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81. 发明申请

US20090171383A1 GASTRIC SPACE OCCUPIER SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：胃肠外营养系统及其使用方法
公开(公告)号：US20090171383A1
公开(公告)日：2009-07-02
申请号：US12270607
申请日：2008-11-13
申请人： David Cole , Samuel T. Crews , Bretton Swope , Andrew Smith , John Lunsford , Daniel J. Balbierz
发明人： David Cole , Samuel T. Crews , Bretton Swope , Andrew Smith , John Lunsford , Daniel J. Balbierz
IPC分类号： A61M29/02
CPC分类号： A61F5/0036 , A61F5/003
摘要： Systems for controlling obesity utilize a number of space occupiers positioned in the stomach to reduce the effective volume of the stomach. Such arrangements provides sufficient stomach volume consumption to induce weight loss, but enable use of space occupiers that are proportioned to minimize the threat of obstruction even if they should migrate into the intestine. In general, numerous small volume space occupiers are placed in the stomach such that the total volume equals or exceeds the single volume of prior art single unit space occupiers. However, each individual space occupier is proportioned so that it will pass without obstruction if it moves into the intestine.
摘要翻译：用于控制肥胖的系统利用位于胃中的多个空间占用者来减少胃的有效体积。这种布置提供足够的胃体积消耗以引起体重减轻，但是能够使用成比例的空间占用者，以尽量减少阻塞的威胁，即使它们应该迁移到肠中。通常，许多小容量空间占用者被放置在胃中，使得总体积等于或超过现有技术的单个单位空间占用者的单个体积。然而，每个单独的空间占有者是成比例的，以便如果它进入肠道，它将不会阻塞。

82. 发明申请

US20080190847A1 Apparatus and Method 审中-公开
标题翻译：仪器与方法
公开(公告)号：US20080190847A1
公开(公告)日：2008-08-14
申请号：US11662378
申请日：2005-09-02
申请人： Alan David Cole Cantwell
发明人： Alan David Cole Cantwell
IPC分类号： C02F3/12 , B01D61/18 , B01D63/08 , B01D65/08 , C02F1/44
CPC分类号： B01D61/18 , B01D63/082 , B01D65/08 , B01D2321/185 , C02F1/444 , C02F3/1273 , Y02W10/15
摘要： An activated sludge system for the purification of wastewater includes a membrane reactor comprising: (i) an array of pairs of vertical membranes (14) parallel to each other, (5) the membranes being spaced apart from each other and being permeate to liquid but substantially impermeable to solid particles, (ii) liquid flow channels between the membranes (14) of each pair, (iii) a liquid-collecting channels communicating with the liquid-flow channels for receiving liquid which has permeated through the membranes (14), and (iv) gaseous fluid sparging ducts (5) allocated to and co-planar with the respective pairs of membranes (14) and extending substantially horizontally for introducing gaseous fluid into a mixture of the liquid and the solid particles about the array, so that the gaseous fluid rises through the gaps (8) among the outer major surfaces of the membranes (14), each of the ducts 5 having therealong only one row of sparge holes (6), those holes (6) being downwardty directed for emitting the gaseous fluid downwardty.
摘要翻译：用于净化废水的活性污泥系统包括膜反应器，包括：（i）彼此平行的一对垂直膜（14），（5）膜彼此间隔开并渗透到液体中，但是固体颗粒基本上是不可渗透的，（ii）每对薄膜（14）之间的液体流动通道，（iii）与液体流动通道连通的液体收集通道，用于接收透过膜（14）的液体，和（iv）分配给各个隔膜（14）并共同平行并且基本上水平地延伸的气态流体喷射管道（5），用于将气态流体引入阵列周围的液体和固体颗粒的混合物中，使得气体流体通过膜（14）的外主表面之间的间隙（8）上升，每个管道5仅具有一排喷射孔（6），那些孔（6）为道导致气体流体向下流动的向下倾向。

83. 发明授权

US07265240B2 Process for the carbonylation of ethylenically unsaturated compounds 有权
标题翻译：烯属不饱和化合物的羰基化方法
公开(公告)号：US07265240B2
公开(公告)日：2007-09-04
申请号：US10524034
申请日：2003-08-04
申请人： Graham R. Eastham , Cristina Jimenez , David Cole-Hamilton
发明人： Graham R. Eastham , Cristina Jimenez , David Cole-Hamilton
IPC分类号： C07C67/36 , C07C51/12 , C07C51/14 , C07C51/16
CPC分类号： B01J31/1895 , B01J31/1616 , B01J31/165 , B01J31/24 , B01J31/2409 , B01J31/2452 , B01J31/2457 , B01J35/0013 , B01J2231/321 , B01J2531/0258 , B01J2531/80 , B01J2531/824 , C07C67/38 , C07C2603/74 , C07F9/5018 , C07F9/5027 , C07F9/5045 , C07F9/52 , C07C69/24
摘要： A process for the carbonylation of ethylenically unsaturated compounds is described. The process comprises reacting an ethylenically unsaturated compound with carbon monoxide in the presence of a source of hydroxyl groups and a catalyst system. The catalyst system is obtained by combining: (a) metal of Group VIII or a compound thereof; and (b) a bidentate phosphine of general formula (I) The carbonylation reaction is carried out at a temperature of between −30° C. to 49° C. and under a CO partial pressure of less than 30×105 N.m−2
摘要翻译：描述了烯键式不饱和化合物的羰基化方法。该方法包括在羟基源和催化剂体系的存在下使烯属不饱和化合物与一氧化碳反应。催化剂体系通过以下方法获得：（a）VIII族金属或其化合物; 和（b）通式（I）的二齿膦羰基化反应在-30℃至49℃的温度和低于30×10 5的CO分压下进行， SUP> Nm

84. 外观设计

USD368884S Wheel rim 失效
公开(公告)号：USD368884S
公开(公告)日：1996-04-16
申请号：US24282
申请日：1994-06-10
申请人： David Cole
设计人： David Cole

85. 发明授权

US5279243A Rotatable bollard for use with wire ropes 失效
标题翻译：可旋转系绳用于钢丝绳
公开(公告)号：US5279243A
公开(公告)日：1994-01-18
申请号：US960823
申请日：1992-10-14
申请人： David Cole
发明人： David Cole
IPC分类号： B63B21/06 , E02B3/24 , B63B21/04
CPC分类号： B63B21/06 , E02B3/24
摘要： For securing a heavy wire rope (hawser), usually to the bow or stern of a large vessel but alternatively to an oil rig or jetty, a bollard comprises(a) a base securable to a deck and having an upstanding cylinder around which is an angled skirt or a plurality of angled brackets;(b) an upper portion having a cylinder which fits rotatably within the base, and on top of which is a round plate on which is fixed a fin, usually a pear-shaped base and the upper portion of which extends at an acute angle to the horizontal and terminates in a narrow peak under which is a notch for retaining the rope, and(c) for retaining the two portions in a desired non-rotating position, corresponding lateral holes in the respective cylinders and at least one locking bar which can be inserted through both cylinders.The upper portion can be rotated manually by inserting a bar in a hole beneath the peak of the fin; or by means of a small motor.The two sections may have respective screw threads.The bollard allows a heavy rope to be secured or released by one man.
摘要翻译：为了固定一根重的钢丝绳（吊索），通常应用于大型船舶的船首或船尾，或者与石油钻井平台或码头相连，护柱包括（a）可以安装在甲板上的底座，其上有一个直立的缸体倾斜的裙部或多个倾斜的支架; （b）具有圆筒的上部，该圆筒可旋转地配合在基座内，并且其顶部是圆形板，其上固定有翅片，通常为梨形基部，其上部以锐角延伸至水平并终止于窄峰，在该峰下方有用于保持绳索的切口，以及（c）用于将两个部分保持在期望的非旋转位置，相应的气缸中的对应的侧孔和至少一个锁定杆通过两个气瓶插入。通过将杆插入翅片顶部下方的孔中可以手动旋转上部; 或通过小型电动机。两个部分可以具有相应的螺纹。系柱可以让一条绳索固定或释放。

86. 发明授权

US1986103A Dual-fed mill 失效
标题翻译：双馈磨机
公开(公告)号：US1986103A
公开(公告)日：1935-01-01
申请号：US60600832
申请日：1932-04-18
申请人： DAVID COLE
发明人： DAVID COLE
IPC分类号： B02C17/04
CPC分类号： B02C17/04

87. 发明申请

US20130261140A1 TRICYCLIC HETEROCYCLES USEFUL AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 有权
标题翻译：作为DIPEPTIDYL PEPTIDASE-IV抑制剂有用的三聚异戊二烯
公开(公告)号：US20130261140A1
公开(公告)日：2013-10-03
申请号：US13990948
申请日：2011-12-01
申请人： Duane A. Burnett , Zhiqiang Zhao , David Cole , Hubert Josien , Dmitri A. Pissarnitski , Thavalakulamgar Sasikumar , Wen-Lian Wu , Martin Domalski
发明人： Duane A. Burnett , Zhiqiang Zhao , David Cole , Hubert Josien , Dmitri A. Pissarnitski , Thavalakulamgar Sasikumar , Wen-Lian Wu , Martin Domalski
IPC分类号： A61K31/519 , C07D487/14
CPC分类号： A61K31/519 , C07D487/14
摘要： The present invention is directed to novel tricyclic heterocycles of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved. I
摘要翻译：本发明涉及结构式I的新型三环杂环，其是二肽基肽酶-IV酶的抑制剂，其可用于治疗或预防涉及二肽基肽酶-IV酶的疾病，例如糖尿病，特别是 2型糖尿病本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及二肽基肽酶-IV酶的疾病中的用途。一世

88. 发明申请

US20120105015A1 Battery Pack Overcharge Protection System 有权
标题翻译：电池组过充保护系统
公开(公告)号：US20120105015A1
公开(公告)日：2012-05-03
申请号：US12916050
申请日：2010-10-29
申请人： Weston Arthur Hermann , Scott Ira Kohn , Philip David Cole , Nicholas Robert Kalayjian
发明人： Weston Arthur Hermann , Scott Ira Kohn , Philip David Cole , Nicholas Robert Kalayjian
IPC分类号： H02J7/06 , H02J7/04
CPC分类号： H02J7/0031 , H02J2007/0037
摘要： An overcharge protection device (OPD) is provided that may be used alone, or in combination with conventional charging protection systems, to protect a battery pack from the occurrence of a potentially damaging overcharging event. The OPD is designed to be coupled to, and interposed between, the terminals of the battery pack. During normal system operation, the OPD has no effect on the operation of the charging system or the battery pack. During an overcharging event, if overcharging is not prevented by another conventional system, the OPD of the invention creates a short across the terminals of the battery pack causing a battery pack fuse designed to provide battery pack short circuit protection to blow, thereby interrupting the current path from the charger to the battery pack and preventing the battery pack from being overcharged.
摘要翻译：提供了可以单独使用或与常规充电保护系统组合使用的过充电保护装置（OPD）来保护电池组免受潜在的破坏性过充电事件的发生。 OPD被设计成耦合到电池组的端子并插入在电池组的端子之间。在正常的系统操作过程中，OPD对充电系统或电池组的操作没有影响。在过充电事件中，如果不是由另一传统系统防止过充电，则本发明的OPD在电池组的端子之间产生短路，导致设计成提供电池组短路保护的电池组熔断器，从而中断电流从充电器到电池组的路径，并防止电池组过充电。

89. 发明授权

US07909222B2 Endoscopic stapling devices and methods 有权
公开(公告)号：US07909222B2
公开(公告)日：2011-03-22
申请号：US12052997
申请日：2008-03-21
申请人： David Cole , Andrew Smith
发明人： David Cole , Andrew Smith
IPC分类号： A61B17/068
CPC分类号： A61B17/072 , A61B17/064 , A61B17/115 , A61B17/32053 , A61B2017/00539 , A61B2017/00818 , A61B2017/07271 , A61B2017/306 , A61F5/0013 , A61F5/0083
摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

90. 发明授权

US07708181B2 Endoscopic stapling devices and methods 有权
公开(公告)号：US07708181B2
公开(公告)日：2010-05-04
申请号：US12052885
申请日：2008-03-21
申请人： David Cole , Andrew Smith , Samuel T. Crews , Bretton Swope , Daniel J. Balbierz
发明人： David Cole , Andrew Smith , Samuel T. Crews , Bretton Swope , Daniel J. Balbierz
IPC分类号： A61B17/068
CPC分类号： A61B17/072 , A61B17/064 , A61B17/115 , A61B17/32053 , A61B2017/00539 , A61B2017/00818 , A61B2017/07271 , A61B2017/306 , A61F5/0013 , A61F5/0083
摘要： Described herein are endoscopic staplers used to apply one or more fasteners to body tissue. In one embodiment, a fastener-applying device, which is preferably a stapler, is passed transorally into the stomach and used to plicate stomach tissue by engaging tissue from inside of the stomach and drawing it inwardly. In the disclosed embodiments, the tissue is drawn inwardly into a vacuum chamber, causing sections of serosal tissue on the exterior of the stomach to be positioned facing one another. The disclosed staplers allow the opposed sections of tissue to be moved into contact with one another, and preferably deliver staples for maintaining contact between the tissue sections at least until serosal bonds form between them. Each of these steps may be performed wholly from the inside of the stomach and thus can eliminate the need for any surgical or laparoscopic intervention. After one or more plications are formed, medical devices may optionally be coupled to the plication(s) for retention within the stomach.

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