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81. 发明专利

NZ541289A Use of multifunctional surface active agents such as lauroylethylenediaminetriacetate (LED3A) to clean contact lenses 未知
公开(公告)号：NZ541289A
公开(公告)日：2008-05-30
申请号：NZ54128903
申请日：2003-12-17
申请人： ALCON INC
发明人： KETELSON HOWARD ALLEN , MEADOWS DAVID L , HONG BOR-SHYUE
IPC分类号： C11D1/10 , C11D1/88 , C11D3/00
摘要： Disclosed is a method of cleaning a contact lens comprising soaking the lens in an aqueous solution comprising an amount of an anionic dissociating compound effective to clean the lens, said compound having the formula (I), wherein R is a straight or branched alkyl or alkenyl group containing from 8 to 18 carbon atoms. Also disclosed is a sterile, aqueous multi-purpose solution for treating contact lenses, comprising: 0.001 to 1 w/v% of the compound of formula (I); an ophthalmically acceptable antimicrobial agent in an amount effective to disinfect contact lenses; and water; said solution having a physiologically compatible pH and an osmolality of 200 to 400 mOsm/kg.

82. 发明专利

DE60319133D1 未知
公开(公告)号：DE60319133D1
公开(公告)日：2008-03-27
申请号：DE60319133
申请日：2003-12-11
申请人： ALCON INC
发明人： KETELSON HOWARD ALLEN
IPC分类号： A61L27/34 , A61L12/14 , A61L29/08 , A61L31/10 , C11D3/00 , C11D3/37
摘要： The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosthetics.

83. 发明专利

CA2507377C USE OF MULTIFUNCTIONAL SURFACE ACTIVE AGENTS TO CLEAN CONTACT LENSES 未知
公开(公告)号：CA2507377C
公开(公告)日：2008-02-19
申请号：CA2507377
申请日：2003-12-17
申请人： ALCON INC
发明人： HONG BOR-SHYUE , MEADOWS DAVID L , KETELSON HOWARD ALLEN
IPC分类号： C11D1/10 , A61L12/14 , C11D1/83 , C11D1/88 , C11D3/00 , C11D3/48
摘要： Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED3A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.

84. 发明专利

DK1576081T3 未知
公开(公告)号：DK1576081T3
公开(公告)日：2007-10-01
申请号：DK03814179
申请日：2003-12-17
申请人： ALCON INC
发明人： HONG BOR-SHYUE , KETELSON HOWARD ALLEN , MEADOWS DAVID L
IPC分类号： C11D3/00 , C11D1/10 , C11D1/88
摘要： Cleaning compositions for contact lenses are described. The compositions contain multifunctional anionic surfactants that include at least two hydrophilic dissociating head groups. The multifunctional surfactants described (e.g., LED 3 A) possess both surface active and chelating properties, and have been found to be particularly effective in removing protein deposits from contact lenses.

85. 发明专利

NO20053580A 未知
公开(公告)号：NO20053580A
公开(公告)日：2005-07-22
申请号：NO20053580
申请日：2005-07-22
申请人： ALCON INC
发明人： MEADOWS DAVID L , HONG BOR-SHYUE , KETELSON HOWARD ALLEN
IPC分类号： C11D1/10 , C11D1/88 , C11D3/00 , C11D1/02
CPC分类号： C11D1/10 , C11D1/88 , C11D3/0078 , Y10S514/912

86. 发明专利

CA2532729A1 SYSTEM AND METHOD FOR DYNAMIC CONTACT ANGLE MEASUREMENT 未知
公开(公告)号：CA2532729A1
公开(公告)日：2005-01-27
申请号：CA2532729
申请日：2004-07-14
申请人： ALCON INC
发明人： MEADOWS DAVID L , KETELSON HOWARD ALLEN
IPC分类号： G01N13/02
摘要： A system and method for dynamic contact angle measurement on a curved materi al are disclosed. One embodiment of the method comprises: initializing a video- based contact angle measuring apparatus; preparing the curved material for contact angle measurement; performing a sessile drop procedure to deposit a drop of liquid on the curved material; capturing an image of the drop on the curved material at a preset time; determining a drop-curved material interfa ce on the image; determining a drop profile on the image; and calculating a set of dynamic contact angles based on the drop-curved material interface and th e drop profile. The contact angle measuring apparatus can further comprise a processor for executing software instructions, a software module comprising processor-executable software instructions for performing at least some of t he steps of the method and a memory, operably coupled to the processor, for storing the processor-executable software instructions. Further, the steps o f determining the drop-curved material interface, determining the drop profile , capturing an image, initializing the contact angle-measuring apparatus and calculating the set of dynamic contact angles can each be at least partially performed via software running on the processor. The contact angle measuring apparatus can also include a camera and a digital frame-grabber for capturin g an image. As a further aspect of the present invention, the curved material can be a hydrogel contact lens either mounted on an external sample stage or in a patient's eye for in vivo contact angle measurements.

87. 发明专利

AU2002367030A1 USE OF INORGANIC NANOPARTICLES TO MODIFY THE VISCOSITYAND OTHER PHYSICAL PROPERTIES OF OPHTHALMIC AND OTIC PHARMACEUTICAL COMPOSITIONS 未知
公开(公告)号：AU2002367030A1
公开(公告)日：2003-07-30
申请号：AU2002367030
申请日：2002-12-20
申请人： ALCON INC
发明人： KETELSON HOWARD ALLEN , MEADOWS DAVID L
IPC分类号： A61K9/00 , A61K9/06 , A61K9/08 , A61K33/22 , A61K47/02 , A61P27/02 , A61P27/16 , A61P31/04 , A61P31/10
摘要： The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical nanoparticles are utilized to modify the rheological properties of the compositions, so as to enhance the viscosity, flow characteristics, lubricity or other characteristics of the compositions. The invention is particularly directed to the provision of lubricant compositions for the eye and ear, and to enhancement of the viscosity, shear thinning and lubricity of artificial tear compositions.

88. 发明专利

AU2002367029A1 USE OF SYNTHETIC INORGANIC NANOPARTICLES AS CARRIERS FOR OPHTHALMIC AND OTIC DRUGS 未知
公开(公告)号：AU2002367029A1
公开(公告)日：2003-07-30
申请号：AU2002367029
申请日：2002-12-20
申请人： ALCON INC
发明人： KETELSON HOWARD ALLEN , MEADOWS DAVID L
IPC分类号： A61K47/02 , A61F20060101 , A61K9/00 , A61K9/14 , A61K31/575 , A61K47/04 , A61P27/02 , A61P27/16 , A61P29/00 , B32B5/16 , B32B15/02 , B32B17/02 , B32B21/02
摘要： The use of nanoparticles of inorganic materials (e.g., synthetic smectite clays) in ophthalmic and otic pharmaceutical compositions is described. The nanoparticles are utilized as biologically inert carriers or depots for ophthalmic and otic drugs. The nanoparticles may also be utilized to modify the rheological properties of the compositions, so as to enhance the viscosity or flow characteristics of the compositions and/or increase the retention time of the compositions in the eye or ear.

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