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81. 发明专利

AU2009327490A1 Microorganisms and methods for conversion of syngas and other carbon sources to useful products 未知
公开(公告)号：AU2009327490A1
公开(公告)日：2011-07-28
申请号：AU2009327490
申请日：2009-07-15
申请人： GENOMATICA INC
发明人： TRAWICK JOHN D , BURK MARK J , BURGARD ANTHONY P
IPC分类号： C12N1/00 , C12N1/21 , C12P5/00
摘要： An exemplary non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme expressed in a sufficient amount to produce isopropanol and includes a succinyl-CoA:3-ketoacid-CoA transferase. Another organism having a 4-hydroxybutryate pathway includes at least one exogenous nucleic acid including an acetoacetyl-CoA thiolase, a 3-hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA transferase, a phosphotrans-4-hydroxybutyrylase, and a 4-hydroxybutyrate kinase. An exemplary organism having a 1,4-butanediol pathway includes an acetoacetyl-CoA thiolase, a 3-Hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA reductase (aldehyde forming), and a 1,4-butanediol dehydrogenase. Such an organism further comprising an acetyl-CoA pathway. Any of the aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4- butanediol.

82. 发明专利

CA2783096A1 METHODS AND ORGANISMS FOR CONVERTING SYNTHESIS GAS OR OTHER GASEOUS CARBON SOURCES AND METHANOL TO 1,3-BUTANEDIOL 未知
公开(公告)号：CA2783096A1
公开(公告)日：2011-06-16
申请号：CA2783096
申请日：2010-11-19
申请人： GENOMATICA INC
发明人： BURGARD ANTHONY P , BURK MARK J , PHARKYA PRITI
IPC分类号： C12P7/52 , C12N1/20
摘要： A non-naturally occurring microbial organism having a 1,3-butanediol (1,3-BDO) pathway includes at least one exogenous nucleic acid encoding a 1,3-BDO pathway enzyme or protein expressed in a sufficient amount to produce 1,3-BDO. A method for producing 1,3-BDO that includes culturing the this non-naturally occurring microbial organism under conditions and for a sufficient period of time to produce 1,3-BDO.

83. 发明专利

CA2746952A1 MICROORGANISMS AND METHODS FOR CONVERSION OF SYNGAS AND OTHER CARBON SOURCES TO USEFUL PRODUCTS 未知
公开(公告)号：CA2746952A1
公开(公告)日：2010-06-24
申请号：CA2746952
申请日：2009-07-15
申请人： GENOMATICA INC
发明人： TRAWICK JOHN D , BURK MARK J , BURGARD ANTHONY P
IPC分类号： C12N1/21 , C12N1/00 , C12N9/00 , C12N15/00 , C12N15/52 , C12P7/02 , C12P7/18
摘要： An exemplary non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme expressed in a sufficient amount to produce isopropanol and includes a succinyl-CoA:3-ketoacid-CoA transferase. Another organism having a 4-hydroxybutryate pathway includes at least one exogenous nucleic acid including an acetoacetyl-CoA thiolase, a 3-hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA transferase, a phosphotrans-4-hydroxybutyrylase, and a 4-hydroxybutyrate kinase. An exemplary organism having a 1,4-butanediol pathway includes an acetoacetyl-CoA thiolase, a 3-Hydroxybutyryl-CoA dehydrogenase, a crotonase, a crotonyl-CoA hydratase, a 4-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl-CoA reductase (aldehyde forming), and a 1,4-butanediol dehydrogenase. Such an organism further comprising an acetyl-CoA pathway. Any of the aforementioned organisms are cultured to produce isopropanol, 4-hydroxybutryate, or 1,4- butanediol.

84. 发明专利

CA2722680A1 MICROORGANISMS FOR THE PRODUCTION OF METHACRYLIC ACID 未知
公开(公告)号：CA2722680A1
公开(公告)日：2009-11-05
申请号：CA2722680
申请日：2009-04-30
申请人： GENOMATICA INC
发明人： BURK MARK J , BURGARD ANTHONY P , OSTERHOUT ROBIN E , PHARKYA PRITI
IPC分类号： C12N1/21 , C12N1/00 , C12N9/00 , C12N15/00 , C12N15/52 , C12P7/40
摘要： The invention provides a non-naturally occurring microbial organism having a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The microbial organism contains at least one exogenous nucleic acid encoding an enzyme in a 2- hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway. The invention additionally provides a method for producing 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid. The method can include culturing a 2-hydroxyisobutyric acid, 3- hydroxyisobutyric acid or methacrylic acid producing microbial organism expressing at least one exogenous nucleic acid encoding a 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid pathway enzyme in a sufficient amount and culturing under conditions and for a sufficient period of time to produce 2-hydroxyisobutyric acid, 3-hydroxyisobutyric acid or methacrylic acid.

85. 发明专利

MY179664A MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 未知
公开(公告)号：MY179664A
公开(公告)日：2020-11-11
申请号：MYPI2017702592
申请日：2013-08-01
申请人： GENOMATICA INC
发明人： BURK MARK J , BURGARD ANTHONY P , SUN JUN , PHARKYA PRITI , OSTERHOUT ROBIN E
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

86. 发明专利

LT3199511T KOMPONENTŲ ATSKYRIMO NUO FERMENTACIJOS SULTINIO BŪDAS 未知
公开(公告)号：LT3199511T
公开(公告)日：2020-03-25
申请号：LT17159134
申请日：2010-06-03
申请人： GENOMATICA INC
发明人： CLARK WARREN , JAPS MICHAEL , BURK MARK J
IPC分类号： C07C31/18 , C07C29/76 , C07C33/02 , C12P7/18

87. 发明专利

AU2015369651B2 Method of producing and processing diamines 未知
公开(公告)号：AU2015369651B2
公开(公告)日：2020-03-12
申请号：AU2015369651
申请日：2015-12-22
申请人： GENOMATICA INC
发明人： SUOMINEN LAURI H , GALLEHER CONNOR J , JAPS MICHAEL , BURK MARK J , TRACEWELL CARA
IPC分类号： C12P13/00 , C12N9/88 , C12N15/52
摘要： Provided is a method of producing and isolating a diamine produced by microbial fermentation that minimizes undesirable salt formation to provide a lower cost process.

88. 发明专利

CA2797409C MICROORGANISMS AND METHODS FOR THE BIOSYNTHESIS OF BUTADIENE 未知
公开(公告)号：CA2797409C
公开(公告)日：2019-12-24
申请号：CA2797409
申请日：2011-05-04
申请人： GENOMATICA INC
发明人： BURK MARK J , BURGARD ANTHONY P , SUN JUN , OSTERHOUT ROBIN E , PHARKYA PRITI
IPC分类号： C12P5/02 , C12N1/21 , C12N15/00 , C12N15/53 , C12N15/54 , C12N15/60
摘要： The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.

89. 发明专利

DK2427544T3 MIKROORGANISMER OG FREMGANGSMÅDER TIL BIOSYNTESE AF ADIPAT, HEXAMETHYLENDIAMIN OG 6-AMINOKAPRONSYRE 未知
公开(公告)号：DK2427544T3
公开(公告)日：2019-10-07
申请号：DK10772921
申请日：2010-05-07
申请人： GENOMATICA INC
发明人： BURK MARK J , BURGARD ANTHONY P , OSTERHOUT ROBIN E , PHARKYA PRITI
IPC分类号： C12N1/38 , C12N15/52 , C12P7/40 , C12P7/44 , C12P13/00 , C12P13/02 , C12P17/10

90. 发明专利

CA2759994C ORGANISMS FOR THE PRODUCTION OF 1,3-BUTANEDIOL 未知
公开(公告)号：CA2759994C
公开(公告)日：2019-06-11
申请号：CA2759994
申请日：2010-04-30
申请人： GENOMATICA INC
发明人： BURGARD ANTHONY P , BURK MARK J , OSTERHOUT ROBIN E , PHARKYA PRITI
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19 , C12N1/20 , C12N9/00 , C12N9/02 , C12N9/04 , C12N15/52 , C12N15/53 , C12P7/18
摘要： A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3- BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4- hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2- one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA- dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl- CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO.

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