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81. 发明申请

WO2010005809A2 POSTURE STATE RESPONSIVE THERAPY DELIVERY USING DWELL TIMES 审中-公开
标题翻译：姿势状态反应性治疗的用药时间
公开(公告)号：WO2010005809A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048852
申请日：2009-06-26
申请人： MEDTRONIC, INC. , SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
发明人： SKELTON, Dennis, M. , DAVIS, Jon, P. , PANKEN, Eric, J.
IPC分类号： A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： Techniques related to classifying a posture state of a living body are disclosed. One aspect relates to sensing at least one signal indicative of a posture state of a living body. Posture state detection logic classifies the living body as being in a posture state based on the at least one signal, wherein this classification may take into account at least one of posture and activity state of the living body. The posture state detection logic further determines whether the living body is classified in the posture state for at least a predetermined period of time. Response logic is described that initiates a response as a result of the body being classified in the posture state only after the living body has maintained the classified posture state for at least the predetermined period of time. This response may involve a change in therapy delivered to the living body.
摘要翻译：公开了与分类活体姿势状态有关的技术。一个方面涉及感测指示活体的姿势状态的至少一个信号。姿势状态检测逻辑基于至少一个信号将生物体分类为处于姿势状态，其中该分类可以考虑活体的姿势和活动状态中的至少一个。姿势状态检测逻辑进一步确定活体是否在姿势状态中被分类了至少预定的时间段。描述响应逻辑，其仅在生物体已经保持分类姿势状态达至少预定时间段之后才开始响应，作为身体被分类到姿势状态的结果。这种反应可能涉及到对生物体进行治疗的改变。

82. 发明申请

WO2010005802A2 POSTURE STATE CLASSIFICATION FOR A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的状态分类
公开(公告)号：WO2010005802A2
公开(公告)日：2010-01-14
申请号：PCT/US2009/048686
申请日：2009-06-25
申请人： MEDTRONIC, INC. , PANKEN, Eric, J. , SKELTON, Dennis, M.
发明人： PANKEN, Eric, J. , SKELTON, Dennis, M.
IPC分类号： A61B5/103 , A61N1/365
CPC分类号： A61N1/36542 , A61B5/1116 , A61B5/1118 , A61B5/686 , A61B5/7264 , A61B2562/0219 , A61N1/36535 , G06F19/00
摘要： One embodiment relates to a medical device including a sensor to provide signals indicative of a detected posture state of a patient. A memory stores one or more defined vectors, each defined vector being associated with a tolerance describing a relationship with the defined vector. A processor determines a respective similarity between the detected vector and each of one or more of the defined vectors and classifies a posture state of the patient based on whether any similarity has a relationship to the respective defined vector that is described by the associated tolerance. In one embodiment, the similarity is determined without regard to a coordinate system of the patient. Another embodiment relates to determining the similarity based on at least one of an inner product, a length of the defined posture vector and a length of the detected vector.
摘要翻译：一个实施例涉及一种医疗设备，其包括用于提供指示患者的检测到的姿势状态的信号的传感器。存储器存储一个或多个定义的向量，每个定义的向量与描述与所定义的向量的关系的公差相关联。处理器确定检测到的矢量与一个或多个定义矢量中的每一个之间的各自的相似度，并且基于任何相似性是否与由相关联的容限描述的相应定义的矢量具有关系来对患者的姿势状态进行分类。在一个实施例中，不考虑患者的坐标系确定相似度。另一实施例涉及基于内积，所定义的姿态向量的长度和所检测的向量的长度中的至少一个来确定相似性。

83. 发明申请

WO2009134474A1 TIME REMAINING TO CHARGE AN IMPLANTABLE MEDICAL DEVICE, CHARGER INDICATOR, SYSTEM AND METHOD THEREFORE 审中-公开
标题翻译：暂时收取可植入医疗器械，充电器指示器，系统和方法的时间
公开(公告)号：WO2009134474A1
公开(公告)日：2009-11-05
申请号：PCT/US2009/031625
申请日：2009-01-22
申请人： MEDTRONIC, INC. , RONDONI, John, C. , DAVIS, Jon, P. , BRIGHT, Kevin, L. , SAHASRABUDHE, Rajeev, M.
发明人： RONDONI, John, C. , DAVIS, Jon, P. , BRIGHT, Kevin, L. , SAHASRABUDHE, Rajeev, M.
IPC分类号： A61N1/378 , A61N1/372 , H02J7/04 , A61N1/05 , A61N1/36
CPC分类号： A61N1/37247 , A61N1/3787 , H02J7/0047
摘要： System and method for estimating a time to recharge a rechargeable power source of an implantable medical device. A plurality of measured parameters relating to the implantable medical device and an external charging device are applied to a model of recharging performance and an estimate is provided to a patient, perhaps in advance of charging. Once charging has begun, updated estimates can be provided until charging is complete. Once charging is complete, the model may be updated to reflect any differences in the estimated time to complete charging and the actual time required to complete charging. The model may be based on limitations to the rate at which charge may be transferred to the rechargeable power source over a plurality of intervals.
摘要翻译：用于估计可植入医疗装置的可再充电电源的再充电时间的系统和方法。与可植入医疗装置和外部充电装置相关的多个测量参数被应用于充电性能的模型，并且可能在充电之前向患者提供估计。一旦收费开始，可以提供更新的估算，直到收费完成。一旦充电完成，该模型可能会更新，以反映完成充电的预计时间和完成充电所需的实际时间的任何差异。该模型可以基于在多个间隔上将电荷转移到可再充电电源的速率的限制。

84. 发明申请

WO2017155632A1 MEDICAL THERAPY TARGET DEFINITION 审中-公开
标题翻译：医疗治疗目标定义
公开(公告)号：WO2017155632A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/015827
申请日：2017-01-31
申请人： MEDTRONIC, INC.
发明人： WU, Jianping , NELSON, Dwight E. , MOLNAR, Gabriela C.
IPC分类号： A61N1/36
摘要： In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes. The parameters may be defined based on a first plurality of electrical signals sensed at a plurality of different positions within the brain of the patient when electrical stimulation is not delivered at each of the positions and a second plurality of electrical signals sensed at each of the plurality of different positions within the brain of the patient in response to electrical stimulation delivered at each of the positions at a plurality of different intensities.
摘要翻译：在一些示例中，系统可以包括多个电极，电刺激电路和控制器。控制器可以被配置为选择待递送至患者的大脑的治疗的一个或多个参数，并且基于所选择的参数并且经由第一个或者第一个或者第一个输入来控制电刺激电路将治疗递送至患者的大脑，或者多个电极中的更多电极。参数可以基于当在各个位置处没有递送电刺激时在患者的脑内的多个不同位置处感测到的第一多个电信号以及在多个位置中的每个位置处感测到的第二多个电信号响应于在多个不同强度下在每个位置处递送的电刺激，在患者的大脑内的不同位置。

85. 发明申请

WO2017083146A1 IMPLANTABLE ELECTRICAL STIMULATOR WITH DEFLECTING TIP LEAD 审中-公开
标题翻译：植入式电动刺激器，具有挠曲尖端引线
公开(公告)号：WO2017083146A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/060073
申请日：2016-11-02
申请人： MEDTRONIC, INC.
发明人： BONDE, Eric H. , KAST, John E. , SCOTT, Erik R. , WEI, Xuan K.
IPC分类号： A61N1/375
CPC分类号： A61N1/375 , A61N1/0551 , A61N1/3605 , A61N1/3787
摘要： In some examples, an implantable medical device includes an implantable housing, a neurostimulator within the housing, a plurality of electrodes, an implantable lead coupled to the housing, and an actuator formed with the housing. The implantable lead includes at least one electrode of the plurality of electrodes and one or more conductors coupling the at least one electrode to the neurostimulator. The actuator is configured to cause at least a portion of the implantable lead to deflect.
摘要翻译：在一些示例中，可植入医疗装置包括可植入壳体，壳体内的神经刺激器，多个电极，联接到壳体的可植入引线以及与壳体一起形成的致动器。可植入引线包括多个电极中的至少一个电极以及将至少一个电极连接到神经刺激器的一个或多个导体。致动器被配置为导致植入式导线的至少一部分偏转。

86. 发明申请

WO2017062577A2 IMPLANTABLE MODULAR ELECTRODE ARRAY ASSEMBLY 审中-公开
标题翻译：可植入模块化电极阵列组件
公开(公告)号：WO2017062577A2
公开(公告)日：2017-04-13
申请号：PCT/US2016/055687
申请日：2016-10-06
申请人： MEDTRONIC, INC.
发明人： OLSON, Robert L.
IPC分类号： A61N1/05 , A61N1/375 , H01R24/60
CPC分类号： A61N1/0529 , A61B5/0478 , A61N1/0531 , A61N1/0551 , A61N1/372 , A61N1/375 , H01R12/79 , H01R24/60 , H01R31/005 , H01R2201/12
摘要： This disclosure describes various modular electrode assemblies. For example, an implantable modular electrode assembly may include a hub including a plurality of electrical contacts configured to receive electrical signals from an implantable medical device, a first electrode module including a first substrate and a first plurality of electrodes on the first substrate, and a second electrode module including a second substrate and a second plurality of electrodes on the second substrate. The first and second electrode modules may be connectable to the hub, where the plurality of electrical contacts electrically communicate with the first and second plurality of electrodes.
摘要翻译：本公开描述了各种模块化电极组件。例如，可植入模块化电极组件可以包括毂，其包括多个电触点，其被配置为从可植入医疗装置接收电信号，第一电极模块包括第一衬底和第一衬底上的第一多个电极，以及所述第二电极模块包括第二基板和所述第二基板上的第二多个电极。第一和第二电极模块可以连接到轮毂，其中多个电触头与第一和第二多个电极电连通。

87. 发明申请

WO2016081099A1 ELECTRODE SELECTION FOR ELECTRICAL STIMULATION THERAPY 审中-公开
标题翻译：电刺激治疗电极选择
公开(公告)号：WO2016081099A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/055542
申请日：2015-10-14
申请人： MEDTRONIC, INC.
发明人： KAEMMERER, William F. , DANI, Siddharth , CONNELLY, Allison T.
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/36185 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/36096 , A61N1/36139 , A61N1/37235 , A61N1/37247
摘要： In one example, a method includes selecting, by one or more processors and based on a representation of sensed electrical signals for a particular patient and a plurality of representations of sensed electrical signals for a plurality of other patients, a combination of electrodes of a plurality of combinations of one or more implantable electrodes for delivery of electrical stimulation to the particular patient.
摘要翻译：在一个示例中，一种方法包括通过一个或多个处理器并且基于针对特定患者的感测电信号的表示和多个其他患者的感测电信号的多个表示来选择多个电极的组合一个或多个可植入电极的组合，用于向特定患者传递电刺激。

88. 发明申请

WO2015134072A1 THERAPEUTIC WINDOW DETERMINATION 审中-公开
标题翻译：治疗窗口决定
公开(公告)号：WO2015134072A1
公开(公告)日：2015-09-11
申请号：PCT/US2014/068378
申请日：2014-12-03
申请人： MEDTRONIC, INC.
发明人： KAEMMERER, William F.
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/36142 , A61N1/37247
摘要： A therapeutic window for at least one electrode of a medical system may be determined based on a volume of tissue expected to be activated ("VTA") by electrical stimulation delivered by the at least one electrode. In some examples, a processor determines the therapeutic window for a particular electrode by at least determining an efficacy threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the efficacy threshold, and determining an adverse-effects threshold based on the VTA expected to result from the delivery of electrical stimulation according to a set of electrical stimulation parameter values including the stimulation parameter at the adverse-effects threshold.
摘要翻译：医疗系统的至少一个电极的治疗窗口可以基于由至少一个电极传递的电刺激预期被激活的组织的体积（“VTA”）来确定。在一些示例中，处理器通过至少基于预期由电刺激输送产生的VTA来确定特定电极的治疗窗口，所述VTA根据包括效力的刺激参数的一组电刺激参数值阈值，并且根据包括在不利影响阈值处的刺激参数的一组电刺激参数值，基于预期由电刺激递送而产生的VTA确定不利影响阈值。

89. 发明申请

WO2015065599A1 DEVICES FOR SENSING PHYSIOLOGICAL SIGNALS DURING STIMULATION THERAPY 审中-公开
标题翻译：在刺激治疗期间用于感测生理信号的装置
公开(公告)号：WO2015065599A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/055553
申请日：2014-09-15
申请人： MEDTRONIC, INC.
发明人： STANSLASKI, Scott R. , CONG, Peng , SANTA, Wesley A. , DENISON, Timothy J.
IPC分类号： A61N1/36 , A61B5/00 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/40 , A61B5/4836 , A61B5/7217 , A61B5/7225 , A61N1/36 , A61N1/3605 , A61N1/36125
摘要： Devices and methods provide for the sensing of physiological signals during stimulation therapy by preventing stimulation waveform artifacts from being passed through to the amplification of the sensed physiological signal. Thus, the amplifiers are not adversely affected by the stimulation waveform and can provide for successful sensing of physiological signals between stimulation waveform pulses. A blanking switch may be used to blank the stimulation waveform artifacts where the blanking switch is operated in a manner synchronized with the stimulation waveform so that conduction in the sensing path is blocked during the stimulation pulse as well as during other troublesome artifacts such as a peak of a recharge pulse. A limiter may be used to limit the amplitude of the sensed signal, and hence the stimulation artifacts, that are passed to the amplifier without any synchronization of the limiter to the stimulation waveform.
摘要翻译：装置和方法通过防止刺激波形伪影通过到感测的生理信号的放大来提供在刺激治疗期间感测生理信号。因此，放大器不受刺激波形的不利影响，并且可以提供刺激波形脉冲之间的生理信号的成功感测。消隐开关可以用于消除刺激波形伪影，其中消隐开关以与刺激波形同步的方式操作，使得感测路径中的传导在刺激脉冲期间以及在其他麻烦的伪像期间被阻塞，例如峰值的充电脉冲。可以使用限制器来限制感测信号的幅度，并且因此限制器将刺激伪影传递到放大器而不限制器与刺激波形的任何同步。

90. 发明申请

WO2013154656A1 ELECTRICAL STIMULATION PROGRAMMING 审中-公开
标题翻译：电刺激编程
公开(公告)号：WO2013154656A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/023058
申请日：2013-01-25
申请人： MEDTRONIC, INC.
发明人： GUPTA, Rahul , GOETZ, Steven M. , LAZAREWICZ, Maciej T. , MOLNAR, Gabriela C. , NELSON, Dwight E. , WU, Jianping
IPC分类号： G06F17/50 , A61N1/372 , A61N1/36
CPC分类号： A61N1/36067 , A61N1/36082 , A61N1/36164 , A61N1/36185 , A61N1/37247
摘要： In one example, the disclosure relates to a method comprising receiving at least one electrical stimulation parameter value defining electrical stimulation for delivery via one or more electrodes to a tissue site, and determining, via one or more processors, a volume of sub-activation threshold impact for tissue from the delivery of the electrical stimulation to the tissue site.
摘要翻译：在一个示例中，本公开涉及一种方法，包括接收限定电刺激的至少一个电刺激参数值，用于经由一个或多个电极递送至组织部位，以及经由一个或多个处理器确定子激活阈值的量对组织从电刺激递送到组织部位的影响。

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