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81. 发明申请

WO1996017373A1 IONISING RADIATION DETECTOR HAVING PROPORTIONAL MICROCOUNTERS 审中-公开
标题翻译：具有比例微球的离子辐射检测器
公开(公告)号：WO1996017373A1
公开(公告)日：1996-06-06
申请号：PCT/FR1995001548
申请日：1995-11-23
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , LEMONNIER, Marc , BUCAILLE, Thierry, Claude , CHARLET, Joël, Robert , BORDESSOULE, Michel , BARTOL, François , MEGTERT, Stephan
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： H01J47/06
CPC分类号： H01J47/06
摘要： An ionising radiation detector comprising a chamber (1) filled with a noble gas and provided with an internal proportional counter (2) defining, between itself and an upper wall of the chamber, an absorption region (A) in which the radiation is ionised. The proportional counter comprises at least one anode (6) and at least one cathode (5) that are parallel to one another and separated by a layer of insulating material (7). Both the cathode and the layer of insulating material include at least one through-hole (8) in which a substantially uniform electric field is provided to form a region where electrons produced by the ionisation of the radiation are multiplied. Said detector is useful in medical imaging, biology, crystallography and particle physics.
摘要翻译：一种电离辐射检测器，包括填充有惰性气体并设置有内部比例计数器（2）的室（1），所述内部比例计数器（2）在其与腔室的上壁之间限定辐射被电离的吸收区域（A）。比例计数器包括至少一个阳极（6）和至少一个阴极（5），它们彼此平行并且被绝缘材料层（7）隔开。阴极和绝缘材料层都包括至少一个通孔（8），其中提供基本均匀的电场以形成通过辐射的电离产生的电子相乘的区域。所述检测器可用于医学成像，生物学，晶体学和粒子物理学。

82. 发明申请

WO1995031927A1 DEVICE FOR CONTROLLING EYE MOVEMENT 审中-公开
标题翻译：用于控制眼睛运动的装置
公开(公告)号：WO1995031927A1
公开(公告)日：1995-11-30
申请号：PCT/FR1995000627
申请日：1995-05-15
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , JOUEN, François , BAUDONNIERE, Pierre-Marie
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61B03/113
CPC分类号： A61B3/113
摘要： A support (12) for a living being, controllably movable in three directions, defines an area (29-I) for the eyes (30-I). A frame (1) comprises two light sources (14), supplying, at the level of the area (29-I) for the eyes (30-I), two infrared light beams (37-I), two cameras (13-I), each for capturing an image derived from the reflection of said light beam (37-I) on an eye (30-I) and processing means for digitalizing the eye images and processing them in real time to calculate the center coordinates of the corneal point (42-I) with reference to the pupil center (41-I). The processing means further control the movement of the support (12) to position the eyes (30-I) precisely in the axis of the cameras (13-I), according to the coordinates of the pupil contour. A mass memory in the microcomputer (2) stores the data relating to a plurality of basic visual tests comprising a selected sequence of visual stimulation images. The response of the eyes to an image provides a gaze direction which is analyzed by processing means.
摘要翻译：用于生物体的支撑件（12）可在三个方向上可控地移动，限定了眼睛（30-I）的区域（29-I）。框架（1）包括两个光源（14），在眼睛（30-I）的区域（29-I）的水平处提供两个红外光束（37-I），两个照相机 I），每个用于捕获从眼睛（30-I）上的所述光束（37-I）的反射导出的图像和用于数字化眼睛图像并且实时处理它们的处理装置，以计算中心坐标参照瞳孔中心（41-I）的角膜点（42-I）。处理装置还根据瞳孔轮廓的坐标进一步控制支撑件（12）的移动以将眼睛（30-I）精确地定位在照相机（13-I）的轴线上。微型计算机（2）中的大容量存储器存储与包括所选择的视觉刺激图像序列的多个基本视觉测试有关的数据。眼睛对图像的响应提供了通过处理手段分析的注视方向。

83. 发明申请

WO1995008110A1 ENZYME IMMUNOASSAY METHOD, METHOD FOR ENZYME IMMUNOASSAYING AN ANTIGEN USING A MODIFIED ELECTRODE AND ASSAY KIT 审中-公开
标题翻译：酶免疫方法，使用改性电极和测定试剂盒免疫抗原的酶的方法
公开(公告)号：WO1995008110A1
公开(公告)日：1995-03-23
申请号：PCT/FR1994001082
申请日：1994-09-15
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DEGRAND, Chantal , LIMOGES, Benoît , LEGAL LASALLE, Annie , RAPICAULT, Stéphane , BROSSIER, Pierre
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01N27/327
CPC分类号： C12Q1/42 , C12Q1/004 , G01N33/581
摘要： Enzyme immunoassay method, method for enzyme immunoassaying an antigen by electrochemical detection, and assay kit used. The object of the invention is to develop assay methods, in which the detection sensitivity of the product formed during the enzymatic reaction is increased. The object is attained using a method consisting in reacting an enzyme (E) with a substrate (S), collecting the ionic or pro-ionic electroactive product obtained at the end of the enzymatic reaction on an electrode (3) with a polyionic compound (1) of opposite charge and measuring the signal produced by said electrode (3).
摘要翻译：酶免疫测定方法，通过电化学检测酶免疫测定抗原的方法和使用的测定试剂盒。本发明的目的是开发测定方法，其中在酶促反应期间形成的产物的检测灵敏度增加。目的是使用包括使酶（E）与底物（S）反应的方法，将在酶反应结束时获得的离子或前离子电活性产物收集在具有聚离子化合物的电极（3）上的方法 1），并测量由所述电极（3）产生的信号。

84. 发明申请

WO1994026100A1 GENETICALLY ENGINEERED MICE CONTAINING ALTERATIONS IN THE GENES ENCODING RETINOIC ACID RECEPTOR PROTEINS 审中-公开
标题翻译：在基因中编码重要酸性受体蛋白质的遗传工程化小鼠
公开(公告)号：WO1994026100A1
公开(公告)日：1994-11-24
申请号：PCT/US1994005746
申请日：1994-05-18
申请人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR, STRASBOURG I , E.R. SQUIBBS & SONS, INC. , MENDELSOHN, Cathy , CHAMBON, Pierre , LUFKIN, Thomas , LOHNES, David , MARK, Manuel , DIERICH, Andrée , GORRY, Philippe , KASTNER, Philippe , LEMEUR, Marianne
发明人： INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE LOUIS PASTEUR, STRASBOURG I , E.R. SQUIBBS & SONS, INC.
IPC分类号： A01K67/00
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2267/03 , C07K14/70567
摘要： The present invention provides mice which are deficient in the normal expression of one or more members of the RAR or RXR class of receptors, to mice heterozygous for such deficiency, and to cell lines, preferably pluripotent or totipotent cell lines, which are heterozygous or homozygous for such deficiency. The present invention further provides the use of any of the above mice and cell lines in situations where the absence of at least one RAR or RXR receptors, or the normal expression thereof, is desirable.
摘要翻译：本发明提供缺乏RAR或RXR类受体的一种或多种成员的正常表达的小鼠，对于这种缺陷杂合的小鼠以及杂合或纯合的细胞系，优选多能或全能细胞系的小鼠对于这种缺陷。在不需要至少一种RAR或RXR受体或其正常表达的情况下，本发明进一步提供了上述任何一种小鼠和细胞系的用途。

85. 发明申请

WO1994016612A1 PROCESS AND DEVICE FOR EYE MOVEMENT ANALYSIS 审中-公开
标题翻译：眼睛运动分析的过程和设备
公开(公告)号：WO1994016612A1
公开(公告)日：1994-08-04
申请号：PCT/FR1994000108
申请日：1994-01-28
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , GUILLEMANT, Philippe , ULMER, Erik
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： A61B03/113
CPC分类号： A61B3/113
摘要： Process and device for the analysis of eye movement in animals or humans. The device comprises first (3) and second (5) video cameras mounted on a spectacle frame (9) and rigidly linked to one another, and form part of a removable unit (16). Said first and second cameras are aimed at points in their respective scenes which are close. The technical field for the invention is that of the manufacture of a device for the measurement of eye movement.
摘要翻译：用于分析动物或人类眼睛运动的过程和装置。该装置包括安装在眼镜框架（9）上并彼此刚性地连接并形成可移除单元（16）的一部分的第一（3）和第二（5）摄像机。所述第一和第二相机瞄准在它们各自的场景中靠近的点。本发明的技术领域是用于测量眼睛运动的装置的制造。

86. 发明申请

WO1994003869A1 ELECTRONIC DEVICE FOR IMAGE ANALYSIS AND ARTIFICIAL VISION 审中-公开
标题翻译：用于图像分析和人工视觉的电子设备
公开(公告)号：WO1994003869A1
公开(公告)日：1994-02-17
申请号：PCT/FR1993000778
申请日：1993-07-29
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , MERIGOT, Alain
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G06F15/66
CPC分类号： G06T1/20
摘要： The invention relates to an electronic device for image analysis and artificial vision comprising an assembly of elementary processors (10) wherein each processor (10), associated with an image pixel, is interconnected by serial links (12) to n neighbouring processors (10), has an internal memory limited in size and may operate in SIMD mode on its internal data. Each processor may be connected or not to its n neighbouring processors according to a connection pattern which is a subpattern of the pattern for connecting physically the processors, enabling the related components of the image to be manipulated directly. An associative operator may be applied to said related components through asynchronous communications. A local member is provided to determine the moment when the data remain stable on the processor, stability detectors for the various processors being centralized by a network of OR gates towards the central controller which may determine the occurrence time of the end of computation. Application particularly to image analysis and to artificial vision.
摘要翻译：本发明涉及一种用于图像分析和人造视觉的电子设备，包括基本处理器（10）的组件，其中与图像像素相关联的每个处理器（10）通过串行链路（12）互连到相邻处理器（10）内部存储器的大小有限，可以在内部数据的SIMD模式下运行。每个处理器可以根据作为用于物理地连接处理器的模式的子模式的连接模式连接到其n个相邻处理器，从而能够直接操纵图像的相关组件。关联运算符可以通过异步通信应用于所述相关组件。提供本地成员来确定数据在处理器上保持稳定的时刻，各种处理器的稳定性检测器由可能确定计算结束的发生时间的中央控制器的或门网络集中。尤其适用于图像分析和人工视觉。

87. 发明申请

WO1993019092A1 DEFECTIVE RECOMBINANT ADENOVIRUSES EXPRESSING CHARACTERISTIC EPSTEIN-BARR VIRUS PROTEINS 审中-公开
标题翻译：表达特征性EPSTEIN-BARR病毒蛋白的有缺陷的重组腺病毒
公开(公告)号：WO1993019092A1
公开(公告)日：1993-09-30
申请号：PCT/FR1992000256
申请日：1992-03-19
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CANCER RESEARCH CAMPAIGN IN LONDON , PERRICAUDET, Michel , RAGOT, Thierry , FINERTY, Susan , MORGAN, Andrew, J.
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CANCER RESEARCH CAMPAIGN IN LONDON
IPC分类号： C07K15/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C12N15/86 , C12N2710/10343 , C12N2710/16222 , C12N2710/16234
摘要： A recombinant vector characterized in that it includes a genomic sequence of a defective adenovirus, i.e. one that lacks the sequences needed for it to replicate, as well as an insert including one or more DNA sequences coding for any characteristic protein of the Epstein-Barr Virus (EBV) which can induce the formation in a patient of EBV-protective neutralizing antibodies and, if required, protective cells, particularly cytotoxic and helper lymphocytes, said insert being under the control of a promoter present in or pre-inserted into the adenovirus genome. Said vector may be used to produce vaccines for diseases caused by EBV in humans or animals.
摘要翻译：一种重组载体，其特征在于其包括缺陷型腺病毒的基因组序列，即缺乏其复制所需的序列的基因组序列，以及包含编码爱泼斯坦 - 巴尔病毒任何特征性蛋白质的一个或多个DNA序列的插入片段（EBV），其可以诱导EBV保护性中和抗体患者的形成，并且如果需要，保护性细胞，特别是细胞毒性和辅助性淋巴细胞，所述插入物处于存在于或预插入腺病毒基因组中的启动子的控制下。所述载体可用于产生由人或动物中的EBV引起的疾病的疫苗。

88. 发明申请

WO1992008741A1 METHOD FOR PREPARING COMPOUNDS FOR GRADUALLY RELEASING GLUCOSAMINE OLIGOMERS, COMPOUNDS THEREBY OBTAINED AND USES THEREOF 审中-公开
标题翻译：用于制备化合物的方法，用于梯度释放葡萄糖胺低聚物，其获得的化合物及其用途
公开(公告)号：WO1992008741A1
公开(公告)日：1992-05-29
申请号：PCT/FR1991000908
申请日：1991-11-18
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , DOMARD, Alain , CARTIER, Noël
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C08B37/00
CPC分类号： A01N43/16 , C07H3/06 , C08B37/003
摘要： Glucosamine oligomers having relatively low degrees of polymerization are provided as active principles or agents in a treatment. It has been shown that by allowing such compounds to rest once isolated, a mixture can be obtained which includes, firstly, at least one isomolecular aggregate which directly and physically combines several molecules of the basic oligomer, whose total molar mass is a multiple of that of said basic oligomer, and secondly, the isolated form of the same oligomer, i.e. in an unaggregated state. In solution, this mixture leads to a pseudo-equilibrium between the above-mentioned components. Therefore, the method provides a controlled-release form of the glucosamine oligomers.

89. 发明申请

WO1992002827A1 PERMANENT MAGNET FOR NMR IMAGING EQUIPMENT 审中-公开
标题翻译：用于NMR成像设备的永久磁铁
公开(公告)号：WO1992002827A1
公开(公告)日：1992-02-20
申请号：PCT/FR1991000617
申请日：1991-07-25
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , AUBERT, Guy
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： G01R33/38
CPC分类号： H01F7/0278 , G01R33/383
摘要： A 'plate'-type magnet is produced for use in a nuclear magnetic resonance imaging machine by forming rings (8, 12, 14) of blocks (1) of magnetic materials and arranging the rings concentrically (15) one inside the other. By making two (6, 7) such plates and arranging them facing each other, a transverse field can be created in the air gap (10) between the plates, the homogeneity of the field can be set at a very high level, and no soft iron magnetic field reversal structures, which in any case are shown to have disadvantages, are needed. The magnet can be used in particular in NMR imaging machines.

90. 发明申请

WO1991016373A1 PROCESS FOR CROSS-LINKING ESTERIFIED (CO)POLYMERS 审中-公开
标题翻译：交联（CO）聚合物的方法
公开(公告)号：WO1991016373A1
公开(公告)日：1991-10-31
申请号：PCT/FR1991000314
申请日：1991-04-16
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SOTRA INDUSTRIES , GONDARD, Christian , MICHEL, Alain
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , SOTRA INDUSTRIES
IPC分类号： C08J03/24
CPC分类号： C08J3/246
摘要： Process for cross-linking (co)polymers comprising ester functions in which a polyalcohol-derived polyester and a polyacid-derived polyester are reacted in the presence of an alkaline alcoholate at a temperature in excess of 180°, compositions for cross-linking and formed products.

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