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71. 发明授权

US09283336B2 Delivery device and related methods 有权
标题翻译：配送装置及相关方法
公开(公告)号：US09283336B2
公开(公告)日：2016-03-15
申请号：US13622122
申请日：2012-09-18
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0028 , A61M15/0035 , A61M15/0038 , A61M15/0045 , A61M15/0048 , A61M15/0075 , A61M15/0081 , A61M2202/064 , A61M2206/16 , B65D83/06
摘要： A dose delivery device with a mouthpiece having an inlet, an outlet, and an air path extending between the inlet and the outlet. A dose chamber having an opening may hold a dose, e.g., for inhalation by a user. A disc element may be arranged to move between a closed position in which the disc element closes the opening of the dose chamber, and an open position in which the disc opens the dose chamber to permit introduction of the dose into the air path of the device. Movement of the disc element from the closed position to the open position may be in a direction away from the dose chamber (e.g., a puller may engage the disc element and pull the element away from the chamber) and may leave a substantial portion of the dose in the dose chamber.
摘要翻译：具有口部的剂量递送装置，其具有在入口和出口之间延伸的入口，出口和空气路径。具有开口的剂量室可以保持剂量，例如用于用户的吸入。盘元件可以被布置成在盘元件关闭剂量室的开口的闭合位置和打开位置之间移动，在该打开位置，盘打开剂量室以允许将剂量引入到装置的空气路径中。盘元件从关闭位置到打开位置的移动可以是远离剂量室的方向（例如，拉拔器可以接合盘元件并将元件拉离腔室），并且可以留下大部分的剂量剂量。

72. 发明授权

US09259376B2 Process for dry powder formulations 有权
标题翻译：干粉配方工艺
公开(公告)号：US09259376B2
公开(公告)日：2016-02-16
申请号：US13701599
申请日：2011-06-02
申请人： Mahmut Bilgic
发明人： Mahmut Bilgic
IPC分类号： A61K9/28 , A61J3/00 , A61K9/48 , A61J3/07 , A61K9/00 , A61M15/00
CPC分类号： A61J3/005 , A61J3/07 , A61K9/0075 , A61K9/4816 , A61M15/0028 , A61M15/0035 , A61M15/0038 , A61M2202/062 , A61M2202/064
摘要： The present invention relates to a process developed for production of a dry powder medicament used in respiratory tract diseases such as asthma and COPD.
摘要翻译：本发明涉及用于生产用于呼吸道疾病如哮喘和COPD的干粉药物的方法。

73. 发明申请

US20140216457A1 INHALATION DEVICE 审中-公开
标题翻译：吸入装置
公开(公告)号：US20140216457A1
公开(公告)日：2014-08-07
申请号：US14248628
申请日：2014-04-09
申请人： Manta Devices, LLC
发明人： Andrew Jones , Richard L. Miller
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M11/02 , A61M15/0003 , A61M15/0005 , A61M15/001 , A61M15/002 , A61M15/0021 , A61M15/0028 , A61M15/0038 , A61M15/0043 , A61M15/0048 , A61M15/0065 , A61M15/0075 , A61M15/0085 , A61M2202/064 , A61M2205/07
摘要： The present invention provides for the integration of drug dispersion methods into a drug or medicine delivery system. The drug dispersion methods used include shear (e.g., air across a drug, with or without a gas assist), capillary flow or a venturi effect, mechanical means such as spinning, vibration, or impaction, and turbulence (e.g., using mesh screens, or restrictions in the air path). These methods of drug dispersion allow for all of the drug in the system to be released, allowing control of the dosage size. These methods also provide for drug metering, fluidization, entrainment, deaggragation and deagglomeration. The present invention also provides for the integration of a drug sealing system into the device. The drug sealing system provides a way of blocking the migration of drug from one area of the package to another. The drug seal system can also provide a method of tightly containing the drug until the package is opened, of directing airflow through the package and of managing and containing the drug during the package/device manufacturing process.
摘要翻译：本发明提供将药物分散方法整合到药物或药物递送系统中。使用的药物分散方法包括剪切（例如，具有或不具有气体辅助的药物的空气），毛细管流动或文丘里效应，诸如旋转，振动或冲击的机械手段和湍流（例如，使用筛网，或限制在空中路径）。这些药物分散方法允许释放系统中的所有药物，从而控制剂量大小。这些方法还提供了药物计量，流化，夹带，解聚和解聚。本发明还提供了将药物密封系统整合到装置中。药物密封系统提供了阻止药物从包装的一个区域迁移到另一个区域的方式。药物密封系统还可以提供紧密包含药物的方法，直到包装打开为止，在包装/装置制造过程中引导气流通过包装并管理和容纳药物。

74. 发明授权

US08528548B2 Inhaler 有权
标题翻译：吸入器
公开(公告)号：US08528548B2
公开(公告)日：2013-09-10
申请号：US12441177
申请日：2007-08-17
申请人： Heinrich Kladders
发明人： Heinrich Kladders
IPC分类号： A61M16/00
CPC分类号： A61M15/0028 , A61M15/0003 , A61M15/0005 , A61M15/0035 , A61M15/0038 , A61M15/0043 , A61M15/0045 , A61M15/0051 , A61M15/0065 , A61M15/0091 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/07 , A61M2205/071 , A61M2205/581 , A61M2205/8225
摘要： An inhaler (1) is proposed for inhaling a preparation (2) from a carrier (3) and/or through a delivery channel (16) as depicted in exemplary FIG. 1. The carrier or delivery channel is preferably flexible, flat, band-shaped, strip-shaped, thread-like, blister-like and/or film-like and can be set in vibration by a stream of air (5). The carrier or delivery channel is preferably set in vibration by a separate element (6), which for its part is set in motion or vibration by the stream of air. Alternatively, or in addition, the inhaler has a pump (10) with a telescopic pump chamber (20) for generating a stream of air for expelling and/or dispersing a preparation.
摘要翻译：建议吸入器（1）用于从载体（3）和/或通过输送通道（16）吸入制剂（2），如图1所示。载体或输送通道优选是柔性的，扁平的，带状的，带状的，线状的，类似泡状的和/或薄膜状的，并且可以通过空气流（5）设定在振动中。载体或输送通道优选地通过单独的元件（6）设置为振动，单独的元件（6），其部分被空气流设置成运动或振动。或者或另外，吸入器具有带有伸缩泵室（20）的泵（10），用于产生用于排出和/或分散制剂的空气流。

75. 发明申请

US20110253141A1 METHODS OF OPERATING DRY POWDER INHALERS HAVING SPIRAL TRAVEL PATHS WITH MICROCARTRIDGES OF DRY POWDER 有权
标题翻译：使用干粉微波炉操作螺旋桨行程的干粉式吸入器的方法
公开(公告)号：US20110253141A1
公开(公告)日：2011-10-20
申请号：US13169486
申请日：2011-06-27
申请人： Michael King , Jeffrey Alan Warden , John Kim , Benjamin Finney , Nicholas Oxley
发明人： Michael King , Jeffrey Alan Warden , John Kim , Benjamin Finney , Nicholas Oxley
IPC分类号： A61M15/00
CPC分类号： A61M15/0028 , A61M15/0003 , A61M15/001 , A61M15/003 , A61M15/0035 , A61M15/0038 , A61M15/004 , A61M15/0043 , A61M15/0051 , A61M15/006 , A61M15/008 , A61M15/0085 , A61M2202/064 , A61M2205/0233 , A61M2205/18 , A61M2205/3379 , A61M2205/35 , A61M2205/505 , A61M2205/581 , A61M2205/583 , A61M2205/6081 , A61M2205/8206
摘要： Dry powder inhalers include: (a) a first generally planar spiral travel path in an inhaler body, wherein the first spiral travel path has a plurality of adjacent curvilinear channels forming lanes with upstanding sidewalls, including an inner lane and an outer lane; and (b) a plurality of discrete sealed microcartridges with substantially rigid bodies disposed in the first travel path, each comprising a pre-metered (typically dose) amount of dry powder, the microcartridges being configured to slidably advance along the first travel path toward an inhalation chamber that merges into an inhalation output port. In operation, at least one microcartridge is held in the inhalation chamber to release the dry powder therein during inhalation.
摘要翻译：干粉吸入器包括：（a）吸入器主体中的第一大致平面的螺旋行进路径，其中第一螺旋行进路径具有多个相邻的曲线通道，其形成具有直立侧壁的车道，包括内车道和外车道; 和（b）多个离散密封的微型组件，其具有设置在第一行进路径中的基本上刚性的物体，每个包含预先计量（典型地为剂量）的干粉末，该微型组件被构造成沿着第一行进路径朝向吸入室合并成吸入口。在操作中，至少一个微型小瓶被保持在吸入室中以在吸入期间将其中的干粉释放出来。

76. 发明申请

US20100269818A1 Semi-automatic emergency medication dose nebulizer 有权
标题翻译：半自动应急用药剂量雾化器
公开(公告)号：US20100269818A1
公开(公告)日：2010-10-28
申请号：US12798884
申请日：2010-04-13
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M11/02
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045 , A61M2209/08
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a pressure burstable seal at one end of the capsule, which is burst by the application of force against the opposite end of the capsule.
摘要翻译：常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个手动力的脉冲至简单的机械输送系统，从而使雾化器可以分两步使用：（a）打开药物胶囊具有简单的开启动作; 和（b）吸入雾化药物。雾化器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有将液体药物直接注入雾化室中，并且没有在雾化器壳体之前重新组装将吸入器吸嘴定位在口中，以吸入雾化药物。输送系统包括在胶囊的一端处的压力可爆破的密封，其通过对胶囊的相对端施加力而爆裂。

77. 发明授权

US07814902B2 Semi-automatic emergency medication dose nebulizer 有权
标题翻译：半自动应急用药剂量雾化器
公开(公告)号：US07814902B2
公开(公告)日：2010-10-19
申请号：US12321854
申请日：2009-01-26
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M11/00
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system delivering the stored medication dose directly to the nebulizing chamber with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication. The delivery system includes a slicing blade to sever the capsule and a looped paddle follower to move the severed portion out of the way of fluid flow.
摘要翻译：常规呼吸雾化器具有紧急药物剂量存储系统，其将存储的药物剂量直接输送到雾化室，其具有单个手动力的脉冲至简单的机械输送系统，从而使雾化器可以分两步使用：（a）打开药物胶囊具有简单的开启动作; 和（b）吸入雾化药物。雾化器可以在不拆卸雾化器壳体的情况下操作，以便暴露雾化室，而不用手动打开液体药物容器，并且不会溢出并且没有将液体药物直接注入雾化室中，并且没有在雾化器壳体之前重新组装将吸入器吸嘴定位在口中，以吸入雾化药物。输送系统包括用于切断胶囊的切片刀片和环形叶片从动件，以将切断的部分移出流体流动的方式。

78. 发明申请

US20100051023A1 INHALER 有权
标题翻译：吸入器
公开(公告)号：US20100051023A1
公开(公告)日：2010-03-04
申请号：US12441177
申请日：2007-08-17
申请人： Heinrich Kladders
发明人： Heinrich Kladders
IPC分类号： A61M11/00
CPC分类号： A61M15/0028 , A61M15/0003 , A61M15/0005 , A61M15/0035 , A61M15/0038 , A61M15/0043 , A61M15/0045 , A61M15/0051 , A61M15/0065 , A61M15/0091 , A61M2016/0021 , A61M2016/0027 , A61M2016/0039 , A61M2202/064 , A61M2205/07 , A61M2205/071 , A61M2205/581 , A61M2205/8225
摘要： An inhaler is proposed for inhaling a preparation from a carrier and/or through a delivery channel. The carrier or delivery channel is preferably flexible, flat, band-shaped, strip-shaped, thread-like, blister-like and/or film-like and can be set in vibration by a stream of air. The carrier or delivery channel is preferably set in vibration by a separate element, which for its part is set in motion or vibration by the stream of air. Alternatively, or in addition, the inhaler has a pump with a telescopic pump chamber for generating a stream of air for expelling and/or dispersing a preparation.
摘要翻译：建议吸入器用于从载体和/或通过输送通道吸入制剂。载体或输送通道优选地是柔性的，平坦的，带状的，带状的，线状的，起泡状和/或膜状的，并且可以通过空气流被设置为振动。载体或输送通道优选地通过单独的元件设置为振动，单独的元件其部分被空气流设置成运动或振动。或者或另外，吸入器具有带有伸缩泵室的泵，用于产生用于排出和/或分散制剂的空气流。

79. 发明申请

US20090071469A1 Semi-automatic emergency medication dose nebulizer 失效
公开(公告)号：US20090071469A1
公开(公告)日：2009-03-19
申请号：US12283303
申请日：2008-09-11
申请人： Robert Abrams
发明人： Robert Abrams
IPC分类号： A61M11/02
CPC分类号： A61M11/02 , A61M15/0028 , A61M15/0031 , A61M15/0038 , A61M15/0041 , A61M15/0081 , A61M15/0083 , A61M16/0063 , A61M2205/583 , A61M2205/587 , A61M2209/045
摘要： A conventional respiratory nebulizer has an emergency medication dose storage system conveniently useable in an emergency to deliver the stored medication dose directly to the nebulizing chamber quickly, reliably, and with a single impulse of manual force to a simple mechanical delivery system, thereby making the nebulizer useable in two steps: (a) opening the medication capsule with a simple opening action; and (b) inhaling the nebulized medication. The nebulizer can be operated without disassembling the nebulizer housing so as to expose the nebulizing chamber and without manually opening the liquid medication container and, without spillage and without manual pouring of the liquid medication directly into the nebulizing chamber, and without reassembling the nebulizer housing before positioning the inhaler mouthpiece in the mouth so as to inhale the nebulized medication.

80. 发明申请

US20060060194A1 Single dose inhaler 有权
标题翻译：单剂量吸入器
公开(公告)号：US20060060194A1
公开(公告)日：2006-03-23
申请号：US10530966
申请日：2003-10-13
申请人： Roberto Oliva
发明人： Roberto Oliva
IPC分类号： A61M15/00 , B65D83/06
CPC分类号： A61M15/0028 , A61M15/0038 , A61M2202/064
摘要： The inhalator comprises a main body affording an inhalation conduit; a second body exhibiting a housing, into which a capsule can be at least partially inserted; the second body being rotatably coupled with the main body, and being able to rotate from an open position, in which the housing is accessible from outside for insertion of a capsule, and a closed position, in which the housing is in communication with the inhalation conduit; means for cutting for cutting off a portion of a capsule which projects from the housing during rotation of the second body from the open position to the closed position.
摘要翻译：吸入器包括提供吸入管道的主体; 呈现壳体的第二主体，胶囊可至少部分插入其中; 第二主体与主体可旋转地联接，并且能够从打开位置旋转，在打开位置，外壳可从外部进入以便插入胶囊;以及关闭位置，其中壳体与吸气连通导管; 用于在将第二主体从打开位置旋转到关闭位置期间切断从壳体突出的一部分胶囊的切割装置。

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