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81. 发明专利

AU2003294759A1 AN EARLY PRE-SYMPTOMATIC PRION DIAGNOSTIC BLOOD TEST FOR ENCEPHALOPATHIES 未知
公开(公告)号：AU2003294759A1
公开(公告)日：2004-06-23
申请号：AU2003294759
申请日：2003-12-01
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , RESINK ANNELIES , FUENTES NATHALIE
IPC分类号： C12N15/74 , C12Q1/68 , C07K14/47

82. 发明专利

AU2003276609A1 QUALITATIVE DIFFERENTIAL SCREENING 未知
公开(公告)号：AU2003276609A1
公开(公告)日：2004-05-25
申请号：AU2003276609
申请日：2003-10-29
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , TOCQUE BRUNO , BRACCO LAURENT , EDON FLORENCE
IPC分类号： C12N15/10 , C12Q1/68
摘要： The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions, deletions located in RNA transcribed genome regions, between two physiological situations, comprising either hybridization of RNA derived from the test situation with cDNA's derived from the reference situation and/or reciprocally, or double-strand hybridization of cDNA derived from the test situation with cDNA's derived from the reference situation; and identifying and/or cloning nucleic acids representing qualitative differences. The invention also concerns compositions or banks of nucleic acids representing qualitative differences between two physiological situations, obtainable by the above method, and their use as probe, for identifying genes or molecules of interest, or still for example in methods of pharmacogenomics, and profiling of molecules relative to their therapeutic and/or toxic effects. The invention further concerns the use of dysregulation of splicing RNA as markers for predicting molecule toxicity and/or efficacy, and as markers in pharmacogenomics.

83. 发明专利

PT1198595E 未知
公开(公告)号：PT1198595E
公开(公告)日：2004-03-31
申请号：PT00962576
申请日：2000-09-05
申请人： EXONHIT THERAPEUTICS SA
发明人： TOCQUE BRUNO , BRACCO LAURENT , SCHWEIGHOFFER FABIEN
IPC分类号： G01N33/49 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12Q1/6809 , G01N33/53 , G01N33/566 , G01N33/569 , G01N33/68

84. 发明专利

AU2003260618A8 Treatment of amyotrophic lateral sclerosis using pgc-1 activity-modulating compounds 未知
公开(公告)号：AU2003260618A8
公开(公告)日：2004-01-06
申请号：AU2003260618
申请日：2003-06-23
申请人： EXONHIT THERAPEUTICS SA
发明人： ANNELIES RESINK , SCHWEIGHOFFER FABIEN
IPC分类号： A61K31/425 , A61P25/28 , G01N33/50 , C12Q1/68 , A61K31/00 , A61K31/366 , A61K38/17 , A61K48/00 , C12N5/10 , G01N33/53 , G01N33/68

85. 发明专利

FR2841141A1 Treatment of amyotrophic lateral sclerosis, especially to increase neuronal survival time, comprises use of PGC1 modulator, e.g. PGC1 synthesis activator, statin or osteopontin inhibitor 未知
公开(公告)号：FR2841141A1
公开(公告)日：2003-12-26
申请号：FR0207783
申请日：2002-06-24
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , RESINK ANNELIES
IPC分类号： A61K31/428 , A61P25/28 , G01N33/50 , A61K31/22 , A61K31/351 , A61K31/40 , A61K31/404 , A61K31/426 , A61K31/427 , A61K31/4418 , C12N5/10 , C12Q1/68 , G01N33/53 , G01N33/68
摘要： Method of treating amyotrophic lateral sclerosis (ALS) comprises the use of a compound (I) that modulates the metabolic activity of PGC1 (PPAR-gamma co-activator 1). (I) is selected from: (a) PGC1 synthesis activators; (b) PPAR-beta agonists; (c) HMG CoA reductase inhibitors; and (d) osteopontin inhibitors. Independent claims are also included for: (1) a method for detecting a predisposition to, the presence of or the stage of development of ALS in a subject, involving determination ( in vitroor ex vivo) of the presence of an alteration in the locus of PGC1 in the subject; (2) a method of screening compounds (II) for activity against ALS, involving determining the effect of (II) on the activity of PGC1 and selecting (II) capable of increasing or mimicking this activity; and (3) a recombinant cell containing a nucleic acid encoding PGC1. ACTIVITY : Neuroprotective. MECHANISM OF ACTION : PGC1 metabolic activity modulator; PGC1 synthesis activator; PPAR-beta agonist; HMG CoA reductase inhibitor; osteopontin inhibitor.

86. 发明专利

AU2003244713A1 HISTONE DEACETYLASE: NOVEL MOLECULAR TARGET OF NEUROTOXICITY 未知
公开(公告)号：AU2003244713A1
公开(公告)日：2003-10-08
申请号：AU2003244713
申请日：2003-03-25
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , RESINK ANNELIES
IPC分类号： G01N33/50 , A61K31/00 , A61K31/7088 , A61P25/00 , C12N15/09 , C12Q1/02 , C12Q1/34 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566
摘要： The present invention concerns the field of biology, genetics and medicine. It particularly pertains to new methods for detecting, characterising and/or treating neurodegenerative diseases, particularly amyotrophic lateral sclerosis. The invention also pertains to methods for identifying or screening for compounds active in these diseases. The invention also relates to the compounds, genes, cells, plasmids or compositions useful for implementing said methods. The invention particularly describes the role of the histone deacetylases, and particularly histone deacetylase 2, in these diseases and its use as a therapeutic, diagnostic or experimental target.

87. 发明专利

FR2980484A1 PROCEDE ET METHODES DE DETECTION DE LA MALADIE D'ALZHEIMER 未知
公开(公告)号：FR2980484A1
公开(公告)日：2013-03-29
申请号：FR1261064
申请日：2012-11-21
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , BRACCO LAURENT
IPC分类号： C12Q1/68 , G01N33/566 , G01N33/68
摘要： La présente demande concerne des méthodes et compositions utilisables pour la détection de la maladie d'Alzheimer chez les mammifères, en particulier les humains. Elle décrit notamment des marqueurs sériques de la maladie d'Alzheimer et leurs utilisations dans des méthodes de diagnostic. Elle concerne également des outils et/ou kits utilisables pour la mise en oeuvre de ces méthodes (réactifs, sondes, amorces, anticorps, puces, cellules, etc.), leur préparation et leurs utilisations. L'invention est utilisable pour détecter la présence ou l'évolution de la maladie d'Alzheimer chez les mammifères, y compris en phase précoce.

88. 发明专利

DK1982704T3 Nyt molekylært mål for neurotoksicitet 未知
公开(公告)号：DK1982704T3
公开(公告)日：2010-10-04
申请号：DK08160783
申请日：2002-08-13
申请人： EXONHIT THERAPEUTICS SA
发明人： RESINK ANNELIES , SCHWEIGHOFFER FABIEN , AIT IKHLEF ALI
IPC分类号： C12N15/09 , C12Q1/68 , A61K31/00 , A61K31/437 , A61K31/522 , A61K31/7088 , A61K45/00 , A61K48/00 , A61P9/10 , A61P25/14 , A61P25/16 , A61P25/28 , A61P37/00 , A61P43/00 , C07D471/04 , C07D473/10 , C12N9/16 , C12Q1/44 , C12Q1/6883

89. 发明专利

PL1638559T3 Zastosowanie pirazolopirydyn w leczeniu deficytów poznawczych 未知
公开(公告)号：PL1638559T3
公开(公告)日：2010-06-30
申请号：PL04767477
申请日：2004-06-25
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , DESIRE LAURENT , RESINK ANNELIES , ROUQUETTE MAGALI
IPC分类号： A61K31/437 , A61P25/16 , A61P25/28

90. 发明专利

ES2337255T3 USO DE PIRAZOLOPIRIDINAS PARA EL TRATAMIENTO DE DEFICIT COGNITIVOS. 未知
公开(公告)号：ES2337255T3
公开(公告)日：2010-04-22
申请号：ES04767477
申请日：2004-06-25
申请人： EXONHIT THERAPEUTICS SA
发明人： SCHWEIGHOFFER FABIEN , DESIRE LAURENT , RESINK ANNELIES , ROUQUETTE MAGALI
IPC分类号： A61K31/437 , A61P25/16 , A61P25/28
摘要： Utilización de etazolato de fórmula (II) **(Ver fórmula)** o de una sal o éster del mismo, para la preparación de una composición farmacéutica dirigida a mejorar la percepción cognitiva en un paciente humano.

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