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81. 发明授权

EP0348475B1 APPARATUS AND METHODS FOR GENERATING PLATELET CONCENTRATE 失效
标题翻译：装置和方法用于生产浓缩血小板。
公开(公告)号：EP0348475B1
公开(公告)日：1994-06-08
申请号：EP89900730.6
申请日：1988-11-22
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： SCHONEDORFER, Donald, W.
IPC分类号： A61M1/34 , A61M1/36
CPC分类号： A61M1/3693 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3696 , A61M2202/0427 , A61M2205/12
摘要： A tubing or harness set (10) is provided having first and second portions sequentially applicable to a microprocessor-controlled hemapheresis instrument (H) for generating platelet concentrate. The first portion includes a reservoir (22) having dual compartments (24, 26) and a separator (46). The instrument (H) and the first portion of the harness set alternately collect whole blood from the donor and reinfuse packed cells into the donor while simultaneously continuously separating whole blood into packed cells and platelet-rich plasma. Upon collection of a predetermined quantity of platelet-rich plasma, the donor is disconnected from the phlebotomy needle (12) of the harness (10), the first harness portion is removed from the instrument (H) and the second harness portion is applied to the instrument (H). The second harness portion includes a separator (62) for receiving platelet-rich plasma from the collection container (60) of the first harness portion and separating such plasma into platelet concentrate and platelet-depleted plasma.

82. 发明授权

EP0299054B1 CENTRIFUGATION PHERESIS SYSTEM 失效
标题翻译：离散化系统
公开(公告)号：EP0299054B1
公开(公告)日：1993-10-13
申请号：EP88901722.4
申请日：1988-01-29
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： BROWN, Richard, I. , SMITH, Sidney , CERNY, David, E. , FOLEY, John, T.
IPC分类号： B01D21/26
CPC分类号： B01D17/0217 , A61M1/025 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3496 , A61M1/3603 , A61M1/3681 , A61M1/3693 , A61M1/3696 , A61M2202/0427 , A61M2205/331 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3393 , B01D21/2405 , B01D21/245 , B01D21/26 , B01D21/262 , B01D21/34 , B01D2221/10 , B04B5/0442 , B04B7/08 , B04B13/00 , B04B2005/045 , G01D5/34715 , A61M2202/0071
摘要： The apparatus comprises an elongate, flexible separation chamber (51) receivable in a slot (46) of a rotor, so that rotation of the rotor causes separation of a fluid, supplied through an inlet port (51a) to the chamber (51), in regions (104,106) along opposite walls (50d,50e) of the chamber. Each component is removed through a corresponding outlet port (51b,51c). One of the outlet ports (51c) is arranged adjacent to the inlet port (51a) and a ramp (111) is provided or formed in the chamber (51) to direct flow of the respective component towards that outlet in a direction opposite to the direction of fluid flow through the inlet.
摘要翻译：该装置包括可容纳在转子的槽（46）中的细长的柔性分离室（51），使得转子的旋转导致通过入口（51a）供应到腔室（51）的流体分离，沿着腔室的相对壁（50d，50e）的区域（104,106）。通过相应的出口（51b，51c）去除每个部件。出口（51c）中的一个布置成邻近入口（51a）并且在室（51）中设置或形成斜面（111），以引导相应部件朝向与该流体流过入口的方向。

83. 发明授权

EP0291515B1 RADIO FREQUENCY METHOD OF SEALING AN ARTICLE 失效
标题翻译：无线电频率密封方法
公开(公告)号：EP0291515B1
公开(公告)日：1993-09-08
申请号：EP87906903.7
申请日：1987-10-06
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： SCHNELL, William, J. , MUNSCH, John, M. , FLAGLER, Robert, W. , FABISIEWICZ, Eugene , SOUBRIER, Pierre
IPC分类号： A61B19/04 , B29C65/04
CPC分类号： B29C65/04 , A61F5/4405 , B29C66/1122 , B29C66/5221 , B29C66/53262 , B29C66/71 , B29C66/81423 , B29C66/81431 , B29C66/81463 , B29C66/83221 , B29L2031/7148 , B29L2031/753 , B29K2027/06
摘要： A method of radio frequency sealing attaches a seal member (30) to a cylindrical, hollow, access port (20) of a container. The method uses two sets of spaced apart die elements (12a, b and 14a, b) to generate an axial electric field along a region where the port and seal member overlap. An external peripheral ring (42) is formed about an exterior surface of the port. The method can be used with containers having a sealed periphery as well as those previously filled with a fluid.

84. 发明授权

EP0345317B1 MICROCRYSTALLINE MATRIX FOR ADMINISTRATION OF BENEFICIAL AGENT 失效
标题翻译：用于管理受益人的微结构矩阵
公开(公告)号：EP0345317B1
公开(公告)日：1993-08-25
申请号：EP88910379.2
申请日：1988-11-08
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： WEINLESS, Naomi, L. , POKROPINSKI, Sharon
IPC分类号： A61M31/00
CPC分类号： A61J1/10 , A61K9/2013 , A61K9/2018 , A61M1/02 , A61M1/1668 , A61M1/1686 , A61M1/28 , A61M5/1409
摘要： Medical solution is passed in a conduit (10) across a solid, microcrystalline mass (18) of beneficial agent to cause the beneficial agent (18) to dissolve in the medical solution. The beneficial agent (18) comprises a mass of citrate or mannitol in a substantially anhydrous form, the mass (18) being shaped and proportioned so that a controlled amount of the beneficial agent (18) dissolves into passing medical solution in a manner that is substantially predetermined. For example, the beneficial agent (18) can dissolve in substantially uniform manner, whereby no substantial portion of the medical solution, such as blood or another parenteral solution, is exposed at a relatively constant flow to a significantly higher concentration of the beneficial agent than other flowing portions of the medical solution. The citrate or mannitol mass of the beneficial agent (18) may include at least one added effective agent for dissolving in the medical solution as the citrate or mannitol dissolve therein.
摘要翻译：医疗溶液通过导管（10）穿过有益剂的固体微晶块（18），以使有益剂（18）溶解在医用溶液中。有益剂（18）包含基本上无水形式的一批柠檬酸盐或甘露糖醇，所述物质（18）的形状和比例成正比，使受控量的有益剂（18）以下列方式溶解于经过的药物溶液：基本上预定。例如，有益剂（18）可以以基本上均匀的方式溶解，由此没有大量部分的药物溶液，例如血液或其他胃肠外溶液以相对恒定的流量暴露于有益剂的显着更高的浓度，医疗解决方案的其他流动部分。有益剂（18）的柠檬酸盐或甘露糖醇物质可以包含至少一种添加的有效剂，其溶解在柠檬酸盐或甘露醇中溶于其中。

85. 发明授权

EP0304479B1 APPARATUS FOR ATTACHING A FITMENT TO A WEB OF FILM 失效
标题翻译：将装置连接到电影网络的装置
公开(公告)号：EP0304479B1
公开(公告)日：1993-06-09
申请号：EP88903070.6
申请日：1988-03-08
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： CHRISTINE, William, C. , HERSCHMAN, George, J. , HAAS, William, R.
IPC分类号： B65B61/00 , B65B61/18
CPC分类号： B65B61/186
摘要： An apparatus for attaching fitments (13) to a web of film (12). The apparatus includes an elongated tube (38), the web of film (12) being passed around at least a portion of the elongated tube (38). A film puncher and remover (50) for punching at least one hole in the web of film and removing the resultant slug is provided. The web of film (12) passes between the elongated tube (38) and the film puncher and remover (50). The apparatus also includes a fitment feed member (96) for feeding a fitment (13) from outside the elongated tube (38) to a fitment pick-up position (100) inside the elongated tube (38). The elongated tube (38) also includes a fitment moving member (120) for moving the fitment from the fitment pick-up position (100) to a fitment attachment position. The fitment attachment position is located so that a portion of the fitment (13) is received by the hole in the web of film (12). The apparatus also includes a sealer (170) for welding the film to the fitment.

86. 发明授权

EP0277176B1 APPARATUS FOR SEALING AND SEVERING A WEB OF FILM 失效
标题翻译：用于密封和覆盖电影网络的装置
公开(公告)号：EP0277176B1
公开(公告)日：1993-06-09
申请号：EP87905104.3
申请日：1987-07-23
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： CHRISTINE, William, C. , LYONS, Steffen , POSEY, John , SCHMIDT, Josef , HERSCHMAN, George, J.
IPC分类号： B32B31/18
CPC分类号： B29C66/80 , B29C65/222 , B29C65/227 , B29C65/38 , B29C65/7433 , B29C66/1122 , B29C66/431 , B29C66/8122 , B29C66/81457 , B29C66/81811 , B29C66/81821 , B29C66/81871 , B29C66/8242 , B29C66/83221 , B29C66/91212 , B29C66/91231 , B29C66/91421 , B29C66/91931 , B29C66/9241 , B29C66/944 , B29K2995/007 , B29L2031/7148 , B65B51/303 , B65B2051/105 , Y10T156/1054 , Y10T156/1313 , Y10T156/1378 , B29K2909/08 , B29K2827/18
摘要： An apparatus (10) for sealing and severing a web of film (15). The apparatus includes a first jaw (12) located on one side of the web of film and a second jaw (16) located on a second side of the web of film. Located within the first jaw is a heater member (14) for sealing and severing the web of film. The heater member is secured so that the time and/or pressure at which the heater member engages the web of film may be varied independent of the first jaw.

87. 发明授权

EP0342222B1 AMPULE FOR CONTROLLED ADMINISTRATION OF BENEFICIAL AGENT 失效
标题翻译：控制管理受益人的药剂
公开(公告)号：EP0342222B1
公开(公告)日：1993-04-28
申请号：EP88910320.6
申请日：1988-11-08
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： WOLF, L., Jr. , GOLDHABER, Rich , LYNN, Daniel, R. , WEINLESS, Naomi, L.
IPC分类号： A61M31/00
CPC分类号： A61M5/1409 , A61M1/02
摘要： An ampule (16) defines a pair of opposed, flexible sides (24), sealingly enclosing a space which contains a mass of beneficial agent (18) which is soluble in aqueous solution. Inlet (17) and outlet (19) ports communicate between the space and the exterior. Flow promoting means (20) are positioned between the mass of beneficial agent (18) and at least one opposed, flexible side (24) to facilitate the formation of a fluid flow path (22) along the mass of beneficial agent (18).

88. 发明授权

EP0305364B1 PURGING SYSTEM FOR A BLOOD TUBING NETWORK 失效
标题翻译：血液管网络采血系统
公开(公告)号：EP0305364B1
公开(公告)日：1993-02-24
申请号：EP87901905.7
申请日：1987-02-25
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： WILLIAMSON,warren , PRINCE, Paul, R.
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3672 , A61M5/385 , A61M39/14 , A61M2205/7536
摘要： Method and apparatus for purging air from a tubing network finds utility as a component part of a blood constituent processing system (10). Collection and returned needles (12, 14) of a disposable tubing network are initially contained within a common antiseptic enclosure (16). A purge fluid (e.g., saline solution) may then be introduced into the interior chamber of the enclosure (16) via one of the needles (12, 14) and withdrawn from the interior chamber of the enclosure (16) via the other of the needles (12, 14). Air entrained in the tubing network may thus be trapped within the common enclosure (16) itself and/or vented therefrom via a one-way valve and hydrophobic microbe filter (72) and/or the entrained air pockets may be encouraged to flow to a separate suitable air trap location (50) of the tubing network whereby the network is purged of air.
摘要翻译：从管网净化空气的方法和装置可用作血液成分处理系统（10）的组成部分。一次性管网的收集和返回的针（12,14）最初被包含在常见的防腐外壳（16）内。然后可以经由一个针（12,14）将清洗流体（例如，盐水溶液）引入到外壳（16）的内部腔室中，并通过另一个从外壳（16）的内部腔室针（12,14）。因此，管道网络中夹带的空气可以通过单向阀和疏水性微生物过滤器（72）本身和/或从其中排出而在公共外壳（16）内被捕获和/或可以鼓励夹带的气囊流到单独的管道网络的合适的空气阱位置（50），从而净化空气。

89. 发明授权

EP0332330B1 Automatic infiltration detection system 失效
标题翻译：自动渗透检测系统
公开(公告)号：EP0332330B1
公开(公告)日：1993-02-03
申请号：EP89302006.5
申请日：1989-02-28
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： Bobo, Donald E., Jr. , Seguine, Dennis R. , Lapp, Theodore R.
IPC分类号： A61M5/14 , F04B51/00
CPC分类号： A61M5/16854 , A61M5/16859 , Y10S128/13

90. 发明授权

EP0297814B1 Film guide system 失效
标题翻译：电影指南系统
公开(公告)号：EP0297814B1
公开(公告)日：1993-02-03
申请号：EP88305843.0
申请日：1988-06-24
申请人： BAXTER INTERNATIONAL INC. (a Delaware corporation)
发明人： Posey, John L.
IPC分类号： B65B61/18 , B65B9/20
CPC分类号： B29C66/47421 , B29C65/18 , B29C65/305 , B29C65/7437 , B29C66/112 , B29C66/1122 , B29C66/131 , B29C66/133 , B29C66/4312 , B29C66/4322 , B29C66/49 , B29C66/81431 , B29C66/8167 , B29C66/83221 , B29C66/836 , B31B70/844 , B65B9/22 , B65B51/26 , B65B61/186 , B65B2220/08 , Y10S493/929 , Y10T156/1309
摘要： A guide system (11) for improving the orientation of a web of film as it passes around a fill tube structure in a form, fill, seal packaging machine is provided. The guide system comprises at least two members (52, 54) removably coupled to the fill tube structure, and so constructed and arranged that they increase the cross-sectional perimeter of the fill tube structure when they are secured thereto. The members cooperating with the fill tube structure to stretch the web of film as it passes around the fill tube structure. An improved apparatus for attaching fitments to a web of film and method is also provided.

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