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81. 发明申请

US20180092731A1 HIGH RESISTANCE IMPLANTED BRONCHIAL ISOLATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20180092731A1
公开(公告)日：2018-04-05
申请号：US15714868
申请日：2017-09-25
申请人： Pulmonx Corporation
发明人： Sri Radhakrishnan , Ryan Olivera
IPC分类号： A61F2/04 , A61B17/12 , A61M16/20
摘要： Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at coughing pressures.

82. 发明授权

US09592008B2 Devices and systems for lung treatment 有权
标题翻译：用于肺部治疗的装置和系统
公开(公告)号：US09592008B2
公开(公告)日：2017-03-14
申请号：US13174565
申请日：2011-06-30
申请人： Ryan Olivera , Srikanth Radhakrishnan
发明人： Ryan Olivera , Srikanth Radhakrishnan
IPC分类号： A61B5/00 , A61B5/107
CPC分类号： A61F2/04 , A61B1/018 , A61B1/2676 , A61B5/1076 , A61B5/6852 , A61B17/12104 , A61B2017/0034 , A61B2090/061 , A61F2002/043 , A61M2025/0008
摘要： Devices, systems, and methods for measuring the diameter of an airway in a human or animal subject are disclosed. The device comprises a flexible catheter body having a proximal end and a distal end. Flexible sizing elements are disposed along and extend approximately orthogonally from the catheter body. The sizing elements have different heights from one another and are configured to fit through the working channel of a bronchoscope. Devices, systems, and methods for redirecting airflow through a lung airway are also disclosed. The method comprises introducing into the airway a catheter comprising a distal end, a proximal end and an elongated portion therebetween, wherein the distal end comprises an airway closing mechanism, and wherein the proximal end comprises an actuator to actuate the airway closing mechanism; and actuating the airway closing mechanism to at least partially close the airway.
摘要翻译：公开了用于测量人或动物受试者中气道直径的装置，系统和方法。该装置包括具有近端和远端的柔性导管本体。灵活的施胶元件沿导管本体大致正交地设置并延伸。尺寸调节元件彼此具有不同的高度，并且被配置成穿过支气管镜的工作通道。还公开了用于将气流重定向通过肺气道的装置，系统和方法。该方法包括将包括远端，近端和其间的细长部分的导管引入气道中，其中远端包括气道关闭机构，并且其中近端包括用于致动气道闭合机构的致动器; 并且致动气道关闭机构以至少部分地关闭气道。

83. 发明授权

US09533116B2 Methods and devices for passive residual lung volume reduction and functional lung volume expansion 有权
标题翻译：被动残余肺容积减少和功能性肺容积扩张的方法和装置
公开(公告)号：US09533116B2
公开(公告)日：2017-01-03
申请号：US13938025
申请日：2013-07-09
申请人： Pulmonx Corporation
发明人： Nikolai Alijuri , Rodney C. Perkins , Niyazi Beyhan
IPC分类号： A61M16/04 , A61M16/20 , A61M39/22 , A61B5/08 , A61B17/12 , A61B6/03 , A61M16/00 , A61M25/10
CPC分类号： A61B17/12104 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/085 , A61B5/6853 , A61B6/03 , A61B6/032 , A61B17/1204 , A61B17/12136 , A61B2017/00022 , A61M16/0434 , A61M16/208 , A61M25/10 , A61M2016/0027 , A61M2016/003 , A61M2025/1052 , A61M2205/3303 , A61M2205/3334 , A61M2205/3344 , A61M2210/1035 , A61M2230/46
摘要： The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment.
摘要翻译：通过在进入肺隔室的气道中密封导管的远端来减少超膨胀的肺隔室的体积。当患者呼气时，空气通过导管中的通道从肺隔间通过。与导管相关联的单向流动元件防止空气在患者吸入时再次进入肺隔室。随着时间的推移，随着空气体积的减小，肺室周围的区域压力会使其崩溃。残余体积减少有效地导致功能性肺容积扩张。任选地，肺隔室可以被密封以便永久地防止空气重新进入肺隔室。

84. 发明授权

US09439583B2 Functional assessment and treatment catheters and methods for their use in the lung 有权
公开(公告)号：US09439583B2
公开(公告)日：2016-09-13
申请号：US13689344
申请日：2012-11-29
申请人： Pulmonx Corporation
发明人： Ajit Nair , Son Gia , Roger Farhnoltz , Nikolai Aljuri
IPC分类号： A61M16/04 , A61M25/01 , A61B5/08 , A61B5/097 , A61B5/085 , A61M25/00 , A61M25/06 , A61B5/00 , A61B17/12 , A61F2/04
CPC分类号： A61B5/4836 , A61B5/08 , A61B5/085 , A61B5/097 , A61B5/6853 , A61B17/12104 , A61F2002/043 , A61M16/04 , A61M16/0406 , A61M16/0866 , A61M25/0075 , A61M25/0662 , A61M2025/0004 , A61M2025/0681
摘要： Lung conditions are diagnosed and optionally treated using a functional assessment catheter or a functional lung assessment and treatment catheter. A flow restrictive component is initially placed in a bronchus or lung passageway upstream from a diseased lung region. The isolated lung region is then functionally assessed through the catheter, while the flow restrictive component remains in place. If the patient is a good candidate for treatment by occlusive or restrictive treatment techniques, the flow resistive component may be left in place. If the patient is not suitable for such treatment, the flow resistive component may be removed.

85. 发明申请

US20140018605A1 SELECTIVE LUNG TISSUE ABLATION 有权
标题翻译：选择性肺组织消退
公开(公告)号：US20140018605A1
公开(公告)日：2014-01-16
申请号：US14033163
申请日：2013-09-20
申请人： Pulmonx Corporation
发明人： Peter P. Soltesz , Nikolai Aljuri , Ajit Nair
IPC分类号： A61B18/02 , A61B18/08 , A61B18/18 , A61M16/04 , A61N5/10 , A61N7/02 , A61M16/00 , A61B18/14 , A61B18/12
CPC分类号： A61B18/00 , A61B18/0206 , A61B18/082 , A61B18/1206 , A61B18/14 , A61B18/1492 , A61B18/1815 , A61B18/20 , A61B2018/00214 , A61B2018/0022 , A61B2018/00541 , A61B2018/00642 , A61B2018/00714 , A61B2018/00797 , A61B2018/00994 , A61B2018/0212 , A61B2018/044 , A61B2018/1435 , A61B2018/144 , A61B2018/1472 , A61B2018/1807 , A61B2018/1861 , A61M16/0057 , A61M16/0434 , A61M16/0463 , A61N5/1001 , A61N7/022
摘要： Medical methods and systems are provided for effecting lung volume reduction by selectively ablating segments of lung tissue.
摘要翻译：提供了通过选择性消融肺组织片段来实现肺容量减小的医学方法和系统。

86. 发明授权

US08523782B2 Minimally invasive determination of collateral ventilation in lungs 有权
标题翻译：肺部旁路通气微创测定
公开(公告)号：US08523782B2
公开(公告)日：2013-09-03
申请号：US12913637
申请日：2010-10-27
申请人： Lutz Freitag , Nikolai Aljuri
发明人： Lutz Freitag , Nikolai Aljuri
IPC分类号： A61B5/08
CPC分类号： A61B5/097 , A61B5/087 , A61B5/6852
摘要： Minimally invasive methods, systems and devices are provided for assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding airway of the target compartment. The feeding airway is occluded by the catheter and the opening and closing of a one-way valve coupled with the catheter is observed. If the valve ceases opening and closing over time, this may indicate that significant collateral ventilation into the target compartment is absent. If the valve continues to open and close over time, significant collateral ventilation into the compartment may be present. Based on the collateral ventilation assessment, a treatment plan may be generated.
摘要翻译：提供微创方法，系统和设备用于评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食气道来评估患者的肺内的目标隔室的旁路通气。进食气道被导管封闭，并且观察到与导管联接的单向阀的打开和关闭。如果阀门随时间停止打开和关闭，这可能表明不存在进入目标舱室的重大旁路通气。如果阀门随着时间的推移继续打开和关闭，则可能存在进入隔室的重大旁路通风。根据旁路通气评估，可能会产生治疗计划。

87. 发明授权

US08454527B2 Minimally invasive determination of collateral ventilation in lungs 有权
标题翻译：肺部旁路通气微创测定
公开(公告)号：US08454527B2
公开(公告)日：2013-06-04
申请号：US12972225
申请日：2010-12-17
申请人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
发明人： Nikolai Aljuri , Anthony Wondka , George Surjan , Kirk Davis , Peter Soltesz , Rodney C. Perkins
IPC分类号： A61B5/08
CPC分类号： A61B5/085 , A61B5/055 , A61B5/08 , A61B5/0813 , A61B5/087 , A61B5/4836 , A61B5/4851 , A61B5/6853 , A61B5/7278 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M2016/0413
摘要： Minimally invasive methods, systems and devices are provided for qualitatively and quantitatively assessing collateral ventilation in the lungs. In particular, collateral ventilation of a target compartment within a lung of a patient is assessed by advancement of a catheter through the tracheobronchial tree to a feeding bronchus of the target compartment. The feeding bronchus is occluded by the catheter and a variety of measurements are taken with the use of the catheter in a manner which is of low risk to the patient. Examples of such measurements include but are not limited to flow rate, volume and pressure. These measurements are used to determine the presence of collateral ventilation and to quantify such collateral ventilation.
摘要翻译：提供了微创方法，系统和装置，用于定性和定量评估肺中的旁路通气。特别地，通过将导管穿过气管支气管树推进到目标隔室的进食支气管来评估患者的肺内的目标隔室的侧支通气。供血支气管被导管阻塞，并且以对患者的风险低的方式使用导管进行各种测量。这种测量的实例包括但不限于流量，体积和压力。这些测量用于确定侧支通气的存在并量化此类旁路通气。

88. 发明授权

US08388682B2 Bronchial flow control devices and methods of use 有权
标题翻译：支气管流量控制装置及使用方法
公开(公告)号：US08388682B2
公开(公告)日：2013-03-05
申请号：US12820393
申请日：2010-06-22
申请人： Michael J. Hendricksen , Michael Barrett
发明人： Michael J. Hendricksen , Michael Barrett
IPC分类号： A61F2/20 , A62B9/00
CPC分类号： A61F2/04 , A61B17/12104 , A61B17/12172 , A61B17/12177 , A61F2002/043 , Y10T29/49826
摘要： Disclosed is an assembly for loading a bronchial flow control device into a container, such as into a delivery catheter. The assembly includes a funnel housing and a puller housing that mate with one another. The funnel housing defines a funnel-shaped loading cavity that receives a flow control device and that gradually reduces in size moving in a first direction. The puller housing is removably attached to the funnel housing and is also removably attachable to a bronchial flow control device that can be positioned in the loading cavity. The puller housing pulls the bronchial flow control device in the first direction through the funnel housing to gradually contract the bronchial flow control device into a compressed state of reduced size relative to the expanded size.
摘要翻译：公开了一种用于将支气管流量控制装置装载到诸如输送导管之类的容器中的组件。该组件包括一个漏斗壳体和一个相互配合的拔出器壳体。漏斗壳体限定漏斗形加载腔，其接纳流量控制装置，并逐渐减小尺寸沿第一方向移动。牵引器壳体可移除地附接到漏斗壳体，并且还可移除地附接到能够定位在加载腔中的支气管流量控制装置。牵引器壳体通过漏斗壳体沿着第一方向拉动支气管流量控制装置，以逐渐将支气管流量控制装置收缩成相对于膨胀尺寸减小尺寸的压缩状态。

89. 发明授权

US08357139B2 Methods and devices for use in performing pulmonary procedures 有权
公开(公告)号：US08357139B2
公开(公告)日：2013-01-22
申请号：US12264849
申请日：2008-11-04
申请人： Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
发明人： Mark E. Deem , Hanson S. Gifford, III , Ronald French , Douglas Sutton
IPC分类号： A61M31/00 , A61F2/20 , A61B1/12 , A62B9/02
CPC分类号： F16K15/147 , A61B17/12022 , A61B17/12104 , A61B17/12131 , A61B17/12172 , A61B17/221 , A61B2017/1205 , A61B2017/2215 , A61B2090/061 , A61F2/04 , A61F2/24 , A61F2/2403 , A61F2/2412 , A61F2/2418 , A61F2/91 , A61F2002/043 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , Y10S128/912
摘要： Systems, methods and devices for performing pulmonary procedures, and in particular treating lung disease. A flow control element includes a valve that prevents airflow in the inhalation direction but permits airflow in the exhalation direction. The flow control element is guided to and positioned at the site by a bronchoscope that is introduced into the patient's trachea and used to view the lungs during delivery of the flow control element. The valve may include one, two or more valve elements, and it may be collapsible for easier delivery. A source of vacuum or suction may be used to increase the amount of fluid withdrawn from the lung tissue. A device for measuring hollow structures, such as bronchioles, and a device for removing a previously-placed flow control element are disclosed as well.

90. 发明授权

US08136526B2 Methods and devices to induce controlled atelectasis and hypoxic pulmonary vasoconstriction 有权
标题翻译：诱导控制性肺不张和低氧性肺血管收缩的方法和装置
公开(公告)号：US08136526B2
公开(公告)日：2012-03-20
申请号：US11682986
申请日：2007-03-07
申请人： Rodney C. Perkins , Nikolai Aljuri , Ajit Nair
发明人： Rodney C. Perkins , Nikolai Aljuri , Ajit Nair
IPC分类号： A61M16/00
CPC分类号： A61F2/04 , A61B17/12104 , A61F2/95 , A61F2002/043 , A61F2002/068
摘要： Lung conditions are treated by implanting a flow restrictor in a passageway upstream from a diseased lung segment. The restrictor will create an orifice at the implantation site which inhibits air exchange with the segment to induce controlled atelectasis and/or hypoxia. Controlled atelectasis can induce collapse of the diseased segment with a reduced risk of pneumothorax. Hypoxia can promote gas exchange with non-isolated, healthy regions of the lung even in the absence of lung collapse.
摘要翻译：通过将流量限制器植入患病肺段上游的通道来治疗肺部疾病。限流器将在植入部位产生一个孔口，该孔口可抑制与该部分的空气交换以诱导受控的肺不张和/或缺氧。控制性肺不张可以诱发患病部位的塌陷，降低气胸风险。即使没有肺塌陷，缺氧也可以促进与非孤立，健康的肺部区域的气体交换。

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