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81. 发明专利

JPH01297069A TACKY ADHESIVE AGENT COMPOSITION 失效
公开(公告)号：JPH01297069A
公开(公告)日：1989-11-30
申请号：JP12938788
申请日：1988-05-25
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NAKAGAWA AKIRA , KOBAYASHI MASAJI , KASAI HIROAKI , HIRANO MUNEHIKO , TOKUBUCHI FUMIAKI , HIRASHIMA NOBUCHIKA
IPC分类号： A61K9/70 , A61L15/58
摘要： PURPOSE:To obtain an ideal sticking agent for external use which is free from contact with air by forming the tacky adhesive agent compsn. consisting of an A-B-A type block copolymer, softener, water absorptive polymer, and alicyclic petroleum resin. CONSTITUTION:The A-B-A type block copolymer refers to a block copolymer of a monovinyl substd. arom. compd. A and conjugate, diolefin copolymer B and the compounding ratio thereof is specified to 10-30 pts.wt. in the tacky adhesive agent compsn. The water absorptive polymer refers to the polymer which gelatinizes and swells by absorbing water of >=10 times its own weight and is prepd. by properly mixing 1 or >=2 kinds of the water absorptive polymers introduced with a light crosslinking bond with, for example, a water soluble polymer. The ratio of said polymer to be compounded is 1-10 pts.wt. in the tacky adhesive agent compsn. The alicyclic petroleum resin refers to a petroleum resin having cyclic skeleton and the ratio of said resin to be compounded is 10-50 pts.wt. Higher fatty acid, liquefied rubber, mineral oil, etc., are used for the softener and the ratio of the softener to be compounded is 10-50 pts.wt. The base is selected from stretchable or non-stretchable bases consisting of, for example, polyethylene, etc.

82. 发明专利

JPH01297059A WARM HEAT STICKING AGENT 失效
公开(公告)号：JPH01297059A
公开(公告)日：1989-11-30
申请号：JP12938888
申请日：1988-05-25
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NAKAGAWA AKIRA , KOBAYASHI MASAJI , KASAI HIROAKI , HIRANO MUNEHIKO , TOKUBUCHI FUMIAKI , HIRASHIMA NOBUCHIKA
IPC分类号： A61F7/08 , A61K9/70
摘要： PURPOSE:To obtain a warm heat sticking agent and exothermic member tacky adhesive agent which have excellent thermal conductive and tacky adhesive characteristics, absorbs secretions such as sweat and are stable to heat by using a tacky adhesive agent consisting of an A-B-A type block copolymer, alicyclic petroleum resin, softener, and a water absorptive high polymer. CONSTITUTION:The A-B-A type block copolymer refers to a block copolymer of a monovinyl substd. arom. compd. A and conjugate diolefin copolymer B and the compounding ratio thereof is specified to 10-30 pts.wt. in the tacky adhesive agent compsn. The water absorptive polymer refers to the polymer which gelatinizes and swells by absorbing water of >=10 times its own weight and is prepd. by properly mixing 1 or >=2 kinds of the water absorptive polymers introduced with a light crosslinking bond with, for example, a water soluble polymer. The ratio of said polymer to be compounded is 1-10 pts.wt. in the tacky adhesive agent compsn. The alicyclic petroleum resin refers to a petroleum resin having cyclic skeleton and the ratio of said resin to be compounded is 10-50 pts.wt. Higher fatty acid, liquefied rubber, mineral oil, etc., are used for the softener and the ratio of the softener to be compounded is 10-50 pts.wt. The warm heat sticking agent is obtd. by combining this tacky adhesive agent with the exothermic member.

83. 发明专利

JPS63203616A CLONIDINE PERCUTANEOUS ADMINISTRATION MATRIX 失效
公开(公告)号：JPS63203616A
公开(公告)日：1988-08-23
申请号：JP3346287
申请日：1987-02-18
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGUCHI HISASHI , MUKAI KATSUYA , KUBOTA YUSUKE
IPC分类号： A61K9/70 , A61K31/415 , A61P9/12 , C07D233/50
摘要： PURPOSE:To obtain the titled preparation of laminate type having excellent initial release of clonidine, developing medicinal effects rapidly, by using a pressure-sensitive adhesive layer containing a specific elastic polymer, a water absorbing high polymer, a natural gum substance and a higher fatty acid ester. CONSTITUTION:In a percutaneous preparation wherein a drug preserving layer, a drug permeation control film and a pressure-sensitive adhesive layer are successively laminated to a substrate, the pressure-sensitive adhesive layer containing (A) an elastic polymer of (A-B)nX or (A-B)n-A type [A is monovinyl- substituted aromatic compound polymer block; B is conjugated diolefin copolymer block; n is 3-7; X is residue of polyfunctional compound to which n polymer chains (A-B) are bonded] as a matrix base, (B) a water absorbing high polymer, (C) a natural gum substance (preferably karaya gum, etc.) and (D) a higher fatty acid ester as essential components. The amount of clonidine added is preferably 8-15wt.% in the drug preserving layer and 2-6wt.% in the pressure-sensitive adhesive layer.

84. 发明专利

JPS63203162A GEL MATRIX 失效
公开(公告)号：JPS63203162A
公开(公告)日：1988-08-23
申请号：JP3575087
申请日：1987-02-20
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGUCHI HISASHI , MUKAI KATSUYA , KUBOTA YUSUKE
IPC分类号： A61F7/10 , A61F7/08 , A61F13/00 , A61L9/01 , A61L15/16

85. 发明专利

JPS617173B2 JPS617173B2 - 失效
公开(公告)号：JPS617173B2
公开(公告)日：1986-03-04
申请号：JP11103878
申请日：1978-09-08
申请人： Hisamitsu Pharmaceutical Co
发明人： NODA KANJI , NAKAGAWA AKIRA , YAMAGATA KENJI , HIRANO MUNEHIKO , YATANI TERUMI , IDE HIROYUKI
IPC分类号： C07C43/13 , A61K31/045 , A61K31/075 , A61K31/19 , A61K31/215 , A61P1/04 , A61P1/16 , A61P29/00 , A61P37/08 , C07C27/00 , C07C31/135 , C07C31/27 , C07C35/08 , C07C41/00 , C07C43/178 , C07C43/196 , C07C51/00 , C07C62/04 , C07C62/10 , C07C67/00 , C07C69/757

86. 发明专利

JPS6054942B2 失效
公开(公告)号：JPS6054942B2
公开(公告)日：1985-12-03
申请号：JP16345878
申请日：1978-12-26
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGATA KENJI , NAKAJIMA YOICHI , YATANI TERUMI , IDE HIROYUKI
IPC分类号： C07C61/08 , C07C51/00 , C07C51/16 , C07C51/235 , C07C62/04 , C07C67/00

87. 发明专利

JPS58433B2 失效
公开(公告)号：JPS58433B2
公开(公告)日：1983-01-06
申请号：JP225675
申请日：1974-12-27
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , YAMAZAKI SHUNZO , ISHIKURA JUJI , YATANI TERUMI , HIRANO MUNEHIKO , IDE HIROYUKI
IPC分类号： C07D471/04 , A61K31/55 , A61P21/02 , A61P25/04 , A61P25/08 , A61P25/20

88. 发明专利

JPS55136228A NOVEL ANTIALLERGIC AGENT 失效
公开(公告)号：JPS55136228A
公开(公告)日：1980-10-23
申请号：JP4213379
申请日：1979-04-06
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGATA KENJI , NAKASHIMA YOUICHI , YATANI TERUMI , IDE HIROYUKI
IPC分类号： A61K31/045 , A61K31/11 , A61K31/19 , A61K31/215 , A61P37/08
摘要： PURPOSE:To nonsteroid antiallergic agent with small side effect, comprising 4- isocyclohexylcyclohexane derivative as an active ingredient. CONSTITUTION:A nonsteroid antiallerigic agent comprising a compound (e.g., 1-methyl-4-isohexylcyclohexane-1-carbaldehyde, 4-isohexylcyclohexane-1-carboxylic acid) shown by the formula (R , R and R are H or methyl; R is carboxyl, formyl, methoxycarbonyl, hydroxymethyl) as an active ingredient. Various kinds of side effects caused by long-term administration of a steroid drug, e.g., adrenal cortical hormones, can be prevented. USE:Ameliorants of liver function, antifibrinolysins, antitumor agents, and antiallerigic agnets for diseases cuased by immunological deficiency, e.g., articular rheumatism, autoimmune disease, asthma, nephritis, etc.

89. 发明专利

JPS55130914A NOVEL ANTIALLERGIC AGENT 失效
公开(公告)号：JPS55130914A
公开(公告)日：1980-10-11
申请号：JP3887779
申请日：1979-03-30
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGATA KENJI , NAKASHIMA YOUICHI , YATANI TERUMI , IDE HIROYUKI
IPC分类号： A61K31/11 , A61K31/12 , A61K31/19 , A61K31/215 , A61K31/275 , A61P37/08
摘要： PURPOSE:To provide an antiallergic agent effective to arthrorheumatism, autoimmune diseases, asthma, nephritis, etc., and containing a specific non-steroidal compound as an effective component. CONSTITUTION:An antiallergic agent containing a compound of formula (R is H or CH3; R is carboxyl, formyl, acetyl, etc.; R is 4-methyl-3-pentenyl or isohexyl), as an effective component. The compound has wide antiallergic activities, e.g. hepatic function-improving action, antifibrinolytic action, anti-ulcer action, and immuno-accelerating action, etc. It can be formed to a capsule, tablet, ointment, etc. by conventional means. For oral or external administration. Dose: 50-900mg/ day.

90. 发明专利

JPS5592349A NEW CYCLOHEXANE DERIVATIVE 失效
公开(公告)号：JPS5592349A
公开(公告)日：1980-07-12
申请号：JP16531878
申请日：1978-12-29
申请人： HISAMITSU PHARMACEUTICAL CO
发明人： NODA KANJI , NAKAGAWA AKIRA , HIRANO MUNEHIKO , YAMAGATA KENJI , NAKASHIMA YOUICHI , YATANI TERUMI , IDE HIROYUKI
IPC分类号： A61K31/16 , A61K31/275 , A61P29/00 , A61P35/00 , A61P37/08 , C07C67/00 , C07C231/00 , C07C233/38 , C07C233/58 , C07C235/40 , C07C253/00 , C07C255/46
摘要： NEW MATERIAL:New cyclohexane derivatives of formula I (R is cyano or carbamoyl; R is H or OH). EXAMPLE:1-Methyl-4-isobexylcyclohexanecarbonitrile. USE:Medicines having pharmacological actions, such as antiallergic action, antitumorigenic action, antirheumatic action and anti-inflammatory action, and their intermediates. PROCESS:Compounds of formula I are obtained as follows: (1) preparation of compounds of formulae X and III according to a reaction formula, (2) catalytic hydrogenation of the compounds of formulae II and III in an alcohol in the presence of platinum oxide or palladium on carbon, and if necessary, (3) hydrolysis of the product with hydrochloric acid, potassium hydroxide, sodium hydroxide, etc, in an alcohol solvent in the presence of hydrogen peroxide.

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