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81. 发明授权

US5159936A Noncontact infrared tympanic thermometer 失效
标题翻译：非接触红外鼓膜温度计
公开(公告)号：US5159936A
公开(公告)日：1992-11-03
申请号：US570205
申请日：1990-08-17
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/01 , A61B20060101 , A61B1/227 , A61B5/00 , G01J20060101 , G01J5/04 , G01J5/06 , G01J5/10 , G01J5/12 , G01J5/14 , G01K11/00 , G01K13/00
CPC分类号： G01J5/04 , A61B1/227 , G01J5/02 , G01J5/028 , G01J5/08 , G01J5/0812 , G01J5/0862 , G01J2005/066 , G01J2005/068 , G01J5/045 , G01J5/049 , G01J5/14
摘要： A noncontact infrared tympanic thermometer which does not require environmental stabilization or waveguide temperature control because it utilizes an optically stabilized infrared detector for detecting the infrared energy emitted by the tympanic membrane. The optical stabilization renders the instrument insensitive to ambient temperature effects and allows it to read true tympanic membrane temperatures unaffected by the temperature of the side walls of the detector package. This selectivity is accomplished by locating a neutral density filter over half of the optical aperture of the detector package such that the neutral density filter "shadows" only one of two thermopile channels for detecting the infrared energy emitted by the tympanic membrane. The two thermopile channels are connected in series opposition such that any optical signal equally present in both channels will yield a zero net output. Since the infrared energy emitted by the walls of the detector package reach each detector equally, the effects of these emissions on the temperature measurement are eliminated. The neutral density filter prevents the energy from the tympanic membrane from falling equally on the two thermopile detectors and similarly cancelling. Instead, the resulting differential signal may be processed along with the ambient temperature signal to determine the temperature of the tympanic membrane. The infrared detector of the invention may also be incorporated into an otoscope.
摘要翻译：一种非接触红外鼓膜温度计，其不需要环境稳定或波导温度控制，因为它使用光学稳定的红外检测器来检测由鼓膜发射的红外能量。光学稳定化使仪器对环境温度的影响不敏感，并允许其读取不受检测器封装侧壁温度影响的真实鼓膜温度。这种选择性是通过将中性密度滤光片定位在检测器封装的光学孔径的一半上来实现的，使得中性密度滤光器仅“阴影”两个热电堆通道中的一个，用于检测由鼓膜发射的红外能量。两个热电堆通道串联连接，使得两个通道中同样存在的任何光信号将产生零净输出。由于检测器组件的壁发射的红外能量均匀地到达每个检测器，所以消除了这些排放对温度测量的影响。中性密度过滤器防止鼓膜的能量均匀地下降到两个热电堆检测器上并且类似地消除。相反，所得到的差分信号可以与环境温度信号一起被处理以确定鼓膜的温度。本发明的红外检测器也可以结合到耳镜中。

82. 发明授权

US5081998A Optically stabilized infrared energy detector 失效
标题翻译：光学稳定的红外能量探测器
公开(公告)号：US5081998A
公开(公告)日：1992-01-21
申请号：US522177
申请日：1990-05-11
申请人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
发明人： Mark Yelderman , Daniel S. Goldberger , James R. Braig
IPC分类号： A61B5/083 , G01J1/24 , G01J5/12 , G01N21/31 , G01N21/35
CPC分类号： A61B5/083 , G01N21/3504 , G01J1/24 , G01J5/12 , G01N2021/3166 , G01N2201/126
摘要： Improved infrared detectors for use in device such as capnographs are provided. A preferred embodiment of an infrared detector of the invention is comprised of paired thermopiles, connect in opposed relation to each other, which are preceded by an analytical or reference filter for passing a desired wavelength and a neutral density filter in the optical path of one of the thermopiles in the pair. The difference between the outputs can be used to eliminate the effects of background thermal noise, thereby improving performance of the detector. Preferably, a reference channel and an analytical channel are provided so that the respective differences between the detectors in each pair can be used to further cancel the effects of background thermal noise.
摘要翻译：提供了改进的红外探测器，用于诸如盖帽仪等设备。本发明的红外检测器的一个优选实施例由成对的热电堆组成，它们彼此相对地连接，其前面是用于使所需波长传递的分析或参考滤波器，以及在这对热电堆。输出之间的差异可以用于消除背景热噪声的影响，从而提高检测器的性能。优选地，提供参考通道和分析通道，使得可以使用每对中的检测器之间的相应差异来进一步抵消背景热噪声的影响。

83. 发明授权

US5042522A Airway adapter with backflush tube 失效
标题翻译：气道适配器带反吹管
公开(公告)号：US5042522A
公开(公告)日：1991-08-27
申请号：US458971
申请日：1990-01-25
申请人： James E. Corenman , Daniel S. Goldberger , Edward M. Richards , Emil P. Rojas , James R. Braig , David A. Gallup
发明人： James E. Corenman , Daniel S. Goldberger , Edward M. Richards , Emil P. Rojas , James R. Braig , David A. Gallup
IPC分类号： A61B5/083 , G01N21/35
CPC分类号： G01N21/3504 , A61B5/083 , G01N2201/121 , Y10T137/4252 , Y10T137/8122
摘要： A backflushing system for an inlet filter in an airway adapter in a gas flow sampling and analyzing system includes a back flush fluid supply conduit and sampling conduit connected to the airway adapter by a single coupling element. Flow of back flush fluid causes material blocking the filter to be washed away into the respiratory conduit for disposal. Flow of backflush fluid is restricted to one way flow through the backflush conduit by a disk shaped valve member mounted in the air way adapter.
摘要翻译：用于气流采样和分析系统中的气道适配器中的入口过滤器的反冲洗系统包括背冲洗流体供应管道和通过单个联接元件连接到气道适配器的取样管道。反冲洗液的流动导致材料阻塞过滤器被冲走到呼吸管道中进行处置。反冲洗流体的流动被限制为通过安装在空气调节适配器中的盘形阀构件通过反冲洗管道的单向流动。

84. 发明授权

US4817013A Multichannel gas analyzer and method of use 失效
标题翻译：多通道气体分析仪及其使用方法
公开(公告)号：US4817013A
公开(公告)日：1989-03-28
申请号：US922043
申请日：1986-10-17
申请人： James E. Corenman , James R. Braig , Daniel S. Goldberger , Emil P. Rojas , James H. Stone
发明人： James E. Corenman , James R. Braig , Daniel S. Goldberger , Emil P. Rojas , James H. Stone
IPC分类号： G01N21/31 , G01N21/35 , G01N21/64
CPC分类号： G01N21/3504 , G01N2021/3129 , G01N2201/121
摘要： An improved gas analyzer system (FIG. 1) and method of use for detecting and displaying the constituent gases of a respiratory gas stream, the system comprising an optical bench (109) through which a respiratory gas flows and in which measurements of the gas are taken; analog input circuits (122) for receiving signals output from the optical bench (109); analog processing circuits (124) for processing signals output from the analog input circuits (122); display processing circuits (128) for processing the signals output from the analog processing circuits (124) and other system circuitry; pixel logic circuits/analog outputs (130) for processing signals output from the display processing circuitry (128) and providing analog output ports; a five button panel (148), an alarm-knob board (144), and a speaker driver (152) for operator interface and activation of audible and visual alarms; a CRT driver for driving the CRT; and a power supply (158) for powering the system.
摘要翻译：一种改进的气体分析器系统（图1）和用于检测和显示呼吸气流的组成气体的方法，该系统包括一个光学平台（109），呼吸气体通过该工作台流动，其中气体的测量是采取模拟输入电路（122），用于接收从光学平台（109）输出的信号; 模拟处理电路（124），用于处理从模拟输入电路（122）输出的信号; 显示处理电路（128），用于处理从模拟处理电路（124）和其它系统电路输出的信号; 用于处理从显示处理电路（128）输出的信号并提供模拟输出端口的像素逻辑电路/模拟输出（130）五按钮面板（148），报警旋钮板（144）和扬声器驱动器（152），用于操作者界面和激活声音和视觉报警器; 用于驱动CRT的CRT驱动器; 以及用于为系统供电的电源（158）。

85. 发明授权

US09848821B2 Systems and methods to reduce fluid contamination 有权
公开(公告)号：US09848821B2
公开(公告)日：2017-12-26
申请号：US13162315
申请日：2011-06-16
申请人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan , David N. Callicoat
IPC分类号： A61B5/00 , B65D33/00 , B65D81/00 , A61D5/00 , A61M1/00 , A61M27/00 , A61B5/145 , A61B5/1459 , A61B5/1495 , A61B5/15 , A61B5/153 , A61B5/157 , A61M5/14 , A61M5/172 , A61M5/145 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/14532 , A61B5/1459 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61B5/157 , A61B5/6866 , A61M5/1415 , A61M5/1452 , A61M5/1723 , A61M2005/14208 , A61M2205/3331 , A61M2205/50 , A61M2205/52 , A61M2230/201
摘要： Methods and systems for determining the concentration of one or more analytes from a sample such as blood or plasma are described. The systems described herein can be configured to withdraw a certain volume of sample from a source of bodily fluid, direct a first portion of the withdrawn sample to an analyte monitoring system and return a second portion of the sample to the patient. The analyte monitoring system can include an automated blood withdrawal system that is configured to withdraw blood from the patient's vasculature at low pressure and/or withdrawal rates so as to reduce or prevent contamination of the withdrawn fluid from the infusion fluids.

86. 发明授权

US09414782B2 Fluid component analysis systems and methods for glucose monitoring and control 有权
公开(公告)号：US09414782B2
公开(公告)日：2016-08-16
申请号：US13619825
申请日：2012-09-14
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172 , A61B5/00 , A61B5/155 , A61B5/145 , A61B5/1455 , A61B5/1495 , G06F19/00 , A61M5/168 , A61M5/14 , A61M5/142
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.

87. 发明授权

US07785258B2 System and method for determining a treatment dose for a patient 有权
标题翻译：用于确定患者治疗剂量的系统和方法
公开(公告)号：US07785258B2
公开(公告)日：2010-08-31
申请号：US11316523
申请日：2005-12-21
申请人： James R. Braig , Peter Rule
发明人： James R. Braig , Peter Rule
IPC分类号： A61B5/00 , A61B5/05 , C12M1/34 , C12M3/00 , C12M1/36 , C12M1/00
CPC分类号： G06F19/3468 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1486 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N21/274 , G01N21/35 , G01N2201/1293 , G06F19/00
摘要： In certain embodiments, a method of maintaining health of a patient uses an analyte detection system. The analyte detection system is coupled to the patient such that a bodily fluid of the patient is accessible to the analyte detection system. The method includes automatically initiating and conducting a measurement of an analyte in the bodily fluid using the analyte detection system. The method further includes determining a treatment dose for the patient based on the measurement using the analyte detection system.
摘要翻译：在某些实施例中，维持患者健康的方法使用分析物检测系统。分析物检测系统耦合到患者，使得患者的体液可被分析物检测系统访问。该方法包括使用分析物检测系统自动启动和进行体液中的分析物的测量。该方法还包括基于使用分析物检测系统的测量确定患者的治疗剂量。

88. 发明申请

US20090131861A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20090131861A1
公开(公告)日：2009-05-21
申请号：US12249831
申请日：2008-10-10
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

89. 发明申请

US20110306856A1 SYSTEMS AND METHODS FOR MEASURING MULTIPLE ANALYTES IN A SAMPLE 有权
标题翻译：用于在样品中测量多个分析物的系统和方法
公开(公告)号：US20110306856A1
公开(公告)日：2011-12-15
申请号：US13156295
申请日：2011-06-08
申请人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
发明人： Peter Rule , James R. Braig , Richard Keenan, II , David Callicoat
IPC分类号： A61B5/157 , A61B6/00
CPC分类号： G01N33/491 , A61B5/1427 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1495 , A61B5/150022 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150801 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B5/7275 , A61B2560/0223 , A61B2560/0233 , A61B2560/0437 , A61B2560/0443 , A61B2562/0238 , A61B2562/08 , G01N21/35 , G01N2021/3174 , G01N2201/1215 , G01N2201/1293 , G06F19/00
摘要： Systems and methods for analyzing multiple components of a fluid sample are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a first component of a fluid sample received from a patient and measure second analyte data in a second component of a fluid sample. In some embodiments, one or more portions of an optical system is movable with respect to other portions of the system in order to optically and/or electrochemically analyze multiple components of a fluid sample. In other embodiments, optical and/or electrochemical analysis can be performed simultaneously on multiple components of a fluid sample. In some embodiments, a first analyte can be measured in a sample (e.g., whole blood) before the sample is separated into its components (e.g., plasma, red blood cells, etc.), and a second analyte can be measured in a component of the sample after separation.
摘要翻译：提供了用于分析流体样品的多个组分的系统和方法。在某些实施方案中，系统可以包括分析物检测系统，其被配置为测量从患者接收的流体样品的第一组分中的第一分析物数据，并测量流体样品的第二组分中的第二分析物数据。在一些实施例中，光学系统的一个或多个部分可相对于系统的其它部分移动，以光学和/或电化学分析流体样品的多个部件。在其它实施方案中，可以在流体样品的多个组分上同时进行光学和/或电化学分析。在一些实施方案中，在将样品分离成其组分（例如血浆，红细胞等）之前，可以在样品（例如全血）中测量第一分析物，并且可以在组分的样品分离后。

90. 发明授权

US07972296B2 Fluid component analysis system and method for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US07972296B2
公开(公告)日：2011-07-05
申请号：US12249831
申请日：2008-10-10
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M31/00
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g. insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

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