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81. 发明授权

US10610326B2 Passive tags, and systems and methods for using them 有权
公开(公告)号：US10610326B2
公开(公告)日：2020-04-07
申请号：US14934019
申请日：2015-11-05
申请人： CIANNA MEDICAL, INC.
发明人： Nikolai Rulkov , Michael John Lopez , John E. Greene
IPC分类号： A61B90/00 , H01L23/60 , A61B90/98 , A61B5/06 , A61B34/20
CPC分类号： A61B90/39 , A61B5/064 , A61B90/04 , A61B90/37 , A61B90/98 , H01L23/60 , A61B5/062 , A61B2034/2051 , A61B2034/2072 , A61B2090/397 , A61B2090/3908 , A61B2090/3941 , A61B2090/3945 , A61B2090/3975 , A61B2090/3979 , A61B2090/3987 , H01L2224/48091 , H01L2224/48091 , H01L2924/00014
摘要： Markers, microwave probes, and related systems and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The marker includes an energy converter e.g., one or more photodiodes, for transforming energy pulses striking the marker into electrical energy, a switch, e.g., FET, coupled to the photodiodes such that light from a probe cause the switch to open and close. A pair of antenna wires are coupled to the switch to provide an antenna, the switch configured to open and close when light strikes the photodiodes to modulate signals from the probe reflected by the antenna back to the probe to identify the location of the marker. The marker also includes an electro static discharge (ESD) protection device coupled to the switch to provide protection against an electrostatic discharge event.

82. 发明授权

US09713437B2 Microwave antenna apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
公开(公告)号：US09713437B2
公开(公告)日：2017-07-25
申请号：US14165253
申请日：2014-01-27
申请人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
发明人： Larry W. Fullerton , John E. Greene , Tommy G. Nguyen , Eduardo Chi Sing
IPC分类号： A61B5/06 , A61B90/98 , A61B5/00 , A61B5/05 , A61B34/20 , A61B90/00
CPC分类号： A61B5/064 , A61B5/0507 , A61B5/4312 , A61B5/6847 , A61B90/39 , A61B2034/2048 , A61B2090/3908 , A61B2090/3925 , A61B2090/3966 , A61B2090/3975 , A61B2090/3987 , A61B2090/3991
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system includes a microwave antenna probe for transmitting and receiving electromagnetic signals to detect one or more markers that are implanted within or around the target tissue region. During use, the marker(s) are implanted into a target tissue region, and the microwave antenna probe is placed against the patient's skin to transmit a signal to the marker(s) and to receive the reflected signal from the marker(s) in order to determine the location of the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the location information from the microwave antenna probe.

83. 发明授权

US09386942B2 Apparatus, systems, and methods for localizing markers or tissue structures within a body 有权
标题翻译：用于在身体内定位标记物或组织结构的装置，系统和方法
公开(公告)号：US09386942B2
公开(公告)日：2016-07-12
申请号：US13053197
申请日：2011-03-21
申请人： Eduardo Chi Sing , Tommy G. Nguyen , Luis Urquidi
发明人： Eduardo Chi Sing , Tommy G. Nguyen , Luis Urquidi
IPC分类号： A61B6/12 , A61B5/06 , A61B5/05 , A61B5/00 , A61B8/08 , A61B19/00 , A61B17/00
CPC分类号： A61B90/39 , A61B5/0507 , A61B5/06 , A61B5/064 , A61B5/4312 , A61B8/0825 , A61B8/0841 , A61B8/481 , A61B10/0041 , A61B17/3468 , A61B90/37 , A61B2017/00438 , A61B2017/00442 , A61B2034/2051 , A61B2034/2072 , A61B2090/3908 , A61B2090/3925 , A61B2090/397 , A61B2090/3975 , A61B2090/3983 , A61B2090/3987
摘要： Apparatus, systems, and methods are provided for localizing lesions within a patient's body, e.g., within a breast. The system may include one or more markers implantable within or around the target tissue region, and a probe for transmitting and receiving electromagnetic signals to detect the one or more markers. During use, the marker(s) are into a target tissue region, and the probe is placed against the patient's skin to detect and localize the marker(s). A tissue specimen, including the lesion and the marker(s), is then removed from the target tissue region based at least in part on the localization information from the probe.
摘要翻译：提供了设备，系统和方法，用于定位患者身体内的损伤，例如在乳房内。系统可以包括可植入在目标组织区域内或周围的一个或多个标记，以及用于发送和接收电磁信号以检测一个或多个标记的探针。在使用期间，标记物进入目标组织区域，并将探针放置在患者皮肤上以检测和定位标记物。然后至少部分地基于来自探针的定位信息从靶组织区域中移除包括病变和标记物的组织标本。

84. 发明授权

US08858415B2 Brachytherapy apparatus and methods for using them 有权
标题翻译：近距离放射治疗仪及其使用方法
公开(公告)号：US08858415B2
公开(公告)日：2014-10-14
申请号：US12764892
申请日：2010-04-21
申请人： Eduardo Chi Sing , George D. Hermann , Mark A. Cole , Mark A. Richart , Than Nguyen , Gail S. Lebovic
发明人： Eduardo Chi Sing , George D. Hermann , Mark A. Cole , Mark A. Richart , Than Nguyen , Gail S. Lebovic
IPC分类号： A61M36/12 , A61N5/10
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。

85. 发明授权

US12048525B2 Impedance reflector detection systems and methods for using them 有权
公开(公告)号：US12048525B2
公开(公告)日：2024-07-30
申请号：US17805617
申请日：2022-06-06
申请人： Cianna Medical, Inc.
发明人： Nikolai Rulkov , John E. Greene
IPC分类号： A61B5/06 , A61B5/00 , A61B90/00 , A61B17/00 , A61B34/20 , A61B90/30
CPC分类号： A61B5/063 , A61B5/0093 , A61B5/064 , A61B90/39 , A61B2017/00867 , A61B2034/2051 , A61B2090/306 , A61B2090/309 , A61B2090/3908 , A61B2090/3966 , A61B2090/397 , A61B2090/3975 , A61B2090/3987
摘要： An impedance reflector apparatus, systems, and methods are provided for detecting a marker implanted within tissue that includes a switch for changing a configuration of an antenna of the marker. The apparatus includes a set of transmit electrodes coupled to a signal generator for transmitting a drive current into tissue to generate an electromagnetic field around the marker, a set of receive electrodes configured to detect voltage signals within the tissue corresponding to the electromagnetic field, and a light source for delivering light pulses into the body to open and close the switch to change the configuration of the antenna of the marker. A processor coupled to the receive electrodes processes the detected voltage signals to identify changes in the electromagnetic field that are synchronized with the light pulses to determine whether the marker is operating properly.

86. 发明申请

US20230098300A1 LOCALIZATION DEVICE, DELIVERY DEVICES, SYSTEMS AND METHODS 有权
公开(公告)号：US20230098300A1
公开(公告)日：2023-03-30
申请号：US17934285
申请日：2022-09-22
申请人： Cianna Medical, Inc.
发明人： David Gilstrap , Amber Velasco , Gregory R. McArthur , Matthew Bainsmith
IPC分类号： A61B34/20 , A61B10/02
摘要： Devices, systems, and methods used to deploy a localization device into a target lesion are disclosed. The system includes a delivery device configurable in a ready-to-deploy state and a deployed state. When the delivery device is in the ready-to-deploy state, biased engagement members are engaged with proximal detents of a handle of the delivery device. When the delivery device is in the deployed state, the biased engagement members are engaged with distal detents. The delivery device is transitioned from the ready-to-deploy state to the deployed state by distal displacement of a plunger relative to the handle. The localization device is deployed from a cannula of the delivery device into the target lesion when the delivery device transitions from the ready-to-deploy state to the deployed state.

87. 发明申请

US20220400976A1 SYSTEMS AND METHODS FOR IDENTIFYING AND LOCATING REFLECTORS USING ORTHOGONAL SEQUENCES OF REFLECTOR SWITCHING 有权
公开(公告)号：US20220400976A1
公开(公告)日：2022-12-22
申请号：US17810471
申请日：2022-07-01
申请人： Cianna Medical, Inc.
发明人： John E. Greene , Nikolai F. Rulkov
IPC分类号： A61B5/06 , A61B90/00 , H01L27/142 , A61B90/98
摘要： Systems and methods are provided for identifying and locating a plurality of reflector markers implanted within a target tissue region within a patient's body. A probe is provided that is activated to transmit electromagnetic signals into the patient's body, receive reflected signals from the patient's body, and in synchronization with transmitting the electromagnetic signals, deliver light pulses into the patient's body. The markers reflector tags modulate reflected signals from the respective markers based on orthogonal code sequences opening and closing respective switches of the markers to modulate the reflective properties of the markers. The probe processes the return signals to separate the reflected signals based at least in part on the code sequences to identify and locate each of the plurality of reflector tags substantially simultaneously.

88. 发明授权

US10201716B2 Brachytherapy apparatus and methods for using them 有权
公开(公告)号：US10201716B2
公开(公告)日：2019-02-12
申请号：US12982823
申请日：2010-12-30
申请人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
发明人： George D. Hermann , Eduardo Chi Sing , Gail S. Lebovic , Mark A. Cole , Mark A. Ritchart , Than Nguyen
IPC分类号： A61M36/12 , A61N5/10
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

89. 发明授权

US08771161B2 Expandable brachytherapy apparatus and methods for using them 有权
标题翻译：可扩展近距离放射治疗仪及其使用方法
公开(公告)号：US08771161B2
公开(公告)日：2014-07-08
申请号：US12642626
申请日：2009-12-18
申请人： Doug S. Sutton , George D. Hermann
发明人： Doug S. Sutton , George D. Hermann
IPC分类号： A61M36/00 , A61N5/10
CPC分类号： A61N5/1014 , A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways. The apparatus may include features to prevent overexpansion of the elongate members and/or to facilitate rapid collapse of the elongate members.
摘要翻译：用于将近距离放射治疗递送到目标组织区域的装置包括细长主体，其包括近端，远端，其尺寸适于引入到组织道中并且承载多个细长构件，包括用于接收辐射源的路径。细长构件可在折叠和膨胀构型之间移动。在使用期间，通过组织产生管道，并且携带细长构件的细长体通过管道前进到目标位置，细长构件处于收缩构型。细长构件在目标位置处被引导到扩展构型，并且例如通过沿着路径引入一个或多个辐射源，传送辐射以在目标位置处理组织。该装置可以包括防止细长构件的过度膨胀和/或促进细长构件的快速塌缩的特征。

90. 发明授权

US08517907B2 Expandable brachytherapy apparatus and methods for using them 有权
公开(公告)号：US08517907B2
公开(公告)日：2013-08-27
申请号：US12277286
申请日：2008-11-24
申请人： Eduardo Chi Sing , Tommy G. Nguyen , George D. Hermann , Than Nguyen , Doug S. Sutton
发明人： Eduardo Chi Sing , Tommy G. Nguyen , George D. Hermann , Than Nguyen , Doug S. Sutton
IPC分类号： A61M36/12
CPC分类号： A61N5/1015 , A61N2005/1018
摘要： Apparatus for delivering brachytherapy to a target tissue region includes an elongate body including a proximal end, a distal end sized for introduction into a tissue tract and carrying a plurality of elongate members including pathways for receiving a source of radiation. The elongate members are movable between collapsed and expanded configurations. During use, a tract is created through tissue, and the elongate body carrying the elongate members is advanced through the tract into a target location with the elongate members in the collapsed configuration. The elongate members are directed to the expanded configuration at the target location, and radiation is delivered to treat tissue at the target location, e.g., by introducing one or more radiation sources along the pathways.

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