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71. 发明申请

US20030202939A1 Methods for using annexin for detecting cell death in vivo and treating associated conditions 审中-公开
公开(公告)号：US20030202939A1
公开(公告)日：2003-10-30
申请号：US10408412
申请日：2003-04-07
申请人： Theseus Imaging Corporation
发明人： Allan M. Green
IPC分类号： A61K051/00 , A61K049/00 , C07K014/47 , C08B037/02 , C07F005/00
CPC分类号： A61K49/14 , A61K49/1863 , A61K49/1866 , A61K49/1869 , A61K51/1251
摘要： The present invention provides methods and compositions for imaging cell death in vivo, as well as methods and compositions for tumor radiotherapy.

72. 发明申请

US20030194373A1 Angiogenesis targeting molecules 审中-公开
标题翻译：血管生成靶向分子
公开(公告)号：US20030194373A1
公开(公告)日：2003-10-16
申请号：US10420205
申请日：2003-04-22
发明人： Theresa Fauconnier , Alfred Pollak , John Thornback , Dennis Eshima
IPC分类号： A61K051/00 , C07K005/06 , C07F005/00
CPC分类号： A61K51/08 , A61K51/088
摘要： The present invention relates to compounds that are effective for targeting sites of angiogenesis for diagnostic and therapeutic purposes. The compounds are of the Formula (I) A-(B)n-C, wherein A is a chelator moiety capable of complexing a radionuclide metal or a moiety capable of binding to a halogen; B is a spacer group; C is an angiogenesis targeting molecule; and n is selected from the integers 0 and 1. The invention also relates to a method of imaging sites of angiogenesis and treating patients through the administration of the compounds of the present invention.
摘要翻译：本发明涉及对于靶向用于诊断和治疗目的的血管生成位点有效的化合物。所述化合物具有式（I）A-（B）n-C，其中A是能够络合放射性核素金属或能够结合卤素的部分的螯合剂部分; B是间隔基; C是血管生成靶向分子; 并且n选自整数0和1.本发明还涉及通过施用本发明化合物对血管生成位点进行成像和治疗患者的方法。

73. 发明申请

US20030187252A1 Porphyrin compounds consisting of porphyrin rings fused in a single direction by three bonds, i.e., one meso-meso carbon bond and two beta-beta carbon bonds and process for their synthesis 失效
标题翻译：由卟啉环组成的卟啉化合物在单一方向上通过三个键融合，即一个内消旋碳键和两个β-β碳键以及它们的合成方法
公开(公告)号：US20030187252A1
公开(公告)日：2003-10-02
申请号：US10343920
申请日：2003-02-06
发明人： Atsuhiro Osuka
IPC分类号： C07F005/00 , C07D487/22
CPC分类号： C07D487/22
摘要： A porphyrin ring-fusion polymer which consists of two or more Zn(II)-porphyrin rings fused in a single direction and in which any two porphyrin rings adjacent to each other are fused by three covalent bonds, that is, one meso-meso carbon bond (i.e., one bond between meso-position carbon atoms) and two null-null carbon bonds (i.e., two bonds between null-position carbon atoms adjacent to the meso-position carbon atoms); a process for preparing the porphyrin ring-fusion polymer regioselectively by conducing the fusion reaction in an aromatic hydrocarbon solvent in the presence of a quinoline and Lewis acid containing rare earth element under reflux; and fused-ring porphyrin compound obtained by subjecting the porphyrin ring-fusion polymer to demetallization or replacement of the Zn atoms by other metal atoms.
摘要翻译：由两个或更多个在单一方向融合的Zn（II） - 卟啉环组成的卟啉环融合聚合物，其中任何两个彼此相邻的卟啉环通过三个共价键，即一个内消旋碳键（即中间位置碳原子之间的一个键）和两个β-β碳键（即与内消旋碳原子相邻的β-位置碳原子之间的两个键）; 在含有稀土元素的喹啉和路易斯酸回流的存在下，通过在芳烃溶剂中进行熔融反应来定向选择性地制备卟啉环聚合聚合物的方法; 和通过使卟啉环融合聚合物通过其它金属原子脱金属或取代Zn原子得到的稠环卟啉化合物。

74. 发明申请

US20030181745A1 Organoindium compounds 失效
标题翻译：有机化合物
公开(公告)号：US20030181745A1
公开(公告)日：2003-09-25
申请号：US10346585
申请日：2003-01-17
申请人： Shipley Company, L.L.C.
发明人： Deodatta Vinayak Shenai-Khatkhate , Ronald L. DiCarlo JR.
IPC分类号： B05D005/12 , C07F005/00
CPC分类号： C23C16/301 , C07F5/00 , C07F5/06
摘要： Disclosed are trialkylindium compounds containing two bulky alkyl groups that are liquids or easily liquefiable solids and have sufficient vapor pressure for use in vapor deposition processes, as well as methods of depositing indium containing films using such compounds.
摘要翻译：公开了含有两个体积大的烷基的三烷基鎓化合物，其是液体或易于液化的固体，并且具有用于气相沉积工艺的足够的蒸气压，以及使用这种化合物沉积含铟膜的方法。

75. 发明申请

US20030180222A1 Peptide-based multimeric targeted contrast agents 审中-公开
标题翻译：基于肽的多聚体靶向造影剂
公开(公告)号：US20030180222A1
公开(公告)日：2003-09-25
申请号：US10209183
申请日：2002-07-30
发明人： Zhaoda Zhang , John C. Amedio , Peter D. Caravan , Stephane Dumas , Andrew Kolodziej , Thomas J. McMurry
IPC分类号： A61K051/00 , A61K049/00 , C07K014/435 , C07F005/00
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
摘要翻译：描述了肽和肽靶向多聚体造影剂，以及制造和使用造影剂的方法。

76. 发明申请

US20030099598A1 Tissue specific fluorescent chelates possessing long wavelength UV excitation 失效
标题翻译：具有长波长紫外线激发的组织特异性荧光螯合物
公开(公告)号：US20030099598A1
公开(公告)日：2003-05-29
申请号：US10278584
申请日：2002-10-22
发明人： Gary E. Kiefer , Darryl J. Bornhop
IPC分类号： A61K049/00 , C07F005/00
CPC分类号： A61K49/0019 , A61K49/0002 , C07F9/6524 , C07F9/65583 , C07F9/6561
摘要： Fluorescent chelates of lanthanide, terbium, europium and dysprosium with tetraazamacrocyclic compounds are discussed which can be used as fluorescent in vitro or in vivo diagnostic agents. These chelates are tissue specific imaging agents for soft tissue cancers.
摘要翻译：讨论了可以用作荧光体外或体内诊断剂的镧系元素，铽，铕和镝与四氮杂环化合物的荧光螯合物。这些螯合物是用于软组织癌的组织特异性成像剂。

77. 发明申请

US20030053954A1 Magnetic resonance imaging agents for the detection of physiological agents 失效
标题翻译：用于检测生理剂的磁共振成像剂
公开(公告)号：US20030053954A1
公开(公告)日：2003-03-20
申请号：US09866512
申请日：2001-05-24
发明人： Thomas J. Meade , Scott Fraser
IPC分类号： A61K049/00 , C07F005/00
CPC分类号： A61K49/085 , A61K49/10 , A61K49/103 , A61K49/106 , A61K49/122 , A61K49/128 , A61K49/14 , A61K49/146
摘要： The invention relates to novel magnetic resonance imaging contrast agents and methods of detecting physiological signals or substances.
摘要翻译：本发明涉及新型磁共振成像造影剂和检测生理信号或物质的方法。

78. 发明申请

US20030051989A1 Method to liberate hydrocarbon fractions from hydrocarbon mixtures 审中-公开
$Method to liberate hydrocarbon fractions from hydrocarbon mixtures$
标题翻译：从烃混合物中释放烃馏分的方法
公开(公告)号：US20030051989A1
公开(公告)日：2003-03-20
申请号：US10174304
申请日：2002-06-17
申请人： Petronetics, LLC.
发明人： Douglas P. Austin
IPC分类号： C07C001/00 , C07C002/00 , C07C004/00 , C07C005/00 , C07C006/00 , C07F001/00 , C07F003/00 , C07F005/00 , C07B031/00
CPC分类号： B01J19/10 , B01J19/008 , B01J2219/0877 , C10G15/08 , C10G32/02 , C10G2300/107 , C10G2400/06
摘要： A method of liberating various existing hydrocarbon fractions from hydrocarbon mixtures without the need of additives, catalysts or heating using ultrasonic cavitation. Ultrasonic energy is provided at a rate sufficient to induce cavitation in the hydrocarbon mixture without causing cracking. The high temperatures and high pressures resulting from cavitation reduce intermolecular forces between hydrocarbons thereby liberating existing lighter hydrocarbons in the diesel range or lighter for recovery via more traditional separation technologies. The resulting upgraded petroleum product exhibits lower distillation curves and decreased pollution causing components. Further, a wide variety of feedstocks can be treated according to the method of this invention.
摘要翻译：一种从烃混合物中释放各种现有烃馏分而不需要添加剂，催化剂或使用超声波空化加热的方法。以足以在烃混合物中引起空化而不引起开裂的速率提供超声波能量。由气穴引起的高温和高压降低了烃之间的分子间力，从而释放柴油范围内的现有轻质烃或更轻，以便通过更传统的分离技术进行回收。所得到的升级后的石油产品显示较低的蒸馏曲线，并减少污染造成的成分。此外，可以根据本发明的方法处理各种各样的原料。

79. 发明申请

US20030027302A1 Bifunctional chelating agent 失效
标题翻译：双功能螯合剂
公开(公告)号：US20030027302A1
公开(公告)日：2003-02-06
申请号：US10204905
申请日：2002-08-26
发明人： Ali Ouadi , Jean-Francois Gestin , Christos Apostolidis
IPC分类号： C12N009/00 , C07J043/00 , C07F005/00 , C07K016/46
CPC分类号： C07F9/6524 , C07D259/00
摘要： The invention concerns a ligand comprising wherein n is an integer from 1 to 5, X represents nullNO2, nullNH2, nullNCS, nullNHCOCH2-Z. NHCOnullWnullCOCNHS, nullNH-Q, nullNHCS-Q, nullNHCOCH2-Q, or nullNHCO(CH2)nullm null-Q where Q is an hapten chosen from the group consisting of steroids, enzymes, proteins, monoclonal antibodies, chimeric antibodies, or fragments thereof or any activated linker ready for coupling reaction, Y is CO2H or PO3H2 W is null(CH2)mnull m is an integer from 1 to 10. Z is chloride, bromide or iodine. 1
摘要翻译：本发明涉及一种配体，其中n为1至5的整数，X表示-NO 2，-NH 2，-NCS，-NHCOCH 2 -Z。 NHCO-W-COCNHS，-NH-Q，-NHCS-Q，-NHCOCH2-Q或-NHCO（CH2）2 m -Q其中Q是选自类固醇，酶，蛋白质，单克隆抗体抗体，嵌合抗体或其片段或任何活化的接头准备好进行偶联反应，Y是CO 2 H或PO 3 H 2 W是 - （CH 2）m-m是1至10的整数.Z是氯，溴或碘。

80. 发明申请

US20030013859A1 CHELATING COMPOUNDS, THEIR COMPLEXES WITH PARAMAGNETIC METALS 失效
标题翻译：化学化合物，它们与配体金属的复合物
公开(公告)号：US20030013859A1
公开(公告)日：2003-01-16
申请号：US09913711
申请日：2001-09-24
发明人： Maurizio Franzini , Andrea Beltrami , Luisella Calabi , Alessandro Maiocchi , Mario Virtuani , Pier Lucio Anelli , Kondareddiar Ramalingam , Ramachandran S. Ranganathan
IPC分类号： C07F015/02 , C07F005/00
CPC分类号： A61K49/10 , A61K49/0438 , A61K49/085 , A61K49/103 , C07F9/3808 , C07F9/5728 , C07J51/00 , Y10S977/93
摘要： Compounds able to chelate bi- and trivalent paramagnetic metal ions, their chelated complexes with said metal ions and the physiologically compatible salts thereof, as well as the use thereof as contrast agents in the technique known as nullMagnetic Resonance Imagingnull (M.R.I.).
摘要翻译：能够螯合双和三价顺磁金属离子的螯合物，它们与所述金属离子的螯合络合物及其生理上相容的盐，以及其在称为“磁共振成像”（M.R.I.）的技术中作为造影剂的用途。

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