专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明申请

WO00037025A2 ANTIBODIES TO TRUNCATED VEGF-D AND USES THEREOF 审中-公开
标题翻译：阻断VEGF-D的抗体及其用途
公开(公告)号：WO00037025A2
公开(公告)日：2000-06-29
申请号：PCT/US1999/031332
申请日：1999-12-21
IPC分类号： G01N33/53 , A61K39/00 , A61K39/395 , A61P9/00 , A61P11/00 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P41/00 , A61P43/00 , C07K16/18 , C07K16/24 , C12N5/10 , C12N15/02 , C12P21/08 , G01N33/577 , A61K
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/50 , Y10S435/81 , Y10S530/809
摘要： The invention is based on the isolation of antibodies that were made to a polypeptide having the amino acid sequence for a truncated VEGF-D. One of these antibodies can interfere with the activity of VEGF-D mediated by VEGFR-2 and interfere with the binding of VEGF-D to VEGFR-3 but does not interfere with the activity of VEGF mediated by VEGFR-2 or bind to VEGF-C. The invention provides pharmaceutical and diagnostic compositions and methods utilizing these antibodies.
摘要翻译：本发明基于对具有截短的VEGF-D的氨基酸序列的多肽的抗体的分离。这些抗体中的一种可以干扰VEGFR-2介导的VEGF-D的活性，并干扰VEGF-D与VEGFR-3的结合，但不影响VEGFR-2介导的VEGF的活性或与VEGF- C。本发明提供使用这些抗体的药物和诊断组合物和方法。

72. 发明申请

WO99015691A1 METHOD FOR DIAGNOSING BONE DYSBOLISM 审中-公开
标题翻译：诊断骨质疏松的方法
公开(公告)号：WO99015691A1
公开(公告)日：1999-04-01
申请号：PCT/JP1998/003421
申请日：1998-07-31
IPC分类号： G01N33/53 , C07K16/24 , C12P21/08 , G01N33/68
CPC分类号： C07K16/24 , G01N33/6893 , G01N2800/108 , Y10S436/811 , Y10S530/809
摘要： A method for diagnosing bone dysbolism, in particular osteoporisis and joint diseases characterized by measuring the concentration of osteoclastogenesis inhibitory factors (OCIFs) in the bodily fluid; a monoclonal antibody equally recognizing monomeric and dimeric OCIFs; a monoclonal antibody selectively recognizing the dimeric OCIF alone; and OCIF assay kits which contain the monoclonal antibodies of the above two types, recognizing different epitopes of OCIFs, and having a high affinity and a dissociation constant with an antigen of 2 x 10 M or below. The above antibodies and kits are useful in diagnosing bone dysbolism, in particular, osteoporosis and joint diseases or analytical reagents for laboratory use, etc.
摘要翻译：一种诊断骨质疏松症，特别是骨质疏松症和关节疾病的方法，其特征在于测量体液中破骨细胞发生抑制因子（OCIF）的浓度; 同样识别单体和二聚OCIF的单克隆抗体; 选择性识别二聚OCIF的单克隆抗体; 和OCIF测定试剂盒，其含有上述两种类型的单克隆抗体，识别OCIF的不同表位，并且具有2×10 -7或更低的抗原的高亲和力和解离常数。上述抗体和试剂盒可用于诊断骨质疏松症，特别是骨质疏松症和关节疾病或实验室用分析试剂等。

73. 发明申请

WO1996034099A2 GENETIC SEQUENCES AND PROTEINS RELATED TO ALZHEIMER'S DISEASE, AND USES THEREFOR 审中-公开
标题翻译：与阿尔茨海默病相关的遗传序列和蛋白质及其用途
公开(公告)号：WO1996034099A2
公开(公告)日：1996-10-31
申请号：PCT/CA1996000263
申请日：1996-04-29
申请人： HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO , ST. GEORGE-HYSLOP, Peter, H. , FRASER, Paul, E. , ROMMENS, Johanna, M.
发明人： HSC RESEARCH AND DEVELOPMENT LIMITED PARTNERSHIP , THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
IPC分类号： C12N15/12
CPC分类号： C12N15/8509 , A01K67/0275 , A01K67/0278 , A01K67/0336 , A01K67/0339 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0312 , A61K38/00 , A61K48/00 , C07K14/4711 , C07K16/28 , C12N2799/021 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S530/809
摘要： The present invention describes the identification, isolation, sequencing and characterization of two human presenilin genes, PS-1 and PS-2, mutations which lead to Familial Alzheimer's Disease. Also identified are presenilin gene homologues in mice, C. elegans and D. melanogaster. Nucleic acids and proteins comprising or derived from the presenilins are useful in screening and diagnosing Alzheimer's Disease, in identifying and developing therapeutics for treatment of Alzheimer's Disease, and in producing cell lines and transgenic animals useful as models of Alzheimer's Disease.
摘要翻译：本发明描述了两种人类早老蛋白基因PS-1和PS-2的识别，分离，测序和表征，导致家族性阿尔茨海默病的突变。还鉴定了小鼠，秀丽隐杆线虫和黑腹果蝇中的早老素基因同系物。包含或衍生自前列环素的核酸和蛋白质可用于筛选和诊断阿尔茨海默氏病，鉴定和开发用于治疗阿尔茨海默病的治疗剂，以及用于产生用作阿尔茨海默病模型的细胞系和转基因动物。

74. 发明申请

WO1990003574A1 HIGH AFFINITY MONOCLONAL ANTIBODIES TO BOWMAN-BIRK INHIBITOR AND IMMUNOASSAY METHODS 审中-公开
标题翻译：对BAMMAN-BIRK抑制剂和免疫测定方法的高亲和力单克隆抗体
公开(公告)号：WO1990003574A1
公开(公告)日：1990-04-05
申请号：PCT/US1989003974
申请日：1989-09-19
申请人： THE UNITED STATES OF AMERICA, as represented by ...
发明人： THE UNITED STATES OF AMERICA, as represented by ... , BRANDON, David, L. , BATES, Anne, H. , FRIEDMAN, Mendel
IPC分类号： G01N33/53
CPC分类号： C07K16/38 , Y10S530/808 , Y10S530/809
摘要： Hybrid cell lines (hybridomas) which produce and secrete high affinity monoclonal antibodies specific for Bowman-Birk inhibitor (BBI) are described. High affinity antibodies to BBI are described that have one or more of the following additional characteristics: (1) they are specific to the active form of BBI, that is, they react and bind with undenatured BBI, but do not bind with BBI which has been denatured by heat or disulfide exchange; (2) they do not react and bind with KTI; (3) they distinguish classical BBI from other BBI's including lima bean protease inhibitor; and (4) they bind BBI-protease complex, e.g., BBI-chymotrypsin. Immunoassay methods using the monoclonal antibodies to analyze BBI specifically in plant, animal or human tissue or fluid or foodstuffs and techniques for immunoaffinity binding of BBI are described.

75. 发明申请

WO1988004302A1 MONOCLONAL ANTIBODIES TO A PAN-MALARIAL ANTIGEN 审中-公开
标题翻译：单克隆抗体针对疟原虫的抗原
公开(公告)号：WO1988004302A1
公开(公告)日：1988-06-16
申请号：PCT/US1987003252
申请日：1987-12-08
申请人： GEORGETOWN UNIVERSITY
发明人： GEORGETOWN UNIVERSITY , TAYLOR, Diana, Wallace
IPC分类号： C07K15/00
CPC分类号： C07K16/205 , A61K38/00 , A61K39/00 , A61K47/6835 , A61K47/6873 , C07K14/445 , C07K16/425 , G01N33/56905 , G01N33/686 , Y02A50/412 , Y10S530/808 , Y10S530/809 , Y10S530/864
摘要： A continuous hybridoma cell line, designated 7H8, which secretes a monoclonal antibody (MAb 7H8) of the IgM class and which binds to a protein present in species of the genus Plasmodium. MAb 7H8 also recognizes an antigen (antigen Pf93) unique to P. falciparum. Methods of isolating the substantially pure antigen using the antibody of the present invention are disclosed. MAb 7H8 is well suited for use in immunometric assays. Preferred is a two-sited assay developed with MAb 7H8. Anti-idiotypic and anti anti-idiotypic antibodies to MAb 7H8 are disclosed. The antibodies and antigens of the present invention are useful for immunodiagnostic and immunotherapeutic treatment of malarial diseases of man and animals.

76. 发明申请

WO1987005031A1 DIAGNOSTIC AND THERAPEUTIC ANTIBODY CONJUGATES 审中-公开
标题翻译：诊断与治疗抗体结合
公开(公告)号：WO1987005031A1
公开(公告)日：1987-08-27
申请号：PCT/US1987000406
申请日：1987-02-25
申请人： CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY , SHIH, Lisa, B. , PRIMUS, F., James , GOLDENBERG, M., David
发明人： CENTER FOR MOLECULAR MEDICINE AND IMMUNOLOGY
IPC分类号： C07K15/00
CPC分类号： A61K49/16 , A61K47/6883 , A61K49/085 , A61K49/128 , A61K51/1093 , A61K2123/00 , Y10S530/809
摘要： Conjugates of diagnostic or therapeutic principles, such as drugs, toxins, chelators, boron compounds and detectable labels, to an antibody, in which the diagnostic or therapeutic principle is first loaded onto a polymer carrier such as an aminodextran or a polypeptide of at least 50 amino acids in length, and this intermediate is in turn site-specifically conjugated to a targeting antibody such as an antitumor antibody. The resultant conjugate substantially retains the immunoreactivity of the antibody, and targets the diagnostic or therapeutic principle to a target tissue or organ where the diagnostic or therapeutic effect is realized.
摘要翻译：诊断或治疗原则（例如药物，毒素，螯合剂，硼化合物和可检测标记）与抗体的缀合物，其中诊断或治疗原理首先加载到聚合物载体如氨基葡聚糖或多至少50个长度的氨基酸，并且该中间体又与靶向抗体如抗肿瘤抗体位点特异性缀合。所得到的缀合物基本上保留抗体的免疫反应性，并将诊断或治疗原理靶向实现诊断或治疗效果的靶组织或器官。

77. 发明申请

WO1987004183A1 MURINE HYBRIDOMA AND DIAGNOSTIC ANTIBODY PRODUCED THEREBY 审中-公开
标题翻译： MURINE HYBRIDOMA AND DIAGNOSTIC ANTIBODY PRODUCVER THEREBY
公开(公告)号：WO1987004183A1
公开(公告)日：1987-07-16
申请号：PCT/US1986002835
申请日：1986-12-31
申请人： NORTHWESTERN UNIVERSITY
发明人： NORTHWESTERN UNIVERSITY , RADOSEVICH, James, A. , ROSEN, Steven, T. , MA, Yixing
IPC分类号： C12N05/00
CPC分类号： G01N33/57423 , G01N33/57492 , Y10S436/813 , Y10S530/808 , Y10S530/809
摘要： L'hybridome HB 8986 produit un anticorps monoclonal de souris qui reconnaît un nouveau déterminant exprimé dans des carcinomes bronchopulmonaires et dans des tumeurs dérivées de lignées de cellules A549. La coloration par immunoperoxydase avec l'hybridome de tissus enfermés dans de la paraffine et conservés dans du formol montre qu'il colore spécifiquement les surfaces cytoplasmique et cellulaire. L'anticorps monoclonal peut distinguer de préférence des carcinomes bronchopulmonaires ayant des différences glandulaires par rapport à d'autres carcinomes bronchopulmonaires. En outre, l'anticorps monoclonal peut identifier des adenocarcinomes dans tout le corps.

78. 发明申请

WO1986001517A1 HERPES VIRUS SPECIFIC IMMUNOLOGICAL MATERIALS AND METHODS 审中-公开
标题翻译： HERPES病毒特异性免疫材料和方法
公开(公告)号：WO1986001517A1
公开(公告)日：1986-03-13
申请号：PCT/US1985001481
申请日：1985-08-05
申请人： UNIVERSITY PATENTS, INC.
发明人： UNIVERSITY PATENTS, INC. , COHEN, Gary, H. , EISENBERG, Roselyn, J.
IPC分类号： C07K15/04
CPC分类号： C07K16/087 , C07K14/005 , C12N2710/16622 , Y10S435/948 , Y10S530/808 , Y10S530/809 , Y10S530/81 , Y10S530/811 , Y10S930/224
摘要： Antibody substances displaying unique, multi-specific immunoreactivities with respect to glycoprotein D of Herpes Simplex Virus types 1 and 2 (HSV gD-1 and gD-2) and structurally related compounds. Illustratively, an IgG Type 2 monoclonal antibody material produced by mouse-mouse hybridoma cell line A.T.C.C. No. HB8606 is capable of in vitro neutralization of HSV-1 and HSV-2 infectivity and of specific immunological reactivity and reversible immunobinding with naturally-occurring and recombinant gD-1 and gD-2 in both native and denatured conformations as well as with proteinaceous materials (produced, e.g., by proteolytic digestion of naturally-occurring materials, by recombinant methods, or by polymerization of amino acids) which comprise a primary structural conformation substantially duplicating part of all or that which is predicted to be extant at residues 266 through 287 of gD-1 and gD-2 ADi.e. PELA(or V)PEDPEDSALLEDPV(or A)GTVA(or S) BD. Disclosed also are novel procedures for detection, quantification and isolation by affinity purification of gD-1, gD-2 and structurally related compounds.

79. 发明申请

WO1982004396A1 PROTECTION AGAINST DENTAL CARIES 审中-公开
标题翻译：保护牙齿
公开(公告)号：WO1982004396A1
公开(公告)日：1982-12-23
申请号：PCT/GB1982000168
申请日：1982-06-04
申请人： UNITED KINGDOM GOVERNMENT , RUSSELL ROY ROBERT BAIRD
发明人： UNITED KINGDOM GOVERNMENT
IPC分类号： A61K39/09
CPC分类号： A61Q11/00 , A61K8/64 , A61K8/99 , A61K39/092 , Y10S435/885 , Y10S514/835 , Y10S530/806 , Y10S530/809 , Y10S530/81 , Y10S530/825
摘要： Une proteine antigenique, appelee antigene C, presente sur les parois cellulaires et dans des cultures de Streptococcus Mutans, notamment du groupe genetique 1 (serotypes c, e et f) est separee des autres proteines antigeniques, notamment de celles qui presentent des reactions croisees avec le tissu cardiaque, pour obtenir une preparation d'antigene pouvant etre utilise en tant que vaccin ou pour la culture d'anticorps destines a etre utilises dans la protection contre la carie dentaire. L'antigene C est detruit ou extrait des parois cellulaires par un traitement avec du dodecyl sulfate de sodium aqueux en ebullition (10gm par litre) pendant dix minutes. Il possede un poids moleculaire egal a 70000 +- 5000 et un point isoelectrique egal a 4,45 +- 0,24. Il est detruit par une enzyme proteolytique et ne presente pas de reaction croisee avec le tissu cardiaque. L'antigene est aussi present dans le filtrat de culture et/ou dans l'extrait de cellule et peut etre rapidement separe de ces sources par une chromatographie d'affinite sur un anticorps immobilise.

80. 发明申请

WO2010055366A3 ANTI-HUMAN IL-21 MONOCLONAL ANTIBODIES 审中-公开
标题翻译：抗人IL-21单克隆抗体
公开(公告)号：WO2010055366A3
公开(公告)日：2010-10-21
申请号：PCT/IB2008005011
申请日：2008-12-08
申请人： ZYMOGENETICS INC , JASPERS STEPHEN R , RIXON MARK W , DILLON STACEY R , RAMSDELL FREDERICK J , KREJSA CECILE M , YI EUGENE C
发明人： JASPERS STEPHEN R , RIXON MARK W , DILLON STACEY R , RAMSDELL FREDERICK J , KREJSA CECILE M , YI EUGENE C
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S530/809
摘要： Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinant IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells, TH cells or TH17 cells.
摘要翻译：提出人抗人IL-21单克隆抗体和产生它们的杂交瘤。这些抗体中的某些具有结合天然人IL-21，人IL-21的突变重组IL-21蛋白和/或肽区的能力。这些人抗IL-21抗体可用于治疗自身免疫性和炎性疾病，特别是由T滤泡辅助细胞，B细胞，TH细胞或TH17细胞介导的疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式