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81. 发明申请

WO1995004283A1 REAGENTS AND METHODS FOR THE DETECTION AND QUANTIFICATION OF TESTOSTERONE IN FLUID SAMPLES 审中-公开
标题翻译：流体样品中TESTOSTERONE检测和定量的试剂和方法
公开(公告)号：WO1995004283A1
公开(公告)日：1995-02-09
申请号：PCT/US1994008604
申请日：1994-08-01
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ADAMCZYK, Maciej , CHEN, Yon-Yih , WALLING, John, A. , JAMES, Bryan, D. , ARTRIP, Sharon, G.
IPC分类号： G01N33/74
CPC分类号： G01N33/53 , C07J1/0022 , C07K16/26 , G01N33/743 , Y02P20/55 , Y10S435/81 , Y10S435/962 , Y10S435/968 , Y10S436/817 , Y10S436/822 , Y10S530/812
摘要： The present invention discloses novel immunogens, antibodies prepared from such immunogens, and labeled reagents useful in immunoassays for the detection and quantification of testosterone in a test sample. Also disclosed are immunoassays using these reagents and methods for synthesizing these reagents. The immunoassays are preferably microparticle enzyme immunoassays (MEIAs) and fluorescence polarization immunoassays (FPIAs). Further discloded are novel starting materials for making the above novel immunogens and labeled reagents. Methods for making the novel immunogens and labeled reagents from the novel starting materials are also disclosed.
摘要翻译：本发明公开了由免疫原制备的新型免疫原，抗体以及用于免疫测定的标记试剂，用于检测和定量测试样品中的睾酮。还公开了使用这些试剂的免疫测定法和合成这些试剂的方法。免疫测定优选为微粒酶免疫测定（MEIAs）和荧光偏振免疫测定（FPIAs）。进一步揭示了制备上述新型免疫原和标记试剂的新型起始材料。还公开了从新型起始材料制备新型免疫原和标记试剂的方法。

82. 发明申请

WO1995001297A1 METHOD FOR HOLDING A SAMPLE CONTAINER 审中-公开
标题翻译：用于容纳样品容器的方法
公开(公告)号：WO1995001297A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007219
申请日：1994-06-27
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ILES, Kenneth, Ernest
IPC分类号： B65G47/90
CPC分类号： B01L9/50 , B01L9/06 , G01N35/0099 , G01N35/04 , Y10S435/809 , Y10S436/809 , Y10S436/81
摘要： A sample container holder (18) is provided for gripping a sample container (34) which contains a sample. The sample container holder (18) comprises a body (42) having a bore (60) for receiving a sample container (34). A flexible element (82) is disposed within the bore (60). A fluid passage is operatively connected with the flexible element (82) for supplying a fluid to the flexible element (82) such that, when the sample container (34) is received in the bore (60) in the body (42) of the sample container holder (18), the flexible element (82) engages the sample container (34) with a conforming, cushioning compression of sufficient magnitude to resist removal of the container (34) from the bore (60). A method of holding a container with a container holder is also provided comprising the following steps. The container is received within a bore on the container holder, and a fluid is conveyed through a fluid passage operatively connected with a flexible element within the bore such that the flexible element engages the container to retain the container within the bore.
摘要翻译：提供样品容器保持器（18），用于夹持包含样品的样品容器（34）。样品容器保持器（18）包括具有用于容纳样品容器（34）的孔（60）的主体（42）。柔性元件（82）设置在孔（60）内。流体通道与柔性元件（82）可操作地连接，用于向柔性元件（82）供应流体，使得当样本容器（34）被容纳在主体（42）中的孔（60）中时样品容器保持器（18），柔性元件（82）以足够大的顺应性缓冲压缩接合样品容器（34），以抵抗容器（34）从孔（60）的移除。还提供了一种容纳容器的容器的方法，包括以下步骤。容器被容纳在容器保持器上的孔内，并且流体被传送通过与孔内的柔性元件可操作地连接的流体通道，使得柔性元件接合容器以将容器保持在孔内。

83. 发明申请

WO1994021635A1 MACROCYCLIC IMMUNOMODULATORS 审中-公开
标题翻译：大肠杆菌免疫调节剂
公开(公告)号：WO1994021635A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002711
申请日：1994-03-14
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LULY, Jay, R. , KAWAI, Megumi , OR, Yat, Su , WIEDEMAN, Paul, E. , WAGNER, Rolf
IPC分类号： C07D471/16
CPC分类号： C07D498/18 , C07D487/14 , C07D513/14 , C07F7/1804 , C07F9/6561 , C07H19/01
摘要： Immunomodulatory macrocyclic compounds having formula (I), and the pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein Y is selected from one of formulae (Ia) and (Ib), as well as pharmaceutical compositions containing the same and methods of their use.
摘要翻译：具有式（I）的免疫调节大环化合物及其药学上可接受的盐，酯，酰胺和前药，其中Y选自式（Ia）和（Ib）之一，以及含有它们的药物组合物及其制备方法使用。

84. 发明申请

WO1994021254A1 SUBSTITUTED ALICYCLIC AMINE-CONTAINING MACROCYCLIC IMMUNOMODULATORS 审中-公开
标题翻译：取代的含有ALICYCLIC的大肠杆菌免疫调节剂
公开(公告)号：WO1994021254A1
公开(公告)日：1994-09-29
申请号：PCT/US1994002684
申请日：1994-03-11
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , KAWAI, Megumi , LULY, Jay, R.
IPC分类号： A61K31/395
CPC分类号： C07D498/18
摘要： Compounds having formula (I), and pharmaceutically acceptable salts, esters, amides and prodrugs thereof, wherein one of R and R is hydrogen, and the other of R and R is a group having formula (II), as well as pharmaceutically compositions containing such compounds and methods of immunomodulative therapy utilizing the same.
摘要翻译：具有式（I）的化合物及其药学上可接受的盐，酯，酰胺和前药，其中R 104和R 105中的一个是氢，R 104和R 105中的另一个是基团具有式（II）的化合物，以及含有这些化合物的药物组合物和利用其的免疫调节治疗方法。

85. 发明申请

WO1994018217A1 NON-A, NON-B, NON-C, NON-D, NON-E HEPATITIS REAGENTS AND METHODS FOR THEIR USE 审中-公开
标题翻译： NON-A，NON-B，N-C，N-D，非E型乙型肝炎试剂及其使用方法
公开(公告)号：WO1994018217A1
公开(公告)日：1994-08-18
申请号：PCT/US1993000928
申请日：1993-02-03
申请人： ABBOTT LABORATORIES , TASSOPOULOS, Nic, C. , HATZAKIS, Angelos, E. , TROONEN, Hugo
发明人： ABBOTT LABORATORIES , KUHNS, Mary, C.
IPC分类号： C07H21/02
CPC分类号： C07H21/00 , A61K39/00 , C07K14/005 , C07K2319/00 , C12N2770/24222
摘要： Hepatitis G Virus (HGV) nucleic aic sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HGV nucleic acid sequences, HGV immunogenic particles, and a method for producing antibodies to HGV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HGV nucleic acid sequences.
摘要翻译：可用于各种诊断和治疗应用的乙型肝炎病毒（HGV）核酸序列，使用HGV核酸序列的试剂盒，HGV免疫原性颗粒和用于产生HGV抗体的方法。还提供了从HGV核酸序列产生抗体，多克隆或单克隆抗体的方法。

86. 发明申请

WO1994015464A1 STRUCTURED LIPIDS 审中-公开
标题翻译：结构化脂肪
公开(公告)号：WO1994015464A1
公开(公告)日：1994-07-21
申请号：PCT/US1994000617
申请日：1994-01-13
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , DEMICHELE, Stephen, Joseph , KARLSTAD, Michael, Donald , BISTRIAN, Bruce, Ryan , MASCIOLI, Edward, Anthony
IPC分类号： A01N37/06
CPC分类号： C07C69/587 , A23L33/115 , A23L33/12 , A61K31/23 , A61K31/232
摘要： There is disclosed structured lipid containing either a gamma-linolenic acid or a dihomogamma-linolenic acid residue, together with an n-3 fatty acid residue and a medium chain fatty acid residue on the same glycerol backbone. This structured lipid is particularly well adapted to the treatment of disease or stress states. The gamma-linolenic or dihomogamma-linolenic acid residues modify the prostanoid synthesis pathway, reducing the level of series "2" prostanoids and elevating the levels of series "1" and "3" prostanoids. The n-3 fatty acid residue enhances the level of series "1" prostanoids as well as increases the production of series "3" prostanoids. The medium chain fatty acid residues enhances the absorption of the structured lipid. There is also disclosed enteral and parenteral diets as well as nutritional supplements containing the structured lipids of the invention.
摘要翻译：公开了在同一甘油主链上含有γ-亚麻酸或二亚麻酸 - 亚麻酸残基以及n-3脂肪酸残基和中链脂肪酸残基的结构化脂质。这种结构化脂质特别适用于治疗疾病或应激状态。 γ-亚麻酸或二亚麻酸亚麻酸残基改变前列腺素合成途径，降低“2”前列腺素类的水平，提高“1”和“3”前列腺素类的水平。 n-3脂肪酸残基提高了“1”型前列腺素类的水平，并增加了“3”型前列腺素类的产生。中链脂肪酸残基增强了结构化脂质的吸收。还公开了肠内和肠胃外饮食以及含有本发明的结构化脂质的营养补充剂。

87. 发明申请

WO1994015293A1 DYNAMIC DATA DISTRIBUTION NETWORK 审中-公开
标题翻译：动态数据分发网络
公开(公告)号：WO1994015293A1
公开(公告)日：1994-07-07
申请号：PCT/US1993010142
申请日：1993-10-22
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , LOWELL, Augustus, P.
IPC分类号： G06F13/00
CPC分类号： G06F9/542 , G06F9/546 , H04L67/26 , H04L69/329
摘要： A dynamic data distribution network (12) for use with a software package (10), which includes modules (14, 16, and 18) that produce data and modules (20, 22, 24, and 26) that consume data. The network includes source files (30) and sink files (32). Each data-consuming module contains one or more sink files, each of which serves as a buffer for one type of data used by the module. Each source file serves as a buffer for one type of data that is generated by a data-producing module. Each source file also contains a sink link table (40) that identifies the individual sink files, which serve as buffers for the data consumers that use that data. Whenever new data is generated, a data distribution task (34) initially stores the data in the associated source file and, then based on the contents of the sink link table, copies the data into the appropriate sink files associated with the data consumers that use the data. The data distribution function also informs the data consumers that new data are available in the sink file with which the data consumer is associated, enabling the data consumers to retrieve the data from the sink files.
摘要翻译：一种与软件包（10）一起使用的动态数据分发网络（12），其包括产生消耗数据的数据和模块（20,22,24和26）的模块（14,16和18）。网络包括源文件（30）和宿文件（32）。每个数据消耗模块包含一个或多个宿文件，每个宿文件用作模块使用的一种类型的数据的缓冲区。每个源文件用作由数据生成模块生成的一种数据类型的缓冲区。每个源文件还包含一个宿链接表（40），它标识个别宿文件，它们作为使用该数据的数据使用者的缓冲区。每当生成新数据时，数据分发任务（34）最初将数据存储在相关联的源文件中，然后基于宿链接表的内容将数据复制到与使用的数据消费者相关联的适当的宿文件中数据。数据分发功能还向数据消费者通知数据消费者与之相关联的接收器文件中的新数据可用，使数据消费者能够从接收器文件中检索数据。

88. 发明申请

WO1994015270A1 METHOD AND APPARATUS FOR PROVIDING A DATA INTERFACE BETWEEN A PLURALITY OF TEST INFORMATION SOURCES AND A DATABASE 审中-公开
标题翻译：在多个测试信息来源和数据库之间提供数据接口的方法和设备
公开(公告)号：WO1994015270A1
公开(公告)日：1994-07-07
申请号：PCT/US1993011934
申请日：1993-12-08
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , EASON, Reginald, L. , FORREST, Keith
IPC分类号： G06F03/00
CPC分类号： G16H10/40 , G06F19/00 , G16H10/60 , G16H40/63 , G16H50/20 , Y10S707/99933
摘要： A data interface (508) which is capable of receiving test information from a variety of biological fluid testing instruments (530) employs first and second processes (512, 522). The first process determines the type of data which is provided by analyzing the format of the test information using a master rules file. Once the type of the source is identified, the first process passes the data and a set of rules to use to parse the data to the second process. The second process extracts the test data from the information provided by the testing instruments using the set of rules identified by the first process. Furthermore, if the test information is received in pieces the present invention can marry the pieces to provide a complete data set to be stored in the database.
摘要翻译：能够从各种生物流体测试仪器（530）接收测试信息的数据接口（508）采用第一和第二过程（512,522）。第一个过程通过使用主规则文件分析测试信息的格式来确定提供的数据类型。一旦识别出源的类型，第一个进程将传递数据和一组规则，以将数据解析到第二个进程。第二个过程使用由第一个过程确定的一组规则，从测试仪器提供的信息中提取测试数据。此外，如果接收到测试信息，本发明可以结合这些片段来提供要存储在数据库中的完整数据集。

89. 发明申请

WO1994014341A1 MEDICAL FOODS FOR THE NUTRITIONAL SUPPORT OF CHILD/ADULT METABOLIC DISEASES 审中-公开
标题翻译：用于营养支持儿童/成人代谢疾病的医疗食品
公开(公告)号：WO1994014341A1
公开(公告)日：1994-07-07
申请号：PCT/US1993010867
申请日：1993-11-10
申请人： ABBOTT LABORATORIES
发明人： ABBOTT LABORATORIES , ACOSTA, Phyllis, Jean, Brown , GRONDALSKI, Richard, Andrew , LIEBRECHT, Jeffrey, Wayne , REYNOLDS, Patricia, Ann
IPC分类号： A23L01/29
CPC分类号： A61K45/06 , A23L33/115 , A23L33/12 , A23L33/16 , A23L33/40 , Y10S514/904 , Y10S514/905
摘要： The present invention relates generally to a novel generic powder base rich in fats, carbohydrates, vitamins, minerals and trace elements which can be readily admixed with specific amino acids to yield several different therapeutic products for use in nutritional support of adults/children having various inherited metabolic diseases.
摘要翻译：本发明一般涉及富含脂肪，碳水化合物，维生素，矿物质和微量元素的新型通用粉末基质，其可以容易地与特定氨基酸混合，以产生用于具有各种遗传的成年人/儿童的营养支持的几种不同的治疗产品代谢疾病

90. 发明申请

WO1994013313A1 6-POSITION MODIFIED DECAPEPTIDE LHRH ANTAGONISTS 审中-公开
标题翻译： 6位置修饰的代谢物LHRH拮抗剂
公开(公告)号：WO1994013313A1
公开(公告)日：1994-06-23
申请号：PCT/US1993011628
申请日：1993-11-30
申请人： ABBOTT LABORATORIES , GREER, Jonathan , HAVIV, Fortuna , FITZPATRICK, Timothy, D. , SWENSON, Rolf, E. , NICHOLS, Charles, J. , MORT, Nicholas, A.
发明人： ABBOTT LABORATORIES
IPC分类号： A61K37/02
CPC分类号： C07K7/23 , A61K38/00
摘要： The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A -D -E -G -J -L -M -Q -R -T . The compounds of the percent invention are characterized by having an OMEGA -amino-functionalized side chain on the D-aminoacyl residue at position 6. The OMEGA -amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.
摘要翻译：本发明提供一类十肽化合物，其是LHRH活性的有效拮抗剂，其具有结构A 1 -D 2 -E 3 -G 4 -J 5 -L 6， -M <7> -Q <8> -R <9> -T <10>。本发明百分比的化合物的特征在于在第6位的D-氨基酰基残基上具有OMEGA-氨基官能化侧链。该侧链的OMEGA-氨基通过连接一个延伸基团被酰基封端的末端氨基。

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