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81. 发明专利

FR2384811B1 未知
公开(公告)号：FR2384811B1
公开(公告)日：1982-11-19
申请号：FR7808364
申请日：1978-03-22
申请人： MAEDA HIROSHI
IPC分类号： C08F8/00 , A61K38/00 , A61P35/00 , C07K1/113 , C07K14/36 , C07K14/37 , C07K14/41 , C07K17/08 , C08F8/30 , C08F8/32 , C08G81/02 , A61K37/02 , C07G7/00
摘要： Neocarzinostatin derivatives having the formula; wherein N represents a neocarzinostatin residue, and R1+R2 represents a residue of polystyrene-maleic acid copolymer having a molecular weight of 2,500 to 80,000. These neocarzinostatin derivatives are prepared by reacting neocarzinostatin with a polystyrene-maleic acid copolymer containing at least one maleic anhydride residue per molecule. The neocarzinostatin derivatives exhibit anticarcinogenic activity.

82. 发明授权

EP1627645B1 ANTITUMOR AGENT AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：抗癌剂及其生产方法
公开(公告)号：EP1627645B1
公开(公告)日：2017-08-23
申请号：EP04707295.4
申请日：2004-02-02
申请人： Maeda, Hiroshi
发明人： MAEDA, Hiroshi , GREISH, Khaled
IPC分类号： A61K47/58 , A61K47/69 , A61K45/06 , A61K47/18 , A61K47/32 , A61P35/00
CPC分类号： A61K33/24 , A61K9/1075 , A61K47/58 , A61K47/6907

83. 发明授权

EP2774625B1 POLYMER-TYPE FLUORESCENT MOLECULE PROBE 有权
标题翻译：聚合物型荧光分子探针
公开(公告)号：EP2774625B1
公开(公告)日：2017-04-12
申请号：EP12829505.2
申请日：2012-09-05
申请人： Maeda, Hiroshi
发明人： MAEDA, Hiroshi , HASHIZUME, Makoto , FANG, Jun , NAKAMURA, Hideaki , QIN, Haibo , HACKBARTH, Steffen , MURATA, Masaharu
IPC分类号： A61K49/00 , A61B1/00 , A61K41/00 , G01N21/64 , A61K47/58 , A61B1/313 , A61B1/04 , G01N33/58 , G01N33/574 , G01N21/33
CPC分类号： A61K49/0082 , A61B1/043 , A61B1/313 , A61K41/0057 , A61K41/0071 , A61K47/58 , A61K49/0017 , A61K49/0034 , A61K49/005 , A61K49/0054 , G01N21/33 , G01N21/6447 , G01N33/574 , G01N33/582 , G01N33/585

84. 发明公开

EP3072910A1 DERIVATIVE OF STYRENE-MALEIC ACID COPOLYMER 审中-公开
标题翻译： DERIVAT EINES STYROL - 马来西亚共聚物
公开(公告)号：EP3072910A1
公开(公告)日：2016-09-28
申请号：EP14864695.3
申请日：2014-11-19
申请人： Maeda, Hiroshi
发明人： NAKAMURA, Hideaki , FANG, Jun , MAEDA, Hiroshi
IPC分类号： C08F8/30 , A61K31/409 , A61K31/555 , A61K31/69 , A61K31/704 , A61K31/7048 , A61K38/22 , A61K45/00 , A61K47/48 , A61P5/00 , A61P31/04 , A61P35/00 , C07K14/575
CPC分类号： A61K31/409 , A61K31/69 , A61K31/704 , A61K38/00 , A61K47/58 , C07K14/575 , C08F8/12 , C08F8/30 , C08F8/32 , C08F8/34 , C08F8/42 , C08F8/44 , C08F220/04 , C08F222/06 , C08F2800/10 , C08F222/08 , C08F212/08 , C08F222/02
摘要： The present invention provides a group of novel SMA derivatives and a covalent conjugate of the derivatives and an active substance. More specifically, the present invention provides: an SMA derivative which contains (i) a styrene-maleic acid copolymer (SMA) and (ii) a side chain (b) that contains a functional group (a) selected from among -NH2, -SH, -OH, -COOH, -NH-(C=NH)-NH 2 and -C(CH 2 -OH) 3 and introduced into a carboxyl group of a maleic acid residue of the SMA via an amide bond or an ester bond, and wherein when a plurality of side chain (b) is introduced into the SMA, the side chains (b) may be identical or different from each other; and a conjugate of this SMA derivative and an active substance.
摘要翻译：本发明提供一组新型SMA衍生物和衍生物与活性物质的共价共轭物。更具体地说，本发明提供：含有（i）苯乙烯 - 马来酸共聚物（SMA）和（ii）侧链（b）的SMA衍生物，其含有选自-NH 2， SH，-OH，-COOH，-NH-（C = NH）-NH 2和-C（CH 2 -OH）3，并通过酰胺键或酯引入SMA的马来酸残基的羧基并且其中当多个侧链（b）引入SMA时，侧链（b）可以彼此相同或不同; 和SMA衍生物与活性物质的共轭物。

85. 发明公开

EP1873204A1 POLYMERIC PHARMACEUTICAL AGENT FOR TREATMENT OF CANCER AND PROCESS FOR PRODUCTION OF THE SAME 有权
标题翻译： POLYMERES PHARMAZEUTISCHES MITTEL ZUR BEHANDLUNG VON KREBS UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP1873204A1
公开(公告)日：2008-01-02
申请号：EP06731788.3
申请日：2006-04-13
申请人： Maeda, Hiroshi
发明人： GREISH, Khaled
IPC分类号： C08L25/04 , A61K31/704 , A61K31/409 , A61K31/7048 , A61K33/24 , A61K47/48 , A61P35/00
CPC分类号： A61K41/0071 , A61K9/0019 , A61K9/107 , A61K31/409 , A61K31/704 , A61K31/7048 , A61K47/58 , A61K47/60 , C08K5/0091 , C08L35/06
摘要： [PROBLEMS] To provide a polymeric pharmaceutical agent which can contain the active ingredient in a larger amount, which can be highly accumulated in tumor tissues, and which has a molecular size that is large enough not to undergo the renal excretion.
[MEANS FOR SOLVING PROBLEMS] The polymeric pharmaceutical agent capable of containing the active ingredient in a large amount can be produced by forming a styrene-maleic acid copolymer (SMA) micelle complex comprising a metalloporphyrin derivative (e.g., zinc protoporphyrin) and an SMA conjugated to each other via non-covalent bonding. This SMA micelle complex can be produced by reacting a metalloporphyrin derivative with an SMA in the absence of a condensing agent under alkaline conditions, solubilizing the resulting product, adjusting the reaction to pH 6 to 8, and collecting a polymeric micelle complex component having the active ingredient contained therein by a procedure for separating a polymeric component.
摘要翻译： [问题]提供可以含有更多量的活性成分的聚合物药剂，其可以高度积累在肿瘤组织中，并且具有足够大的分子尺寸，不能进行肾脏排泄。 [能够解决问题的手段]能够大量含有活性成分的聚合物药剂可以通过形成包含金属卟啉衍生物（例如锌原卟啉锌）和SMA共轭体系的苯乙烯 - 马来酸共聚物（SMA）胶束复合物通过非共价结合彼此。该SMA胶束复合物可以通过在碱性条件下在不存在缩合剂的情况下使金属卟啉衍生物与SMA反应，使所得产物溶解，将反应调节至pH6至8，并收集具有活性的聚合物胶束复合物组分通过分离聚合物组分的方法含有的成分。

86. 发明公开

EP1746409A1 ON-LINE INTERNAL QUALITY EXAMINING METHOD AND DEVICE 审中-公开
标题翻译：互联网在线 - QUALITÄTSUNTERSUCHUNGSVERFAHRENUND VORRICHTUNG
公开(公告)号：EP1746409A1
公开(公告)日：2007-01-24
申请号：EP05739011.4
申请日：2005-04-28
申请人： Maeda, Hiroshi
发明人： Maeda, Hiroshi
IPC分类号： G01N21/27 , G01N21/01 , G01N21/35 , G01N21/85
CPC分类号： G01N21/31 , B07C5/3416 , B07C2501/009 , G01N21/3563 , G01N21/85 , G01N21/88 , G01N21/8806 , G01N2021/8845
摘要： To provide a method and an apparatus for inspecting, in a non-destructive manner, internal qualities such as diseases and defects and physiological defects, which cannot be seen in an appearance, along with measurement of taste component values such as a sugar degree and an acid degree of fruits, which are agricultural products. An object is conveyed by conveying means that has a transmitted light path piercing in the vertical direction in the center thereof and is provided with a seat adhering to an object in an annular shape, with a predetermined position on a conveyance path set as an inspection position, a light shielding cylinder, which vertically lowers to, adheres to, and covers an upper part of the object, is advanced synchronously with the object, and beams are projected toward the object from both left and right sides using small lamps. Upper condensing means for condensing transmitted light through the light shielding cylinder downward over the inspection position and upper spectroscopic means connected to the upper condensing means by an optical fiber are provided. Lower condensing means for condensing transmitted light upward below a transmitted light exit of the seat and lower spectroscopic means connected to the lower side condensing means by an optical fiber are provided. An analyzer that subjects spectroscopic spectrum data SA obtained from the upper side spectroscopic means and spectroscopic spectrum SB obtained from the lower side spectroscopic means to spectrum analysis, respectively, and calculates taste component values such as a sugar degree and an acid degree from the upper and the lower spectrum and detects various physiological defects and diseases and defects to output a defect degree is provided.
摘要翻译：提供一种用于以非破坏性方式检查外观上看不到的内部品质，如外观上看不到的内容，以及味道成分值如糖度和水果的酸度，这是农产品。物体由具有在其中心沿垂直方向穿透的透射光路的输送装置输送，并且设置有附接到环状物体的座位，在作为检查位置的输送路径上具有预定位置垂直地降低，粘附并覆盖物体的上部的遮光筒与物体同步地前进，并且使用小的灯将光束从左右两侧投影到物体上。上聚光装置用于将透过的光通过遮光筒向下聚集在检查位置上，而上分光装置通过光纤连接到上聚光装置。提供用于将透射光向上聚集在座椅的透射光出口下方的下聚光装置和通过光纤连接到下侧聚光装置的下分光装置。将从上侧分光装置得到的分光光谱数据SA和从下侧分光装置得到的分光光谱SB分别进行光谱分析的分析装置，分别从上部和下部计算诸如糖度和酸度的味成分值提供较低的光谱并检测各种生理缺陷和疾病和缺陷以输出缺陷程度。

87. 发明公开

EP1627645A1 ANTITUMOR AGENT AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译： VERFAHREN ZU SEINER HERSTELLUNG的抗菌剂
公开(公告)号：EP1627645A1
公开(公告)日：2006-02-22
申请号：EP04707295.4
申请日：2004-02-02
申请人： Maeda, Hiroshi
发明人： MAEDA, Hiroshi , GREISH, Khaled
IPC分类号： A61K47/48 , A61K45/06 , A61K47/18 , A61K47/32 , A61P35/00
CPC分类号： A61K33/24 , A61K9/1075 , A61K47/58 , A61K47/6907
摘要： The present invention relates to polymeric antitumor agent which is formed in polymeric micelle complex by intermolecular bonding or mutual interaction between styrene maleic acid copolymer (SMA) and low molecule antitumor agent which is anthracyclins drug such as pirarubicin, doxorubicin, epirbicin, daunorbicin, acralbicin, or alkaloid antitumor agent such as cis-platinum, and taxol.
These polymeric antitumor agents may improve specificity to cancer cells so that it improves antitumor effect, while it may not be concentrated at normal organ or tissue, so that adverse effect may be diminished.
These polymeric antitumor agents may be prepared by dissolving SMA and low molecule antitumor agent in aqueous solution, then in the presence of aqueous soluble carbodiimide, amino acids, or polyamine, adjusting pH to form micelle complex and recovering polymer fraction.
摘要翻译：本发明涉及通过苯乙烯马来酸共聚物（SMA）和低分子抗肿瘤剂之间的分子间键合或相互作用形成聚合物胶束复合物的聚合物抗肿瘤剂，其是蒽环类药物，例如吡柔比星，多柔比星，表赤霉素，柔红霉素，或生物碱抗肿瘤剂如顺铂和紫杉醇。这些聚合物抗肿瘤剂可以提高对癌细胞的特异性，从而提高抗肿瘤作用，而不会将其集中在正常的器官或组织上，从而可能减少不利影响。这些聚合物抗肿瘤剂可以通过将SMA和低分子抗肿瘤剂溶解在水溶液中，然后在水溶性碳二亚胺，氨基酸或多胺的存在下，调节pH以形成胶束复合物并回收聚合物级分来制备。

88. 发明公开

EP1421938A4 ANTITUMOR AGENTS AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译：抗肿瘤手段与方法用于生产
公开(公告)号：EP1421938A4
公开(公告)日：2005-11-23
申请号：EP02758880
申请日：2002-08-29
申请人： MAEDA HIROSHI
发明人： MAEDA HIROSHI , SAWA TOMOHIRO
IPC分类号： A61K31/409 , A61K47/48 , A61P35/00 , A61P43/00 , C07D487/22
CPC分类号： C07D487/22 , A61K47/60
摘要： Antitumor agents containing, as the active ingredient, a metal porphyrin derivative having a hemoxygenase activity and bonded to an amphipathic or water-soluble polymer (in particular, Zn-protoporphyrin (Zn-PP) bonded to polyethylene glycol). Because of being bonded to an amphipathic or water-soluble polymer such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable antitumor effect owing to tumor-selective delivery.

89. 发明公开

EP1421938A1 ANTITUMOR AGENTS AND PROCESS FOR PRODUCING THE SAME 有权
标题翻译： VERFAHREN ZU IHRER HERSTELLUNG的ANTITUMORALE MITTEL
公开(公告)号：EP1421938A1
公开(公告)日：2004-05-26
申请号：EP02758880.5
申请日：2002-08-29
申请人： Maeda, Hiroshi
发明人： MAEDA, Hiroshi , SAWA, Tomohiro
IPC分类号： A61K31/409 , A61K47/48 , A61P35/00 , A61P43/00 , C07D487/22
CPC分类号： C07D487/22 , A61K47/60
摘要： Anticancer agents which contain as the active ingredient heme oxygenase inhibitory metalloporphyrin derivatives which are conjugated with amphipathic or water-soluble polymers (in particular, Zn-protoporphyrin (ZnPP) conjugated with polyethylene glycol). Because of being conjugated to amphipathic or water-soluble polymers, such as polyethylene glycol, the active ingredient can be administered by intravenous injection and can exert a remarkable anticancer effect owing to tumor-selective delivery.
摘要翻译：含有与两亲性或水溶性聚合物（特别是与聚乙二醇缀合的锌原卟啉（ZnPP））缀合的作为活性成分的血红素加氧酶抑制性金属卟啉衍生物的抗癌剂。由于与两亲性或水溶性聚合物（例如聚乙二醇）缀合，活性成分可通过静脉注射施用，并且由于肿瘤选择性递送而具有显着的抗癌作用。

90. 发明授权

EP0898968B1 Antitumor agent comprising a complex of an oxidoreductase and a polymer and a substrate of the enzyme 有权
标题翻译：抗肿瘤剂，其包含氧化还原酶的复合物和聚合物和酶的底物
公开(公告)号：EP0898968B1
公开(公告)日：2003-06-25
申请号：EP98115722.5
申请日：1998-08-20
申请人： Maeda, Hiroshi
发明人： Maeda, Hiroshi , Sawa, Tomohiro , Akaike, Takaaki
IPC分类号： A61K38/44 , C12N11/08 , A61K47/48
CPC分类号： C12Y117/03002 , A61K31/522 , A61K38/44 , A61K45/06 , A61K47/60 , C12N11/08 , A61K2300/00

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