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81. 发明申请

US20110118273A1 PYRROLO-PYRIDINE, PYRROLO-PYRIMIDINE AND RELATED HETEROCYCLIC COMPOUNDS 失效
标题翻译：吡咯并吡啶，吡咯并吡啶和相关的杂环化合物
公开(公告)号：US20110118273A1
公开(公告)日：2011-05-19
申请号：US13014066
申请日：2011-01-26
申请人： Jun Yuan , Peter Hrnciar , Qin Guo , George D. Maynard
发明人： Jun Yuan , Peter Hrnciar , Qin Guo , George D. Maynard
IPC分类号： A61K31/519 , C07D487/04 , A61P29/00 , A61P37/00 , A61P37/06 , A61P11/06 , A61P17/06 , A61P25/28 , A61P25/00 , A61P11/00 , A61P9/10 , A61P13/12 , A61P27/02 , A61P31/18
CPC分类号： C07D471/04
摘要： Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R2, R5, E, Z1, Z3, Z4, and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.
摘要翻译：吡咯并 - 吡啶，吡咯并 - 嘧啶和相关的杂环化合物，其分子式如下：其中R，R 2，R 5，E，Z 1，Z 3，Z 4和Ar如本文所定义。这些化合物是C5a受体的配体。本发明优选的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物以高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。此外，本发明提供了标记的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物，其可用作C5a受体定位的探针。

82. 发明申请

US20100267698A1 Benzimidazole and Pyridylimidazole Derivatives 审中-公开
标题翻译：苯并咪唑和吡啶基咪唑衍生物
公开(公告)号：US20100267698A1
公开(公告)日：2010-10-21
申请号：US12652435
申请日：2010-01-05
申请人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
发明人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
IPC分类号： A61K31/55 , C07D401/14 , A61K31/4439 , C07D403/06 , A61K31/4184 , A61K31/4196 , A61K31/41 , C07D413/14 , A61K31/4245 , C07D471/04 , A61K31/437 , C07D417/14 , A61K31/427 , C07D473/00 , A61K31/52 , C07D403/14 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/00 , C12N5/079 , C12Q1/02
CPC分类号： C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A受体的苯并二氮杂位点的化合物。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I化合物的新方法。本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A受体定位的探针。

83. 发明授权

US07769866B2 Virtual connectivity with subscribe-notify service 有权
标题翻译：与订阅通知服务的虚拟连接
公开(公告)号：US07769866B2
公开(公告)日：2010-08-03
申请号：US10619332
申请日：2003-07-14
申请人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
发明人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
IPC分类号： G06F15/16
CPC分类号： H04L61/2571 , H04L29/12009 , H04L29/12518 , H04L63/12 , H04L67/26 , H04W80/04 , H04W88/18
摘要： A middle layer network protocol enhancement, virtual connectivity (VC) makes the network attachment point changes of local and remote peers transparent to applications that use network services. A virtual connectivity module local to each peer translates communication connection parameters from apparent to real and vice versa, as well as sending and receiving secure connection updates directly to and from peers. Unlike Mobile IP, no routing infrastructure modifications are required. A subscribe-notify service provides connection update notifications when direct peer-to-peer connection updates are not possible, for example, when two communicating peers move simultaneously or when the moving peer is communicating with a peer behind network address translation (NAT). Methods for detecting these conditions are disclosed, as is a virtual connectivity protocol and virtual connectivity module architecture.
摘要翻译：中间层网络协议增强，虚拟连接（VC）使本地和远程对等体的网络连接点更改对使用网络服务的应用程序透明化。每个对等体本地的虚拟连接模块将通信连接参数从明显转换为实际，反之亦然，以及直接向对方发送和接收安全连接更新。与移动IP不同，不需要进行路由基础架构修改。当直接对等连接更新不可行时，例如当两个通信对等体同时移动或当移动对等体与网络地址转换（NAT）之后的对等体通信时，订阅通知服务提供连接更新通知。公开了用于检测这些条件的方法，以及虚拟连接协议和虚拟连接模块架构。

84. 发明授权

US07581010B2 Virtual connectivity with local connection translation 有权
标题翻译：虚拟连接与本地连接转换
公开(公告)号：US07581010B2
公开(公告)日：2009-08-25
申请号：US10619330
申请日：2003-07-14
申请人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
发明人： Chuanxiong Guo , Jun Yuan , Qian Zhang , Wenwu Zhu
IPC分类号： G06F15/16
CPC分类号： H04L63/12 , H04L29/06 , H04L29/12009 , H04L29/12518 , H04L61/2571 , H04L69/32 , H04W8/14 , H04W36/0011 , H04W80/04
摘要： A middle layer network protocol enhancement, virtual connectivity (VC) makes the network attachment point changes of local and remote peers transparent to applications that use network services. A virtual connectivity module local to each peer translates communication connection parameters from apparent to real and vice versa, as well as sending and receiving secure connection updates directly to and from peers. Unlike Mobile IP, no routing infrastructure modifications are required. A subscribe-notify service provides connection update notifications when direct peer-to-peer connection updates are not possible, for example, when two communicating peers move simultaneously or when the moving peer is communicating with a peer behind network address translation (NAT). Methods for detecting these conditions are disclosed, as is a virtual connectivity protocol and virtual connectivity module architecture.
摘要翻译：中间层网络协议增强，虚拟连接（VC）使本地和远程对等体的网络连接点更改对使用网络服务的应用程序透明化。每个对等体本地的虚拟连接模块将通信连接参数从明显转换为实际，反之亦然，以及直接向对方发送和接收安全连接更新。与移动IP不同，不需要进行路由基础架构修改。当直接对等连接更新不可行时，例如当两个通信对等体同时移动或当移动对等体与网络地址转换（NAT）之后的对等体通信时，订阅通知服务提供连接更新通知。公开了用于检测这些条件的方法，以及虚拟连接协议和虚拟连接模块架构。

85. 发明申请

US20080313162A1 METHODS AND SYSTEMS FOR CONTEXT BASED QUERY FORMULATION AND INFORMATION RETRIEVAL 有权
标题翻译：基于上下文的查询配置和信息检索的方法和系统
公开(公告)号：US20080313162A1
公开(公告)日：2008-12-18
申请号：US11762214
申请日：2007-06-13
申请人： Ali Bahrami , Jun Yuan
发明人： Ali Bahrami , Jun Yuan
IPC分类号： G06F17/30
CPC分类号： G06F17/30967
摘要： A method for context-based query formulation and information retrieval and aggregation is described. The method includes modeling one or more workflow activities utilized to perform work tasks, preparing at least one meta-querying template, to generate queries that utilize the modeled workflow activities, retrieving information relevant to the work task as determined utilizing the at least one meta-querying template, and aggregating the retrieved information for presentation to the user.
摘要翻译：描述了基于上下文的查询配置和信息检索和聚合的方法。该方法包括对用于执行工作任务的一个或多个工作流活动进行建模，准备至少一个元查询模板，以生成利用建模的工作流活动的查询，检索与使用至少一个元查询模板确定的工作任务相关的信息，查询模板，并汇总检索到的信息以呈现给用户。

86. 发明申请

US20080227793A1 Benzimidazole and Pyridylimidazole Derivatives 失效
标题翻译：苯并咪唑和吡啶基咪唑衍生物
公开(公告)号：US20080227793A1
公开(公告)日：2008-09-18
申请号：US11942480
申请日：2007-11-19
申请人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
发明人： Guiying Li , Pamela Albaugh , Kevin S. Currie , Guolin Cai , Linda M. Gustavson , Kyungae Lee , Alan Hutchison , George D. Maynard , Jun Yuan , Ling Hong Xie , Manuka Ghosh , Nian Liu , George P. Luke , Scott Mitchell , Martin Patrick Allen , Spiros Liras
IPC分类号： A61K31/496 , C07D403/06 , A61K31/4184 , C07D471/04 , G01N33/566 , A61P25/18 , A61P25/24 , C12N5/06 , A61K31/437 , C07D403/14
CPC分类号： C07D401/04 , C07D233/20 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/06 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D473/00 , C07D491/08 , C07D491/10
摘要： This invention relates to benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds, all of which may be described by of Formula I The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Novel processes for preparing compounds of Formula I are disclosed.This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
摘要翻译：本发明涉及苯并咪唑，吡啶基咪唑和相关双环杂芳基化合物，所有这些可以由式I描述。本发明特别涉及以高选择性和高亲和力结合GABA A的苯并二氮杂部位的化合物， / SUB>受体。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗某些中枢神经系统（CNS）疾病中的用途。公开了制备式I化合物的新方法。本发明还涉及式I的苯并咪唑，吡啶基咪唑和相关的双环杂芳基化合物与一种或多种其它CNS剂的组合用于增强其它CNS剂的作用。此外，本发明涉及使用这些化合物作为组织切片中GABA A A受体定位的探针。

87. 发明授权

US07399823B1 Antimicrobial theta defensins and methods of using same 有权
标题翻译：抗微生物θ防御素及其使用方法
公开(公告)号：US07399823B1
公开(公告)日：2008-07-15
申请号：US10009317
申请日：2000-05-10
申请人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
发明人： Michael E. Selsted , Yi-Quan Tang , Jun Yuan , Andre J. Ouellette
IPC分类号： A61K38/00
CPC分类号： C07K7/08 , A61K38/12 , C07K14/4723 , C12P21/00 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to an isolated cyclic peptide, theta defensin, having antimicrobial activity, and to theta defensin analogs. A theta defensin can have the amino acid sequence Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8, wherein Xaa1 to Xaa8 are defined; wherein Xaa1 can be linked through a peptide bond to Xaa8; and wherein crosslinks can be formed between Xaa3 and Xaa3, between Xaa5 and Xaa5, and between Xaa7 and Xaa7. For example, the invention provides a theta defensin having the amino acid sequence Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg (SEQ ID NO:1), wherein the Gly at position 1 (Gly-1) is linked through a peptide bond to Arg-18, and wherein disulfide bonds are present between Cys-3 and Cys-16, between Cys-5 and Cys-14, and between Cys-7 and Cys-12. The invention also provides nucleic acids encoding theta defensins and antibodies that specifically bind a theta defensin. In addition, the invention relates to methods of using theta defensin to reduce or inhibit microbial growth or survival.
摘要翻译：本发明涉及具有抗微生物活性的分离的环肽，θ防御素，以及θ防御素类似物。 θ防御素可以具有氨基酸序列Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa1-Xaa6-Xaa4-Xaa4-Xaa1-Xaa1-Xaa6-Xaa4-Xaa5-Xaa1-Xaa3-Xaa7-Xaa8，其中Xaa1至Xaa8是定义其中Xaa1可通过肽键与Xaa8连接; 并且其中可以在Xaa3和Xaa3之间，Xaa5和Xaa5之间以及Xaa7和Xaa7之间形成交联。例如，本发明提供具有氨基酸序列Gly-Phe-Cys-Arg-Cys-Leu-Cys-Arg-Arg-Gly-Val-Cys-Arg-Cys-Ile-Cys-Thr-Arg的θ防御素 SEQ ID NO：1），其中位置1处的Gly（Gly-1）通过肽键与Arg-18连接，并且其中二硫键存在于Cys-3和Cys-16之间，Cys-5和Cys之间 -14，以及Cys-7和Cys-12之间。本发明还提供编码θ防御素和特异性结合θ防御素的抗体的核酸。此外，本发明涉及使用θ防御素来减少或抑制微生物生长或存活的方法。

88. 发明申请

US20070022107A1 Methods and apparatus for generic semantic access to information systems 有权
标题翻译：通用语义访问信息系统的方法和设备
公开(公告)号：US20070022107A1
公开(公告)日：2007-01-25
申请号：US11186253
申请日：2005-07-21
申请人： Jun Yuan , Babak Hamidzadeh
发明人： Jun Yuan , Babak Hamidzadeh
IPC分类号： G06F17/30
CPC分类号： G06F17/30684 , G06F17/30731 , G06F17/30734
摘要： A method of providing information from at least one information resource. A semantic query is received that includes one or more generic constructs referencing an ontology relating to a domain of the information resource(s). A representation of the semantic query in an ontology representation language is inferred from the constructs. The query representation is used to access the information resource(s). This method allows a user to formulate database queries semantically without knowledge as to underlying data structures.
摘要翻译：一种从至少一个信息资源提供信息的方法。接收到语义查询，其包括引用与信息资源的域相关的本体的一个或多个通用构造。本体表示语言中的语义查询的表示从结构中推断出来。查询表示用于访问信息资源。这种方法允许用户在语义上制定数据库查询，而不需要基础数据结构的知识。

89. 发明授权

US07122080B2 Integrated process for simultaneous beneficiation, leaching, and dewatering of kaolin clay suspension 有权
公开(公告)号：US07122080B2
公开(公告)日：2006-10-17
申请号：US10214359
申请日：2002-08-08
申请人： Robert J. Pruett , Jun Yuan , Christopher R. L. Golley , Michael J. Garska
发明人： Robert J. Pruett , Jun Yuan , Christopher R. L. Golley , Michael J. Garska
IPC分类号： C04B14/04
CPC分类号： C09C1/42 , B03D3/06 , C01P2004/61 , C01P2004/62 , C01P2006/22 , C01P2006/40 , C01P2006/60 , C01P2006/80 , Y02P20/125
摘要： The present invention provides an improved method of beneficiating and dewatering kaolin clays. The product of the improved process is a brightened, dewatered kaolin, suitable for use in pigments and paper coating compositions. The improved beneficiation process provides refined kaolin for pigments and other purposes of the same or better quality as prior art processes, but with the use of fewer steps and materials, at significant cost and environmental savings.

90. 发明申请

US20060124033A1 Fine platy kaolin composition 有权
标题翻译：精细高岭土组成
公开(公告)号：US20060124033A1
公开(公告)日：2006-06-15
申请号：US10531257
申请日：2003-12-15
申请人： Robert Pruett , Jun Yuan , Bomi Bilimoria , Roger Wygant , Anthony Lyons
发明人： Robert Pruett , Jun Yuan , Bomi Bilimoria , Roger Wygant , Anthony Lyons
IPC分类号： C04B14/04
CPC分类号： C09C1/42 , C01P2004/20 , C01P2004/54 , C01P2004/60 , C01P2006/22 , D21H19/40 , D21H21/52
摘要： The present invention relates to a kaolin composition having improved physical properties, for example, for use in the production of paper products. The composition can comprise kaolin having a shape factor of at least about 20. The kaolin can have a particle size distribution such that at least about 94% by weight of the kaolin can have an esd of less than about 2 μm and/or at least about 80% by weight of the kaolin can have an esd of less than 1 μm. The amount of the kaolin having an esd of less than about 0.25 μm can range from about 25% to about 60% by weight. The Hercules viscosity of the kaolin product is less than 4000 rpm at 18 dynes at 63% solids and less than 1500 rpm at 18 dynes at 69% solids when measured using the “A” bob. The present invention also relates to an improved method for making the kaolin product from sedimentary kaolin.
摘要翻译：本发明涉及具有改善的物理性能的高岭土组合物，例如用于生产纸制品。该组合物可以包含具有至少约20的形状因子的高岭土。高岭土可以具有使得高岭土的至少约94重量％的esd可以具有小于约2μm的esd和/或至少约80重量％的高岭土可以具有小于1m的esd。具有小于约0.25μm的esd的高岭土的量可以为约25重量％至约60重量％。高岭土产品的Hercules粘度在18达因数时为63％固体，小于1500转/分钟，18达因时为69％固体，当使用“A”鲍伯测量时。本发明还涉及一种由沉淀高岭土制备高岭土产品的改进方法。

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