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81. 发明申请

WO2014123879A1 NATURAL KILLER CELLS FROM PLACENTA 审中-公开
标题翻译：自然杀伤细胞从PLACENTA
公开(公告)号：WO2014123879A1
公开(公告)日：2014-08-14
申请号：PCT/US2014/014632
申请日：2014-02-04
申请人： ANTHROGENESIS CORPORATION
发明人： ZHANG, Xiaokui , HARIRI, Robert, J. , VOSKINARIAN-BERSE, Vanessa , KANG, Lin , LAW, Eric , ABBOT, Stewart
IPC分类号： A61K35/14
CPC分类号： A61K35/17 , A61K31/454 , A61K2035/122 , C12N5/0646 , C12N2501/05
摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta, e.g ., from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta, e.g ., from placental perfusate, and umbilical cord blood.
摘要翻译：本文提供胎盘灌洗液，胎盘灌洗液细胞，胎盘衍生的中间体天然杀伤细胞，来自胎盘和脐带血的合并的天然杀伤细胞及其组合。本文还提供了包含其的组合物，以及使用胎盘灌注液，胎盘灌洗液细胞，胎盘衍生的中间体天然杀伤细胞和组合的天然杀伤细胞及其组合的方法，以抑制肿瘤细胞，癌细胞的生长或增殖，并且治疗患有肿瘤细胞的个体。本文还提供了用胎盘灌注液，胎盘灌洗液衍生的细胞，来自胎盘的天然杀伤细胞（例如胎盘灌注液）和/或包含天然的组合的天然杀伤细胞来治疗具有肿瘤或移植物抗宿主病的个体的方法来自胎盘的杀伤细胞，例如胎盘灌洗液和脐带血。

82. 发明申请

WO2014063035A2 TREATMENT OF PAIN USING AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译：使用粘连衍生的附属细胞治疗疼痛
公开(公告)号：WO2014063035A2
公开(公告)日：2014-04-24
申请号：PCT/US2013/065653
申请日：2013-10-18
申请人： ANTHROGENESIS CORPORATION
发明人： HERZBERG, Uri , HARIRI, Robert, J. , GURNEY, Jodi, P.
IPC分类号： A61K35/50
CPC分类号： A61K35/50 , A61K35/28 , A61K35/51 , C12N5/0605 , A61K2300/00
摘要： Provided herein are methods of treatment of an individual having pain, e.g., neuropathic pain, comprising administering to the individual a therapeutically effective amount of tissue culture plastic adherent amnion-derived cells (AMDACs).
摘要翻译：本文提供了治疗患有疼痛的个体（例如神经性疼痛）的方法，其包括向个体施用治疗有效量的组织培养物，塑性粘附羊膜来源的细胞（AMDAC）。

83. 发明申请

WO2014028453A3 NATURAL KILLER CELLS AND USES THEREOF 审中-公开
公开(公告)号：WO2014028453A3
公开(公告)日：2014-02-20
申请号：PCT/US2013/054677
申请日：2013-08-13
申请人： ANTHROGENESIS CORPORATION , LAW, Eric , KANG, Lin , JANKOVIC, Vladimir , ZHANG, Xiaokui , ABBOT, Stewart , HARIRI, Robert, J.
发明人： LAW, Eric , KANG, Lin , JANKOVIC, Vladimir , ZHANG, Xiaokui , ABBOT, Stewart , HARIRI, Robert, J.
IPC分类号： C12N5/07 , C12N5/078 , C12N5/0783
摘要： Provided herein are methods of producing natural killer (NK) cells and NK progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of NK cells and NK progenitor cell populations using a three-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells, the NK cell populations, and the NK progenitor cell populations produced by the methods described herein to an individual having the cancer or viral infection.

84. 发明申请

WO2013126379A1 DEVICES AND METHODS FOR THAWING BIOLOGICAL MATERIAL 审中-公开
标题翻译：用于治疗生物材料的装置和方法
公开(公告)号：WO2013126379A1
公开(公告)日：2013-08-29
申请号：PCT/US2013/026819
申请日：2013-02-20
申请人： ANTHROGENESIS CORPORATION
发明人： MURPHY, Brian
IPC分类号： F25D21/08 , F28F7/00 , F24H1/18
CPC分类号： B65D81/18 , B01L7/00 , B01L9/06 , B01L2300/123 , B01L2300/185 , B01L2300/1855 , B01L2300/1877 , B65D25/04 , F24V30/00
摘要： Provided herein are devices and methods for thawing frozen biological material.
摘要翻译：本文提供了用于解冻冷冻生物材料的装置和方法。

85. 发明申请

WO2011127117A1 ANGIOGENESIS USING PLACENTAL STEM CELLS 审中-公开
标题翻译：使用平面干细胞的血管生成
公开(公告)号：WO2011127117A1
公开(公告)日：2011-10-13
申请号：PCT/US2011/031335
申请日：2011-04-06
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
发明人： ABBOT, Stewart , EDINGER, James , FRANCKI, Aleksander , HARIRI, Robert, J. , JANKOVIC, Vladimir , KAPLUNOVSKY, Aleksandr , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073 , A61K35/50
CPC分类号： A61K35/50 , A61K9/0019 , A61K9/0085 , A61K35/28 , A61L27/3633 , A61L27/3683 , A61L27/3808 , A61L27/3834 , A61L27/3886 , A61L27/3895 , C12N5/0605 , A61K2300/00
摘要： Provided herein are methods of treating individuals having diseases or disorders of the circulatory system, using placental cells, e.g., the placental stem cells and placental multipotent cells (PDACs) described herein, and populations of such placental cells. The invention also provides methods of angiogenesis using such cells or populations of cells comprising such cells.
摘要翻译：本文提供了使用胎盘细胞（例如本文所述的胎盘干细胞和胎盘多潜能细胞（PDAC））以及这些胎盘细胞群来治疗患有循环系统疾病或病症的个体的方法。本发明还提供了使用这种细胞或包含这种细胞的细胞群的血管生成方法。

86. 发明申请

WO2010059828A1 AMNION DERIVED ADHERENT CELLS 审中-公开
标题翻译： AMNION衍生的附属细胞
公开(公告)号：WO2010059828A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065152
申请日：2009-11-19
申请人： ANTHROGENESIS CORPORATION , ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , KAPLUNOVSKY, Aleksandr , JANKOVIC, Vladimir , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav, D. , PAREDES, Jennifer , WANG, Jia-Lun
发明人： ABBOT, Stewart , EDINGER, James, W. , FRANCKI, Aleksandar , KAPLUNOVSKY, Aleksandr , JANKOVIC, Vladimir , LABAZZO, Kristen , LAW, Eric , PADLIYA, Neerav, D. , PAREDES, Jennifer , WANG, Jia-Lun
IPC分类号： C12N5/073
CPC分类号： A61K35/50 , A61K35/12 , C12N5/0605
摘要： Provided herein are novel angiogenic cells from amnion, referred to as amnion derived adherent cells, and populations of, and compositions comprising, such cells. Further provided herein are methods of obtaining such cells and methods of using the cells in the treatment of individuals.
摘要翻译：本文提供了来自羊膜的新型血管生成细胞，称为羊膜来源的贴壁细胞，以及包含这些细胞的群体和组合物。本文还提供了获得这样的细胞的方法和使用细胞治疗个体的方法。

87. 发明申请

WO2008100497A1 HEPATOCYTES AND CHONDROCYTES FROM ADHERENT PLACENTAL STEM CELLS; AND CD34+, CD45- PLACENTAL STEM CELL-ENRICHED CELL POPULATIONS 审中-公开
标题翻译：来自同种异体干细胞的肝细胞和细胞因子; 和CD34 +，CD45-细胞干细胞增殖细胞群体
公开(公告)号：WO2008100497A1
公开(公告)日：2008-08-21
申请号：PCT/US2008/001830
申请日：2008-02-12
申请人： ANTHROGENESIS CORPORATION , EDINGER, James, W. , HARIRI, Robert, J. , WANG, Jia-Lun , YE, Qian , PEREIRA, Marian , ABRAMSON, Sascha, Dawn , LABAZZO, Kristen, S.
发明人： EDINGER, James, W. , HARIRI, Robert, J. , WANG, Jia-Lun , YE, Qian , PEREIRA, Marian , ABRAMSON, Sascha, Dawn , LABAZZO, Kristen, S.
IPC分类号： C12N5/08 , A61K35/50 , A01K67/027 , A61P1/16 , A61L27/38 , A61F2/30 , A61P19/00
CPC分类号： C12N5/067 , A01K67/0271 , A01K2267/0337 , A61K2035/128 , C12N5/0605 , C12N5/0607 , C12N5/0655 , C12N2500/30 , C12N2500/36 , C12N2500/62 , C12N2501/15 , C12N2501/999 , C12N2506/02 , C12N2506/03 , C12N2533/32 , C12N2533/40 , C12N2533/74
摘要： Provided herein are methods and compositions for the production of hepatocytes from placenta stem cells. Further provided herein is the use of such hepatocytes in the treatment of, and intervention in, for example, trauma, inflammation, and degenerative disorders of the liver. Also provided herein are compositions and methods relating to combinations of nanofibrous scaffolds and adherent placental stem cells and methods of using the same in cartilage repair. Finally, provided herein are compositions and methods relating to nonadherent, CD34 + CD45 - stem cells from placenta.
摘要翻译：本文提供了用于从胎盘干细胞产生肝细胞的方法和组合物。本文进一步提供的是这种肝细胞在治疗和干预例如肝脏的创伤，炎症和退行性疾病中的用途。本文还提供了与纳米纤维支架和贴壁胎盘干细胞的组合有关的组合物和方法及其在软骨修复中的使用方法。最后，本文提供的是与来自胎盘的非粘附的CD34 + CD45 +干细胞相关的组合物和方法。

88. 发明申请

WO2008042441A1 USE OF UMBILICAL CORD BIOMATERIAL FOR OCULAR SURGERY 审中-公开
标题翻译：用于眼科手术的脐带生物材料的使用
公开(公告)号：WO2008042441A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/021363
申请日：2007-10-03
申请人： ANTHROGENESIS CORPORATION , LIU, Qing , RAY, Cynthia
发明人： LIU, Qing , RAY, Cynthia
IPC分类号： A61K35/44 , A61L27/36 , A61P27/00 , A61P27/06 , A61P27/12
CPC分类号： A61K35/44 , A61L27/3604 , A61L27/3641 , A61L2430/16
摘要： The present application is directed to a method of performing ocular surgery using biomaterial from placenta and/or umbilical cord, wherein the biomaterial is contacted with a tissue of the eye, or tissue surrounding the eye, affected by the surgery. The biomaterial is also used in surgery performed to repair trauma to the eye, whether deliberately or accidentally caused. The eye surgery can be, e.g., glaucoma surgery, oculoplastic surgery, cataract surgery, vitreo-retinal surgery, refractive surgery, retinal surgery, eye muscle surgery, or the like.
摘要翻译：本申请涉及一种使用来自胎盘和/或脐带的生物材料进行眼外科手术的方法，其中所述生物材料与受手术影响的眼睛组织或围绕眼睛的组织接触。生物材料也用于手术以修复眼睛的创伤，无论是故意的还是意外引起的。眼科手术可以是例如青光眼手术，眼部肿瘤手术，白内障手术，玻璃体视网膜手术，屈光手术，视网膜手术，眼肌手术等。

89. 发明申请

WO2007146123A2 PLACENTAL NICHE AND USE THEREOF TO CULTURE STEM CELLS 审中-公开
标题翻译：特别的NICHE及其用于培养干细胞
公开(公告)号：WO2007146123A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/013507
申请日：2007-06-08
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohammad, A.
发明人： HEIDARAN, Mohammad, A.
IPC分类号： C12N5/073
CPC分类号： C12N5/0605 , C12N2500/25 , C12N2500/36 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/92
摘要： The present invention provides methods for culturing, expanding and differentiating stem cells, particularly human embryonic stem cells. The methods comprise culturing the stem cells for a period of time on a collagen biofabric, particularly a collagen biofabric derived from the amniotic membrane, chorion, or both, from mammalian placenta.
摘要翻译：本发明提供了培养，扩增和分化干细胞，特别是人胚胎干细胞的方法。所述方法包括在哺乳动物胎盘上胶原生物制剂，特别是衍生自羊膜，绒毛膜或两者的胶原生物制剂将干细胞培养一段时间。

90. 发明申请

WO2007079184A2 CO-CULTURE OF PLACENTAL STEM CELLS AND STEM CELLS FROM A SECOND SOURCE 审中-公开
标题翻译：第二来源雌性干细胞和干细胞共培养研究
公开(公告)号：WO2007079184A2
公开(公告)日：2007-07-12
申请号：PCT/US2006/049492
申请日：2006-12-28
申请人： ANTHROGENESIS CORPORATION , HEIDARAN, Mohamad , WANG, Jia-lun , YE, Qian , ZEITLIN, Andrew
发明人： HEIDARAN, Mohamad , WANG, Jia-lun , YE, Qian , ZEITLIN, Andrew
IPC分类号： C12N5/0789
CPC分类号： C12N5/0647 , A61K35/50 , A61K35/51 , A61K2035/124 , C12N5/0605 , C12N2502/02 , C12N2502/025 , G01N33/56966
摘要： The present invention relates to a combination of placental stem cells and stem or progenitor cells derived from a second source, wherein the combination shows improved engraftment as compared to placental stem cells or stem cells from a second source, alone. The combination is referred to as a combined stem cell population. The invention also provides in vitro and in vivo methods for identifying and producing combined stem cell populations, and models of engraftment. In accordance with the present invention, the placental stem cells may be combined with, e.g., umbilical cord blood-derived stem or progenitor cells, fetal or neonatal stem cells or progenitor cells, adult stem cells or progenitor cells, hematopoietic stem cells or progenitor cells, stem or progenitor cells derived from bone marrow, etc.
摘要翻译：本发明涉及胎盘干细胞和源自第二来源的干细胞或祖细胞的组合，其中所述组合显示与来自第二来源的胎盘干细胞或干细胞相比改善的植入，单独。该组合被称为组合干细胞群体。本发明还提供了用于鉴定和生产组合干细胞群体的体外和体内方法以及植入模型。根据本发明，胎盘干细胞可与例如脐带血源干细胞或祖细胞，胎儿或新生干细胞或祖细胞，成体干细胞或祖细胞，造血干细胞或祖细胞，源自骨髓的干细胞或祖细胞等。

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