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    • 81. 发明申请
    • Security apparatus for motor vehicles
    • 机动车安全装置
    • US20060170536A1
    • 2006-08-03
    • US11116467
    • 2005-04-28
    • Cheng-Hung YuCheng-Peng Liu
    • Cheng-Hung YuCheng-Peng Liu
    • B60R25/10G08B3/10G08B23/00
    • G10K9/22
    • A security apparatus for motor vehicles is disclosed, and is featured in integrating all the components into one body as an all-in-one form and in filling resin into the housing of the security apparatus so as to completely cover an electric circuit unit and the interior surface of a siren. The present invention is alternately featured in providing a metal cover covering the externally-exposed surface of the siren for protecting the siren; providing fastening elements each of which has a head hole of special pattern, thereby preventing the security apparatus from being unlawfully dismantled; and providing several detecting modes and power-saving modes, so as to effectively and reliably provide the antitheft function for motor vehicles.
    • 公开了一种用于机动车辆的安全装置,其特征在于将所有部件作为一体式形成一体,并将树脂填充到安全装置的壳体中,以完全覆盖电路单元,并且 警笛的内表面。 本发明的另一特征在于提供一种覆盖警报器的外部暴露表面的金属盖,用于保护警报; 提供每个具有特殊图案的头孔的紧固元件,从而防止安全装置被非法拆除; 并提供多种检测模式和省电模式,有效可靠地为汽车提供防盗功能。
    • 83. 发明申请
    • Compositions and methods for bone formation and remodeling
    • 用于骨形成和重塑的组合物和方法
    • US20050196349A1
    • 2005-09-08
    • US10849067
    • 2004-05-19
    • Dianqing WuYazhou ZhangPeng LiuXiaofeng LiJie ZhangJufang ShanDean Engelhardt
    • Dianqing WuYazhou ZhangPeng LiuXiaofeng LiJie ZhangJufang ShanDean Engelhardt
    • A61K9/68G01N33/48G01N33/50G01N33/53G01N33/68G06F19/00A61K7/28
    • G01N33/6893A61K38/00G01N33/6887G01N2500/00G01N2800/10G01N2800/108
    • The mechanism by which the high bone mass (HBM) mutation (G171V) of the Wnt coreceptor LRP5 regulates the canonical Wnt signaling was investigated. The mutation was previously shown to reduce Dkk protein-1-mediated antagonism, suggesting that the first YWTD repeat domain where G171 is located may be responsible for Dkk protein-mediated antagonism. However, we found that the third YWTD repeat, but not the first repeat domain, is required for DKK1-mediated antagonism. Instead, we found that the G171V mutation disrupted the interaction of LRP5 with Mesd, a chaperon protein for LRP5/6 that is required for the coreceptors' transport to cell surfaces, resulting in less LRP5 molecules on the cell surface. Although the reduction in the level of cell surface LRP5 molecules led to a reduction in Wnt signaling in a paracrine paradigm, the mutation did not appear to affect the activity of coexpressed Wnt in an autocrine paradigm. Together with the observation that osteoblast cells produce autocrine canonical Wnt, Wnt7b, and that osteocytes produce paracrine Dkk1, we believe that the G171V mutation may cause an increase in Wnt activity in osteoblasts by reducing the number of targets for paracrine Dkk1 to antagonize without affecting the activity of autocrine Wnt.
    • 研究了Wnt共同受体LRP5的高骨量(HBM)突变(G171V)调节规范Wnt信号传导的机制。 以前显示突变可以降低Dkk蛋白-1介导的拮抗作用,这表明G171位于第一个YWTD重复结构域可能是Dkk蛋白介导的拮抗作用的原因。 然而,我们发现第三个YWTD重复,但不是第一个重复结构域,是DKK1介导的拮抗作用所必需的。 相反,我们发现G171V突变破坏了LRP5与Mesd的相互作用,Mesd是共受体转运到细胞表面所需的LRP5 / 6的伴侣蛋白,导致细胞表面上较少的LRP5分子。 尽管细胞表面LRP5分子水平的降低导致旁分泌范例中Wnt信号传导的降低,但突变似乎不影响共表达Wnt在自分泌范式中的活性。 连同观察到成骨细胞产生自分泌的正常Wnt,Wnt7b,并且该骨细胞产生旁分泌的Dkk1,我们认为G171V突变可能通过减少旁分泌Dkk1靶向拮抗的数目而引起成骨细胞中Wnt活性的增加,而不影响 自分泌Wnt的活性。
    • 86. 发明申请
    • Pedestal assembly for computer enclosures
    • 计算机外壳的基座组件
    • US20050150435A1
    • 2005-07-14
    • US10946720
    • 2004-09-21
    • Hsuan-Tsung ChenYing TinPin-Shian WuPeng Liu
    • Hsuan-Tsung ChenYing TinPin-Shian WuPeng Liu
    • A47B57/00A47B91/00G06F1/16G06F1/18H05K5/00
    • A47B91/005G06F1/181
    • A pedestal assembly (20) includes a chassis (200), a gear wheel (300) pivotably mounted to the chassis, two supporting members (400) coupled to the chassis, and a coil spring (500) received between the chassis and the gear wheel. The chassis includes a stop portion (222) depending downwardly from a side of a top wall (210) thereof. The gear wheel includes first teeth (330) extending from a periphery thereof. Each supporting member includes a rack (440) comprises second teeth (444) engaging with the first teeth, and a first clasping portion (448) formed on an outer side thereof. When one of the first clasping portions is locked by the stop portion, the coil spring is compressed, while when the first clasping portion is unlocked from the stop portion, the coil spring is decompressed and drives the gear wheel to rotate to cause the supporting members to move relative to the gear wheel.
    • 基座组件(20)包括底盘(200),可枢转地安装到底盘的齿轮(300),联接到底盘的两个支撑构件(400)和容纳在底盘和齿轮之间的螺旋弹簧(500) 轮。 底盘包括从其顶壁(210)的侧面向下悬垂的止挡部分(222)。 齿轮包括从其周边延伸的第一齿(330)。 每个支撑构件包括齿条(440),齿条(440)包括与第一齿啮合的第二齿(444)和形成在其外侧上的第一夹紧部分(448)。 当第一夹紧部中的一个被止动部锁定时,螺旋弹簧被压缩,而当第一夹紧部从止动部解锁时,螺旋弹簧被减压并驱动齿轮旋转,从而使支撑构件 相对于齿轮移动。