专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

71. 发明授权

US08802659B2 Bicyclic aryl sphingosine 1-phosphate analogs 有权
标题翻译：双环芳基鞘氨醇1-磷酸类似物
公开(公告)号：US08802659B2
公开(公告)日：2014-08-12
申请号：US13389054
申请日：2010-08-05
申请人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
发明人： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC分类号： C07C43/00 , C07C47/575 , C07C229/36 , C07C311/51 , C07D205/04 , C07D207/16 , C07D211/62 , C07D215/227 , C07D239/74 , C07D403/06
CPC分类号： A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
摘要： Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
摘要翻译：提供了在一种或多种S1P受体上具有激动剂活性的化合物。化合物是鞘氨醇类似物，其在磷酸化之后可以作为S1P受体的激动剂。

72. 发明授权

US08785494B2 Calcium sensing receptor modulating compounds and pharmaceutical use thereof 失效
标题翻译：钙感应受体调节化合物及其药物用途
公开(公告)号：US08785494B2
公开(公告)日：2014-07-22
申请号：US13322522
申请日：2010-05-26
申请人： Bjarne Nørremark
发明人： Bjarne Nørremark
IPC分类号： A61K31/21 , A61K31/215 , A61K31/195 , A61K31/135
CPC分类号： A61K31/195 , C07C229/46 , C07C2601/08 , A61K31/215 , A61K31/135 , C07C227/18 , C07C69/738 , C07C67/343
摘要： The invention relates to novel calcium-sensing receptor (CaSR) modulating trifluoromethylphenylene cyclopentylene compounds represented in formula (I) and derivatives thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.
摘要翻译：本发明涉及将用于治疗的所述化合物，用于治疗的所述化合物，包含所述化合物的药物组合物的式（I）所示的三氟甲基亚苯基亚环戊基化合物及其衍生物的新型钙感受受体（CaSR）涉及用所述化合物治疗疾病的方法，以及所述化合物在制备药物中的用途。

73. 发明授权

US08758785B2 Composition for external use and method for producing the same 有权
标题翻译：外用组合物及其制造方法
公开(公告)号：US08758785B2
公开(公告)日：2014-06-24
申请号：US14140302
申请日：2013-12-24
申请人： Chanel Parfums Beaute
发明人： Masayoshi Miyamoto , Tomomi Kuromiya , Daisuke Suzuki
IPC分类号： A61K8/02 , A61K31/215
CPC分类号： A61K8/044 , A61K8/0241 , A61K8/44 , A61K2800/412 , A61K2800/652 , A61Q19/02 , C07C227/42 , C07C2601/14 , Y10T428/2982 , C07C229/46
摘要： A composition for external use containing a physiologically acceptable salt of a tranexamate as an active ingredient, which is dispersed in the composition in the state of fine particles, is provided. Thereby, a physiologically acceptable salt of the tranexamate is dissolved in a solvent to prepare a solution, to which a salting-out agent is added to precipitate the salt. Such salt is so dispersed in a composition for external use in the state of fine particles that the tranexamate salt can be mixed without using a large amount of an oil component to obtain a composition for external use affording excellent feel of use and stability.
摘要翻译：提供一种外用组合物，其含有作为活性成分的静脉注射用生理学上可接受的盐，以细颗粒状态分散在组合物中。由此，将溶解在溶剂中的氨甲喋呤的生理学上可接受的盐溶解于其中，加入盐析剂使其沉淀。这种盐分散在细粒状态的外用组合物中，可以将不含大量油性成分的氨甲磺酸盐盐混合，得到外用的使用感和稳定性的外用组合物。

74. 发明授权

US08530517B2 Retinoid derivatives endowed with cytotoxic and/or antiangiogenic properties 失效
标题翻译：维甲酸衍生物具有细胞毒性和/或抗血管生成特性
公开(公告)号：US08530517B2
公开(公告)日：2013-09-10
申请号：US13141831
申请日：2009-12-21
申请人： Walter Cabri , Giuseppe Giannini , Gianfranco Battistuzzi , Domenico Alloatti , Claudio Pisano , Sabrina Dallavalle , Tiziana Brunetti
发明人： Walter Cabri , Giuseppe Giannini , Gianfranco Battistuzzi , Domenico Alloatti , Claudio Pisano , Sabrina Dallavalle , Tiziana Brunetti
IPC分类号： A61K31/192 , C07C235/32
CPC分类号： C07K5/06043 , C07C69/54 , C07C69/708 , C07C229/08 , C07C229/46 , C07C235/20 , C07C255/16 , C07C271/44 , C07C271/52 , C07C271/54 , C07C309/66 , C07C2601/02 , C07C2603/74 , C07D209/48 , C07D211/58 , C07D295/08 , C07D295/13 , C07D295/14
摘要： The present invention relates to new retinoid derivatives of formula I and to pharmaceutical compositions containing them for the treatment of patients affected by pathologies such as arthritic conditions, tumors, metastatic cancer, diabetic retinopathy, psoriasis, chronic inflammatory diseases or atherosclerosis.
摘要翻译：本发明涉及式I的新类维生素A衍生物和含有它们的药物组合物，用于治疗受病理学影响的患者，例如关节炎病症，肿瘤，转移性癌症，糖尿病性视网膜病变，牛皮癣，慢性炎性疾病或动脉粥样硬化。

75. 发明申请

US20130058990A1 COMPOSITION CONTAINING A DIBENZOYLMETHANE SCREENING AGENT AND A HYDROPHILIC OR WATER-SOLUBLE MEROCYANIN UV-SCREENING AGENT; PROCESS FOR PHOTOSTABILIZING THE DIBENZOYLMETHANE SCREENING AGENT 有权
标题翻译：含有二苯甲基氯乙烯筛选剂的组合物和水解或水溶性紫外线屏蔽剂; 二苯甲基氯化物筛选剂的光化学方法
公开(公告)号：US20130058990A1
公开(公告)日：2013-03-07
申请号：US13634194
申请日：2011-03-07
申请人： Herve Richard , Benoit Muller
发明人： Herve Richard , Benoit Muller
IPC分类号： A61K8/49 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/11 , C07D295/145 , C07C229/46 , C07C317/48 , C07D277/04 , C07D263/06 , C07D211/46 , A61Q17/04 , C07C309/18
CPC分类号： A61K8/35 , A61K8/40 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/466 , A61K8/49 , A61K8/4926 , A61Q17/04 , C07C229/30 , C07C229/46 , C07C255/30 , C07C255/31 , C07C309/12 , C07C309/14 , C07C309/15 , C07C309/22 , C07C309/23 , C07C317/48 , C07C2601/16 , C07D211/46 , C07D263/14 , C07D277/10
摘要： The present invention relates to a cosmetic composition containing a combination i) of at least one screening agent of the dibenzoylmethane derivative type and ii) of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II) below: in which at least one or two of the radicals contain: either an alkylsulfonate radical in its acid or salified form, or one or two hydroxyl radicals. The invention also relates to a process for the radiation-photostabilization of at least one screening agent of the dibenzoylmethane derivative type with an effective amount of at least one particular hydrophilic or water-soluble merocyanin UV-screening agent, especially corresponding to one of the formulae (I) or (II).
摘要翻译：本发明涉及包含至少一种二苯甲酰甲烷衍生物类型的筛选剂的组合i）和ii）至少一种特别亲水或水溶性的花青素UV-筛选剂的化妆品组合物，特别是对应于式（I）或（II）：其中至少一个或两个基团含有：其酸或盐化形式的烷基磺酸根基团或一个或两个羟基基团。本发明还涉及至少一种二苯甲酰甲烷衍生物类型的筛选剂与有效量的至少一种特别的亲水或水溶性的花青素UV-筛选剂的辐射光稳定化方法，特别是对应于式（I）或（II）。

76. 发明申请

US20120295923A1 Aminocyclohexanes and Aminotetrahydropyrans and Related Compounds As Gamma-Secretase Modulators 审中-公开
标题翻译：氨基环己烷和氨基四氢吡喃和相关化合物作为γ分泌酶调节剂
公开(公告)号：US20120295923A1
公开(公告)日：2012-11-22
申请号：US13575370
申请日：2011-01-19
申请人： Christopher William Am Ende , Benjamin Adam Fish , Douglas Scott Johnson , Ricardo Lira , Christopher John O'Donnell , Martin Youngjin Pettersson , Corey Michael Stiff
发明人： Christopher William Am Ende , Benjamin Adam Fish , Douglas Scott Johnson , Ricardo Lira , Christopher John O'Donnell , Martin Youngjin Pettersson , Corey Michael Stiff
IPC分类号： A61K31/505 , A61K31/196 , A61K31/421 , C07D263/32 , C07D309/14 , A61K31/35 , C07D239/26 , C07D277/30 , A61K31/426 , A61K31/438 , C07D221/20 , C07D221/22 , A61K31/439 , A61K31/4433 , C07D405/04 , C07D213/55 , A61K31/4418 , A61P25/00 , A61P25/18 , C07C229/42
CPC分类号： C07C229/46 , C07C255/24 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/42 , C07D213/55 , C07D221/20 , C07D221/22 , C07D239/26 , C07D263/32 , C07D271/12 , C07D275/02 , C07D277/28 , C07D307/52 , C07D307/79 , C07D309/04 , C07D309/14 , C07D311/04 , C07D405/04
摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
摘要翻译：公开了化合物的化合物和药学上可接受的盐，其中化合物具有说明书中定义的式I的结构。还公开了相应的药物组合物，治疗方法，合成方法和中间体。

77. 发明申请

US20120244204A1 COMPOSITION FOR EXTERNAL USE AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：用于外部使用的组合物及其制备方法
公开(公告)号：US20120244204A1
公开(公告)日：2012-09-27
申请号：US13514623
申请日：2010-12-03
申请人： Masayoshi Miyamoto , Tomomi Kuromiya , Daisuke Suzuki
发明人： Masayoshi Miyamoto , Tomomi Kuromiya , Daisuke Suzuki
IPC分类号： A61K31/215 , C07C211/17 , A61Q19/08 , A61K8/04 , A61Q19/00
CPC分类号： A61K8/044 , A61K8/0241 , A61K8/44 , A61K2800/412 , A61K2800/652 , A61Q19/02 , C07C227/42 , C07C2601/14 , Y10T428/2982 , C07C229/46
摘要： A method for producing a composition for external use containing a physiologically acceptable salt of a tranexamate as an active ingredient, which is dispersed in the composition in the state of fine particles, includes dissolving a physiologically acceptable salt of the tranexamate in a solvent to prepare a solution, to which a salting-out agent is added to precipitate the salt. Such salt is so dispersed in a composition for external use in the state of fine particles, that the tranexamate salt can be mixed without using a large amount of an oil component to obtain a composition for external use affording excellent feel of use and stability.
摘要翻译：包含以细颗粒状态分散在组合物中的含有作为活性成分的作为有效成分的氨基甲酸酯的生理学上可接受的盐的外用组合物的制造方法包括将溶剂中的生理上可接受的盐酸盐溶解在溶剂中，溶液，加入盐析剂以沉淀盐。这样的盐分散在细粒状态的外用组合物中，可以在不使用大量油性成分的情况下混合氨甲磺酸盐，得到外用的使用感和稳定性的组合物。

78. 发明授权

US07893292B2 Merocyanine derivatives for cosmetic use 有权
标题翻译：用于化妆品使用的花青衍生物
公开(公告)号：US07893292B2
公开(公告)日：2011-02-22
申请号：US12378566
申请日：2009-02-17
申请人： Barbara Wagner , Thomas Ehlis , Stefan Müller
发明人： Barbara Wagner , Thomas Ehlis , Stefan Müller
IPC分类号： C07C255/00 , A61K8/00 , A61K8/18 , A61K8/49 , A61K31/13 , A61K31/16 , A61Q17/04 , A01N33/00 , A01N33/02
CPC分类号： C07D295/116 , A61K8/41 , A61K8/44 , A61K8/46 , A61K8/494 , A61K8/81 , A61Q17/00 , A61Q17/02 , C07C225/20 , C07C229/46 , C07C255/31 , C07C317/48 , C07C2601/14 , C07C2601/16 , C07D295/155
摘要： Described are merocyanine derivatives of formula wherein R2 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; a cyano group; or R1 and R2 together with the nitrogen atom linking them form a —(CH2)m— ring which is optionally interrupted by —O— or by —NR7—; R4 is a cyano group; or -Q1-R5; Q1 is —COO—; —CONH—; —CO—; —SO2—; or —CONR6—; R5 is C1-C22alkyl; cyclo-C3-C8alkyl; or unsubstituted or C1-C6alkyl-substituted C6-C20aryl; R6 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; R7 is hydrogen; C1-C22alkyl; cyclo-C3-C8alkyl; unsubstituted or C1-C6alkyl- or C1-C6alkoxy-substituted C6-C20aryl; the cyclohexene radical C is not substituted or substituted by one or more C1-C5alkyl; m is from 3 to 7; n is from 2 to 4; and o is from 2 to 4. Said merocyanine derivatives are useful in protecting human and animal hair and skin from UV radiation and to cosmetic compositions comprising said derivatives.
摘要翻译：描述的是下式的部花青衍生物其中R2是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 氰基; 或R 1和R 2与连接它们的氮原子一起形成 - （CH 2）m - 环，其任选被-O-或-NR 7 - 间隔; R4是氰基; 或-Q1-R5; Q1是-COO-; -CONH-; -CO-; -SO2-; 或-CONR6-; R5是C1-C22烷基; 环C 3 -C 8烷基; 或未取代的或C 1 -C 6烷基取代的C 6 -C 20芳基; R6是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; R7是氢; C 1 -C 22烷基; 环-C 3 -C 8烷基; 未取代的或C 1 -C 6烷基 - 或C 1 -C 6烷氧基取代的C 6 -C 20芳基; 环己烯基C不被一个或多个C 1 -C 5烷基取代或取代; m为3〜7; n为2〜4; 和o为2至4.所述的部花青衍生物可用于保护人和动物毛发和皮肤免受紫外线辐射和包含所述衍生物的化妆品组合物。

79. 发明授权

US07834013B2 Aminophenylcyclopropyl carboxylic acids and derivatives as agonists to GPR40 失效
标题翻译：氨基苯基环丙基羧酸及其衍生物作为GPR40的激动剂
公开(公告)号：US07834013B2
公开(公告)日：2010-11-16
申请号：US10595892
申请日：2004-11-15
申请人： David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, Jr.
发明人： David Francis Corbett , Kate Anna Dwornik , Dulce Maria Garrido , Stephen Carl McKeown , Wendy Yoon Mills , Andrew James Peat , Terrence Lee Smalley, Jr.
IPC分类号： A61K31/5375 , A61K31/4439 , A61K31/426 , A61K31/381 , A61K31/196 , C07D295/14 , C07D417/12 , C07D277/20 , C07D333/24 , C07C229/46
CPC分类号： C07C229/46 , C07C237/24 , C07C323/37 , C07C2601/02 , C07D213/38 , C07D277/28 , C07D277/34 , C07D295/13 , C07D307/52 , C07D333/20 , C07D407/12
摘要： The present invention relates generally to novel therapeutic compounds and more particularly to novel compounds, their use as GPR40 agonists, processes for their manufacture, and intermediates useful in their preparation.
摘要翻译：本发明一般涉及新的治疗化合物，更具体地涉及新化合物，它们作为GPR40激动剂的用途，其制备方法和用于其制备的中间体。

80. 发明授权

US07718646B2 Cyclohexyl(alkyl)propanolamines, preparation method and pharmaceutical compositions containing same 有权
公开(公告)号：US07718646B2
公开(公告)日：2010-05-18
申请号：US12144843
申请日：2008-06-24
申请人： Philippe R. Bovy , Roberto Cecchi , Gilles Courtemanche , Tiziano Croci , Ambrogio Oliva , Nunzia Viviani
发明人： Philippe R. Bovy , Roberto Cecchi , Gilles Courtemanche , Tiziano Croci , Ambrogio Oliva , Nunzia Viviani
IPC分类号： A61K31/553 , C07D263/54 , C07D267/02 , C07C311/01
CPC分类号： C07C311/21 , C07C229/46 , C07C311/08 , C07C317/22 , C07C2601/14
摘要： The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —SO2NH(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1-C4)alkyl group or with a (C1-C4)alkoxy group; R1 represents a hydrogen atom or a (C1-C4)alkyl group, a —CO(C1-C4)alkyl group, a phenyl-(C1-C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1-C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1-C4)alkyl group, an —SO2phenyl-(C1-C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1-C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogen atom, a (C1-C6)alkyl group, a (C1-C4)alkoxy group, a —COO(C1-C4)alkyl group, a —CO(C1-C4)alkyl group, an —NHSO2(C1-C4)alkyl group, an —NHSO2phenyl-(C1-C4)alkyl groups, —NO2, —CN, —CONR4R5, —COOH, or a 4,5-dihydro-1,3-oxazol-2-yl or 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl group; R4 and R5 represent, independently, a hydrogen atom, a phenyl, a (C1-C4)alkyl group or a phenyl-(C1-C4)alkyl group or R4 and R5 with the nitrogen atom to which they are attached, may form a ring of 5 to 7 atoms in total; and to the salts or solvates thereof, to the pharmaceutical compositions containing them, to a process for the preparation thereof and to intermediates in this process.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式