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81. 发明申请

US20040210962A1 Implementation of a mitochondrial mutator 审中-公开
标题翻译：线粒体变异体的实现
公开(公告)号：US20040210962A1
公开(公告)日：2004-10-21
申请号：US10806038
申请日：2004-03-22
申请人： The Board of Regents of the University of Nebraska
发明人： Sally Mackenzie , Ricardo Vilela Abdelnoor
IPC分类号： A01H001/00 , C12N015/82 , C12Q001/68 , C07H021/04 , C12N005/04
CPC分类号： C07H21/04 , C07K14/415 , C12N15/8289
摘要： Plant MSH1 polynucleotides and polypeptides are described. Also described are methods for the use and modulation of such MSH1 polynucleotides and polypeptides.
摘要翻译：描述植物MSH1多核苷酸和多肽。还描述了使用和调节这种MSH1多核苷酸和多肽的方法。

82. 发明申请

US20040194225A1 Sulfur dye protection systems and compositions and methods employing same 审中-公开
标题翻译：硫化染料保护系统及其组合物和方法
公开(公告)号：US20040194225A1
公开(公告)日：2004-10-07
申请号：US10821139
申请日：2004-04-09
申请人： The Board of Regents of the University of Nebraska
发明人： Jiping Wang
IPC分类号： D06M010/00
CPC分类号： C11D3/046 , C09B49/00 , C09B67/0077 , C11D3/168 , C11D3/40 , C11D7/10 , C11D17/041 , D06P1/30 , D06P1/67341 , D06P5/02 , Y10S8/918
摘要： The present invention relates to sulfur dye protection systems and compositions and methods employing same, as well as processes for making sulfur dyes, especially bleach stable sulfur dyes, processes for dying textiles with sulfur dyes and textiles dyed by such processes. More particularly, the present invention relates to modifying existing dyes and/or making newly formed sulfur dyes. Even more particularly, the present invention relates to materials that can chemically or physically interact with sulfur dyes to protect the sulfur dyes from oxidation by oxidizing agents, such as bleaching agents.
摘要翻译：本发明涉及硫化染料保护体系及其组合物和使用方法，以及制备硫化染料，特别是漂白稳定硫化染料的方法，用硫染料染色纺织品和通过这些方法染色的织物的方法。更具体地说，本发明涉及改性现有染料和/或制备新形成的硫化染料。更具体地说，本发明涉及能够与硫化染料进行化学或物理相互作用以保护硫化染料免受氧化剂如漂白剂氧化的材料。

83. 发明申请

US20040013662A1 Microbubble compositions and methods for oligonucleotide delivery 有权
标题翻译：微泡组合物和寡核苷酸递送方法
公开(公告)号：US20040013662A1
公开(公告)日：2004-01-22
申请号：US10355388
申请日：2003-01-31
申请人： The Board of Regents of the University of Nebraska
发明人： Thomas R. Porter , Patrick L. Iversen
IPC分类号： A61K038/47 , A61K038/42 , A61K038/38
CPC分类号： A61K41/0028 , A61K47/6925 , A61K49/223
摘要： The invention relates to a new and improved pharmaceutical composition and method for delivery of therapeutic agents. The methods and composition of the invention can be used with several therapeutic agents and can achieve site specific delivery of a therapeutic or diagnostic substance. This can allow for lower doses and for improved efficacy with drugs which traditionally reach targeted sites and can result in improved utility for agents such as oligonucleotides and polynucleotides which are plagued with problems with biodistribution.
摘要翻译：本发明涉及用于递送治疗剂的新的和改进的药物组合物和方法。本发明的方法和组合物可以与几种治疗剂一起使用，并且可以实现治疗或诊断物质的位点特异性递送。这可以允许较低剂量和用于改善传统上达到目标部位的药物的功效，并且可以导致药物如寡核苷酸和多核苷酸的改善效用，这些药物被困扰生物分布的问题。

84. 发明申请

US20020091234A1 Compositions and methods for enhancing immune responses mediated by antigen-presenting cells 有权
标题翻译：用于增强由抗原呈递细胞介导的免疫应答的组合物和方法
公开(公告)号：US20020091234A1
公开(公告)日：2002-07-11
申请号：US09954349
申请日：2001-09-17
申请人： The Board of Regents of the University of Nebraska
发明人： Sam D. Sanderson , Michael A. Hollingsworth , Richard A. Tempero
IPC分类号： C07K007/08 , C07K007/06 , A61K039/00
CPC分类号： A61K39/385 , A61K38/00 , A61K2039/6031 , C07K14/472 , C07K14/57 , C07K16/18 , C07K16/2869 , C07K2317/34 , C07K2317/73
摘要： Molecular adjuvants are disclosed comprising an antigen presenting cell-targeting ligand linked to an immunogen. In particular, these molecular adjuvants are employed in compositions designed to deliver the specific immunogen to antigen presenting cells and simultaneously deliver signals to those cells that produce the desired immune response. Methods are also disclosed for delivery of these molecular adjuvants to patients, resulting in the transduction of activating signals to the targeted antigen presenting cell, thereby enhancing the immune response to the co-delivered immunogen.
摘要翻译：公开了包含与免疫原连接的抗原呈递细胞靶向配体的分子佐剂。特别地，这些分子佐剂用于将特异性免疫原递送至抗原呈递细胞的组合物中，同时将信号传递给产生所需免疫应答的那些细胞。还公开了将这些分子佐剂递送给患者的方法，导致将活化信号转导至靶向抗原呈递细胞，从而增强对共同递送的免疫原的免疫应答。

85. 发明申请

US20020055983A1 Computer server having non-client-specific persistent connections 审中-公开
标题翻译：具有非客户端特定持久连接的计算机服务器
公开(公告)号：US20020055983A1
公开(公告)日：2002-05-09
申请号：US10008035
申请日：2001-11-05
申请人： The Board of Regents of the University of Nebraska
发明人： Stephen M. Goddard
IPC分类号： G06F015/16
CPC分类号： H04L29/06 , H04L67/1002 , H04L67/1008 , H04L67/2814 , H04L67/2819 , H04L67/2842 , H04L69/16 , H04L69/161 , H04L69/329 , H04L2029/06054
摘要： Standalone and cluster-based servers, including Web servers, control the amount of data processed concurrently by such servers to thereby control server operating performance. Each server preferably includes a dispatcher for receiving data requests from clients, and at least one back-end server for processing such requests. The dispatcher preferably maintains a persistent connection, or a set of persistent connections, with the back-end server, and forwards the data requests received from clients to the back-end server over the persistent connections. Thus, instead of maintaining a one-to-one mapping of back-end connections to front-end connections as is done in the prior art, the back-end connections can be maintained by the dispatcher and used repeatedly for sending data between the dispatcher and the back-end server. In this manner, back-end connection overhead is markedly reduced.
摘要翻译：独立和基于群集的服务器（包括Web服务器）控制这些服务器并发处理的数据量，从而控制服务器的运行性能。每个服务器优选地包括用于从客户端接收数据请求的调度器和用于处理这些请求的至少一个后端服务器。调度员优选地与后端服务器维护持久连接或一组持久连接，并且通过持久连接将从客户端接收的数据请求转发到后端服务器。因此，不像现有技术那样维持后端连接到前端连接的一对一映射，而是可以由调度器维护后端连接，并重复使用以在调度器之间发送数据和后端服务器。以这种方式，后端连接开销显着降低。

86. 发明授权

US11602278B2 Apparatus for assessing user frailty 有权
公开(公告)号：US11602278B2
公开(公告)日：2023-03-14
申请号：US16230369
申请日：2018-12-21
申请人： The Board of Regents of the University of Nebraska
发明人： Jason M. Johanning
IPC分类号： A61B5/0205 , G06F9/451 , G16H40/63 , A61B5/00 , A61B5/22 , A61B5/11 , A61B5/01 , A61B5/1455 , A61B5/021 , A61B5/024
摘要： An apparatus for assessing user frailty is disclosed. In embodiments, the apparatus includes a housing that defines (or is defined by) a body and a handle coupled to the body. The apparatus includes a force sensor at least partially disposed within the handle. The apparatus further includes an inertial sensor at least partially disposed within the housing. The apparatus may further include a user interface device disposed within a cavity of the body. The user interface device may be coupled to the force sensor and the inertial sensor via one or more signal paths. In embodiments, the user interface device includes a controller with a touchscreen coupled to the controller.

87. 发明申请

US20230042897A1 DISTAL RADIUS PLATING SYSTEM 有权
公开(公告)号：US20230042897A1
公开(公告)日：2023-02-09
申请号：US17889947
申请日：2022-08-17
申请人： The Board of Regents of the University of Nebraska
发明人： Daniel Firestone
IPC分类号： A61B17/80
摘要： Systems and methods are described for treating distal radius fractures using a plating system. In an aspect, a distal radius plating system includes a volar plate body for interfacing with a volar side of a distal portion of a radius bone. The volar plate body has a volar head portion extending from the volar plate body and terminating at a distal edge, the volar head portion including a first set of apertures to receive fixation fasteners therethrough to fix to the radius bone. The distal radius plating system also includes a radial longitudinal portion extending from a radial edge of the volar plate body to interface with the radial styloid of the radius bone while the volar plate body is positioned on the volar side of the distal portion of the radius bone.

88. 外观设计

USD975274S1 Precision syringe plunger 有权
公开(公告)号：USD975274S1
公开(公告)日：2023-01-10
申请号：US29739559
申请日：2020-06-26
申请人： The Board of Regents of the University of Nebraska
设计人： Donny Suh , Tyler Scherr , Ronald Linke , Samantha Busch , Phil Leopold , Chris Steadham , Brian Walsh

89. 发明授权

US11446067B2 Distal radius plating system 有权
公开(公告)号：US11446067B2
公开(公告)日：2022-09-20
申请号：US16977299
申请日：2019-03-01
申请人： The Board of Regents of the University of Nebraska
发明人： Daniel Firestone
IPC分类号： A61B17/80 , A61B17/56
摘要： Systems and methods are described for treating distal radius fractures using a plating system. In an aspect, a distal radius plating system includes a volar plate body for interfacing with a volar side of a distal portion of a radius bone. The volar plate body has a volar head portion extending from the volar plate body and terminating at a distal edge, the volar head portion including a first set of apertures to receive fixation fasteners therethrough to fix to the radius bone. The distal radius plating system also includes a radial longitudinal portion extending from a radial edge of the volar plate body to interface with the radial styloid of the radius bone while the volar plate body is positioned on the volar side of the distal portion of the radius bone.

90. 发明申请

US20210386562A1 UPPER LIMB PROSTHESES 有权
公开(公告)号：US20210386562A1
公开(公告)日：2021-12-16
申请号：US17286382
申请日：2019-10-18
申请人： The Board of Regents of the University of Nebraska
发明人： Jorge Zuniga , Jean Peck , Walker Arce , Rakesh Srivastava , James Pierce , Keaton Young
IPC分类号： A61F2/58 , A61F2/68
摘要： An upper limb prosthetic device may comprise a hybrid-drive prosthetic device that includes one or more actuators fixed to a first arm portion and one or more cables extending from the one or more actuators along one or more cable paths defined through the first arm portion and a second arm portion to a terminal device/device assembly, where the one or more cables are configured to be actuated by the one or more actuators and are further configured to be actuated by pivoting the second arm portion toward the first arm portion, Alternatively, or additionally, the upper limb prosthetic device may comprise a modular prosthetic device that includes a modular terminal device assembly with removably coupled first, second, and third modular links configured to control the respective yaw, pitch, and roll of an end effector (e.g a prosthetic hand, a tool, an instrument or any other attachment).

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