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81. 发明申请

WO2006005725A3 N CONTAINING CONDENSED HETEROCYCLES WITH ANTITUMOR EFFECTS 审中-公开
标题翻译： N含有具有抗肿瘤作用的浓缩杂环
公开(公告)号：WO2006005725A3
公开(公告)日：2006-06-01
申请号：PCT/EP2005053271
申请日：2005-07-08
申请人： SPEEDEL EXPERIMENTA AG , HEROLD PETER , MAH ROBERT , TSCHINKE VINCENZO , SCHUMACHER CHRISTOPH , STOJANOVIC ALEKSANDAR , QUIRMBACH MICHAEL
发明人： HEROLD PETER , MAH ROBERT , TSCHINKE VINCENZO , SCHUMACHER CHRISTOPH , STOJANOVIC ALEKSANDAR , QUIRMBACH MICHAEL
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I), in which L, R, R 1 , R 2 , W, X, Y, Z and n have the meanings explained in more detail in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物，其中L，R，R 1，R 2，W，X，Y，Z和n 具有在描述中更详细解释的含义，其制备方法以及这些化合物作为药物，特别是芳香酶抑制剂的用途。

82. 发明申请

WO2006005741A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2006005741A2
公开(公告)日：2006-01-19
申请号：PCT/EP2005053306
申请日：2005-07-11
申请人： SPEEDEL EXPERIMENTA AG , HEROLD PETER , MAH ROBERT , STUTZ STEFAN , STOJANOVIC ALEKSANDAR , TSCHINKE VINCENZO , JOTTERAND NATHALIE , BEHNKE DIRK
发明人： HEROLD PETER , MAH ROBERT , STUTZ STEFAN , STOJANOVIC ALEKSANDAR , TSCHINKE VINCENZO , JOTTERAND NATHALIE , BEHNKE DIRK
IPC分类号： C07D413/14 , A61K31/538 , C07D413/12
CPC分类号： C07D413/12 , C07D413/14
摘要： The application relates to novel substituted piperidines of the general formula (I) in which R 1 , R 2 , R 3 , R 4 , W, X, Z, m and n are each as defined in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新的取代的哌啶，其中R 1，R 2，R 3，R 3， 4，W，X，Z，m和n各自在说明书中详细描述，其制备方法和这些化合物作为药物，特别是作为肾素抑制剂的用途。

83. 发明申请

WO2006005726A3 HETEROCYCLIC COMPOUNDS 审中-公开
公开(公告)号：WO2006005726A3
公开(公告)日：2006-01-19
申请号：PCT/EP2005/053272
申请日：2005-07-08
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , MARTI, Christiane , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , MARTI, Christiane , QUIRMBACH, Michael
IPC分类号： C07D471/06 , C07D487/06 , C07D491/06 , C07D487/16 , C07D471/16 , C07D491/16 , A61K31/4188 , A61K31/4353 , A61K31/519 , A61K31/55 , A61P5/40
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R 1 , R 2 , V, W, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.

84. 发明申请

WO2005118557A3 HETEROCYCLIC COMPOUNDS AND THEIR USE AS ALDOSTERONE SYNTHASE INHIBITORS 审中-公开
公开(公告)号：WO2005118557A3
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052417
申请日：2005-05-27
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , QUIRMBACH, Michael
IPC分类号： C07D471/04 , A61K31/415 , C07D417/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) in which R, R 1 ,R 2 , W, X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.

85. 发明申请

WO2005118540A3 BICYCLIC, NITROGEN-CONTAINING HETEROCYCLES AS AROMATASE INHIBITORS 审中-公开
公开(公告)号：WO2005118540A3
公开(公告)日：2005-12-15
申请号：PCT/EP2005/052416
申请日：2005-05-27
申请人： Speedel Experimenta AG , HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , QUIRMBACH, Michael
发明人： HEROLD, Peter , MAH, Robert , TSCHINKE, Vincenzo , SCHUMACHER, Christoph , QUIRMBACH, Michael
IPC分类号： C07D221/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) (I*) in which R, R 1 , R 2 , X, Y, Z and n have the meanings defined in the description, to a process for their preparation and to the use of these compounds as medicaments, in particular as aromatase inhibitors.

86. 发明申请

WO2005070877A1 DIAMINO ALCOHOLS AND THEIR USE AS RENIN INHIBITORS 审中-公开
标题翻译： DIAMINO酒精及其作为RININ抑制剂的用途
公开(公告)号：WO2005070877A1
公开(公告)日：2005-08-04
申请号：PCT/EP2005/050272
申请日：2005-01-21
申请人： SPEEDEL EXPERIMENTA AG , HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
发明人： HEROLD, Peter , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane , QUIRMBACH, Michael
IPC分类号： C07C233/36
CPC分类号： C07D207/27 , C07C233/36 , C07C233/78 , C07C311/05 , C07D205/04 , C07D207/12 , C07D207/273 , C07D209/18 , C07D211/34 , C07D211/76 , C07D213/56 , C07D223/10 , C07D239/10 , C07D277/42 , C07D295/13 , C07D295/15 , C07D303/48 , C07D309/04 , C07D333/34 , C07D413/06 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 each have the definitions illustrated in detail in the description, to a process for their preparation, and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和用途的这些化合物作为药物，特别是作为肾素抑制剂。

87. 发明申请

WO2005070870A2 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005070870A2
公开(公告)日：2005-08-04
申请号：PCT/EP2005050273
申请日：2005-01-21
申请人： SPEEDEL EXPERIMENTA AG , HEROLD PETER , STUTZ STEFAN , STOJANOVIC ALEKSANDAR , TSCHINKE VINCENZO , MARTI CHRISTIANE , QUIRMBACH MICHAEL
发明人： HEROLD PETER , STUTZ STEFAN , STOJANOVIC ALEKSANDAR , TSCHINKE VINCENZO , MARTI CHRISTIANE , QUIRMBACH MICHAEL
IPC分类号： C07C213/08 , C07C215/06 , C07C215/20 , C07C213/00
CPC分类号： C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/08 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和使用这些化合物作为药物，特别是作为肾素抑制剂。

88. 发明申请

WO2005037803A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：WO2005037803A1
公开(公告)日：2005-04-28
申请号：PCT/EP2004/052466
申请日：2004-10-07
申请人： Speedel Experimenta AG , HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane
发明人： HEROLD, Peter , MAH, Robert , STUTZ, Stefan , STOJANOVIC, Aleksandar , TSCHINKE, Vincenzo , MARTI, Christiane
IPC分类号： C07D241/08
CPC分类号： C07D413/14 , C07D241/04 , C07D413/12
摘要： Novel piperazine derivatives of the general formulae (I) and (II), with the substituent definitions as illustrated in detail in the description are described. The compounds are suitable especially as renin inhibitors and have high potency.
摘要翻译：描述通式（I）和（II）的新型哌嗪衍生物与描述中详细说明的取代基定义。该化合物特别适合作为肾素抑制剂，具有高效力。

89. 发明申请

WO2004013753A3 DATA PROCESSING DEVICE AND METHOD FOR INTERACTIVE MULTIPLE USER ACCESS TO LARGE DATA VOLUMES 审中-公开
标题翻译：数据处理设备和方法用于交互式多用户访问大数据量
公开(公告)号：WO2004013753A3
公开(公告)日：2004-08-26
申请号：PCT/EP0308201
申请日：2003-07-25
申请人： HEROLD PETER , KANTZ ECKHARD
发明人： HEROLD PETER , KANTZ ECKHARD
IPC分类号： G06F17/30 , G06Q40/00 , H04N5/913 , G06F9/46 , G06F17/60
CPC分类号： G06Q40/04 , H04N5/913 , H04N2005/91364
摘要： The invention relates to a data processing device and to a method for interactive multiple user access to large data volumes within a given response time, comprising a plurality of computer nodes (40), each of which is equipped with its own working memory (44), and a load distribution and result synthesis device (20) for distributing at least one data processing process initiated by an interactive user query to a plurality of computer nodes (40) and for the synthesis of a full response to the interactive user query based on individual, partial responses supplied by the computer nodes (40), wherein the total data volume is initially broken down into disjunctive partial volumes, each of which is fully stored in the working memory (44) of a computer node (40) allocated thereto on a one-to-one basis, wherein the fraction of the data processing process initiated by the interactive user query that has been allocated to each computer node (40) is predetermined in such a way that it is fully completed within a length of time that is longer or shorter than a predetermined maximum length of time. Each computer node (40) generates its partial response on the basis of the partial volume of the total data volume allocated thereto and stored in its working memory (44) independently of all other partial volumes of the total data volume stored in the working memories (44) of the other computer nodes (40).
摘要翻译：本发明涉及一种用于交互式多用户接入到大的总量的具有预定的响应时间数据的一个数据处理装置和方法，包括多个每个都有其自己的存储器（44）的配置的计算机，用于把至少一个节点（40）和一个负载分裂和导致合成装置（20）交互式用户请求发起Datenverarbèitungsprozess到所述多个计算节点（40）和用于从每个（40）提供部分响应的计算节点，其特征在于，数据的总量是预先分割为不相交的子集，其中的每一个的合成总答案的交互式用户请求是完全在工作存储器是它的唯一相关联的计算机节点（40），存储（44），其中的由交互式用户请求的数据处理过程，使得vorbestim的启动的每个计算机节点中的（40）分别关联部分 MT是，它小于或等于一个预定的最大持续时间的时间周期内完成，并且其中，在存储在其相关联的基础上，并在其存储器中的每个计算机节点（40）（44）的总数据量的子集无论外来其它的其他计算机节点（40）的部分存储器（44）存储生成其部分响应的全部数据的子集。

90. 发明申请

WO02092828A9 PROCESS FOR THE PREPARATION OF SUBSTITUTED CARBOXYLIC ACID ESTERSBY ENZYMATIC HYDROLYSIS 审中-公开
标题翻译：制备取代羧酸的酯化酶水解方法
公开(公告)号：WO02092828A9
公开(公告)日：2004-05-06
申请号：PCT/EP0204640
申请日：2002-04-26
申请人： SPEEDEL PHARMA AG , STUTZ STEFAN , HEROLD PETER
发明人： STUTZ STEFAN , HEROLD PETER
IPC分类号： C12P7/62 , C12P41/00 , C07C69/533 , C07C69/65
CPC分类号： C12P7/62 , C12P41/005
摘要： A process for the preparation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by enzymatic hydrolysis, comprising the steps: a) enzymatic hydrolysis of racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters in aqueous and alkaline medium in the presence of an esterase; b) isolation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by extraction with an organic solvent; c) isolation of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids from the aqueous-alkaline medium; d) Esterification of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids, e) subsequent racemization to form 2-alkyl-5-halogenpent-4-ene carboxylic esters; and f) return of the racemate obtained in step e) to step a), if necessary together with fresh racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters. The process permits the undesired R-stereoisomers to be converted into the desired 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters to avoid waste product from the synthesis.
摘要翻译：通过酶水解制备2（S） - 烷基-5-胡椒基-4-戊烯羧酸酯的方法，包括以下步骤：a）将外消旋的2-烷基-5-胡椒基-4-烯羧酸酯酶水性和碱性介质在酯酶存在下进行; b）通过用有机溶剂萃取分离2（S） - 烷基-5-苯基-4-戊烯酸酯; c）从水性 - 碱性介质中分离2（R） - 烷基-5-胡椒基-4-戊烯羧酸; d）2（R） - 烷基-5-胡椒基-4-烯羧酸的酯化，e）随后的外消旋化以形成2-烷基-5-胡椒戊-4-烯羧酸酯; 和f）如果必要，将步骤e）中获得的外消旋物质与新鲜外消旋的2-烷基-5-胡椒基-4-烯羧酸酯一起返回到步骤a）。该方法允许将不期望的R-立体异构体转化为所需的2（S） - 烷基-5-胡椒基-4-烯羧酸酯，以避免合成中的废物。

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