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81. 发明申请

US20050036916A1 Sampling device 审中-公开
标题翻译：取样装置
公开(公告)号：US20050036916A1
公开(公告)日：2005-02-17
申请号：US10498418
申请日：2002-12-12
申请人： Andrew Thomas , Neil Shand , Andrew Langdown
发明人： Andrew Thomas , Neil Shand , Andrew Langdown
IPC分类号： G01N1/00 , B01L3/00 , G01N1/02 , G01N1/04
CPC分类号： B01L3/5055 , G01N1/02 , G01N2001/007 , G01N2001/028
摘要： A sampling device comprising a foldable support means suitable for supporting a sample collection substrate having at least one sample collection surface, the support means being foldable between a first position in which, in use, the at least one sample collection surface is deployed for the collection of a sample and a second position in which a collected sample is protected against contamination and/or loss.
摘要翻译：一种采样装置，其包括适于支撑具有至少一个样品收集表面的样品收集基底的可折叠支撑装置，所述支撑装置可在第一位置和第二位置之间折叠，在第一位置中，在使用中将所述至少一个样品收集表面部署用于收集的样品和第二位置，其中收集的样品被保护免受污染和/或损失。

82. 发明申请

US20160146759A1 CIRCUIT AND METHOD OF PROVIDING A STABLE DISPLAY FOR EDDY CURRENT INSTRUMENTS 有权
标题翻译：为EDDY电流仪器提供稳定显示器的电路和方法
公开(公告)号：US20160146759A1
公开(公告)日：2016-05-26
申请号：US14550217
申请日：2014-11-21
申请人： Andrew Thomas
发明人： Andrew Thomas
IPC分类号： G01N27/90
CPC分类号： G01N27/9046 , G01N27/908
摘要： A rotary bolt hole eddy current inspection scanner using a differential eddy current probe, the circuitry of the scanner is embodied with a filtering circuit with three filters: FIR (Finite Impulse Response), a low pass filter, and a phase control filter (by means of a Hilbert transform). The result from a scan of a bolt hole is an output signal on an impedance plane exhibiting a “backwards 6” shape of stable size when the scanner changes its rotating rate significantly.
摘要翻译：使用差分涡流探头的旋转螺栓孔涡流检测扫描器，扫描器的电路具有滤波电路，滤波电路具有三个滤波器：FIR（有限脉冲响应），低通滤波器和相位控制滤波器希尔伯特变换）。扫描螺栓孔的结果是当扫描仪显着改变其旋转速率时，阻抗平面上的输出信号呈现出具有稳定尺寸的“向后6”形状。

83. 发明申请

US20150212184A1 PACKET BASED DDS MINIMIZING MATHEMATICAL AND DAC NOISE 有权
标题翻译：基于分组的DDS最小化数字和DAC噪声
公开(公告)号：US20150212184A1
公开(公告)日：2015-07-30
申请号：US14163600
申请日：2014-01-24
申请人： Andrew Thomas
发明人： Andrew Thomas
IPC分类号： G01R35/00
CPC分类号： G06F1/0321 , G01N27/9046 , G06F1/022 , G06F17/5045
摘要： Disclosed are a method of and an apparatus devising a packet based DDS circuitry for performing packet based a direct digital synthesizing (DDS) function within an electronic testing instrument. The circuitry comprising a DDS logic circuit configured to execute direct digital syntheses on a plurality of consecutive packets of sine-like waves, each packet having a length of a period precisely chosen such that the sine wave at the end of one packet matches up with the sine wave at the start of the immediate subsequent packet. Also disclosed is an eddy current testing circuitry using multiple outputs of the single packet based DDS, one of the output is used in a circuit producing reference signals approximating the response signals. With the usage of the packet based DDS, the reference signal can be highly effective in nulling the unchanging portion of the response signals.
摘要翻译：公开了一种设计基于分组的DDS电路的方法和装置，用于基于电子测试仪器内的直接数字合成（DDS）功能执行分组。该电路包括DDS逻辑电路，该DDS逻辑电路经配置以在正弦波的多个连续分组上执行直接数字合成，每个分组具有精确选择的周期的长度，使得一个分组结束时的正弦波与正弦波在即时后续数据包的开始。还公开了使用基于单个分组的DDS的多个输出的涡流测试电路，其中一个输出用于产生近似响应信号的参考信号。通过使用基于分组的DDS，参考信号可以在使响应信号的不变部分归零时非常有效。

84. 发明授权

US08829763B2 Apparatus for and a method of improved timing control for non-destructive testing and inspection 有权
标题翻译：用于非破坏性测试和检查的改进的时序控制的装置和方法
公开(公告)号：US08829763B2
公开(公告)日：2014-09-09
申请号：US13434276
申请日：2012-03-29
申请人： Andrew Thomas
发明人： Andrew Thomas
IPC分类号： G01N29/34 , H01L41/09
CPC分类号： G01N29/343 , G01N29/04 , G01N29/043 , G01N29/34 , G01N33/00 , G01N2033/0096 , G01N2291/0237 , G01N2291/02854 , H01L41/042 , H03K5/131
摘要： A pulse generation circuit and method includes using digital signals to trigger a first and second varying analog signals and detecting when they reach one or more reference levels. In response to the first and second varying analog signals reaching one or more reference levels, a first and a second digital control signals are produced and provided as input to a pulser producing a voltage excitation pulse having a width and timing defined by the first and second digital control signals.
摘要翻译：脉冲发生电路和方法包括使用数字信号来触发第一和第二变化的模拟信号并检测它们何时达到一个或多个参考电平。响应于第一和第二变化的模拟信号达到一个或多个参考电平，产生第一和第二数字控制信号作为脉冲发生器的输入，产生具有由第一和第二信号定义的宽度和定时的电压激励脉冲数字控制信号。

85. 发明授权

US08748418B2 1,4-oxazepines as BACE1 and/or BACE2 inhibitors 失效
标题翻译： 1,4-氧氮杂作为BACE1和/或BACE2抑制剂
公开(公告)号：US08748418B2
公开(公告)日：2014-06-10
申请号：US13415873
申请日：2012-03-09
申请人： Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Mark Rogers-Evans , Didier Rombach , Andrew Thomas , Thomas Woltering , Wolfgang Wostl
发明人： Emanuele Gabellieri , Wolfgang Guba , Hans Hilpert , Harald Mauser , Alexander V. Mayweg , Mark Rogers-Evans , Didier Rombach , Andrew Thomas , Thomas Woltering , Wolfgang Wostl
IPC分类号： A61K31/553 , C07D413/02 , C07D267/10
CPC分类号： C07D267/10 , C07D413/12
摘要： The present invention relates to 1,4-Oxazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.
摘要翻译：本发明涉及具有BACE1和/或BACE2抑制活性的式I的1,4-氧氮杂，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用于例如治疗和/或预防性治疗。阿尔茨海默病和2型糖尿病。

86. 发明授权

US08712716B2 Circuitry for measuring and compensating phase and amplitude differences in NDT/NDI operation 有权
标题翻译：用于测量和补偿NDT / NDI操作中的相位和幅度差的电路
公开(公告)号：US08712716B2
公开(公告)日：2014-04-29
申请号：US13194568
申请日：2011-07-29
申请人： Andrew Thomas , Marc Dulac
发明人： Andrew Thomas , Marc Dulac
IPC分类号： G06F19/00
CPC分类号： G01N29/32 , G01N29/36 , G01N29/4436
摘要： Disclosed are a method and an NDT/NDI inspection device deploying digital circuitry to conduct detection and compensation of phase and amplitude shift in responding signals. A digital waveform generator, such as a direct digital synthesizer (DDS) is used to generate a digital sine-wave of a specific frequency and amplitude, mimicking the pulser frequency and amplitude. The sine-wave is converted to analog signal through a DAC and transmitted to the transducer. The received analog sine-wave from the transducer is converted back to a digital signal through an ADC. The transmitted and received digital signals are then compared for phase and amplitude differences. A null circuit involving another waveform generating component is employed to compensate the detected phase and amplitude differences. As a result the phase and amplitude differences are effectively eliminated before being further processed and analyzed for defects information.
摘要翻译：公开了一种方法和NDT / NDI检测装置，其部署数字电路以进行响应信号中的相位和幅度偏移的检测和补偿。诸如直接数字合成器（DDS）的数字波形发生器用于产生特定频率和幅度的数字正弦波，模拟脉冲发生器的频率和振幅。正弦波通过DAC转换为模拟信号并传输到传感器。来自传感器的接收到的模拟正弦波通过ADC转换回数字信号。然后将发送和接收的数字信号进行相位和幅度差分比较。采用涉及另一个波形发生部件的零电路来补偿检测到的相位和幅度差异。因此，在进一步处理和分析缺陷信息之前，相位和幅度差异被有效地消除。

87. 发明授权

US08697696B2 Triazole compounds II 有权
标题翻译：三唑化合物II
公开(公告)号：US08697696B2
公开(公告)日：2014-04-15
申请号：US13287152
申请日：2011-11-02
申请人： Stephen Deems Gabriel , Andrew Thomas
发明人： Stephen Deems Gabriel , Andrew Thomas
IPC分类号： C07D403/12 , C07D405/14 , C07D413/14 , C07D417/06 , C07D417/14
CPC分类号： C07D413/14 , C07D403/12 , C07D405/14 , C07D417/06 , C07D417/14
摘要： The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, u, v, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. The compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as pharmaceuticals.
摘要翻译：本发明涉及式（I）的新三唑化合物，其中A，X，Y，u，v，R 1，R 2和R 3如本文所述，以及其药学上可接受的盐。本发明的化合物对GABA Aα5受体具有亲和性和选择性。此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。

88. 发明授权

US08410104B2 Pyridazines 有权
标题翻译：哒嗪
公开(公告)号：US08410104B2
公开(公告)日：2013-04-02
申请号：US12768765
申请日：2010-04-28
申请人： Matthew C. Lucas , Andrew Thomas
发明人： Matthew C. Lucas , Andrew Thomas
IPC分类号： A61K31/501 , C07D413/12 , C07D413/14
CPC分类号： C07D413/12
摘要： The present invention is concerned with isoxazole-pyridazines of formula I, having affinity and selectivity for GABA A α5 receptor, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful as cognitive enhancer or for the therapeutic and/or prophylactic treatment of cognitive disorders like Alzheimer's disease.
摘要翻译：本发明涉及式I的异恶唑 - 哒嗪，对GABA Aα5受体具有亲和力和选择性，其制备方法，含有它们的药物组合物及其作为治疗活性物质的用途。本发明的活性化合物可用作认知增强剂或用于治疗和/或预防性治疗认知障碍如阿尔茨海默氏病。

89. 发明申请

US20120115868A1 NOVEL TRIAZOLE COMPOUNDS II 有权
标题翻译：新型三唑化合物II
公开(公告)号：US20120115868A1
公开(公告)日：2012-05-10
申请号：US13287152
申请日：2011-11-02
申请人： Stephen Deems Gabriel , Andrew Thomas
发明人： Stephen Deems Gabriel , Andrew Thomas
IPC分类号： A61K31/422 , C07D405/14 , A61K31/4155 , A61K31/5377 , C07D417/06 , A61K31/427 , C07D417/14 , A61K31/4439 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/22 , A61P25/30 , A61P25/14 , A61P25/16 , A61P25/24 , C07D413/14
CPC分类号： C07D413/14 , C07D403/12 , C07D405/14 , C07D417/06 , C07D417/14
摘要： The present invention is concerned with novel triazole compounds of formula (I) wherein A, X, Y, u, v, R1, R2, and R3 are as described herein, as well as pharmaceutically acceptable salts thereof. The compounds of present invention have affinity and selectivity for the GABA A α5 receptor. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as pharmaceuticals.
摘要翻译：本发明涉及式（I）的新三唑化合物，其中A，X，Y，u，v，R 1，R 2和R 3如本文所述，以及其药学上可接受的盐。本发明的化合物对GABA Aα5受体具有亲和性和选择性。此外，本发明涉及制备式（I）化合物，包含它们的药物组合物及其作为药物的用途。

90. 发明申请

US20120095011A1 NOVEL COMPOUNDS 审中-公开
标题翻译：新型化合物
公开(公告)号：US20120095011A1
公开(公告)日：2012-04-19
申请号：US13313097
申请日：2011-12-07
申请人： Bernard Barlaam , Andrew Pape , Andrew Thomas
发明人： Bernard Barlaam , Andrew Pape , Andrew Thomas
IPC分类号： A61K31/506 , A61P35/00 , A61P35/02 , C07D403/12
CPC分类号： C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14
摘要： The invention provides compounds of formula in which R1, R2, R3 and R4 have the meanings defined in the specification; processes for their preparation; pharmaceutical compositions containing them; a process for preparing the pharmaceutical compositions; and their use in therapy.
摘要翻译：本发明提供式R1化合物，其中R1，R2，R3和R4具有本说明书中定义的含义; 其准备过程; 含有它们的药物组合物; 制备药物组合物的方法; 及其在治疗中的应用。

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