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81. 发明申请

WO2010006169A2 2-METHYLENE-19, 26-DINOR-(20S, 22E, 25R)-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-METHYLENE-19,26-DINOR-（20S，22E，25R） - 维生素D类似物
公开(公告)号：WO2010006169A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050106
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, F. , CHIELLINI, Grazia , GRZYWACZ, Pawell , PLUM, Lori, A. , CLAGETT-DAME, Margaret
发明人： DELUCA, Hector, F. , CHIELLINI, Grazia , GRZYWACZ, Pawell , PLUM, Lori, A. , CLAGETT-DAME, Margaret
IPC分类号： C07C401/00 , A61K31/593 , A61P3/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/02
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24
摘要： This invention discloses 2-methylene-19,26-dinor-(20S,22E,25R)- vitamin D analogs, and specifically 2-methylene-19,26-dinor-(20S,22E,25R)-lα,25- dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also shows no activity in vivo on bone calcium mobilization and relatively low intestinal calcium transport activity compared to the native hormone lα,25-dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基-19,26-二酮（20S，22E，25R） - 维生素D类似物，特别是2-亚甲基-19,26-二酮（20S，22E， 25R）-1α，25-二羟基维生素D3及其药物用途。该化合物表现出转录活性以及在阻止未分化细胞增殖和诱导其向单核细胞分化中的明显活性，因此证明其用作抗癌剂并用于治疗皮肤疾病例如牛皮癣以及皮肤病症例如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足。与天然激素Iα，25-二羟基维生素D 3相比，该化合物在体内对骨钙动员没有活性和相对低的肠钙转运活性，因此可用于治疗人的自身免疫性疾病或炎症性疾病以及肾性骨营养不良。这种化合物也可以用于治疗或预防肥胖症。

82. 发明申请

WO2010006162A2 2-METHYLENE-(20E)-20(22)-DEHYDRO-19-NOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-亚甲基 - （20E）-20（22） - 脱氢-19-维生素D类似物
公开(公告)号：WO2010006162A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050094
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, E. , TADI, Padmaja, Bulli , PLUM, Lori, A. , CLAGETT-DAME, Margaret
发明人： DELUCA, Hector, E. , TADI, Padmaja, Bulli , PLUM, Lori, A. , CLAGETT-DAME, Margaret
IPC分类号： C07C401/00 , A61K31/593
CPC分类号： C07C401/00
摘要： This invention discloses 2-methylene-(20E)-20(22)-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(20E)-20(22)-dehydro-19-nor-lα,25- dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also shows lower activity in vivo on bone calcium mobilization and similar in vivo intestinal calcium transport activity compared to the native hormone lα,25-dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （20E）-20（22） - 脱氢-19-去甲 - 维生素D类似物，特别是2-亚甲基 - （20E）-20（22） - 脱氢 -19-去甲-1α，25-二羟基维生素D3及其药物用途。该化合物表现出相对高的转录活性以及明显的抑制未分化细胞增殖和诱导其向单核细胞分化的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病例如牛皮癣以及皮肤病如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足。与天然激素Iα，25-二羟基维生素D 3相比，该化合物在体内对骨钙动员和体内肠钙转运活性也表现出较低的活性，因此可用于治疗人体内的自身免疫性疾病或炎性疾病以及肾性骨病。这种化合物也可以用于治疗或预防肥胖症。

83. 发明申请

WO2010006135A2 2-METHYLENE-(17Z)-17(20)-DEHYDRO-19,21-DINOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （17Z）-17（20） - 甲基-19,21-三酮 - 维生素D类似物
公开(公告)号：WO2010006135A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050060
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, F. , TADI, Bulli, Padmaja , PLUM, Lori, A. , CLAGETT-DAME, Margaret
发明人： DELUCA, Hector, F. , TADI, Bulli, Padmaja , PLUM, Lori, A. , CLAGETT-DAME, Margaret
IPC分类号： C07C401/00 , A61K31/593 , A61P3/04 , A61P17/00 , A61P17/06 , A61P29/00 , A61P35/00 , A61P37/02
CPC分类号： C07C401/00 , C07C2601/14 , C07C2602/24
摘要： This invention discloses 2-methylene-(17Z)-17(20)-dehydro-19,21 -dinor-vitamin D analogs, and specifically 2-methylene-(17Z)-17(20)-dehydro-19,21-dinor-1α,25-dihydroxyvitamin D 3 , and pharmaceutical uses therefor. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has significant calcemic activity in vivo having about the same bone calcium mobilization activity and intestinal calcium transport activity as the native hormone 1α,25-dihydroxyvitamin D 3 , and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （17Z）-17（20） - 脱氢-19,21-二 - 维生素D类似物，特别是2-亚甲基 - （17Z）-17（20） - 脱氢-19,21-二酮-1α，25-二羟基维生素D 3及其制药用途。该化合物表现出相对高的转录活性以及明显的抑制未分化细胞增殖和诱导其向单核细胞分化的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病例如牛皮癣以及皮肤病如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足。该化合物在体内也具有显着的钙血活性，具有与天然激素1α，25-二羟基维生素D 3类似的大致相同的骨钙动员活性和肠钙转运活性，因此可用于治疗自身免疫性疾病或人类的炎性疾病以及肾性骨营养不良。这种化合物也可以用于治疗或预防肥胖症。

84. 发明申请

WO2010006129A2 2-METHYLENE-(22E)-25-(1-METHYLENE-HEXYL)-26,27-CYCLO-22-DEHYDRO-19-NOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-亚甲基 - （22E）-25-（1-亚甲基 - 己基）-26,27-环-22-脱氢-19-维生素D类似物
公开(公告)号：WO2010006129A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/050054
申请日：2009-07-09
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, F. , RAFAL, Barycki , PLUM, Lori, A. , CLAGETT-DAME, Margaret
发明人： DELUCA, Hector, F. , RAFAL, Barycki , PLUM, Lori, A. , CLAGETT-DAME, Margaret
IPC分类号： C07C401/00 , A61K31/593
CPC分类号： C07C401/00 , C07C2601/02
摘要： This invention discloses 2-methylene-(22E)-25-(l-methylene-hexyl)-26,27- cyclo-22-dehydro-19-nor-vitamin D analogs, and specifically 2-methylene-(22E)-25- ( 1 -methylene-hexyl)-26,27-cyclo-22-dehydro- 19-nor- 1 α,24(R)-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits relatively high transcription activity as well as pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti¬ cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also shows lower activity in vivo on bone calcium mobilization and intestinal calcium transport activity compared to the native hormone lα,25- dihydroxyvitamin D3, and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （22E）-25-（1-亚甲基 - 己基）-26,27-环-22-脱氢-19-去甲 - 维生素D类似物，具体为2 （22E）-25-（1-亚甲基 - 己基）-26,27-环-22-脱氢-19-去甲-1α，24（R） - 二羟基维生素D3及其制药用途。该化合物表现出相对高的转录活性以及明显的抑制未分化细胞增殖和诱导其向单核细胞分化的活性，因此证明其用作抗 - 用于治疗牛皮癣等皮肤疾病以及皮肤病如皱纹，皮肤松弛，皮肤干燥和皮脂分泌不足等。与天然激素Iα，25-二羟基维生素D 3相比，该化合物在体内对骨钙动员和肠钙转运活性也显示出较低的活性，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。这种化合物也可以用于治疗或预防肥胖症。

85. 发明申请

WO2009111695A1 METHODS OF INCREASING EPIDERMAL SKIN THICKNESS BY TOPICAL ADMINISTRATION OF A 19-NOR CONTAINING VITAMIN D COMPOUND 审中-公开
标题翻译：通过19-NOR含维生素D化合物的局部给药增加皮肤厚度的方法
公开(公告)号：WO2009111695A1
公开(公告)日：2009-09-11
申请号：PCT/US2009036323
申请日：2009-03-06
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , NIEVES NIRCA J , AHRENS JAMIE
发明人： DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , NIEVES NIRCA J , AHRENS JAMIE
IPC分类号： A61K31/59 , A61P17/00
CPC分类号： A61K31/59
摘要： Methods of increasing the thickness of the epidermal layer in the skin of a human comprising topically administering a therapeutically effective dose of an active pharmaceutical ingredient comprising a vitamin D analog including 2-methylene-l 9-nor- 20(S)-I a-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(S)-2-methylene- la,25-dihydroxyvitamin D3, 2-methylene-19-nor-(24R)-la,25-dihydroxyvitamin D2, 2- methylene- 1 a,25-dihydroxy-( 17E)- 17(20)-dehydro- 19-nor- vitamin D3, 2-methylene- (20R,25S)- 19,26-dinor- 1 a,25-dihydroxyvitamin D3, 2-methylene-l 8, 19-dinor-(20S)- 1 a,25- dihydroxyvitamin D3, 2-methylene-l 9-nor- la-hydroxy-pregnacalciferol, la-hydroxy-2- methylene- 19-nor-homopregnacalciferol, (20R)- 1 a-hydroxy-2-methylene- 19-nor- bishomopregnacalciferol, 2-methylene-(20S)-19-nor-la-hydroxy-trishomopregnacalciferol, 2-methylene-(20R)-23,23 -difluoro- 1 a-hydroxy- 19-nor-bishomopregnacalciferol, 2- methylene-(20S)-23,23 -difluoro- 1 a-hydroxy- 19-nor-bishomopregnancalciferol, 2- (3'hydroxypropyl-l',2'-idene)-19,23,24-trinor-(20S)-la-hydroxyvitamin D3, or 13,13- dimethyl-cfe.s-C,D analog of (20S)-2-methylene-la,25-dihydroxy-l 9-nor- vitamin D3, and pharmaceutical topical formulations and topical dosage forms thereof using a pharmaceutically suitable carrier vehicle.
摘要翻译：增加人皮肤中表皮层厚度的方法，包括局部施用治疗有效剂量的活性药物成分，其包含维生素D类似物，包括2-亚甲基-9-去甲基（S）-Ia- 羟基 - 双代孕代孕甾醇，19-降-26,27-二亚甲基-20（S）-2-亚甲基-1a，25-二羟基维生素D3，2-亚甲基-19-去甲 - （24R）-la，25-二羟基维生素D2,2 - 二甲基-1a，25-二羟基 - （17E）-17（20） - 脱氢-19-去甲维生素D3，2-亚甲基 - （20R，25S） - 19,26-二烯-17α-二羟基维生素 D3，2-亚甲基-18,19-二烯 - （20S）-1a，25-二羟基维生素D 3，2-亚甲基-9-去甲酰基 - 羟基 - 孕代孕甾醇，1α-羟基-2-亚甲基-19- （20R）-1α-羟基-2-亚甲基-19-去甲基 - 二钙孕甾胆钙醇，2-亚甲基 - （20S）-19-去甲酰基 - 羟基 - 三孕代孕代胆甾醇，2-亚甲基 - （20R）-23 ，23-二氟-1α-羟基-19-去氧胆钙孕激素，2-亚甲基 - （20S）-23,23-二氟-11α-羟基-19-去甲基二孕（3'羟基丙基-1'，2'-亚苯基）-19,23,24-三硝基 - （20S）-la-羟基维生素D3或13,13-二甲基-cfe.sC，D类似物（ 20S）-2-亚甲基-1a，25-二羟基-9-去甲维生素D3，以及使用药学上合适的载体载体的药物局部制剂及其局部剂型。

86. 发明申请

WO2009086438A3 2-METHYLENE-(20S,25R)-19,26-DINOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （20S，25R）-19,26-丁酮 - 维生素D类似物
公开(公告)号：WO2009086438A3
公开(公告)日：2009-08-27
申请号：PCT/US2008088273
申请日：2008-12-24
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , CHIELLINI GRAZIA , GRZYWACZ PAWEL
发明人： DELUCA HECTOR F , CLAGETT-DAME MARGARET , PLUM LORI A , CHIELLINI GRAZIA , GRZYWACZ PAWEL
IPC分类号： C07D401/00 , A61K31/593 , A61P3/14 , A61P17/06 , A61P19/02 , A61P35/02 , A61P37/06
CPC分类号： C07C401/00
摘要： This invention discloses 2-methylene-(20S,25R)-19,26-dinor- vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-la,25- dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient serum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （20S，25R）-19,26-二 - 维生素D类似物，特别是2-亚甲基 - （20S，25R）-19,26-二炔-1,25-二羟基维生素D 3和药物为此使用。该化合物在阻止未分化细胞的增殖和诱导其向单核细胞的分化方面表现出明显的活性，因此证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病如皱纹，皮肤松弛，皮肤干燥，血清分泌不足。该化合物如果有钙化活性也很少，因此可用于治疗人的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

87. 发明申请

WO2009086439A2 2-METHYLENE-(20S,25S)-19,26-DINOR-VITAMIN D ANALOGS 审中-公开
标题翻译： 2-甲基 - （20S，25S）-19,26-维生素D类似物
公开(公告)号：WO2009086439A2
公开(公告)日：2009-07-09
申请号：PCT/US2008/088275
申请日：2008-12-24
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, F. , CLAGETT-DAME, Margaret , PLUM, Lori, A. , CHIELLINI, Grazia , GRZYWACZ, Pawel
发明人： DELUCA, Hector, F. , CLAGETT-DAME, Margaret , PLUM, Lori, A. , CHIELLINI, Grazia , GRZYWACZ, Pawel
IPC分类号： C07C401/00 , A61K31/593 , A61P3/14 , A61P17/06 , A61P35/02 , A61P37/06 , A61P19/02
CPC分类号： C07C401/00
摘要： This invention discloses 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25S)-19,26-dinor-lα,25- dihydroxyvitamin D 3 , and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
摘要翻译：本发明公开了2-亚甲基 - （20S，25S）-19,26-二 - 维生素D类似物，特别是2-亚甲基 - （20S，25S）-19,26-二氢-α，25-二羟基维生素D 3和药物用它。该化合物在阻止未分化细胞的增殖并诱导其分化为单核细胞方面表现出显着的活性，从而证明其用作抗癌剂并用于治疗皮肤疾病如牛皮癣以及皮肤病症如皱纹，松弛皮肤，皮肤干燥，皮脂分泌不足。该化合物也具有很少（如果有的话）钙活性，因此可用于治疗人体中的自身免疫性疾病或炎性疾病以及肾性骨营养不良。该化合物也可用于治疗或预防肥胖症。

88. 发明申请

WO2008125901A2 2-METHYLENE-1ALPHA,25-DIHYDROXY-18,19,21-TRINORVITAMIN D3 AND USES THEREOF 审中-公开
标题翻译： 2-甲基-1ALPHA，25-二羟基-18,19,23-三氢维纳明D3及其用途
公开(公告)号：WO2008125901A2
公开(公告)日：2008-10-23
申请号：PCT/IB2007/003971
申请日：2007-04-06
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION , DELUCA, Hector, F. , PLUM, Lori, A. , CLAGETT-DAME, Margaret , BARYCKI, Rafal
发明人： DELUCA, Hector, F. , PLUM, Lori, A. , CLAGETT-DAME, Margaret , BARYCKI, Rafal
IPC分类号： C07C401/00 , A61K31/59 , A61P19/08 , A61P19/10 , A61P3/04 , A61P37/00
CPC分类号： C07C401/00 , Y02P20/55
摘要： Compounds of formula I are provided where X 1 , X 2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译：提供式I化合物，其中X 1，X 2和X 3独立地选自H或羟基保护基。这些化合物用于制备药物组合物，并且可用于治疗各种生物学条件。

89. 发明申请

WO2007092721A8 VITAMIN D ANALOG: RAK, METHODS AND USES THEREOF 审中-公开
标题翻译：维生素D类似物：RAK，其方法和用途
公开(公告)号：WO2007092721A8
公开(公告)日：2008-10-09
申请号：PCT/US2007061404
申请日：2007-01-31
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , CHIELLINI GRAZIA , GRZYWACZ PAWEL , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07C401/00 , A61K31/59 , A61P13/12 , A61P17/06 , A61P19/00 , A61P35/00
CPC分类号： C07C401/00 , A61K8/67 , A61Q19/08 , C07F7/1856 , Y02P20/55
摘要： Compounds of formula (IA) or (IB) are provided where X 1 , X 2 and X 3 are independently selected from H or hydroxy protecting groups and R 1 is selected from straight or branched chain alkyl groups having from 1 to 8 carbon atoms; straight or branched chain alkenyl groups having from 2 to 8 carbon atoms; straight or branched chain hydroxy-substituted alkyl groups having from 1 to 8 carbon atoms; straight and branched chain hydroxy-substituted alkenyl groups having from 2 to 8 carbon atoms. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
摘要翻译：提供式（IA）或（IB）化合物，其中X 1，X 2和X 3独立地选自H或羟基保护基基团和R 1选自具有1至8个碳原子的直链或支链烷基; 具有2-8个碳原子的直链或支链烯基; 具有1至8个碳原子的直链或支链羟基取代的烷基; 具有2-8个碳原子的直链和支链羟基取代的烯基。这些化合物用于制备药物组合物，并且可用于治疗各种生物学条件。

90. 发明申请

WO2008026078A3 19-NOR-VITAMIN D ANALOGS WITH 1,2,OR 3,2 HETEROCYCLIC RING 审中-公开
标题翻译：具有1,2或3,2个杂环环的19-维生素D模拟物
公开(公告)号：WO2008026078A3
公开(公告)日：2008-07-31
申请号：PCT/IB2007003641
申请日：2007-04-06
申请人： WISCONSIN ALUMNI RES FOUND , DELUCA HECTOR F , SICINSKI RAFAL R , GLEBOCKA AGNIESZKA , PLUM LORI A , CLAGETT-DAME MARGARET
发明人： DELUCA HECTOR F , SICINSKI RAFAL R , GLEBOCKA AGNIESZKA , PLUM LORI A , CLAGETT-DAME MARGARET
IPC分类号： C07D311/74 , A61K31/352 , A61P3/04
CPC分类号： C07D311/74
摘要： 19-nor-vitamin D analogs having an additional heterocyclic ring connecting the 3ß-oxygen and carbon-2 or the 1a-oxygen and carbon-2 of the A-ring of the analog, and pharmaceutical uses therefore, are described. These compounds exhibit significant activity in mobilization of bone, making them therapeutic agents for the treatment or prophylaxis of osteoporosis, osteomalacia, osteopenia, renal osteodystrophy and hypoparathyroidism.
摘要翻译：描述了具有连接类似物的A-ring的3β-氧和碳-2或1a-氧和碳-2的附加杂环的19-维生素D类似物，以及药用。这些化合物在骨骼运动中表现出显着的活性，使其成为治疗或预防骨质疏松症，骨软化症，骨质减少症，肾性骨营养不良和甲状旁腺功能低下的治疗剂。

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