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71. 发明专利

JPS5152191A 7 ARUFUA METOKISHISEFUEMUKAGOBUTSUNO SEIHO 失效
公开(公告)号：JPS5152191A
公开(公告)日：1976-05-08
申请号：JP12281874
申请日：1974-10-24
申请人： SANKYO CO
发明人： SHIMIZU BUNJI , SAITO AKIO , KANEKO MASAKATSU
IPC分类号： C07D501/57 , A61K31/545 , C07D501/04 , C07D501/28 , C07D501/36 , C07D501/40

72. 发明专利

JPS4924993A 失效
公开(公告)号：JPS4924993A
公开(公告)日：1974-03-05
申请号：JP6463072
申请日：1972-06-27
IPC分类号： C07D501/36 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/40

73. 发明专利

JPS49284A 失效
公开(公告)号：JPS49284A
公开(公告)日：1974-01-05
申请号：JP2791073
申请日：1973-03-09
IPC分类号： C07D501/04 , A61K31/545 , C07D20060101 , C07D501/12 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/40 , C12P35/06

74. 发明授权

US07847093B2 Processes for the preparations of cefepime 失效
标题翻译：头孢吡肟制剂工艺
公开(公告)号：US07847093B2
公开(公告)日：2010-12-07
申请号：US10552858
申请日：2004-04-15
申请人： Johannes Ludescher , Hubert Sturm , Siegfried Wolf
发明人： Johannes Ludescher , Hubert Sturm , Siegfried Wolf
IPC分类号： C07D501/46 , C07D501/40
CPC分类号： C07D501/06 , C07D501/40 , C07D513/04
摘要： This invention provides processes for preparing cefepime, including crystalline intermediates of Formula V.
摘要翻译：本发明提供了头孢吡肟制备方法，包括式Ⅴ的结晶中间体。

75. 发明授权

US5559108A Cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物
公开(公告)号：US5559108A
公开(公告)日：1996-09-24
申请号：US445628
申请日：1995-05-22
申请人： Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco, Jr. , John A. Wichtowski , Joanne J. Bronson , Stanley V. D'Andrea , Thomas W. Hudyma
发明人： Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco, Jr. , John A. Wichtowski , Joanne J. Bronson , Stanley V. D'Andrea , Thomas W. Hudyma
IPC分类号： C07D501/40 , A61K31/545 , A61K31/546 , A61P31/04 , C07D501/00 , C07D501/44 , C07D501/46 , C07D501/38
CPC分类号： C07D501/00
摘要： Novel cephem derivatives represented by the general formula ##STR1## in which the Acyl substituent is a group of the formula ##STR2## where Ar is a substituted phenyl or optionally substituted naphthyl or benzthiazolyl group and A is a substituted-pyridinium group are gram-positive antibiotics, especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.
摘要翻译：由通式“IMAGE”表示的新型头孢烯衍生物，其中酰基取代基是式IMAMA的基团，其中Ar是取代的苯基或任选被取代的萘基或苯并噻唑基，A是取代的吡啶鎓基是革兰氏阳性抗生素，特别适用于治疗由耐甲氧西林金黄色葡萄球菌引起的疾病。

76. 发明授权

US5019570A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US5019570A
公开(公告)日：1991-05-28
申请号：US223988
申请日：1988-07-25
申请人： Jean C. Arnould , Dominique Boucherot , David H. Davies , Frederick H. Jung , Colin J. Strawson
发明人： Jean C. Arnould , Dominique Boucherot , David H. Davies , Frederick H. Jung , Colin J. Strawson
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D209/04 , C07D209/42 , C07D215/22 , C07D215/48 , C07D215/54 , C07D215/56 , C07D217/22 , C07D217/26 , C07D237/28 , C07D239/28 , C07D239/72 , C07D239/74 , C07D239/80 , C07D239/88 , C07D239/90 , C07D241/00 , C07D241/44 , C07D251/54 , C07D311/04 , C07D311/08 , C07D311/18 , C07D311/22 , C07D311/76 , C07D471/00 , C07D501/00 , C07D501/04 , C07D501/24 , C07D501/38 , C07D501/40 , C07D501/46 , C07D501/48 , C07D501/56 , C07D501/57
CPC分类号： C07D501/46 , C07D501/40
摘要： Cephalosporin derivatives having a 3-position substituent of the formula I are described: ##STR1## wherein R.sup.1 is hydrogen, alkenyl or optionally substituted alkyl, Het us a 5- or 6-membered heterocyclic ring bonded via a carbon atom to the amide linkage, wherein Het is selected from a group of the formulae II-III: ##STR2## wherein A is CH or a nitrogen atom; B is oxygen, sulphur or a group NR.sup.4 ; one or two of D, E, F and G are nitrogen atoms and the remainder are CH groups: or Het is a pyrazinone, pyridinone, pyridazinone or pyrimidinone ring, or is a thione equivalent of such a ring, said rings having a substituent R.sup.4 on one nitrogen atom, or is pyranone, or pyranthione; the ring Het being fused by any adjacent carbon atoms to the benzene ring; and Het being attached to the --CH.sub.2 NR.sup.1 CO-- group via a carbon atom;R.sup.2 is hydroxy or an in vivo hydrolyzable ester thereof;R.sup.3 is ortho to R.sup.2 and is hydroxy or an in vivo hydrolyzable ester thereof; and R.sup.4 has various values. The use of such compounds as antibacterial agents is described as are processes for their preparation and intermediates therefor.

77. 发明授权

US4960766A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4960766A
公开(公告)日：1990-10-02
申请号：US930427
申请日：1986-11-14
申请人： Takao Takaya , Kazuo Sakane , Kenzi Miyai , Kohji Kawabata
发明人： Takao Takaya , Kazuo Sakane , Kenzi Miyai , Kohji Kawabata
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D231/12 , C07D277/28 , C07D501/00 , C07D501/18 , C07D501/36 , C07D501/40 , C07D501/46 , C07D501/56
CPC分类号： C07D501/46 , Y02P20/55
摘要： The invention relates to cephem compounds characterized by a substituted 2-pyrazoliomethyl group and a 7-(aminothiazolyl)(alkoxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infections diseases.
摘要翻译：本发明涉及特征为取代的2-吡唑基甲基和7-（氨基噻唑基）（烷氧基亚氨基） - 乙酰胺基及其某些衍生物的头孢烯化合物，其包含该化合物并用于治疗感染性疾病。

78. 发明授权

US4667027A Cephem compounds and their production 失效
标题翻译：头孢烯化合物及其生产
公开(公告)号：US4667027A
公开(公告)日：1987-05-19
申请号：US681783
申请日：1984-12-14
申请人： Setsuo Harada , Yukimasa Nozaki , Hideo Ono
发明人： Setsuo Harada , Yukimasa Nozaki , Hideo Ono
IPC分类号： C07D501/28 , C07D501/57 , C12P35/06 , C12P35/08 , A61K31/545 , C07D501/40
CPC分类号： C12P35/06 , C12P35/08
摘要： A compound of the formula: ##STR1## wherein R.sup.1 stands for hydrogen or formylamino, R.sup.2 is a residue of amino acid selected from the group consisting of serine and alanine, or a peptide of at least one of these amino acids, or hydrogen, R.sup.3 stands for --NH--C(.dbd.NH)--NH.sub.2 or --CH.sub.2 NH.sub.2, or its salt, which can be produced by cultivating a microorganism belonging to the genus Xanthomonas, is useful as a therapeutic agent against infectious disease caused by bacteria.
摘要翻译：下式的化合物：其中R1代表氢或甲酰氨基，R2是选自丝氨酸和丙氨酸的氨基酸残基，或这些氨基酸中的至少一个的肽或氢，R3 代表通过培养属于黄单胞菌属的微生物产生的-NH-C（= NH）-NH 2或-CH 2 NH 2或其盐可用作抗细菌感染性疾病的治疗剂。

79. 发明授权

US4563523A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4563523A
公开(公告)日：1986-01-07
申请号：US399328
申请日：1982-07-19
申请人： Gordon C. D. Smith
发明人： Gordon C. D. Smith
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/18 , C07D501/38 , C07D501/40 , C07D501/44 , C07D501/46
CPC分类号： C07D501/18 , C07D501/40
摘要： The invention relates to the novel compound (6R,7R)-7-(D-5-benzamido-5-carboxypentanamido)-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylate and salts thereof, which may be prepared in substantially pure form. The novel compounds are useful for the preparation of (6R,7R)-7-amino-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylate or salts thereof, which are themselves useful for the preparation of 7-substituted 3-pyridiniummethyl cephalosporin antibiotics such as ceftazidime and cephaloridine.
摘要翻译：本发明涉及新化合物（6R，7R）-7-（D-5-苯甲酰氨基-5-羧戊酸酰胺基）-3-（1-吡啶鎓甲基） - 头孢-3-烯-4-羧酸酯及其盐，以基本纯净的形式准备。新化合物可用于制备（6R，7R）-7-氨基-3-（1-吡啶鎓甲基）头孢-3-烯-4-羧酸盐或其盐，它们本身可用于制备7-取代的 3-吡啶鎓甲基头孢菌素类抗生素如头孢他啶和头孢哌啶。

80. 发明授权

US4168309A Cephalosporins having a 7-(carboxy substituted .alpha.-etherified oximinoarylacetamido) group 失效
标题翻译：头孢菌素具有7-（羧基取代的{60-乙酰肟基芳基乙酰胺基）基团
公开(公告)号：US4168309A
公开(公告)日：1979-09-18
申请号：US838366
申请日：1977-09-30
申请人： Barry E. Ayres
发明人： Barry E. Ayres
IPC分类号： C07D501/44 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D501/38 , C07D501/40 , C07D501/46 , C07D501/60
CPC分类号： C07D501/38
摘要： Antibiotic compounds of the general formula ##STR1## [wherein R is a phenyl, thienyl or furyl group; R.sup.a and R.sup.b which may be the same or different, are each selected from hydrogen, C.sub.1-4 alkyl, C.sub.2-4 alkenyl, C.sub.3-7 cycloalkyl, phenyl, naphthyl, thienyl, furyl, carboxy, C.sub.2-5 alkoxycarbonyl and cyano, or R.sup.a and R.sup.b together with the carbon atom to which they are attached form a C.sub.3-7 cycloalkylidene or cycloalkenylidene group; m or n are each 0 or 1 such that the sum of m and n is 0 or 1; and R.sup.1 together with the nitrogen atom to which it is attached form a saturated or partially saturated 4-10 membered heterocyclic ring which may contain one or more further heteroatoms selected from 0,N and S and which may be substituted by a lower alkyl, lower alkoxy, lower acyloxy, lower alkoxycarbonyl, hydroxy, carboxy, amino, acylamino, substituted or unsubstituted carbamoyl or aryl group, or such a heterocyclic ring fused with a benzene ring] and non-toxic derivatives thereof, the compounds being syn isomers or existing as mixtures of syn and anti isomers.
摘要翻译：通式（I）的抗生素化合物[其中R是苯基，噻吩基或呋喃基; R a和R b可以相同或不同，各自选自氢，C 1-4烷基，C 2-4烯基，C 3-7环烷基，苯基，萘基，噻吩基，呋喃基，羧基，C 2-5烷氧基羰基和氰基，或 R a和R b与它们所连接的碳原子一起形成C 3-7亚环烷基或亚环烯基; m或n各自为0或1，使得m和n的和为0或1; 并且R 1与其连接的氮原子一起形成饱和或部分饱和的4-10元杂环，其可以含有一个或多个另外的选自O，N和S的杂原子，并且其可以被低级烷基取代，低级烷基烷氧基，低级酰氧基，低级烷氧基羰基，羟基，羧基，氨基，酰氨基，取代或未取代的氨基甲酰基或芳基，或与苯环稠合的杂环]及其无毒衍生物，所述化合物为顺式异构体或存在顺式和反式异构体的混合物。

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