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81. 发明公开

EP2267035A3 Measuring Degree of Polymerisation for Meningococcal Capsular Saccharides that Contain Sialic Acid 审中-公开
标题翻译：确定荚膜脑膜炎球菌多糖的聚合的含有唾液酸的程度
公开(公告)号：EP2267035A3
公开(公告)日：2011-03-02
申请号：EP10179767.8
申请日：2005-05-23
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Bardotti, Angela
IPC分类号： C08B37/00 , A61K39/095
CPC分类号： A61K39/095 , C08B37/00 , Y10T436/143333
摘要： The degree of polymerisation (DP) is an important parameter for analysis of saccharide antigens, particularly in glycoconjugates. The invention provides methods that can be used to measure DP for capsular saccharides, particularly for meningococcal saccharides e . g . from serogroups W135 and Y. A preferred method is based on reduction of terminal sialic acid residues on saccharides, with DP then being calculated by comparing the molar ratio of total sialic acid to reduced sialic acid.

82. 发明授权

EP1725871B1 SEPARATION OF UNCONJUGATED AND CONJUGATED SACCHARIDES BY SOLID PHASE EXTRACTION 无效
标题翻译：固相萃取法分离未结合和结合的糖化物
公开(公告)号：EP1725871B1
公开(公告)日：2011-03-02
申请号：EP05718410.3
申请日：2005-03-17
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： BARDOTTI, Angela , RICCI, Stefano , PROIETTI, Daniela
IPC分类号： G01N33/548
CPC分类号： G01N33/56911 , A61K39/095 , A61K2039/6087 , G01N30/02 , G01N33/5308 , G01N2333/22 , G01N2400/10 , Y10T436/143333 , B01D15/363
摘要： The invention is based on the use of solid phase extraction for separating conjugated saccharide from unconjugated saccharide in sample, e.g. a vaccine. Solid phase extraction (SPE) provides faster and more reproducible separation of conjugated saccharides, thereby allowing quantitative separation of these saccharides. The separation of conjugated and unconjugated saccharide using SPE may be advantageously combined with a quantitative conjugate analysis to provide improved quality control for conjugate vaccines. The SPE separation is compatible with existing quantitative conjugate analysis techniques, such as high performance anion exchange chromatography with pulsed amperometric detection (HPAEC-PAD).
摘要翻译：本发明基于使用固相萃取从样品中未结合的糖分离结合的糖，例如，一种疫苗。固相萃取（SPE）提供更快且更可重复的共轭糖分离，从而允许定量分离这些糖。使用SPE分离缀合的和未缀合的糖可以有利地与定量缀合物分析相结合以提供缀合物疫苗的改进的质量控制。 SPE分离与现有的定量共轭分析技术兼容，例如使用脉冲安培检测（HPAEC-PAD）的高性能阴离子交换色谱。

83. 发明公开

EP2278008A2 Streptococcus pneumoniae proteins and nucleic acids 审中-公开
标题翻译：蛋白质在NUKLEINSÄURENVON STREPTOCOCCUS PNEUMONIAE
公开(公告)号：EP2278008A2
公开(公告)日：2011-01-26
申请号：EP10179925.2
申请日：2002-03-27
申请人： Novartis Vaccines and Diagnostics S.r.l. , J. Craig Venter Institute, Inc.
发明人： Masignani, Vega , Tettelin, Herve , Fraser, Claire
IPC分类号： C12N15/31 , C12N1/21 , C12Q1/68 , A61K39/09 , A61P31/04 , C07K14/315 , C07K16/12 , G01N33/68
CPC分类号： C07K14/3156 , A61K39/00 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins and nucleic acid sequences from Streptococcus pneumoniae, together with a genome sequence. These are useful for the development of vaccines, diagnostics, and antibiotics.
摘要翻译：本发明提供了来自肺炎链球菌的蛋白质和核酸序列，以及基因组序列。这些可用于开发疫苗，诊断和抗生素。

84. 发明公开

EP2277896A1 Nucleic acids and proteins from streptococcus groups A & B 审中-公开
标题翻译：来自链球菌群A和B的核酸和蛋白质
公开(公告)号：EP2277896A1
公开(公告)日：2011-01-26
申请号：EP10179744.7
申请日：2001-10-29
申请人： Novartis Vaccines and Diagnostics S.r.l. , J. Craig Venter Institute, Inc.
发明人： Telford, John , Masignani, Vega , Grandi, Guido , Fraser, Claire , Tettelin, Herve , Scarselli, Maria
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译：本发明提供了来自B组链球菌（无乳链球菌）和A组链球菌（酿脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。数据表明蛋白质是疫苗，免疫原性组合物和/或诊断剂的有用抗原。蛋白质也是抗生素的靶标。

85. 发明公开

EP2277894A1 Nucleic acids and proteins from streptococcus groups A & B 审中-公开
标题翻译： Nukleinsäureund Proteine von Gruppen A und B Streptokokken
公开(公告)号：EP2277894A1
公开(公告)日：2011-01-26
申请号：EP10179732.2
申请日：2001-10-29
申请人： Novartis Vaccines and Diagnostics S.r.l. , J. Craig Venter Institute, Inc.
发明人： Telford, John , Masignani, Vega , Grandi, Guido , Fraser, Claire , Tettelin, Herve , Scarselli, Maria
IPC分类号： C07K14/315
CPC分类号： C07K14/315 , A61K38/00 , A61K39/00 , A61K39/092 , A61K2039/505 , A61K2039/53 , C07K16/1275 , C07K16/40 , C07K2319/00 , C12N9/1088 , C12Y205/01018 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins from group B streptococcus (Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
摘要翻译：本发明提供来自B族链球菌（无乳链球菌）和A型链球菌（化脓链球菌）的蛋白质，包括氨基酸序列和相应的核苷酸序列。给出数据以显示蛋白质是疫苗，免疫原性组合物和/或诊断的有用抗原。蛋白质也是抗生素的靶标。

86. 发明公开

EP2277538A1 Combined meningitis vaccines 审中-公开
标题翻译：结合脑膜炎疫苗
公开(公告)号：EP2277538A1
公开(公告)日：2011-01-26
申请号：EP10180408.6
申请日：2004-10-04
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Contorni, Mario
IPC分类号： A61K39/095 , A61K39/102 , A61K39/09
CPC分类号： A61K47/4833 , A61K9/19 , A61K39/095 , A61K39/102 , A61K39/39 , A61K47/646 , A61K2039/55505 , A61K2039/6037 , A61K2039/6068 , A61K2039/70
摘要： Addition of a Hib conjugate to meningococcal conjugates enhances the overall activity against meningococcus serogroup W135.
摘要翻译：向脑膜炎球菌偶联物添加Hib偶联物增强了针对脑膜炎球菌血清组W135的整体活性。

87. 发明公开

EP2275551A2 Neisserial antigenic peptides 失效转让
标题翻译：奈瑟球菌抗原肽
公开(公告)号：EP2275551A2
公开(公告)日：2011-01-19
申请号：EP10178490.8
申请日：2000-10-30
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Galeotti, Cesira , Grandi, Guido , Masignani, Vega , Mora, Marirosa , Pizza, Mariagrazia , Rappuoli, Rino , Ratti, Giulio , Scarlato, Vincenzo , Scarselli, Maria
IPC分类号： C12N15/31 , C07K14/22 , C07K16/12 , A61K39/095 , A61K39/40 , A61K48/00 , G01N33/53 , G01N33/569
CPC分类号： A61K39/095 , A61K39/00 , A61K48/00 , A61K2039/55505 , C07K14/22
摘要： This invention provides, among other things, proteins, polypeptides, and fragments thereof, derived from the bacteria Neisseria meningitidis B. Also provided are nucleic acids encoding for such proteins, polypeptides, and/or fragments, as well as nucleic acids complementary thereto ( e.g., antisense nucleic acids). Additionally, this invention provides antibodies which bind to the proteins, polypeptides, and/or fragments. This invention further provides expression vectors useful for making the proteins, polypeptides, and/or fragments, as well as host cells transformed with such vectors. This invention also provides compositions of the proteins, polypeptides, fragments, and/or nucleic acids, for use as vaccines, diagnostic reagents, immunogenic compositions, and the like. Methods of making the compositions and methods of treatment with the compositions are also provided. This invention also provides methods of detecting the proteins, polypeptides, fragments, and/or nucleic acids.
摘要翻译：本发明尤其提供了源自细菌脑膜炎奈瑟球菌B的蛋白质，多肽及其片段。还提供了编码这些蛋白质，多肽和/或片段的核酸以及与其互补的核酸（例如，，反义核酸）。此外，本发明提供了与蛋白质，多肽和/或片段结合的抗体。本发明还提供了用于制备蛋白质，多肽和/或片段的表达载体，以及用这种载体转化的宿主细胞。本发明还提供了用作疫苗，诊断试剂，免疫原性组合物等的蛋白质，多肽，片段和/或核酸的组合物。还提供了制备该组合物的方法和用该组合物治疗的方法。本发明还提供了检测蛋白质，多肽，片段和/或核酸的方法。

88. 发明公开

EP2270176A1 Streptococcus pneumoniae proteins and nucleic acids 审中-公开
标题翻译：蛋白质和Nukleinsäurenvon肺炎链球菌
公开(公告)号：EP2270176A1
公开(公告)日：2011-01-05
申请号：EP10179948.4
申请日：2002-03-27
申请人： Novartis Vaccines and Diagnostics S.r.l. , J. Craig Venter Institute, Inc.
发明人： Masignani, Vega , Tettelin, Herve , Fraser, Claire
IPC分类号： C12N15/31 , C12N1/21 , C12Q1/68 , A61K39/09 , A61P31/04 , C07K14/315 , C07K16/12 , G01N33/68
CPC分类号： C07K14/3156 , A61K39/00 , Y02A50/464 , Y02A50/466
摘要： The invention provides proteins and nucleic acid sequences from Streptococcus pneumoniae. These are useful for the development of vaccines, diagnostics, and antibiotics.
摘要翻译：本发明提供了来自肺炎链球菌的蛋白质和核酸序列。这些可用于开发疫苗，诊断和抗生素。

89. 发明公开

EP2266605A1 Vaccines comprising aluminium adjuvants and histidine 审中-公开
标题翻译：含有铝佐剂和组氨酸的疫苗
公开(公告)号：EP2266605A1
公开(公告)日：2010-12-29
申请号：EP10179753.8
申请日：2002-07-26
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Contorni, Mario , Maffei, Massimo
IPC分类号： A61K39/39 , A61P31/00 , A61K39/095
CPC分类号： A61K38/00 , A61K39/095 , A61K39/39 , A61K2039/55505 , Y02A50/466
摘要： To improve the stability of vaccines comprising aluminium salt(s), the invention uses the amino acid histidine. This can improve pH stability and adjuvant adsorption and can reduce antigen hydrolysis. Histidine is preferably present during adsorption to the aluminium salt(s). The antigen in the vaccine may be a protein or a saccharide and is preferably from N.meningitidis.
摘要翻译：为了提高包含铝盐的疫苗的稳定性，本发明使用氨基酸组氨酸。这可以改善pH稳定性和佐剂吸附并且可以减少抗原水解。组氨酸优选在吸附到铝盐过程中存在。疫苗中的抗原可以是蛋白质或糖类，优选来自脑膜炎奈瑟球菌。

90. 发明公开

EP2258389A1 Improved bacterial outer membrane vesicles 有权转让
标题翻译：改进的细菌外膜囊泡
公开(公告)号：EP2258389A1
公开(公告)日：2010-12-08
申请号：EP10179783.5
申请日：2003-09-01
申请人： Novartis Vaccines and Diagnostics S.r.l.
发明人： Pizza, Mariagrazia , Serruto, Davide , Rappuoli, Rino
IPC分类号： A61K39/095 , A61K39/104 , A61K39/112 , A61K9/00
CPC分类号： A61K39/095 , A61K2039/55555 , C07K14/22 , C12N1/06 , C12N1/20 , C12N13/00
摘要： Existing methods of meningococcal OMV preparation involve the use of detergent during disruption of the bacterial membrane. According to the invention, membrane disruption is performed substantially in the absence of detergent. The resulting OMVs which retain important bacterial immunogenic components, particularly (i) the protective NspA surface protein, (ii) protein NMB2132 and (iii) protein NMB1870.A typical process involves the following steps: (a) treating bacterial cells in the substantial absence of detergent; (b) centrifuging the composition from step (a) to separate the outer membrane vesicles from treated cells and cell debris, and collecting the supernatant; (c) performing a high speed centrifugation of the supernatant from step (b) and collecting the outer membrane vesicles in a pellet; (d) re-dispersing the pellet from step (c) in a buffer; (e) performing a second high speed centrifugation in accordance with step (c), collecting the outer membrane vesicles in a pellet; (f) re-dispersing the pellet from step (e) in an aqueous medium.
摘要翻译：现有的脑膜炎球菌OMV制备方法涉及在破坏细菌膜期间使用去污剂。根据本发明，膜破裂基本上在不含洗涤剂的情况下进行。（i）保护性NspA表面蛋白质，（ii）蛋白质NMB2132和（iii）蛋白质NMB1870，所产生的OMVs保留了重要的细菌免疫原性组分。典型的方法包括以下步骤：（a）的洗涤剂; （b）离心步骤（a）的组合物以从处理的细胞和细胞碎片中分离外膜囊泡，并收集上清液; （c）对来自步骤（b）的上清液进行高速离心并将外膜囊泡收集在沉淀中; （d）将来自步骤（c）的颗粒重新分散在缓冲液中; （e）根据步骤（c）进行第二次高速离心，收集沉淀中的外膜囊泡; （f）将来自步骤（e）的粒料再分散在含水介质中。

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