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81. 发明申请

WO2014019599A1 MODIFIED HUMAN TYROSINASE AND METHODS FOR ITS PRODUCTION 审中-公开
标题翻译：改性人类酪氨酸酶及其生产方法
公开(公告)号：WO2014019599A1
公开(公告)日：2014-02-06
申请号：PCT/EP2012/064853
申请日：2012-07-30
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA , BERGANTINO, Elisabetta , BUBACCO, Luigi , FOGAL, Stefano
发明人： BERGANTINO, Elisabetta , BUBACCO, Luigi , FOGAL, Stefano
IPC分类号： C12N9/02
CPC分类号： C12Y114/18001 , C12N9/0071
摘要： The present invention concerns the field of tyrosinase enzymes. In particular the present invention relates to modified recombinant human tyrosinases suitable for use in the identification of protein activity modulators.
摘要翻译：本发明涉及酪氨酸酶的领域。特别地，本发明涉及适用于鉴定蛋白质活性调节剂的修饰重组人酪氨酸酶。

82. 发明申请

WO2012127012A1 BIPHENYL TRICYCLIC QUINAZOLINE COMPOUNDS 审中-公开
标题翻译： BIPHENYL TRICYCLIC QUINAZOLINE化合物
公开(公告)号：WO2012127012A1
公开(公告)日：2012-09-27
申请号：PCT/EP2012/055145
申请日：2012-03-22
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA , CHILIN, Adriana , MARZARO, Giovanni , GUIOTTO, Adriano , CONCONI, Maria Teresa , CASTAGLIUOLO, Ignazio
发明人： CHILIN, Adriana , MARZARO, Giovanni , GUIOTTO, Adriano , CONCONI, Maria Teresa , CASTAGLIUOLO, Ignazio
IPC分类号： G06F19/00 , A61K45/06 , C07D491/056
CPC分类号： A61K45/06 , C07D491/056
摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are multiple inhibitors of tyrosine kinase activity.
摘要翻译：本发明涉及某些新化合物。具体地，本发明涉及式（I）的化合物及其盐。本发明的化合物是酪氨酸激酶活性的多种抑制剂。

83. 发明申请

WO2009043374A1 APERIODIC MULTILAYER STRUCTURES 审中-公开
标题翻译： APERIODIC多层结构
公开(公告)号：WO2009043374A1
公开(公告)日：2009-04-09
申请号：PCT/EP2007/060477
申请日：2007-10-02
申请人： CONSIGLIO NAZIONALE DELLE RICERCHE - INFM ISTITUTO NAZIONALE PER LA FISICA DELLA MATERIA , UNIVERSITA' DEGLI STUDI DI PADOVA , REFLECTIVE X-RAY OPTICS LLC. , PELIZZO, Maria-Guglielmina , NICOLOSI, Piergiorgio , SUMAN, Michele , WINDT, David L.
发明人： PELIZZO, Maria-Guglielmina , NICOLOSI, Piergiorgio , SUMAN, Michele , WINDT, David L.
IPC分类号： G03F7/20 , G21K1/06 , G02B5/08
CPC分类号： G03F7/70958 , B82Y10/00 , G02B5/0891 , G02B27/0012 , G03F1/24 , G03F7/70233 , G21K1/062 , G21K2201/061 , Y10T428/24612
摘要： Aperiodic mult ilayer structures An aperiodic multilayer structure (2, 2') comprising a plurality of alternating layers of a first (4, 4') and a second (6, 6') material and a capping layer (10, 10') covering these alternating layers, wherein the structure (2, 2') is characterized in that the thickness of the alternating layers chaotically varies in at least a portion of said structure (2, 2'). The invention further comprises design method comprising the step of define a time interval and a first plurality of periodic multilayer structures (A), then calculate a first merit function ( ∫ R(λ ) 10 * I(λ)dλ ) and define a first domain for each first structures. The method further includes the step of apply at least one rando m mutation to each first structures inside the associated first domain and calculate a second merit function ( ∫R(λ) 10 * I(λ)dλ for the at least one mutation. Then, the method proceeds with a co mparison of each first merit functions with the second merit function of the associated at least one mutation and if said second merit function is enhanced with respect to the first merit function, the at least one mutation is substituted for the structure of the first plurality and a second domain is defined for thw mutation, otherwise, the structure of the first plurality is maintained inside the corresponding first domain. The method further includes the step of calculate a mean value of the merit functions o f the first plurality of structures or mutations present in each first or second domain and define a threshold value to said mean value; then, for each first plurality of structures or mutations present in each first or second domain whose merit function is enhanced of the threshold with respect to the mean value, subst itute a third domain to the first or second domain unt il the corresponding merit function is enhanced of said predetermined threshold. Then, the preceding step are repeated unt il the time interval has lapsed and the merit funct ions of the first plurality of structures or mutations present in each first domain are compared and the structure or mutation whose merit function is the more enhanced is selected.
摘要翻译：非周期多层结构包括多个第一（4,4''）和第二（6,6'）材料的交替层和覆盖层（10,10'）的非周期多层结构（2,2'），覆盖这些交替层，其中所述结构（2,2'）的特征在于，所述交替层的厚度在所述结构（2,2'）的至少一部分中混沌变化。本发明还包括设计方法，包括定义时间间隔和第一多个周期性多层结构（A）的步骤，然后计算第一优值函数（ΔR（？）10 * I（？）d？）并定义每个第一个结构的第一个域。所述方法还包括对所述相关联的第一结构域内的每个第一结构应用至少一个rando m突变的步骤，并计算所述至少一个突变的第二优点函数（ΔR（α）10 * I（？）d？）。然后，该方法进行每个第一优点函数与相关联的至少一个突变的第二优值函数的比较，并且如果针对第一优值函数增强所述第二优值函数，则将至少一个突变替换为所述第一多个结构和第二结构域被定义用于突变，否则，所述第一多个结构的结构被保持在所述对应的第一域内，所述方法还包括以下步骤：计算所述第一和第二域的优点函数的平均值存在于每个第一或第二结构域中的多个结构或突变，并且对所述平均值定义阈值;然后，对于每个第一或第二结构中存在的每个第一多个结构或突变 cond域，其优点函数相对于平均值增加阈值，将第三域替换为第一或第二域，其中对应的优值函数被增强为所述预定阈值。然后，重复上述步骤，并且比较每个第一域中存在的第一多个结构或突变的优点函数，并且选择其优点功能更强的结构或突变。

84. 发明申请

WO2007085542A1 TRANSPARENT PHOTOLUMINESCENT COMPOSITE MATERIAL 审中-公开
标题翻译：透明光致发光复合材料
公开(公告)号：WO2007085542A1
公开(公告)日：2007-08-02
申请号：PCT/EP2007/050324
申请日：2007-01-15
申请人： DEGUSSA NOVARA TECHNOLOGY S.P.A. , ENEA - ENTE PER LE NUOVE TECHNOLOGIE. L'ENERGIA É L'AMBIENTE , UNIVERSITA DEGLI STUDI DI PADOVA , COSTA, Fulvio , GINI, Lucia , BORSELLA, Elisabetta , MAURO, Falconieri , MATTEI, Giovanni , TRAVE, Enrico
发明人： COSTA, Fulvio , GINI, Lucia , BORSELLA, Elisabetta , MAURO, Falconieri , MATTEI, Giovanni , TRAVE, Enrico
IPC分类号： C09K11/65 , C03C14/00
CPC分类号： C09K11/7706 , C03C4/12 , C03C14/006 , C03C2214/16 , C03C2214/34
摘要： Transparent composite material photoluminescing at 1.54 µm, comprising a silica matrix doped with erbium oxide in a percentage by weight of between 0.01 and 5%, characterized in that it comprises silicon carbide nanocrystals of dimensions smaller than 25 nanometres in a percentage of up to 15% by weight.
摘要翻译：在1.54μm下光致发光的透明复合材料，其包含掺杂有氧化铒的二氧化硅基质，其重量百分比为0.01至5％，其特征在于，其包含尺寸小于25纳米的碳化硅纳米晶体，其百分比高达15％重量。

85. 发明申请

WO2007066226A3 METHODS AND COMPOSITIONS RELATING TO ADHESINS AS ADJUVANTS 审中-公开
公开(公告)号：WO2007066226A3
公开(公告)日：2007-06-14
申请号：PCT/IB2006/003908
申请日：2006-12-06
申请人： UNIVERSITA DEGLI STUDI DI PADOVA , NOVARTIS VACCINES AND DIAGNOSTICS SRL , MAZZON, Cristina , PAPINI, Emanuele , FRANZOSO, Susanna
发明人： MAZZON, Cristina , PAPINI, Emanuele , FRANZOSO, Susanna
IPC分类号： A61K39/39
摘要： This invention is in the field of immunology and relates to the discovery that adhesins are potent activators of dendritic cells.

86. 发明申请

WO2007028421A1 PROCESS FOR THE PRODUCTION OF NANO-PARTICLES 审中-公开
标题翻译：生产纳米颗粒的方法
公开(公告)号：WO2007028421A1
公开(公告)日：2007-03-15
申请号：PCT/EP2005/054489
申请日：2005-09-09
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA , BERTUCCO, Alberto , CALICETI, Paolo , ELVASSORE, Nicola
发明人： BERTUCCO, Alberto , CALICETI, Paolo , ELVASSORE, Nicola
IPC分类号： B01J2/04
CPC分类号： B01J2/04
摘要： Process for the preparation of solid micro- or nano-particles, comprising the following steps: melting a solid component; solution, under pressure, of a first compressed gas into the molten solid component, to create a pressurised semisolid or liquid mixture; generating a dispersion of the semisolid or liquid mixture with a second compressed gas, which does not completely dissolve into the semisolid or liquid mixture; expansion of the dispersion obtained at the previous step with evaporation of the first gas and formation of micro or nanosized particles of the solid component. An apparatus for performing said process is also provided.
摘要翻译：制备固体微米或纳米颗粒的方法，包括以下步骤：熔化固体组分; 在压力下将第一压缩气体溶解到熔融固体组分中，以产生加压的半固体或液体混合物; 产生半固体或液体混合物与不完全溶解到半固体或液体混合物中的第二压缩气体的分散体; 通过第一气体的蒸发和前述步骤中获得的分散体的膨胀，形成固体组分的微观或纳米尺寸的颗粒。还提供了一种用于执行所述处理的装置。

87. 发明申请

WO2002090313A1 ALOE-EMODIN DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEOPLASIAS 审中-公开
标题翻译： ALOE-EMODIN衍生物及其在治疗NEOPLASIAS中的应用
公开(公告)号：WO2002090313A1
公开(公告)日：2002-11-14
申请号：PCT/IB2002/001604
申请日：2002-05-10
申请人： UNIVERSITA' DEGLI STUDI DI PADOVA , PALU', Giorgio , CARLI, Modesto , PECERE, Teresa , ZAGOTTO, Giuseppe
发明人： PALU', Giorgio , CARLI, Modesto , PECERE, Teresa , ZAGOTTO, Giuseppe
IPC分类号： C07C69/017
CPC分类号： C07C69/76 , C07C69/40 , C07C69/60 , C07C69/708 , C07C69/80 , C07C229/08 , C07C229/36 , C07C2603/24 , C07D209/20 , C07F9/094 , C07H15/244
摘要： The invention relates to aloe-emodin (AE) derivatives and their use as anticancer drugs. Saids derivatives show a specific cytotoxicity to tumour cells, also of neuroectodermal origin, to which they may in particular act as aloe-emodin prodrugs. Said pharamcological profile makes them particularly suitable for use in the treatment of neoplasias. Thereofore, pharmaceutical compositions containing said compound may be usefully used in the treatment of neoplasias. It has surprisingly been found that aloe-emodin derivatives in position 3' (bearing either a positive or negaive charge) exhibit improved sollubility properties and, at the same time, in vitro show cytotoxicity to tumour cells, also of neuroectodermal origin.
摘要翻译：本发明涉及芦荟大黄素（AE）衍生物及其作为抗癌药物的用途。嗜锇衍生物对肿瘤细胞也具有特异性细胞毒性，也可能是神经外胚层起源的，它们特别可以作为芦荟大黄素前药。所述的药理学特征使它们特别适用于治疗肿瘤。因此，含有所述化合物的药物组合物可用于治疗肿瘤。令人惊讶地发现，位置3'（带正电荷或负电荷）的芦荟大黄素衍生物显示出改善的溶解性质，并且同时体外显示出对神经外胚层起源的肿瘤细胞的细胞毒性。

88. 发明专利

CA3088229A1 COMBINATION TREATMENT OF SARCOGLYCANOPATHIES 未知
公开(公告)号：CA3088229A1
公开(公告)日：2019-07-18
申请号：CA3088229
申请日：2019-01-10
申请人： GENETHON , INST NAT SANTE RECH MED , UNIV D'EVRY VAL D'ESSONNE , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： RICHARD ISABELLE , SANDONA DORIANNA
IPC分类号： A61K31/427 , A61K31/47 , A61P21/00
摘要： Sarcoglycanopathies are autosomal recessive diseases caused by mutations in the one of the genes coding for any sarcoglycans (SG). The inventors previously showed that the application of small molecules developed to rescue ?F508-CFTR trafficking, and known as CFTR correctors, improved the maturation of several a-sarcoglycan mutants that were consequently rescued at the plasma membrane (WO 014086687). Now, the inventors show that some specific CFTR correctors provide additive and even synergic effect when administered in combination.

89. 发明专利

IT201800008274A1 METODO IMMUNOMETRICO PER ANALISI CLINICHE BIOLOGICHE 未知
公开(公告)号：IT201800008274A1
公开(公告)日：2020-03-02
申请号：IT201800008274
申请日：2018-08-31
申请人： ALIFAX SRL , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： GALIANO PAOLO , AMENDOLA VINCENZO , BRAVIN CARLO , DI COLA GIOVANNI
IPC分类号： G01N33/50

90. 发明申请

WO2021094931A1 METHOD AND DEVICE FOR DETECTING THE AMOUNT OF LIMESCALE IN LIQUID HEATING DEVICES 审中-公开
公开(公告)号：WO2021094931A1
公开(公告)日：2021-05-20
申请号：PCT/IB2020/060596
申请日：2020-11-11
申请人： I.R.C.A. S.P.A. INDUSTRIA RESISTENZE CORAZZATE E AFFINI , UNIVERSITA' DEGLI STUDI DI PADOVA
发明人： ZOPPAS, Federico , DE MOLINER, Antonio , BORTOLUZZI, Christian , CEOTTA, Christian , OBOE, Roberto
IPC分类号： A47J31/52 , A47J31/54 , A47J31/60
摘要： A method and device for detecting the amount of limescale that accumulates in liquid heating devices, in particular for heating water. The method is capable of establishing, through simple temperature measurements, if the amount of limescale deposited on the heater element of a device for heating liquids is such as to jeopardize the correct operation thereof and provides the user with information on the need to clean the aforesaid heater.

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