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81. 发明申请

WO2005056004A1 N-ALKYL PYRROLES AS HMG-COA REDUCTASE INHIBITORS 审中-公开
标题翻译： N-烷基吡咯烷酮作为HMG-COA还原酶抑制剂
公开(公告)号：WO2005056004A1
公开(公告)日：2005-06-23
申请号：PCT/IB2004/003871
申请日：2004-11-22
申请人： WARNER-LAMBERT COMPANY LLC , BRATTON, Larry, Don , MILLER, Steven, Robert , PFEFFERKORN, Jeffrey, Allen , SORENSON, Roderick, Joseph , SONG, Yuntao , SUN, Kuai-lin , TRIVEDI, Bharat, Kalidas , UNANGST, Paul, Charles , CHENG, Xue-Min , LEE, Chitase , POEL, Toni-Jo
发明人： BRATTON, Larry, Don , MILLER, Steven, Robert , PFEFFERKORN, Jeffrey, Allen , SORENSON, Roderick, Joseph , SONG, Yuntao , SUN, Kuai-lin , TRIVEDI, Bharat, Kalidas , UNANGST, Paul, Charles , CHENG, Xue-Min , LEE, Chitase , POEL, Toni-Jo
IPC分类号： A61K31/40
CPC分类号： C07D207/34 , C04B35/632 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/12
摘要： HMGCo-A reductase inhibitor compounds useful as hypocholesterolemic and hypolipidemic compounds are provided. Also provided are pharmaceutical compositions of the compounds. Methods of making and methods of using the compounds are also provided. Formula (I).
摘要翻译：提供了可用作低胆固醇血症和降血脂化合物的HMGCo-A还原酶抑制剂化合物。还提供了化合物的药物组合物。还提供了制备方法和使用该化合物的方法。式（I）。

82. 发明申请

WO2005051410A1 HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：WO2005051410A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/039331
申请日：2004-11-19
申请人： BRISTOL-MYERS SQUIBB COMPANY , SCOLA, Paul, Michael , CAMPBELL, Jeffrey, Allen , SIN, Ny , SUN, Li-Qiang , WANG, Xiangdong, Alan
发明人： SCOLA, Paul, Michael , CAMPBELL, Jeffrey, Allen , SIN, Ny , SUN, Li-Qiang , WANG, Xiangdong, Alan
IPC分类号： A61K38/06
CPC分类号： A61K31/40 , A61K31/4709 , A61K38/00 , C07K5/0808 , C07K5/0827
摘要： Hepatitis C virus inhibitors are disclosed having the general formula (I) wherein A, R 2 , R 3 , R', B and Y are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有通式（I）的丙型肝炎病毒抑制剂，其中A，R 2，R 3，R'，B和Y在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

83. 发明申请

WO2004094452A3 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS 审中-公开
标题翻译：丙型肝炎病毒性肝炎肽抑制剂
公开(公告)号：WO2004094452A3
公开(公告)日：2005-05-19
申请号：PCT/US2004011824
申请日：2004-04-16
申请人： SQUIBB BRISTOL MYERS CO , MCPHEE FIONA , CAMPBELL JEFFREY ALLEN , LI WENYING , D ANDREA STANLEY , ZHENG ZHIZHEN BARBARA , GOOD ANDREW CHARLES , CARINI DAVID J , JOHNSON BARRY L , SCOLA PAUL MICHAEL
发明人： MCPHEE FIONA , CAMPBELL JEFFREY ALLEN , LI WENYING , D ANDREA STANLEY , ZHENG ZHIZHEN BARBARA , GOOD ANDREW CHARLES , CARINI DAVID J , JOHNSON BARRY L , SCOLA PAUL MICHAEL
IPC分类号： A61K38/00 , A61K38/12 , C07K20060101 , C07K5/083 , C07K5/12 , C07K7/00 , C12P7/62 , C12P13/04 , C12P41/00
CPC分类号： C07K5/0804 , A61K38/00 , C12P7/62 , C12P13/04 , C12P41/005
摘要： Macrocyclic isoquinoline are disclosed having the general formula: A compound of formula 1: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的大环异喹啉：式1化合物：其中R 1至R 9，Q和W在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

84. 发明申请

WO2005026893A2 AUTOMATED GENERATION OF REPORTS REFLECTING STATISTICAL ANALYSES OF SUPPLY CHAIN PROCESSES 审中-公开
标题翻译：反馈供应链流程统计分析报告的自动生成
公开(公告)号：WO2005026893A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/028787
申请日：2004-09-03
申请人： SENSITECH INC. , SCHMIDTBERG, Rupert, A. , LESHUK, Jeffrey, Allen
发明人： SCHMIDTBERG, Rupert, A. , LESHUK, Jeffrey, Allen
IPC分类号： G06F
CPC分类号： G08B25/00 , G01K2215/00 , G06Q10/06 , G06Q10/063 , G06Q10/0639 , G06Q10/08 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A product supply chain may be viewed not just as a series of discrete, unrelated shipment transactions, but as a "process" (or pipeline) that can be subject to statistical process control. The present invention is directed to novel systems and methods for collecting data concerning one or more aspects of a supply chain, for performing statistical analysis on the collected data to facilitate the identification of anomalies or inefficiencies in the process, and for communicating the results of such statistical analysis to those responsible for the supply chain so that remedial measures may be taken, if appropriate. Among other things, a method for performing statistical analysis on at least one monitored aspect of a product supply chain is disclosed that involves storing, in memory accessible to at least one processor, first data reflecting at least one first determined value of at least one monitored aspect of a first shipment of at least one first item occurring in the supply chain, and storing, in memory accessible to the at least one processor, second data reflecting at least one second determined value of at least one monitored aspect of a second shipment of at least one second item occurring in the supply chain. The at least one processor is used to automatically generate at least one report reflecting a statistical analysis of the first data and the second data.
摘要翻译：产品供应链不仅可以被视为一系列离散的，不相关的装运交易，而且可以作为可以进行统计过程控制的“流程”（或流程）。本发明涉及用于收集关于供应链的一个或多个方面的数据的新颖的系统和方法，用于对收集的数据执行统计分析，以便于识别该过程中的异常或低效率，并且用于传达这样的结果对供应链负责人进行统计分析，以便酌情采取补救措施。除其他之外，公开了一种用于对产品供应链的至少一个监控方面进行统计分析的方法，其涉及在至少一个处理器可访问的存储器中存储反映至少一个被监视的至少一个的至少一个第一确定值的第一数据在供应链中发生的至少一个第一项目的第一批货物的方面，以及在所述至少一个处理器可访问的存储器中存储第二数据，所述第二数据反映至少一个受监控方面的至少一个第二确定值至少一个第二个项目发生在供应链中。至少一个处理器用于自动生成反映第一数据和第二数据的统计分析的至少一个报告。

85. 发明申请

WO2005024794A2 AUTOMATED IDENTIFICATION OF ANOMALOUS CONDITIONS IN SUPPLY CHAIN PROCESSES 审中-公开
标题翻译：自动识别供应链过程中的异常情况
公开(公告)号：WO2005024794A2
公开(公告)日：2005-03-17
申请号：PCT/US2004028789
申请日：2004-09-03
申请人： SENSITECH INC , SCHMIDTBERG RUPERT A , LESHUK JEFFREY ALLEN
发明人： SCHMIDTBERG RUPERT A , LESHUK JEFFREY ALLEN
IPC分类号： G06Q10/00 , G11B
CPC分类号： G08B25/00 , G01K2215/00 , G06Q10/06 , G06Q10/063 , G06Q10/0639 , G06Q10/08 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A product supply chain may be viewed not just as a series of discrete, unrelated shipment transactions, but as a "process" (or pipeline) that can be subject to statistical process control, The present invention is directed to novel systems and methods for collecting data concerning one or more aspects of a supply chain for performing statistical analysis on the collected data to facilitate the identification of anomalies or inefficiencies in the process, and for communicating the results of such statistical analysis to those responsible for the supply chain so that remedial measures may be taken, if appropriate. Among other things, a method for analyzing a supply chain process is disclosed that involves automatically determining whether a plurality of data points, each representing at least one determined value of at least one monitored aspect of a supply chain, match a pattern indicative of an anomalous condition in the supply chain process.
摘要翻译：产品供应链不仅可视为一系列离散的，不相关的装运交易，而且可视为可进行统计过程控制的“过程”（或流程）。本发明涉及用于收集的新颖的系统和方法关于供应链的一个或多个方面的数据，用于对收集的数据进行统计分析，以便于识别过程中的异常或低效率，并将这种统计分析的结果传达给负责供应链的人员，以便采取补救措施如果合适，可以采取。其中包括一种用于分析供应链过程的方法，其涉及自动确定多个数据点，每个数据点各自表示供应链的至少一个监控方面的至少一个确定值，与指示异常的模式相匹配供应链过程中的条件。

86. 发明申请

WO2005024585A2 USING ADVANCED SHIPPING NOTIFICATION INFORMATION FOR SUPPLY CHAIN PROCESS ANALYSIS 审中-公开
标题翻译：使用高级货运通知信息供应链流程分析
公开(公告)号：WO2005024585A2
公开(公告)日：2005-03-17
申请号：PCT/US2004/028792
申请日：2004-09-03
申请人： SENSITECH INC. , SCHMIDTBERG, Rupert, A. , LESHUK, Jeffrey, Allen
发明人： SCHMIDTBERG, Rupert, A. , LESHUK, Jeffrey, Allen
IPC分类号： G06F
CPC分类号： G08B25/00 , G01K2215/00 , G06Q10/06 , G06Q10/063 , G06Q10/0639 , G06Q10/08 , G06Q10/083 , G06Q10/0833 , G06Q10/087
摘要： A product supply chain may be viewed not just as a series of discrete, unrelated shipment transactions, but as a "process" (or pipeline) that can be subject to statistical process control. The present invention is directed to novel systems and methods for collecting data concerning one or more aspects of a supply chain, for performing statistical analysis on the collected data to facilitate the identification of anomalies or inefficiencies in the process, and for communicating the results of such statistical analysis to those responsible for the supply chain so that remedial measures may be taken, if appropriate. Among other things, a method is disclosed that involves storing, in memory accessible to at least one processor, an electronic copy of an advanced shipping notification (ASN) that was transmitted from a shipping location to a receiving location in advance of shipping at least one item therebetween, and also storing, in memory accessible to the at least one processor, data reflecting at least one determined value of at least one monitored aspect of the shipment between the shipping location and the receiving location. The at least one processor uses at least some information from the ASN stored in memory, together with at least a portion of the data stored in memory, to generate at least one report involving the at least one determined value.
摘要翻译：产品供应链不仅可视为一系列离散的，不相关的装运交易，而且可视为可进行统计过程控制的“流程”（或流程）。本发明涉及用于收集关于供应链的一个或多个方面的数据的新颖的系统和方法，用于对收集的数据执行统计分析以便于识别该过程中的异常或低效率，并且用于传达这样的结果对供应链负责人进行统计分析，以便酌情采取补救措施。除其他之外，公开了一种方法，其涉及在至少一个处理器可访问的存储器中存储先前运送通知（ASN）的电子副本，该电子副本从运送位置传送到接收位置之前运送至少一个并且还存储在所述至少一个处理器可访问的存储器中，反映在所述运送位置和所述接收位置之间的所述装运的至少一个被监视方面的至少一个确定值的数据。至少一个处理器使用存储在存储器中的ASN的至少一些信息以及存储在存储器中的数据的至少一部分来生成涉及至少一个确定值的至少一个报告。

87. 发明申请

WO2005020585A1 VIDEO COMFORT NOISE ADDITION TECHNIQUE 审中-公开
标题翻译：视频舒适噪音添加技术
公开(公告)号：WO2005020585A1
公开(公告)日：2005-03-03
申请号：PCT/US2004/025366
申请日：2004-08-04
申请人： THOMSON LICENSING S.A. , BOYCE, Jill, MacDonald , GOMILA, Cristina , COOPER, Jeffrey, Allen
发明人： BOYCE, Jill, MacDonald , GOMILA, Cristina , COOPER, Jeffrey, Allen
IPC分类号： H04N7/26
CPC分类号： H04N19/90 , H04N19/102 , H04N19/136 , H04N19/44 , H04N19/86
摘要： A decoding arrangement (10, 100, 1000) for decoding pictures in an incoming video stream includes a noise generator (16, 16') for adding a dither signal containing random noise to the pictures after video decoding, to improve the subjective video quality. The noise generator adds noise to each pixel in an amount correlated to additive noise of pixels in a prior picture, either a previously displayed picture (i.e., a previously decoded picture to which noise has been added), or a previously decoded picture.
摘要翻译：用于对输入视频流中的图像进行解码的解码装置（10,100,1000）包括用于在视频解码之后将包含随机噪声的抖动信号添加到图像的噪声发生器（16,16'），以改善主观视频质量。噪声发生器以与先前图像中的像素的附加噪声相关联的量（即，已经被添加了噪声的先前解码的图像）或先前解码的图像来增加每个像素的噪声。

88. 发明申请

WO2004094452A2 MACROCYCLIC ISOQUINOLINE PEPTIDE INHIBITORS OF HEPATITIS C VIRUS 审中-公开
标题翻译：丙型肝炎病毒性肝炎肽抑制剂
公开(公告)号：WO2004094452A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011824
申请日：2004-04-16
申请人： BRISTOL-MYERS SQUIBB COMPANY , MCPHEE, Fiona , CAMPBELL, Jeffrey Allen , LI, Wenying , D'ANDREA, Stanley , ZHENG, Zhizhen Barbara , GOOD, Andrew Charles , CARINI, David J. , JOHNSON, Barry L. , SCOLA, Paul Michael
发明人： MCPHEE, Fiona , CAMPBELL, Jeffrey Allen , LI, Wenying , D'ANDREA, Stanley , ZHENG, Zhizhen Barbara , GOOD, Andrew Charles , CARINI, David J. , JOHNSON, Barry L. , SCOLA, Paul Michael
IPC分类号： C07K
CPC分类号： C07K5/0804 , A61K38/00 , C12P7/62 , C12P13/04 , C12P41/005
摘要： Macrocyclic isoquinoline are disclosed having the general formula: A compound of formula 1: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.
摘要翻译：公开了具有以下通式的大环异喹啉：式1化合物：其中R 1至R 9，Q和W在说明书中描述。还公开了包含化合物的组合物和使用该化合物抑制HCV的方法。

89. 发明申请

WO2004087055A2 USE OF FGF- 18 PROTEIN, TARGET PROTEINS AND THEIR RESPECTIVE ENCODING NUCLEOTIDE SEQUENCES TO INDUCE CARTILAGE FORMATION 审中-公开
标题翻译：使用FGF-18蛋白，目标蛋白及其相关的编码核苷酸序列来诱导细胞形成
公开(公告)号：WO2004087055A2
公开(公告)日：2004-10-14
申请号：PCT/US2004/009264
申请日：2004-03-26
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , WHITSETT, Jeffrey, Allen
发明人： WHITSETT, Jeffrey, Allen
IPC分类号： A61K
CPC分类号： A61K38/1825 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/077 , A01K2217/15 , A01K2217/203 , A01K2227/105 , A01K2267/03 , A61K38/1709 , A61K38/177 , A61K38/18 , A61K38/1841 , A61K38/1875 , A61K48/00 , C07K14/46 , C07K14/50 , Y02A50/411 , A61K2300/00
摘要： The use of fibroblast growth factor (FGF)-18 protein, certain of its downstream target genes and respective expressed proteins, in particular sonic hedgehog (Shh), Shh protein, β-catenin, β-catenin protein, and the Wnt family of proteins that stimulate β-catenin, and the respective nucleotide sequences encoding this protein, particularly for inducing cartilage formation, particularly for the purpose of generating, repairing, reconstructing, or de novo formation of, cartilaginous tissue. Therapies for which FGF-18 and the target proteins are useful include repair and reconstruction of various tissues in conducting airways such as the trachea, bronchi, lung and larynx caused by, for example, tracheal-bronchial abnormalities, tracheal-laryngo or bronchial malaria. Other therapies for which FGF-18 and the target proteins would be useful include other cartilaginous tissues, such as those of joint and skeletal tissue caused by, for example, arthritis and meniscus abnormalities in joints.
摘要翻译：使用成纤维细胞生长因子（FGF）-18蛋白，其某些下游靶基因和各自表达的蛋白质，特别是声刺猬（Shh），Shh蛋白，β-连环蛋白，β-连环蛋白和Wnt蛋白家族刺激β-连环蛋白，以及编码该蛋白质的各自的核苷酸序列，特别是用于诱导软骨形成，特别是为了产生，修复，重建或从头形成软骨组织的目的。 FGF-18和靶蛋白有用的疗法包括由例如气管支气管异常，气管 - 喉或支气管疟疾引起的气管，如气管，支气管，肺和喉等气道的修复和重建。 FGF-18和靶蛋白可用的其它疗法包括其它软骨组织，例如由关节炎和关节炎中的半月板异常引起的关节和骨骼组织的其它组织。

90. 发明申请

WO2004032827A3 HEPATITIS C VIRUS INHIBITORS 审中-公开
标题翻译： HEPATITIS C病毒抑制剂
公开(公告)号：WO2004032827A3
公开(公告)日：2004-10-14
申请号：PCT/US0315856
申请日：2003-05-20
申请人： SQUIBB BRISTOL MYERS CO , RIPKA AMY , CAMPBELL JEFFREY ALLEN , GOOD ANDREW CHARLES , SCOLA PAUL MICHAEL , SIN NY , VENABLES BRIAN
发明人： RIPKA AMY , CAMPBELL JEFFREY ALLEN , GOOD ANDREW CHARLES , SCOLA PAUL MICHAEL , SIN NY , VENABLES BRIAN
IPC分类号： A61K31/40 , A61K38/06 , C07D207/04 , C07K5/078
CPC分类号： A61K38/06 , A61K31/40 , C07D207/16 , C07K5/06165 , C07K5/0823
摘要： The present invention relates to tripeptide compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. In particular, the present invention provides novel tripeptide analogs, pharmaceutical compositions containing such analogs and methods for using these analogs in the treatment of HCV infection.
摘要翻译：本发明涉及用于治疗丙型肝炎病毒（HCV）感染的三肽化合物，组合物和方法。特别地，本发明提供新颖的三肽类似物，含有这些类似物的药物组合物和使用这些类似物治疗HCV感染的方法。

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