专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

81. 发明专利

JP2000111560A PEPTIDE INCLUDING IMMUNOLOGICALLY ACTIVE REGION OF HEPATITIS C VIRUS 失效
公开(公告)号：JP2000111560A
公开(公告)日：2000-04-21
申请号：JP31736099
申请日：1999-11-08
申请人： ROCHE DIAGNOSTICS GMBH
发明人： SEIDEL CHRISTOPH DR , WIENHUES-THELEN URSULA-HENRIKE , URBAN SCHMITT , JUNG GUENTHER-GERHARD , IHLENFELDT HANS-GEORG , KLAAS WOLFGANG
IPC分类号： G01N33/53 , C07K7/08 , C07K14/18 , G01N33/576
摘要： PROBLEM TO BE SOLVED: To divide HCV antibodies into types with peptide including immunologically active region of hepatitis C virus(HCV) selected from partial sequence of a plurality kinds of specified amino acids and 6-amino acids length or more. SOLUTION: In order to divide antibodies to HCV into types required are an ability for producing antibodies to the sequence thereof, and an individual virus type which becomes a base for distinguishment of an individual virus isolated substance, or an antigen satisfying variability in virus subtypes. This can be satisfied with amino acid 384-414, amino acid 1738-1759, amino acid 2217-2236, amino acid 2402-2419, amino acid 2345-2357, and peptide including immunologically active region of HCV selected from partial sequence having at least 6-amino acid length. The peptide is useful for determination of origin of an individual virus isolated substance or sub-type thereof.

82. 发明专利

JP2000095799A REDUCTION OF INTERFERENCE IN IMMUNOASSAY WITH SUBSTANCE INDUCED FROM FRAMEWORK REGION OF ANTIBODY 失效
公开(公告)号：JP2000095799A
公开(公告)日：2000-04-04
申请号：JP18046199
申请日：1999-06-25
申请人： ROCHE DIAGNOSTICS GMBH
发明人： NUSSBAUM SABINE DR , MOESSNER ELLEN DR , LENZ HELMUT DR , PRAAST GERALD DR
IPC分类号： G01N33/531 , C07K16/18 , G01N33/53 , G01N33/543 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide an improved method for detecting analytes (esp. a tumor marker), being more excellent than state-of-the-art, in which the interference due to nonspecific substance such as HAMA is reduced. SOLUTION: When detecting an analyte (esp. a tumor marker) in a sample immunologically, the method of this invention is to add to a test preparation a substance including a peptide sequence from the framework region of variable domain of a detecting antibody or an antibody for immunothrapy or scintigraphy in order to reduce interference. The above substance can reduce interference in immunoassay, is useful as an inhibitor for that purpose.

83. 发明专利

JP2000053579A COMBINED USE OF BONE MORPHOGENETIC PROTEIN FOR CARTILAGE INDUCTION AND DORSALIZING FACTOR 失效
公开(公告)号：JP2000053579A
公开(公告)日：2000-02-22
申请号：JP10126299
申请日：1999-04-08
申请人： ROCHE DIAGNOSTICS GMBH
发明人： BRUSHER HELMUT , DONNY CARROLA , PRETZEL GABRIEL
IPC分类号： A61K38/00 , A61K31/00 , A61K38/18 , A61K38/22 , A61P19/00 , A61P19/08
摘要： PROBLEM TO BE SOLVED: To obtain a composition capable of inducing cartilage cell from mesenchymal stem cell and restoring the cartilage cell by combining a bone- morphogenetic protein with a dorsalizing factor. SOLUTION: The objective composition contains (A) a bone-morphogenetic protein (preferably BMP-2, BMP-4, BMP-5, BMP7 or hedgehog protein) and (B) a dorsalizing factor (preferably noggin, chordin or follistatin) at a ratio of 10:1 to 1:10. The composition is preferably further incorporated with a biocompatible matrix (preferably hyaluronic acid, alginic acid salt or collagen). Further preferable composition contains an expression vector capable of expressing the components A and B or a combination of a vector capable of expressing the component A with a vector capable of expressing the component B as essential components. The composition is expected to be usable for the treatment of a patient necessitating the cartilage restoration.

84. 发明专利

JPH11326329A IMMUNOLOGICAL METHOD FOR DETERMINING PROSTATE GLAND SPECIFIC ANTIGEN 失效
公开(公告)号：JPH11326329A
公开(公告)日：1999-11-26
申请号：JP9526199
申请日：1999-04-01
申请人： ROCHE DIAGNOSTICS GMBH
发明人： HOESEL WOLFGANG DR , PETER JOCHEN
IPC分类号： G01N33/53 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To improve and simplify an immunological method for detecting a concentration of a free PSA(prostate gland specific antigen), a total PSA and a PSA-serpin complex by adding a nucleophilic reagent containing amine to a sample. SOLUTION: A nucleophilic reagent containing amine is added to a sample before a concentration of a total PSA is determined according to an immunological method improved for determining the PSA by incubation of the sample and at least one of antibodies which specifically bonds with a free PS, but does not bond with a complex PSA. This process is preferred to determine the free PSA, total PSA and PSA-serpin complex. The complex of the PSA and serpin, particularly, ACT is stable and resistant to a severe state of a temperature or a pH. The PSA-serpin complex can be cut by adding the nucleophilic reagent containing amine. The obtained PSA is stable, which goes true also in the presence of a blood serum. In other words, a new complex is not formed.

85. 发明专利

JPH11228389A PRODUCTION OF AMORPHOUS PRODUCT BY CONVECTION DRYING 失效
公开(公告)号：JPH11228389A
公开(公告)日：1999-08-24
申请号：JP31162998
申请日：1998-11-02
申请人： ROCHE DIAGNOSTICS GMBH
发明人： GABEL ROLF-DIETER DR , MATTERN MARKUS DR , WINTER GERHARD DR , WIRL ALEXANDER , WOOG HEINRICH DR
IPC分类号： F26B3/084 , A23L3/40 , A61K9/14 , A61K9/16 , A61K47/18 , B01D1/14 , B01D1/18 , F26B3/02 , F26B3/12
摘要： PROBLEM TO BE SOLVED: To provide a mild, adaptable, readily reproducible, rapid and economic method for embedding a biological substance, especially a human protein. SOLUTION: This method for producing a dried amorphous product containing a mixture for stabilization besides a biologically active substance, especially therapeutically active substance comprises producing a solution or a suspension of a mixture comprising a biological substance, (a) a hydrocarbon and at least one polar or nonpolar group-containing zwitter ion or its derivative and/or (b) at least two polar or nonpolar group-containing zwitter ions or their derivatives and/or (c) at least one polar or nonpolar group-containing zwitter ion or polar or number of nonpolar group-containing zwitter ions or their derivatives, adjusting the relative water content of a stationary phase at 50-300 deg.C inlet air temperature to

86. 发明专利

JP2010163456A Process for production of amorphous product by convection drying 审中-公开
标题翻译：通过对流干燥生产不规则产品的方法
公开(公告)号：JP2010163456A
公开(公告)日：2010-07-29
申请号：JP2010088665
申请日：2010-04-07
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： GABEL ROLF-DIETER DR , MATTERN MARKUS DR , WINTER GERHARD DR , WIRL ALEXANDER , WOOG HEINRICH DR
IPC分类号： A61K9/14 , F26B3/084 , A23L3/40 , A61K9/16 , A61K47/18 , A61K47/26 , A61K47/36 , B01D1/14 , B01D1/18 , F26B3/02 , F26B3/12
CPC分类号： A61K9/1617 , A61K9/1623 , A61K47/183 , B01D1/18 , F26B3/02 , Y10S435/81 , Y10S514/911 , Y10S514/97
摘要： PROBLEM TO BE SOLVED: To provide a development of a mild, adaptable, easily reproducible, rapid and economical drying process for a biological substance, particularly for embedding a human protein.
SOLUTION: The method is a process for production of the dried amorphous product including a biologically active substance, particularly a therapeutically active substance and a mixture for stabilization, and comprises: preparing a solution or a suspension of a mixture of the biologically active substance and (a) a carbohydrate and at least one zwitter ionic substance or its derivative having a polar or a non-polar group and/or (b) at least two zwitter ionic substances or their derivatives having polar or non-polar groups and/or (c) at least one zwitter ionic substance having a polar or a non-polar group or multiple zwitter ionic substances or their derivatives having polar or non-polar groups; and drying by convection drying adjusting the relative water content of the solid phase at
摘要翻译：要解决的问题：为生物物质，特别是用于嵌入人类蛋白质提供温和，适应性，易于重现，快速和经济的干燥方法的开发。解决方案：该方法是生产干燥无定形产物的方法，包括生物活性物质，特别是治疗活性物质和用于稳定化的混合物，并且包括：制备生物活性物质的混合物的溶液或悬浮液物质和（a）碳水化合物和至少一种具有极性或非极性基团的两性离子物质或其衍生物和/或（b）具有极性或非极性基团的至少两个两性离子物质或其衍生物和/ 或（c）具有极性或非极性基团或多个两性离子物质的至少一种两性离子物质或其具有极性或非极性基团的衍生物; 并通过对流干燥进行干燥，通过50-300℃的入口空气温度调节固相的相对含水量<70％。版权所有（C）2010，JPO＆INPIT

87. 发明专利

JP2010042022A Magnetic pigment 有权
标题翻译：磁性颜料
公开(公告)号：JP2010042022A
公开(公告)日：2010-02-25
申请号：JP2009238436
申请日：2009-10-15
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： KLEIBER JOERG , WALTER THOMAS , HARTTIG HERBERT DIPL CHEM DR , LESNIAK CHRISTOPH , MENNIG MARTIN , RIEDLING MICHAEL , SCHMIDT HELMUT
IPC分类号： C12N15/09 , C03C14/00 , C12Q1/68 , C23C30/00
CPC分类号： C23C30/00 , C12Q1/6806 , Y10S428/90 , Y10S435/814 , Y10T428/12042 , Y10T428/2996 , C12Q2563/149 , C12Q2563/143
摘要： PROBLEM TO BE SOLVED: To provide a material suitable for immobilizing a biological material, and to provide a simple method for isolating a biological material, especially a nucleic acid, also suitable for using in usual diagnostic methods. SOLUTION: The method includes conducting an enzymatic reaction in a nucleic acid. Specifically, the method comprises the following process: A nucleic acid derived from a sample containing the nucleic acid in a liquid is isolated by adsorption to magnetic particles having glass surfaces, and subsequently used as a substrate in an enzymatic reaction, and then isolated in the presence of a chaotropic salt. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供适于固定生物材料的材料，并提供也适用于通常诊断方法中使用的生物材料特别是核酸的简单方法。解决方案：该方法包括在核酸中进行酶反应。具体地说，该方法包括以下方法：通过吸附到具有玻璃表面的磁性颗粒中分离来自含有液体中的核酸的样品的核酸，随后在酶反应中用作底物，然后在存在离液盐。版权所有（C）2010，JPO＆INPIT

88. 发明专利

JP2009198521A Storage container for analytical device 有权
标题翻译：分析装置的储存容器
公开(公告)号：JP2009198521A
公开(公告)日：2009-09-03
申请号：JP2009137783
申请日：2009-06-09
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： SACHERER KLAUS-DIETER
IPC分类号： G01N35/02 , B01L3/00 , B01L99/00 , G01N35/04
摘要： PROBLEM TO BE SOLVED: To provide a compact storage container for analytical devices, i.e., test elements, sampling elements and lancets that can be manufactured inexpensively in large numbers and that can reliably protect the analytical devices located therein against damaging environmental influences such as light, moisture or mechanical influences.
SOLUTION: The storage container for holding two or several analytical devices is made of a hard material and includes separate chambers each of which can hold at most one analytical device. The chambers are in a regular geometric arrangement in relation to one another, and each chamber has at least two opposite openings each sealed by a foil. Each chamber has a means for fixing the position of an analytical device in the chamber. The analytical device slightly bends in the chamber, and the position of the analytical device can be fixed by the bending stress generated as a result. Further, a system for storing analytical devices is provided including the storage container and two or more analytical devices. The analytical devices are fixed in the chambers of the storage container to protect the sealing foil against a fall, impact (knocked) or unexpected mechanical stress such as vibration.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供用于分析装置的紧凑型存储容器，即可以大量廉价制造的测试元件，采样元件和刺血针，并且可靠地保护位于其中的分析装置免受破坏性的环境影响，例如如光，水分或机械影响。用于保持两个或多个分析装置的储存容器由硬质材料制成，并且包括分开的室，每个室最多可以容纳一个分析装置。这些腔室相对于彼此具有规则的几何布置，并且每个腔室具有至少两个相对的开口，每个开口由箔片密封。每个室具有用于将分析装置的位置固定在室中的装置。分析装置在室内稍微弯曲，并且分析装置的位置可以由于产生的弯曲应力而被固定。此外，提供了一种用于存储分析装置的系统，包括存储容器和两个或更多个分析装置。分析装置固定在储存容器的腔室中，以保护密封箔免受跌倒，撞击（敲击）或意外的机械应力如振动。版权所有（C）2009，JPO＆INPIT

89. 发明专利

JP2008194450A Bayonet type luer locking connection member for insulin pump 审中-公开
标题翻译：用于胰岛素泵的BAYONET型LUER锁定连接件
公开(公告)号：JP2008194450A
公开(公告)日：2008-08-28
申请号：JP2007320384
申请日：2007-12-12
申请人： F Hoffmann La Roche Ag , Roche Diagnostics Gmbh , エフ.ホフマン−ラロシュアーゲーF. Hoffmann−La Roche Aktiengesellschaft , ロシュダイアグノスティックスゲーエムベーハー
发明人： AESCHLIMANN RETO , WEIBEL MICHAEL
IPC分类号： A61M39/02
CPC分类号： F16L37/107 , A61M39/1011 , A61M2039/1033 , A61M2039/1077
摘要： PROBLEM TO BE SOLVED: To provide a closure member or a closure device, providing a releasable closure having durability for a long period with high reliability. SOLUTION: The closure device for forming connection, especially fluid connection, comprises a first closure member, including a first adapter 1, an engagement member 2 movable or slidable to the first adaptor, and an elastic member 5 disposed between the first adapter and the engagement member or to connect them to each other. COPYRIGHT: (C)2008,JPO&INPIT

90. 发明专利

JP2008012530A Dry polymer bead preparation 有权
标题翻译：干聚合物制备
公开(公告)号：JP2008012530A
公开(公告)日：2008-01-24
申请号：JP2007157849
申请日：2007-06-14
申请人： Roche Diagnostics Gmbh , ロシュダイアグノスティックスゲーエムベーハー
发明人： HARTTIG HERBERT DIPL CHEM DR
IPC分类号： B03C1/00 , B01J19/08 , B03C1/01 , C08J3/12 , G01N1/10 , G01N33/543 , H01F1/36 , H01F1/44
CPC分类号： B03C1/01 , C08J3/124 , G01N33/5434 , G01N2446/80
摘要： PROBLEM TO BE SOLVED: To provide a polymer bead preparation which can assume a resuspended form with no flocculation.
SOLUTION: A method for concentrating a magnetic bead-containing suspension comprises the step of immobilizing particles including magnetic beads by applying a magnetic field effect to the suspension and the step of separating a suspension fluid containing non-magnetic beads.
COPYRIGHT: (C)2008,JPO&INPIT

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式