开涉及从湿法处理的磷酸中去除重金属离子，特别是镉，铜，铅和汞离子的方法。为此，将粗酸与由吸附剂和二有机基二硫代磷酸酯组成的混合物接触，或者在用酯处理后，酸与吸附剂单独接触，纯化的磷酸最终与酯分离，吸附剂。

82. 发明授权

US08987489B2 Method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ether and the use thereof 有权
标题翻译：使用乙烯基醚制备单羧基官能化二烷基次膦酸，酯和盐的方法及其用途
公开(公告)号：US08987489B2
公开(公告)日：2015-03-24
申请号：US13132196
申请日：2009-10-06
申请人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
发明人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
IPC分类号： C07F9/32 , C07F9/30 , C07F9/48 , C08K5/5313 , C09K21/12 , C08L21/00
CPC分类号： C07F9/30 , C07F9/301 , C07F9/32 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C08L21/00 , C09K21/12
摘要： A method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ether. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, the salt or the ester (II) thereof, b) reacting the alkylphosphonous acid so obtained, the salt or the ester (II) thereof with a vinyl ether of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting this derivative (VI) with an oxidant or in the presence of a catalyst C to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III), wherein the catalysts A and C are transition metals and/or transition metal compounds, and the catalyst B is a peroxide-forming compound and/or a peroxo compound and/or an azo compound.
摘要翻译：使用乙烯基醚制备单羧基官能化的二烷基次膦酸，酯和盐的方法。该方法的特征在于以下步骤：a）在催化剂A存在下使次膦酸源（I）与烯烃（IV）反应，得到烷基亚磷酸，其盐或其酯（II），b）使所得的烷基亚磷酸，其盐或其酯（II）与式（V）的乙烯基醚在催化剂B的存在下反应，得到单官能化的二烷基次膦酸衍生物（VI），和c）使该衍生物 VI）与氧化剂或催化剂C的存在下反应，得到单羧基官能化的二烷基次膦酸衍生物（III），其中催化剂A和C为过渡金属和/或过渡金属化合物，催化剂B为过氧化物形成化合物和/或过氧化合物和/或偶氮化合物。

83. 发明授权

US08772519B2 Process for preparing mono-allyl-functionalized dialkylphosphinic acids, salts and esters thereof with allylic compounds, and the use thereof 失效
标题翻译：用烯丙基化合物制备单烯丙基官能化二烷基次膦酸，其盐和酯的方法及其用途
公开(公告)号：US08772519B2
公开(公告)日：2014-07-08
申请号：US13127110
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C07F9/30 , C07F9/32 , C07F5/06
CPC分类号： C09K21/12 , C07F9/302 , C07F9/3217 , C08K5/5313
摘要： The invention relates to a process for preparing mono-allyl-functionalized dialkylphosphinic acids, esters and salts with allylic compounds, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) in the presence of a catalyst A to give an alkylphosphonous acid, or salt or ester thereof (II), b) the alkylphosphonous acid, or salt or ester thereof (II) thus formed is reacted with allylic compounds of the formula (V) in the presence of a catalyst B and of a base to give a mono-allyl-functionalized dialkylphosphinic acid derivative (III), where R1, R2, R3, R4, R5, R6, R7, R8, R9 are the same or different and are each independently, inter alia, H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, and X is H, C1-C18-alkyl, C6-C18-aryl, C6-C18-aralkyl, C6-C18-alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonated nitrogen base, and the catalysts A and B are transition metals and/or transition metal compounds and/or catalyst systems which are composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及用烯丙基化合物制备单烯丙基官能化二烷基次膦酸，酯和盐的方法，其特征在于a）在催化剂A存在下，使次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基亚磷酸或其盐或酯（II），b）将如此形成的烷基亚膦酸或其盐或酯（II）与式（Ⅴ）的烯丙基化合物在催化剂B的存在下反应，和得到单烯丙基官能化的二烷基次膦酸衍生物（III）的碱，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9相同或不同，并且各自独立地为H， C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，X是H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18 - 烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/或质子化氮碱，催化剂A和B是过渡金属和/或过渡金属 nds和/或由过渡金属和/或过渡金属化合物和至少一种配体组成的催化剂体系。

84. 发明授权

US08735476B2 Method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid and the use thereof 有权
标题翻译：使用羧酸的乙烯基酯制备单羧基官能化的二烷基次膦酸，酯和盐的方法及其用途
公开(公告)号：US08735476B2
公开(公告)日：2014-05-27
申请号：US13132153
申请日：2009-10-06
申请人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
发明人： Michael Hill , Mathias Dietz , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313
CPC分类号： C09K21/12 , C07F9/301 , C07F9/4816 , C07F9/4866 , C08K5/5313
摘要： The invention relates to a method for producing mono-carboxy-functionalized dialkylphosphinic acids, esters and salts using a vinyl ester of a carboxylic acid. The method is characterized by the following steps: a) reacting a phosphinic acid source (I) with olefins (IV) in the presence of a catalyst A to give an alkylphosphinic acid, the salt or the ester (II) thereof, b) reacting the alkylphosphinic acid so obtained, the salt or the ester (II) thereof with a vinyl ester of a carboxylic acid of formula (V) in the presence of a catalyst B to give a mono-functionalized dialkylphosphinic acid derivative (VI) and c) reacting the mono-functionalized dialkylphosphinic acid derivative (VI) so obtained in the presence of a catalyst C to give a mono-functionalized dialkylphosphinic acid derivative (VII) and d) reacting the mono-functionalized dialkylphosphinic acid derivative (VII); with an oxidant or in the presence of a catalyst D to give a mono-carboxy-functionalized dialkylphosphinic acid derivative (III).
摘要翻译：本发明涉及使用羧酸的乙烯基酯制备单羧基官能化的二烷基次膦酸，酯和盐的方法。该方法的特征在于以下步骤：a）在催化剂A存在下使次膦酸源（I）与烯烃（IV）反应，得到烷基次膦酸，其盐或其酯（II），b）使如此获得的烷基次膦酸，其盐或其酯（II）与式（V）的羧酸的乙烯基酯在催化剂B的存在下反应，得到单官能化的二烷基次膦酸衍生物（Ⅵ）和c）使在催化剂C存在下得到的单官能化二烷基次膦酸衍生物（Ⅵ）反应，得到单官能化二烷基次膦酸衍生物（Ⅶ），和d）使单官能化二烷基次膦酸衍生物（Ⅶ）反应; 与氧化剂或在催化剂D存在下反应，得到单羧基官能化的二烷基次膦酸衍生物（III）。

85. 发明申请

US20110213078A1 Method for Producing Mono-Aminofunctionalized Dialkylphosphinic Acids and Esters and Salts Thereof by Means of Acrylnitriles and Use Thereof 有权
标题翻译：通过丙烯腈生产单氨基官能化二烷基膦酸及其酯及其盐的方法及用途
公开(公告)号：US20110213078A1
公开(公告)日：2011-09-01
申请号：US13127072
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08L67/02 , C07F9/30 , C07F9/32 , C07F5/06 , C07F7/28 , C08G63/183 , C08L77/06 , C08G69/26
CPC分类号： C07F9/3211 , C07F9/301 , C07F9/3264 , C07F9/4816 , C07F9/4866 , C08K5/5313 , C09K21/12
摘要： The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof by means of acrylnitriles, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with an acrylnitrile of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst C or a reduction agent, wherein R1, R2, R3, R4, R5, R6, R7 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl and X stands for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and Y stands for a mineral acid, a carboxylic acid, a Lewis acid or an organic acid, n=an integer or fractional number of 0 to 4 and the catalysts A and C are formed by transition metals, transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand, and catalyst B is formed by compounds forming peroxides, peroxo compounds, azo compounds, alkali metals, alkaline earth metals, alkali hydrides, alkaline earth hydrides and/or alkali alcoholates and alkaline earth alcoholates.
摘要翻译：本发明涉及一种通过丙烯腈生产单氨基官能化二烷基次膦酸及其酯及其盐的方法，其特征在于a）将次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基膦酸盐或盐酯（II），b）将由此得到的烷基膦酸，其盐或酯（II）与式（V）的丙烯腈反应，得到单官能化二烷基次膦酸衍生物（Ⅵ）在催化剂B存在下，和c）将由此得到的单官能化二烷基次膦酸衍生物（Ⅵ）反应，得到单氨基官能化二烷基次膦酸衍生物（Ⅲ），其中催化剂C或还原剂存在下，其中对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基，R 1，R 2，R 3，R 4，R 5，R 6，R 7相同或不同，彼此独立烷基芳基，X代表H，C1-C18烷基，C6-C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K 和/或质子化的氮碱，Y表示无机酸，羧酸，路易斯酸或有机酸，n = 0至4的整数或分数，催化剂A和C由过渡金属形成由过渡金属和/或过渡金属化合物和至少一种配体组成的过渡金属化合物和/或催化剂体系和催化剂B通过形成过氧化物，过氧化合物，偶氮化合物，碱金属，碱土金属，碱金属氢化物，碱土金属氢化物和/或碱金属醇盐和碱土金属盐。

86. 发明申请

US20110213061A1 Method for Producing Mono-Aminofunctionalized Dialkylphosphinic Acids and Esters and Salts Thereof and Use Thereof 审中-公开
标题翻译：单氨基官能化二烷基膦酸及其酯及其盐的制备方法及用途
公开(公告)号：US20110213061A1
公开(公告)日：2011-09-01
申请号：US13125359
申请日：2009-10-06
申请人： Michael Hill , Werner Krause , Martin Sicken
发明人： Michael Hill , Werner Krause , Martin Sicken
IPC分类号： C08K5/5313 , C07F9/30 , C08L67/02 , C08L77/06
CPC分类号： C09K21/12 , C07F9/301 , C07F9/3211 , C08K5/5313
摘要： The invention relates to a method for producing mono-aminofunctionalized dialkylphosphinic acids and esters and salts thereof, characterized in that a) a phosphinic acid source (I) is reacted with olefins (IV) to yield an alkylphosphonic acid, salt or ester (II) thereof in the presence of a catalyst A, b) the thus obtained alkylphosphonic acid, salt or ester (II) thereof is reacted with acetylenic compounds of formula (V) to yield a mono-functionalized dialkylphosphinic acid derivative (VI) in the presence of a catalyst B, and c) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VI) is reacted with a hydrogen cyanide source to yield a mono-functionalized dialkylphosphinic acid derivative (VII) in the presence of a catalyst C, and d) the thus obtained mono-functionalized dialkylphosphinic acid derivative (VII); is reacted to yield a mono-aminofunctionalized dialkylphosphinic acid derivative (III) in the presence of a catalyst D or a reduction agent, wherein R1, R2, R3, R4, R5, R6 are the same or different and stand independently of each other, among other things, for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, and X stands for H, C1-C18 alkyl, C6-C18 aryl, C6-C18 aralkyl, C6-C18 alkylaryl, Mg, Ca, Al, Sb, Sn, Ge, Ti, Fe, Zr, Zn, Ce, Bi, Sr, Mn, Cu, Ni, Li, Na, K and/or a protonized nitrogen base, and Y stands for a mineral acid, a carboxylic acid, a Lewis acid or an organic acid, n=0 to 4 and the catalysts A, B, C and D are formed by transition metals, transition metal compounds and/or catalyst systems composed of a transition metal and/or a transition metal compound and at least one ligand.
摘要翻译：本发明涉及一种用于制备单氨基官能化二烷基次膦酸及其酯和盐的方法，其特征在于a）将次膦酸源（I）与烯烃（Ⅳ）反应，得到烷基膦酸盐或酯（Ⅱ）在催化剂A存在下，将由此得到的烷基膦酸，其盐或酯（II）与式（Ⅴ）的炔属化合物反应，得到单官能化二烷基次膦酸衍生物（Ⅵ）催化剂B和c）由此获得的单官能化二烷基次膦酸衍生物（VI）与氰化氢源反应，在催化剂C存在下得到单官能化二烷基次膦酸衍生物（Ⅶ），和d）得到单官能化二烷基次膦酸衍生物（VII）; 在催化剂D或还原剂的存在下反应得到单氨基官能化二烷基次膦酸衍生物（III），其中R1，R2，R3，R4，R5，R6相同或不同并且彼此独立，对于H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基，C 6 -C 18烷基芳基，X代表H，C 1 -C 18烷基，C 6 -C 18芳基，C 6 -C 18芳烷基， C18烷基芳基，Mg，Ca，Al，Sb，Sn，Ge，Ti，Fe，Zr，Zn，Ce，Bi，Sr，Mn，Cu，Ni，Li，Na，K和/或质子化氮碱，Y 代表无机酸，羧酸，路易斯酸或有机酸，n = 0〜4，催化剂A，B，C和D由过渡金属，过渡金属化合物和/或催化剂体系过渡金属和/或过渡金属化合物和至少一种配体。

87. 发明申请

US20080233128A1 Treatment of Viral Infections 审中-公开
标题翻译：病毒感染的治疗
公开(公告)号：US20080233128A1
公开(公告)日：2008-09-25
申请号：US11933691
申请日：2007-11-01
申请人： Werner Krause
发明人： Werner Krause
IPC分类号： A61K39/42 , A61P31/12
CPC分类号： A61K39/39541 , Y02A50/394 , A61K2300/00
摘要： A method of treating viral infections comprises administering to a patient a regimen that is able to temporarily reduce the number or functionality of the host cells which the virus uses for its reproduction in a controlled manner. Preferably, host cells are part of the immune system.
摘要翻译：治疗病毒感染的方法包括向患者施用能够以受控方式暂时降低病毒用于其繁殖的宿主细胞的数量或功能性的方案。优选地，宿主细胞是免疫系统的一部分。

88. 发明申请

US20070191933A1 Reduction of restenosis 审中-公开
标题翻译：减少再狭窄
公开(公告)号：US20070191933A1
公开(公告)日：2007-08-16
申请号：US11594992
申请日：2006-11-09
申请人： Werner Krause
发明人： Werner Krause
IPC分类号： A61F2/82
CPC分类号： A61L31/16 , A61K2039/505 , A61L2300/256 , A61L2300/426 , C07K16/2893
摘要： A method of reducing restenosis comprises administering to a patient a stent and reducing, shutting down or modifying functioning of the immune system in a controlled manner. In a preferred embodiment T-cell depletion or T-cell modification is used for controlling the immune system. The T-cell depletor or T-cell modifier is administered either separately or as part of the stent. Alternatively, an ex-vivo procedure may be used.
摘要翻译：减少再狭窄的方法包括向患者施用支架并以受控的方式减少，关闭或改变免疫系统的功能。在优选的实施方案中，T细胞消耗或T细胞修饰用于控制免疫系统。 T细胞释放细胞或T细胞调节剂分别或作为支架的一部分施用。或者，可以使用离体程序。

89. 发明申请

US20070027297A1 Modified polyethylenephosphinic acids and their salts 失效
标题翻译：改性聚亚乙基次膦酸及其盐
公开(公告)号：US20070027297A1
公开(公告)日：2007-02-01
申请号：US11540476
申请日：2006-09-29
申请人： Martin Sicken , Werner Krause , Norbert Weferling , Hans-Peter Schmitz
发明人： Martin Sicken , Werner Krause , Norbert Weferling , Hans-Peter Schmitz
IPC分类号： C08G79/02
CPC分类号： C08K5/5313 , C07F9/305 , C08G79/04 , C09K21/14
摘要： The invention relates to polymeric phosphinic acids and their salts of the formula (I) where X is hydrogen or 1/m of a metal of valency m, or is a protonated nitrogen base, R1 and R2 are identical or different and are hydrogen, a carboxy group, a carboxylic acid derivative, an unsubstituted or substituted alkyl group having from 1 to 10 carbon atoms, phenyl, benzyl, or alkyl-substituted aromatic systems, R3 and R4 may be identical or different and are an unsubstituted or substituted alkyl group having from 2 to 20 carbon atoms, or are OX, with the above meaning for X, and u is the average number of monomer units. The invention further relates to a process for preparing the abovementioned compounds, and to their use.
摘要翻译：本发明涉及式（I）的聚合物次膦酸及其盐，其中X是氢或1 / m的价态m的金属，或是质子化的氮碱，R 1和R 2， R 2是相同或不同的并且是氢，羧基，羧酸衍生物，未取代或取代的具有1-10个碳原子的烷基，苯基，苄基或烷基取代的芳族体系，R R 3和R 4可以相同或不同，为未取代或取代的碳原子数为2〜20的烷基，或为O X，X为上述含义，和（超出（u是单体单元的平均数）。本发明还涉及制备上述化合物的方法及其用途。

90. 发明授权

US5885548A Multiply substituted DTPA derivatives and their metal complexes, and their metal complexes, pharmaceutical agents that contain these complexes, their use in diagnosis and therapy, as well as process for the production of pharmaceutical agents 失效
标题翻译：倍增取代的DTPA衍生物及其金属络合物及其金属络合物，含有这些复合物的药物，它们在诊断和治疗中的应用，以及制备药剂的方法
公开(公告)号：US5885548A
公开(公告)日：1999-03-23
申请号：US565024
申请日：1995-11-30
申请人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
发明人： Franz-Karl Maier , Michael Bauer , Werner Krause , Ulrich Speck , Gabriele Schuhmann-Giampiere , Andreas Muhler , Thomas Balzer , Wolf-Rudiger Press
IPC分类号： A61K31/16 , A61K31/20 , A61K31/28 , A61K49/00 , A61K49/04 , A61K49/06 , A61K51/00 , A61P1/16 , A61P39/02 , C07C229/16 , C07C229/22 , C07C229/24 , C07C229/36 , C07C229/76 , C07C323/63 , A61B5/055
CPC分类号： A61K49/06 , A61K49/0002 , A61K49/0004 , A61K49/04 , Y10S514/836 , Y10T436/24
摘要： The invention relates to new, multiply substituted diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, that contain an element of atomic numbers 20-32, 39-51 or 57-83, pharmaceutical agents that contain these compounds, their use as contrast media and antidotes, and process for the production of pharmaceutical agents.
摘要翻译：本发明涉及含有原子序数20-32,39-51或57-83的元素的新的多取代的二亚乙基三胺五乙酸衍生物，它们的配合物和络合盐，含有这些化合物的药剂，它们作为造影介质的用途和解毒剂，以及生产药剂的方法。

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