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81. 发明申请

US20100098634A1 Imaging Agents Useful for Identifying AD Pathology 有权
标题翻译：用于识别AD病理学的成像剂
公开(公告)号：US20100098634A1
公开(公告)日：2010-04-22
申请号：US12509259
申请日：2009-07-24
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J.H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Wei Zhang , Umesh B. Gangadharmath , Dhanalakshmi Kasi , Kai Chen , Anjana Sinha , Eric Wang , Gang Chen , Peter J.H. Scott , Henry Clifton Padgett , Qianwa Liang , Zhiyong Gao , Tieming Zhao , Chunfang Xia
IPC分类号： A61K51/04 , C07D277/02 , C07D495/02 , C07D209/34 , C07D221/02 , C07D455/00 , C07D417/00 , C07D487/00 , C07D401/02 , C07D471/00 , C07D209/82 , C07D307/91 , A61P25/28 , G01N33/53
CPC分类号： C07D417/14 , A61K51/0406 , A61K51/0453 , A61K51/0455 , A61K51/0459 , C07D277/64 , C07D277/68 , C07D417/04 , C07D471/04 , C07D498/14 , C07D513/04 , C07D513/14
摘要： Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease.
摘要翻译：本文提供了包含本文公开的式的化合物和组合物，其中所述化合物是淀粉样蛋白结合化合物。根据本发明的淀粉样蛋白结合化合物可以以适于淀粉样蛋白沉积物的体内成像的量施用于患者，并且可以区分具有淀粉样沉积物的神经组织和正常神经组织。本发明的淀粉样蛋白探针可用于检测和定量疾病中的淀粉样蛋白沉积物，包括例如唐氏综合症，家族性阿尔茨海默氏病。在另一个实施方案中，所述化合物可用于治疗或预防神经变性疾病。本文还提供了允许化合物分布到脑组织中并对脑组织成像的方法，其中与正常对照结合水平相比，化合物与脑组织的结合增加指示哺乳动物患有或有发展神经变性疾病的风险。

82. 发明申请

US20100074910A1 Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment 有权
标题翻译：通过分子成像实现高治疗指标，引导靶向药物治疗
公开(公告)号：US20100074910A1
公开(公告)日：2010-03-25
申请号：US12455346
申请日：2009-06-01
申请人： Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Dhanalakshmi Kasi , Umesh B. Gangadharmath , Peter J.H. Scott , Gang Chen , Vani P. Mocharla
发明人： Hartmuth C. Kolb , Joseph C. Walsh , Kai Chen , Dhanalakshmi Kasi , Umesh B. Gangadharmath , Peter J.H. Scott , Gang Chen , Vani P. Mocharla
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , A61K38/16 , A61P35/00
CPC分类号： A61K51/088 , A61K51/082
摘要： The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods.
摘要翻译：本公开提供了在需要这种治疗的患者中治疗癌症的方法，所述方法包括通过使用在肿瘤部位对癌症靶标特异的标记的生物标志物向患者进行分子成像程序来资格评估患者的治疗性治疗; 以及施用治疗有效量的包含连接于与抗体连接的化学治疗剂或靶向剂的靶向剂的化合物。本发明的实施方案还包括使用这些方法的化合物和组合物。

83. 发明授权

US07666392B2 Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins 有权
标题翻译：点击化学衍生的环肽衍生物作为整合素的成像剂
公开(公告)号：US07666392B2
公开(公告)日：2010-02-23
申请号：US11901730
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
IPC分类号： A61K49/00
CPC分类号： A61K51/088 , A61K51/082
摘要： The present application is directed to radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译：本申请涉及放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。

84. 发明授权

US07494044B2 Carton, carton blank and associated methodology 有权
标题翻译：纸箱，纸箱和相关方法
公开(公告)号：US07494044B2
公开(公告)日：2009-02-24
申请号：US10957941
申请日：2004-10-04
申请人： Joseph C. Walsh , Robert L. Conatser
发明人： Joseph C. Walsh , Robert L. Conatser
IPC分类号： B65D5/56
CPC分类号： B65D5/4266 , B65D5/56
摘要： A carton blank may be formed having at least one score line therein. A second layer of material may overlay at least a portion of the first layer, including the score line, thus defining an overlaid score area. The overlaid score area may include at least a portion in which the second layer is not adhered to the first layer.
摘要翻译：可以形成纸箱坯件，其中具有至少一个刻痕线。第二层材料可以覆盖第一层的至少一部分，包括刻痕线，从而限定重叠的刻痕区域。覆盖得分区域可以包括至少一个第二层不粘附到第一层的部分。

85. 发明授权

US07419653B2 Method for preparing radiolabeled thymidine having low chromophoric byproducts 有权
标题翻译：制备具有低发色副产物的放射性标记的胸苷的方法
公开(公告)号：US07419653B2
公开(公告)日：2008-09-02
申请号：US11603703
申请日：2006-11-22
申请人： Joseph C. Walsh , Henry C. Padgett , Tanea Ysaguirre
发明人： Joseph C. Walsh , Henry C. Padgett , Tanea Ysaguirre
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K51/0491 , C07H19/048 , Y02P20/55
摘要： The invention is a method and related precursor for preparing 18F-FLT. The precursor has a butoxycarbonyl protecting group at the 5′-position that results in low amounts of chromophoric byproducts being formed during deprotection. The method for preparing 18F-FLT is efficient and makes the final purification step less complicated.
摘要翻译：本发明是一种用于制备F-FL-FLT的方法和相关前体。该前体在5'-位具有丁氧羰基保护基，导致在脱保护期间形成少量的发色副产物。制备 F-FLT的方法是有效的，并且使得最终的纯化步骤不那么复杂。

86. 发明申请

US20080170992A1 Click chemistry-derived cyclopeptide derivatives as imaging agents for integrins 有权
标题翻译：点击化学衍生的环肽衍生物作为整合素的成像剂
公开(公告)号：US20080170992A1
公开(公告)日：2008-07-17
申请号：US11901730
申请日：2007-09-17
申请人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
发明人： Hartmuth C. Kolb , Kai Chen , Joseph C. Walsh , Qianwa Liang , Henry Clifton Padgett , Farhad Karimi
IPC分类号： A61K51/00 , A61K38/12
CPC分类号： A61K51/088 , A61K51/082
摘要： The present application is directed to radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT).
摘要翻译：本申请涉及放射性标记的环状多肽，包含放射性标记的环状多肽的药物组合物，以及使用放射性标记的环状多肽的方法。这样的多肽可用于成像研究，例如正电子发射断层扫描（PET）或单光子发射计算机断层扫描（SPECT）。

87. 发明授权

US07036714B2 Carton blank, carton and method of forming the carton 有权
公开(公告)号：US07036714B2
公开(公告)日：2006-05-02
申请号：US09972575
申请日：2001-10-05
申请人： Joseph C. Walsh , Robert L. Conatser , Raymond S. Kastanek
发明人： Joseph C. Walsh , Robert L. Conatser , Raymond S. Kastanek
IPC分类号： B65D3/00
CPC分类号： B65D5/6623
摘要： A carton blank having an outer layer of a relatively rigid material, a first inner layer of a relatively rigid material superposed over a portion of the outer layer and a second inner layer of a relatively flexible layer of a fluid impervious material is provided with first and second weakened portions so that, after a carton has been formed from the carton blank, filled with a desired material and sealed, the first weakened portion may be broken to form a flip top lid which when moved in an arcuate path will gradually sever the second weakened portion to form an opening in the carton so that an amount of the desired material may be removed from the carton. The carton also may include a feature which allows the flip top lid to be securely re-closed after initial opening of the lid.

88. 发明授权

US06889892B2 Container and methods associated therewith 有权
标题翻译：与其相关的容器和方法
公开(公告)号：US06889892B2
公开(公告)日：2005-05-10
申请号：US10053732
申请日：2002-01-18
申请人： Joseph C. Walsh , Robert L. Conatser , Raymond S. Kastanek
发明人： Joseph C. Walsh , Robert L. Conatser , Raymond S. Kastanek
IPC分类号： B31B1/90 , B65D5/43 , B65D5/74 , B65D5/54 , B65D5/66
CPC分类号： B65D5/744
摘要： Disclosed herein is a container defining an interior and an exterior provided with a first access panel and a second access panel for creating an opening for passage between the interior and the exterior, and methods for making and using such a container.
摘要翻译：本文公开了一种限定内部和外部的容器，其设置有第一检修面板和用于产生用于在内部和外部之间通过的开口的第二检查面板，以及用于制造和使用这种容器的方法。

89. 发明授权

US5632404A Carton blank 失效
标题翻译：纸箱空白
公开(公告)号：US5632404A
公开(公告)日：1997-05-27
申请号：US587467
申请日：1996-01-17
申请人： Joseph C. Walsh
发明人： Joseph C. Walsh
IPC分类号： B31B7/00 , B65D5/56 , B65P5/56
CPC分类号： B65D5/563 , B32B37/12 , B31B2217/0084
摘要： A carton blank comprising a relatively rigid material having an inner surface, having a central body portion and opposite edge portions and wherein a relatively flexible material, preferably fluid impervious, having a central body portion and opposite edge portions has its central body portion secured to the central body portion of the relatively rigid material and the opposite edge portions of the relatively rigid material and the relatively flexible material are not secured to each other. In some instances strips of another relatively flexible material are secured to the opposite edge portions of the relatively flexible material but are not secured to the opposite edge portions of the reactively rigid material. In other instances, a plurality of spaced apart strips of a relatively flexible material are superposed over portions of a relatively rigid material and a plastic coating is applied to the exposed surfaces thereof.
摘要翻译：一种纸箱坯料，其包括具有内表面的相对刚性的材料，其具有中心主体部分和相对的边缘部分，并且其中具有中心主体部分和相对边缘部分的优选不透流体的相对柔性材料的中心主体部分固定到相对刚性材料的中心主体部分和相对刚性材料的相对边缘部分和相对柔性的材料彼此不固定。在一些情况下，另一相对柔性材料的条带被固定到相对柔性材料的相对边缘部分，但是不固定到反应刚性材料的相对边缘部分。在其他情况下，多个间隔开的相对柔性材料的条带重叠在相对刚性材料的部分上，并且将塑料涂层施加到其暴露的表面上。

90. 发明授权

US5531852A Apparatus and method for end sealing a carton 失效
标题翻译：用于封闭纸箱的装置和方法
公开(公告)号：US5531852A
公开(公告)日：1996-07-02
申请号：US234824
申请日：1994-04-28
申请人： Joseph C. Walsh , Robert L. Conatser
发明人： Joseph C. Walsh , Robert L. Conatser
IPC分类号： B31B50/62 , B65B7/20 , B32B31/26 , B31B1/00
CPC分类号： B65B7/20 , B31B1/00 , B31B2201/6021 , Y10T156/1051
摘要： Apparatus and method for forming a sealed end portion of a carton wherein at least one surface of the carton is formed from a material that functions as an adhesive when heated to a predetermined temperature and wherein each open end portion is sealed by folding minor flaps to close at least a portion of the open end portion, moving the carton by a relatively fixed elongated reinforcing strip of material, heating the material in at least a portion of a first major flap to the predetermined temperature, folding the first major flap so that at least a portion of the elongated reinforcing strip of material is located between fold lines of the folded minor flaps and the folded first major flap, folding a second major flap to a superposed relationship with the first major flap and applying pressure to the first and second major flaps against the elongated reinforcing strip of material while continuing the movement of the carton until the first and second major flaps are sealed together.
摘要翻译：用于形成纸箱的密封端部的装置和方法，其中纸板箱的至少一个表面由加热到预定温度时用作粘合剂的材料形成，并且其中每个开口端部分通过折叠小的折片来封闭所述开口端部分的至少一部分通过相对固定的细长加强材料条移动所述纸箱，将所述第一主瓣的至少一部分中的材料加热到预定温度，折叠所述第一主瓣，使得至少细长的加强材料条的一部分位于折叠的小折翼和折叠的第一主瓣的折叠线之间，将第二主瓣折叠成与第一主瓣相叠加的关系并向第一和第二主瓣施加压力抵靠细长的材料加强条，同时继续纸箱的移动，直到第一和第二主瓣被密封在一起。

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