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81. 发明公开

EP1883446A2 AN IMPLANTABLE THERAPY SYSTEM FOR TREATING A LIVING BEING WITH AN ACTIVE FACTOR 有权转让
标题翻译：植物系列治疗方法ZUR BEHANDLUNG EINES LEBEWESENS MIT EINEM WIRKFAKTOR
公开(公告)号：EP1883446A2
公开(公告)日：2008-02-06
申请号：EP06722946.8
申请日：2006-05-15
申请人： NsGene A/S
发明人： TORNØE, Jens , WAHLBERG, Lars, U.
IPC分类号： A61M31/00 , A61K9/00 , A61F2/00
CPC分类号： A61K9/0024 , A61M31/002
摘要： The invention provides a device for Encapsulated Cell Therapy. The device includes an implantable capsule containing cells which secrete a biologically active compound for providing a biological function. The capsule has a semi permeable outer membrane for delivery of the compound e.g. at a site in the central nervous system or the spinal cord, e.g. in the brain of a patient. The capsule is connected to a tether which e.g. facilitates removal of the capsule from the patient. To facilitate insertion of the capsule into the patient, a stiffener may be attached to the tether to make the tether more rigid. The invention further provides a container for storing a cell therapy device and a method of locating the device in the body of a patient.
摘要翻译：本发明提供了一种用于封装细胞治疗的装置。该装置包括含有分泌用于提供生物功能的生物活性化合物的细胞的可植入胶囊。胶囊具有用于递送化合物的半透过性外膜例如。在中枢神经系统或脊髓的部位，例如，在病人的大脑中。胶囊连接到系绳上，有助于从患者移除胶囊。为了便于将胶囊插入患者体内，可以将加强件连接到系绳上以使系绳更加刚性。本发明还提供了一种用于存储细胞治疗装置的容器和将装置定位在患者体内的方法。

82. 发明公开

EP1636260A2 IMPROVED SECRETION OF NEUBLASTIN 有权
标题翻译： VERBESSERTE SEZERNIERUNG VON NEUBLASTIN
公开(公告)号：EP1636260A2
公开(公告)日：2006-03-22
申请号：EP04736510.1
申请日：2004-06-10
申请人： NSGENE A/S , Biogen Idec MA, Inc.
发明人： WAHLBERG, Lars, U. , GROENBORG, Mette , KUSK, Philip , TORNOEE, Jens , PEDERSON, Nels, E. , SISK, William, P.
IPC分类号： C07K14/475 , C12N15/62 , C12N5/10 , A61K9/00 , A61K48/00 , A61P25/28 , C12N15/86
CPC分类号： C12N15/86 , A01K2217/05 , A61K9/0051 , A61K9/0085 , A61K48/0075 , C07K14/4756 , C12N2740/15043 , C12N2740/15052
摘要： The present invention concerns methods and compositions for producing a neublastin polypeptide as well as local delivery of neublastin to specific regions of the nervous system including the central nervous system for example by gene therapy. The biologically active neublastin polypeptide is produced from a construct not encoding naturally occurring neublastin pro-region, i.e. a construct comprising a nucleic acid with a promoter sequence operably linked to a nucleotide sequence encoding a signal peptide and a neublastin polypeptide, wherein said nucleotide sequence does not encode a neublastin pro-region.
摘要翻译：本发明涉及用于产生新斯的斯多肽多肽的方法和组合物，以及例如通过基因治疗将神经系统局部递送至神经系统的特定区域，包括中枢神经系统。生物活性的新斯的斯多肽由不编码天然存在的新伯斯匹林前区的构建体产生，即包含具有可操作地连接到编码信号肽和新伯斯特蛋白多肽的核苷酸序列的启动子序列的核酸的构建体，其中所述核苷酸序列不编码新伯斯坦的亲区。

83. 发明公开

EP1385938A1 METHOD AND CULTURE MEDIUM FOR PRODUCING NEURAL CELLS EXPRESSING TYROSINE HYDROXYLASE 审中-公开
标题翻译：方法和培养基的神经细胞的产生表达酪氨酸羟化酶
公开(公告)号：EP1385938A1
公开(公告)日：2004-02-04
申请号：EP02729919.7
申请日：2002-04-23
申请人： NSGENE A/S
发明人： MEIJER, Xia , GRONBORG, Mette,c/o NsGene A/S , WAHLBERG, Lars,c/o NsGene A/S
IPC分类号： C12N5/08 , C12N5/06 , C12N5/02 , A61K35/30 , A61P25/00
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0619 , C12N2500/25 , C12N2500/46 , C12N2501/01 , C12N2501/105 , C12N2501/11 , C12N2501/113 , C12N2501/115 , C12N2501/119 , C12N2501/13 , C12N2501/23 , C12N2501/235 , C12N2501/392 , C12N2501/395 , C12N2510/04
摘要： The invention provides a means for efficiently generating large numbers of TH expressing neural cells for neurotransplantation into a host to treat neurodegenerative disease, neurological trauma, stroke, or in other neurodegenerative disease, neurological trauma, stroke, or in other diseases of the nervous system involving loss of neural cells, particularly Parkinson's disease.

84. 发明公开

EP2290079A3 Neurotrophic factors 审中-公开
标题翻译：神经营养因子
公开(公告)号：EP2290079A3
公开(公告)日：2011-09-07
申请号：EP10181304.6
申请日：1999-07-05
申请人： NsGene A/S
发明人： Johansen, Teit E. , Blom, Nikolai , Hansen, Claus
IPC分类号： C12N15/12 , C07K14/475 , C12Q1/68 , G01N33/53 , G01N33/50 , C07K16/22 , A61K38/18 , A61K48/00 , G01N33/68
CPC分类号： C07K14/4756 , A61K38/00 , A61K48/00
摘要： The invention relates to neublastin neurotrophic factor polypeptides, nucleic acids encoding neublastin polypeptides, and antibodies that bind specifically to neublastin polypeptides as well as methods of making and methods of using the same.

85. 发明公开

EP2195013A1 THERAPEUTIC USE OF A GROWTH FACTOR, METRNL 有权转让
标题翻译：治疗维生素EERES WACHSTUMSFAKTORS，METRNL
公开(公告)号：EP2195013A1
公开(公告)日：2010-06-16
申请号：EP09776234.8
申请日：2009-07-07
申请人： NsGene A/S
发明人： JØRGENSEN, Jesper, Roland , FJORD-LARSEN, Lone , WAHLBERG, Lars, Ulrik , ANDRADE, Nuno, Miguel Gomes
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： A61K38/185 , A61K9/0046 , A61K38/00 , A61L31/10 , A61L31/16 , A61L2300/414 , C07K14/475 , C07K14/48
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells, in particular to the therapy based on the biological function of a secreted therapeutic protein, METRNL, in particular for the treatment of disorders of the nervous system. METRNL is a Nerve Survival and Growth factor with neuroprotective and/or neurogenesis effects.
摘要翻译：本发明涉及蛋白质，基因和细胞的治疗用途领域，特别涉及基于分泌型治疗性蛋白质METRNL的生物学功能的治疗，特别是用于治疗神经系统疾病。 METRNL是具有神经保护和/或神经发生作用的神经存活和生长因子。

86. 发明授权

EP1677833B1 Virus vector for use in in vivo gene therapy of Parkinson's disease 有权
标题翻译：用于帕金森氏病的体内基因治疗中使用的病毒载体
公开(公告)号：EP1677833B1
公开(公告)日：2010-03-10
申请号：EP04791259.7
申请日：2004-10-20
申请人： NsGene A/S
发明人： TORNOE, Jens , ROSENBLAD, Carl , WAHLBERG, Lars
IPC分类号： A61K48/00 , C12N15/12 , C07K14/475 , C12N15/867 , A61P25/16 , C12N5/18
CPC分类号： A61K38/185 , A61K48/00 , A61K48/005 , A61K48/0066 , C07K14/475 , C12N15/86 , C12N2740/15043 , C12N2750/14143

87. 发明授权

EP1745069B1 THERAPEUTIC USE OF GROWTH FACTOR NSG33 有权转让
标题翻译：生长因子的NsG33的治疗用途
公开(公告)号：EP1745069B1
公开(公告)日：2009-05-06
申请号：EP05717160.5
申请日：2005-03-30
申请人： NsGene A/S
发明人： GRØNBORG, Mette , KUSK, Philip , BLOM, Nikolaj , PETERSEN, Thomas, Nordahl , JOHANSEN, Teit, E. , BRUNAK, Søren , WAHLBERG, Lars
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A01K67/027 , A01K2207/05 , A01K2207/20 , A01K2227/105 , A01K2267/0356 , A61K38/00 , A61K38/17 , A61K38/185 , C12N2799/027
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.

88. 发明公开

EP1869162A1 A HUMAN IMMORTALISED NEURAL PRECURSOR CELL LINE 审中-公开
标题翻译：永生化神经VORLÄUFERZELLINIE
公开(公告)号：EP1869162A1
公开(公告)日：2007-12-26
申请号：EP06722877.5
申请日：2006-03-30
申请人： NsGene A/S
发明人： JULIUSSON, Bengt
IPC分类号： C12N5/00 , C12N5/08
CPC分类号： C12N5/0623 , A61K9/0085 , A61K35/12 , A61K2035/128 , C12N2510/04 , C12N2533/32 , C12N2533/52
摘要： The present invention relates to an immortalized human neural precursor cell line, NGC-407. The cell line has been established from human foetal tissue. The cell line has been immortalized using a retroviral vector containing the v-myc oncogene. The cell line is a neural progenitor cell line capable of differentiating into to astrocytes and neurons including dopaminergic neurons. NGC-407 cells are capable of migrating to glioblastoma tumours implanted into rat brains and form gap junctions with the tumour cells. NGC-407 cells expressing a suicide gene can be be used for delivering activated prodrugs in the form of activated nucleoside analogs to tumours.

89. 发明公开

EP1745069A2 THERAPEUTIC USE OF A GROWTH FACTOR, NSG33 有权转让
标题翻译：生长因子的NsG33的治疗用途
公开(公告)号：EP1745069A2
公开(公告)日：2007-01-24
申请号：EP05717160.5
申请日：2005-03-30
申请人： NSGENE A/S
发明人： GRØNBORG, Mette , KUSK, Philip , BLOM, Nikolaj , PETERSEN, Thomas, Nordahl , JOHANSEN, Teit, E. , BRUNAK, Søren , WAHLBERG, Lars
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A01K67/027 , A01K2207/05 , A01K2207/20 , A01K2227/105 , A01K2267/0356 , A61K38/00 , A61K38/17 , A61K38/185 , C12N2799/027
摘要： The present invention relates to the field of therapeutic use of proteins, genes and cells. More specifically the invention relates to therapy based on the biological function of a secreted therapeutic protein, NsG33, in particular for the treatment of disorders of the nervous system. NsG33 is a nerve survival and growth factor with antiapoptotic effects on a cell line with neuronal potential and with neuroprotective and/or neurogenesis effects on a neural precursor cell line and on primary striatal cultures. The invention also relates to novel bioactive NsG33 polypeptide fragments and the corresponding encoding DNA sequences.

90. 发明公开

EP1709161A2 HUMAN THERAPEUTIC CELLS SECRETING NERVE GROWTH FACTOR 有权
标题翻译：神经生长因子分泌人治疗性细胞
公开(公告)号：EP1709161A2
公开(公告)日：2006-10-11
申请号：EP05707792.7
申请日：2005-01-18
申请人： NSGENE A/S
发明人： TORNOE, Jens , KUSK, Philip , WAHLBERG, Lars
IPC分类号： C12N5/10 , C07K14/48 , A61K9/22 , A61K38/18 , C12N15/85 , A61P25/00
CPC分类号： A61K38/185 , A61K9/0024 , A61K47/34 , A61K2035/126 , A61L31/16 , A61L2300/414 , A61L2300/64 , C07K14/48 , C07K2319/02 , C12N2510/02 , C12N2510/04
摘要： The present invention relates to human cell lines genetically modified to overexpress bioactive NGF. In another aspect the present invention relates to encapsulated human cell lines genetically modified to overexpress bioactive NGF, which can be used in therapy of Alzheimer's disease, peripheral neuropathy and other neurological disorders amenable to local and prolonged NGF therapy.

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