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81. 发明授权

US07221136B2 Sondes for locating underground pipes and conduits 有权
标题翻译：用于定位地下管道和管道的探头
公开(公告)号：US07221136B2
公开(公告)日：2007-05-22
申请号：US10886856
申请日：2004-07-08
申请人： Mark S. Olsson , Jan Soukup , Jeffrey A. Prsha , Michael E. Turgeon , David A. Cox , Ray Merewether
发明人： Mark S. Olsson , Jan Soukup , Jeffrey A. Prsha , Michael E. Turgeon , David A. Cox , Ray Merewether
IPC分类号： G01R19/00 , G01R33/00
CPC分类号： G01V3/081
摘要： A sonde includes an elongate flexible ferromagnetic core and a coil surrounds an intermediate segment of the core. A housing surrounds and supports the coil. An electronic drive circuit is mounted in the housing for supplying the coil with an electric signal that will induce the core to emit electromagnetic signals at a predetermined strength and frequency that can be remotely detected. Self-contained battery powered float-type and pill-type sondes are also disclosed.
摘要翻译：探测器包括细长的柔性铁磁芯和线圈围绕芯的中间段。壳体围绕并支撑线圈。电子驱动电路安装在壳体中，用于向线圈提供电信号，该电信号将引起磁芯以能够远程检测的预定强度和频率发射电磁信号。还公开了独立电池供电的浮动型和药丸型探针。

82. 发明授权

US4058610A 7-D-(.alpha.-Acylamino-arylacetamido)-cephalosporanic acid derivatives 失效
标题翻译： 7-D - （{6-羧基 - 芳基乙酰氨基） - 头孢烷酸衍生物
公开(公告)号：US4058610A
公开(公告)日：1977-11-15
申请号：US720101
申请日：1976-09-03
申请人： David A. Cox , Braham Shroot
发明人： David A. Cox , Braham Shroot
IPC分类号： C07D265/32 , C07D501/36 , A61K31/545
CPC分类号： C07D265/32
摘要： Novel antibacterial agents; namely, 7-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid derivatives having the formula: ##STR1## wherein R.sup.1 is thienyl, 2-furyl, phenyl, substituted thienyl or substituted phenyl; R is hydroxyl; R.sup.2 is hydrogen, hydroxy, acetoxy, carbamoyloxy, N-pyridyl, azido or heterocyclic thio group; R and R.sup.2 when taken together represent an oxygen atom; R.sup.3 is sulpho or COOR.sup.4' wherein R.sup.4' is hydrogen or R.sup.4 wherein R.sup.4 is lower alkyl, 5-indanyl, naphthyl, phenyl, or substituted phenyl, CONR.sup.5 R.sup.6, wherein each of R.sup.5 and R.sup.6 is hydrogen, lower alkyl or cycloalkyl; or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a saturated heterocyclic group; X is oxygen or sulphur, a direct link, carbonyl, methylene, hydroxymethylene, sulphinyl, sulphonyl or an imino group of the formula --NR.sup.7 --, wherein R.sup.7 is hydrogen, lower alkyl, lower alkenyl, or benzyl; and each of alk.sup.1 and alk.sup.2 is a divalent saturated aliphatic hydrocarbon group containing from 1 to 3 carbon atoms; the pharmaceutically acceptable salts thereof, and methods for their preparation.
摘要翻译：新型抗菌剂; 即具有下式的7-（α-酰基氨基 - 芳基乙酰胺基） - 头孢烷酸衍生物：其中R 1是噻吩基，2-呋喃基，苯基，取代的噻吩基或取代的苯基; R是羟基; R2是氢，羟基，乙酰氧基，氨基甲酰氧基，N-吡啶基，叠氮基或杂环硫基; 当R和R 2一起表示氧原子时; R 3是磺基或COOR 4'，其中R 4'是氢或R 4，其中R 4是低级烷基，5-二氢化茚基，萘基，苯基或取代的苯基，CONR 5 R 6，其中R 5和R 6各自是氢，低级烷基或环烷基; 或R 5和R 6与它们所连接的氮原子一起形成饱和杂环基; X是氧或硫，直链，羰基，亚甲基，羟亚甲基，亚磺酰基，磺酰基或式-NR7-的亚氨基，其中R7是氢，低级烷基，低级烯基或苄基; alk1和alk2各自为含有1至3个碳原子的二价饱和脂族烃基; 其药学上可接受的盐及其制备方法。

83. 发明授权

US4006230A 7-D-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid derivatives 失效
标题翻译： 7-D - （{ - 酰基氨基 - 芳基乙酰氨基） - 头孢烷酸衍生物
公开(公告)号：US4006230A
公开(公告)日：1977-02-01
申请号：US635297
申请日：1975-11-26
申请人： David A. Cox , Braham Shroot
发明人： David A. Cox , Braham Shroot
IPC分类号： C07D265/32 , C07D501/20 , C07D501/24 , C07D501/32
CPC分类号： C07D265/32
摘要： Novel antibacterial agents; namely, 7-(.alpha.-acylamino-arylacetamido)-cephalosporanic acid derivatives having the formula: ##STR1## wherein R.sup.1 is thienyl, 2-furyl, phenyl, substituted thienyl or substituted phenyl; R is hydroxyl; R.sup.2 is hydrogen, hydroxy, acetoxy, carbamoyloxy, N-pyridyl, azido or heterocyclic thio group; R and R.sup.2 when taken together represent an oxygen atom; R.sup.3 is sulpho or COOR.sup.4.sup.' wherein R.sup.4.sup.' is hydrogen or R.sup.4 wherein R.sup.4 is lower alkyl, 5-indanyl, naphthyl, phenyl, or substituted phenyl, CONR.sup.5 R.sup.6, wherein each of R.sup.5 and R.sup.6 is hydrogen, lower alkyl or cycloalkyl; or R.sup.5 and R.sup.6 together with the nitrogen atom to which they are attached form a saturated heterocyclic group; X is oxygen or sulphur, a direct link, carbonyl, methylene, hydroxymethylene, sulphinyl, sulphonyl or an imino group of the formula --NR.sup.7 --, wherein R.sup.7 is hydrogen, lower alkyl, lower alkenyl, or benzyl; and each of alk.sup.1 and alk.sup.2 is a divalent saturated aliphatic hydrocarbon group containing from 1 to 3 carbon atoms; the pharmaceutically acceptable salts thereof, and methods for their preparation.
摘要翻译：新型抗菌剂; 即具有下式的7-（α-酰基氨基 - 芳基乙酰胺基） - 头孢烷酸衍生物：其中R 1是噻吩基，2-呋喃基，苯基，取代的噻吩基或取代的苯基; R是羟基; R2是氢，羟基，乙酰氧基，氨基甲酰氧基，N-吡啶基，叠氮基或杂环硫基; 当R和R 2一起表示氧原子时; R 3是磺基或COOR 4，其中R 4'是氢或R 4，其中R 4是低级烷基，5-二氢化茚基，萘基，苯基或取代的苯基，CONR 5 R 6，其中R 5和R 6各自是氢，低级烷基或环烷基 ; 或R 5和R 6与它们所连接的氮原子一起形成饱和杂环基; X是氧或硫，直链，羰基，亚甲基，羟亚甲基，亚磺酰基，磺酰基或式-NR7-的亚氨基，其中R7是氢，低级烷基，低级烯基或苄基; alk1和alk2各自为含有1至3个碳原子的二价饱和脂族烃基; 其药学上可接受的盐及其制备方法。

84. 发明授权

US3976783A Method of stimulating the heart employing ureido substituted phenyl-alkanolamine, alkylamine and .alpha.-aminoalkyl ketone derivatives 失效
标题翻译：使用脲基取代的苯基 - 链烷醇胺，烷基胺和{60-氨基烷基酮衍生物刺激心脏的方法
公开(公告)号：US3976783A
公开(公告)日：1976-08-24
申请号：US443034
申请日：1974-02-15
申请人： David A. Cox , Ian T. Barnish , Anthony G. Evans
发明人： David A. Cox , Ian T. Barnish , Anthony G. Evans
IPC分类号： C07C275/34 , A61K31/17
CPC分类号： C07C275/34
摘要： Method of stimulating the heart employing substituted 1-phenyl-2-alkylamino-alkanols, 1-phenyl-2-alkylamino-alkanes and .alpha.-aminoalkyl phenyl ketones is disclosed.
摘要翻译：公开了使用取代的1-苯基-2-烷基氨基 - 链烷醇，1-苯基-2-烷基氨基 - 烷烃和α-氨基烷基苯基酮刺激心脏的方法。

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