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    • 85. 发明申请
    • MICROEMULSION OR MICROSUSPENSION PROCESS FOR THE PRODUCTION OF A POLYMER DISPERSION, AND POLYMER PARTICLES OBTAINABLE BY THE PROCESS
    • WO2022112481A1
    • 2022-06-02
    • PCT/EP2021/083117
    • 2021-11-26
    • UNIVERSITÄT REGENSBURG
    • KUNZ, WernerKRICKL, SebastianBLAHNIK, JonasSCHMID, Klaus
    • C08F2/22C08F2/32C08F120/14C08F20/00
    • Provided is a process for the preparation of a polymer dispersion, comprising (a) a step of providing an oil-in-water microemulsion, which oil-in-water microemulsion comprises (i) dispersed domains comprising one or more types of radically polymerizable monomers which are insoluble in water or which have a miscibility gap with water, (ii) water, (iii) a hydrotrope which comprises a compound selected from compounds of the formula R1-(O-R2)m-O-R3 or of the formula R4-OH, or a mixture of two or more of these compounds, wherein R1 is a hydrocarbyl group which is free of any moiety with more than 6 carbon atoms attached to each other, m is 1 or 2, R2 is, independently for each occurrence if m is more than 1, selected from ethanediyl (-CH2-CH2-) and isopropanediyl (-CH(CH3)-CH2-), R3 is selected from hydrogen, methyl, ethyl, propyl, and -CH2-COOH, and R4 is a C3 to C6 alkyl group, and (iv) a radical initiator, and wherein, if the total amount of all radically polymerizable monomers in the oil-in-water microemulsion is 100 mol%, a molar ratio of the radically polymerizable monomers which are insoluble in water or which have a miscibility gap with water is 75 mol% to 100 mol%, and a molar ratio of other radically polymerizable monomers is 0 mol% to 25 mol%, and the oil-in-water microemulsion is substantially free of any surfactant selected from the group consisting of nonionic surfactants comprising a linear alkyl chain with more than 6 carbon atoms, cationic surfactants and anionic surfactants; and (b) a step of polymerizing the monomers comprised by the oil-in-water microemulsion to provide the polymer dispersion. Moreover, a polymer dispersion and polymer particles are provided which are obtainable by the process in accordance with the invention.
    • 89. 发明申请
    • TRANSURETHRAL CATHETER DEVICE FOR BLEEDING CONTROL IN PELVIC FRACTURES
    • WO2020200985A1
    • 2020-10-08
    • PCT/EP2020/058458
    • 2020-03-26
    • UNIVERSITÄT REGENSBURG - UNIVERSITÄTSKLINIKUM
    • KERSCHBAUM, Maximilian
    • A61M25/10A61B17/12A61F2/00
    • The inventions relates to a transurethral catheter device for bleeding control in pelvic fractures. The catheter device comprises an expandable body assembly with at least one expandable body. The expandable body assembly comprises a proximal portion, a center portion and a distal portion. The expandable body assembly is configured to be expanded from a collapsed state to an expanded state by expanding the at least one expandable body. The expandable body assembly is further configured to be inserted into the urinary bladder of a patient via the urethra in the collapsed state. In the expanded state, the proximal portion has a length l 1 and a width w 1 , the center portion a length l 2 and a width w 2 , the distal portion a length l 3 and a width w 3 , and the expandable body assembly a total length l. A displacement volume V of the expandable body assembly in the expanded state is larger than 0.5 liters. The width w 2 is smaller than 50% of the width w 3 . The width w 1 is larger than a width w 1 of the proximal portion in the collapsed state and the width w 3 is larger than a width w 3 of the distal portion in the collapsed state. The length l 1 is smaller than 25 % of the total length l. This allows for arranging the expandable body assembly in the expanded state in the urinary bladder such that the proximal portion is adjacent to the internal urethral orifice of the urinary bladder and the center portion is adjacent to the ureter orifices of the urinary bladder, but not in contact with the ureter orifices.