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71. 发明申请

US20110150851A1 NUTRITIONAL COMPOSITION FOR INFANTS DELIVERED VIA CAESAREAN SECTION 审中-公开
标题翻译：通过CAESAREAN部分提供的婴儿的营养成分
公开(公告)号：US20110150851A1
公开(公告)日：2011-06-23
申请号：US13001991
申请日：2009-06-19
申请人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
发明人： Joachim Schmitt , Francis Lecroix , Pierre Jesenne , Bernd Stahl , Günther Boehm , Emmanuel Perrin
IPC分类号： A61K35/74 , A61P31/04
CPC分类号： A23C9/1234 , A23C9/1236 , A23C21/026 , A23L29/30 , A23L33/135 , A23L33/21 , A23L33/40 , A23V2002/00 , A61K35/744 , A61K35/745 , A61K35/747 , A23V2200/3204 , A23V2200/3202 , A23V2250/28 , A23V2200/32
摘要： The present invention relates to compositions to be administered to infants delivered via caesarean section and in particular to a product comprising inactivated cells and/or bacterial cell fragments of Gram-negative bacteria and of optionally inactivated Gram-positive bacteria. Thereby it is possible to stimulate a fast colonisation of the intestinal microbiota of said infants.
摘要翻译：本发明涉及给予通过剖宫产递送的婴儿的组合物，特别涉及包含革兰氏阴性细菌的灭活细胞和/或细菌细胞片段以及任选灭活的革兰氏阳性细菌的产品。因此，可以刺激所述婴儿的肠道微生物群的快速定植。

72. 发明授权

US07498162B2 Lactic acid bacteria capable of reducing an individual's tendency to develop allergic reactions 失效
标题翻译：能降低个体发展过敏反应倾向的乳酸菌
公开(公告)号：US07498162B2
公开(公告)日：2009-03-03
申请号：US10362249
申请日：2001-09-21
申请人： Jacques Edouard Germond , Blaise Corthesy , Beat Mollet , Rodolphe Fritsche
发明人： Jacques Edouard Germond , Blaise Corthesy , Beat Mollet , Rodolphe Fritsche
IPC分类号： C12N1/20 , A01N63/00
CPC分类号： A23C9/1234 , A23C9/1236 , A23C2220/202 , A23L29/065 , A23L33/10 , A23Y2220/43 , A23Y2240/41 , A23Y2300/00 , A61K35/745 , A61K35/747 , A61K2039/52 , C12N1/20
摘要： The present invention pertains to novel strains of lactic acid bacteria that are capable to reduce an individual's tendency to mount allergic reactions. In particular, the present invention relates to the generation of lactic acid bacteria strains that express proteins including tolerogenic peptides and the use thereof in reducing an individual's tendency to mount allergic reactions. The invention also pertains to food or pharmaceutical compositions containing said micro-organisms or active fractions thereof.
摘要翻译：本发明涉及能够降低个体倾向于过敏反应的新型乳酸菌菌株。特别地，本发明涉及表达包括耐受性肽的蛋白质的乳酸菌菌株的生成及其在减少个体倾向于过敏反应的用途中的用途。本发明还涉及含有所述微生物或其活性级分的食品或药物组合物。

73. 发明申请

US20050053582A1 Method of improving the efficacy of lactic acid bacterial starter cultures and improved starter culture compositions 审中-公开
标题翻译：提高乳酸菌发酵剂培养和改善发酵培养组合物功效的方法
公开(公告)号：US20050053582A1
公开(公告)日：2005-03-10
申请号：US10718000
申请日：2003-11-21
申请人： Boerge Kringelum , Dan Nillson , Kim Soerensen
发明人： Boerge Kringelum , Dan Nillson , Kim Soerensen
IPC分类号： A23C9/123 , C12N1/20 , C12N1/21 , C12N9/02 , C12P7/56 , C12P39/00 , A61K48/00
CPC分类号： C12R1/46 , A23C9/1236 , C12N1/20 , C12N9/0036 , C12P7/56 , C12P39/00 , C12R1/225
摘要： Methods of enhancing the growth rate and/or controlling the metabolic activity of lactic acid bacteria and of improving the shelf life and/or the quality of an edible product using lactic acid bacterial organisms which are defective in their pyruvate metabolism. There is also provided starter culture compositions comprising such defective lactic acid bacteria as helper organisms and lactic acid bacterial starter culture strains. Useful helper organisms are Lactococcus strains which are defective with respect to pyruvate formate lyase (Pfl) and/or lactate dehydrogenase (Ldh) activity. The helper organisms may overexpress a gene coding for a NAD+ regenerating enzyme such as NADH oxidase encoded by nox gene.
摘要翻译：提高生长速度和/或控制乳酸菌的代谢活性的方法，以及使用其丙酮酸代谢缺陷的乳酸菌生物改善食用产品的保存期限和/或质量的方法。还提供了包含作为辅助生物的有缺陷的乳酸菌和乳酸菌发酵菌培养菌株的起始培养组合物。有用的辅助生物体是相对于丙酮酸甲酸裂解酶（Pfl）和/或乳酸脱氢酶（Ldh）活性有缺陷的乳球菌属菌株。辅助生物体可能过表达编码NAD +再生酶的基因，如由nox基因编码的NADH氧化酶。

74. 发明申请

US20030077814A1 Novel lactic acid bacteria 审中-公开
标题翻译：新型乳酸菌
公开(公告)号：US20030077814A1
公开(公告)日：2003-04-24
申请号：US10122543
申请日：2002-04-15
发明人： Jong Suk Oh
IPC分类号： C12N001/20
CPC分类号： A23G9/363 , A23C9/1234 , A23C9/1236 , A23C15/123 , A23C19/062 , A23D7/0056 , A23D9/007 , A23G9/366 , A61K35/744 , A61K35/747 , C12R1/225 , C12R1/46
摘要： Enterococcus spp. 1357, Lactobacillus spp. V20 and Lactococcus spp. 1370, and H2O2-producing Streptococci have a potent and lasting inhibitory activity on the production of water-insoluble glucan (mutan) and dental plaque in human mouth, or the growth of anaerobic bacteria causing gingivitis, periodontitis, and accompanied halitosis.
摘要翻译：肠球菌属 1357，Lactobacillus spp。 V20和乳球菌属 1370和H2O2产生的链球菌对人口中水不溶性葡聚糖（mutan）和牙菌斑的产生或引起牙龈炎，牙周炎和伴生口臭的厌氧菌的生长具有有效和持久的抑制活性。

75. 发明授权

US06235511B1 Compositions prepared to contain active dextran sucrase produced by Leuconostoc mesenteroides ssp. cremoris 失效
标题翻译：制备含有明串珠菌肠球菌生产的活性葡聚糖蔗糖酶的组合物 cremoris
公开(公告)号：US06235511B1
公开(公告)日：2001-05-22
申请号：US09439005
申请日：1999-11-12
申请人： Jürg Aebischer , Nicola D'Amico , Dominique De Maleprade , Kurt Eyer , Corinne Lesens , Jean-Richard Neeser , Roberto Reniero , Daniel Schmid
发明人： Jürg Aebischer , Nicola D'Amico , Dominique De Maleprade , Kurt Eyer , Corinne Lesens , Jean-Richard Neeser , Roberto Reniero , Daniel Schmid
IPC分类号： C12N910
CPC分类号： A61Q19/00 , A23C9/1216 , A23C9/1236 , A23C2220/206 , A23L29/06 , A23L29/065 , A23L29/273 , A61K8/73 , A61K8/99 , A61K2800/85 , C12N9/1051 , C12P19/08 , C12Y204/01005
摘要： A food or cosmetic composition containing active dextran sucrase enzymes which are produced by a strain of Leuconostoc mesenteroides ssp. cremoris and which synthesize dextran. In addition to culturing the strain in a food or cosmetic composition containing sucrose to obtain a composition containing the active enzymes, the strain may be cultured in a culture medium containing sucrose to obtain a culture product containing the active dextran sucrase enzymes which may be isolated from the culture product and incorporated into a food or cosmetic substance.
摘要翻译：含有活性葡聚糖蔗糖酶的食品或化妆品组合物，其通过肠衣明珠细菌菌株产生。 cremoris，并合成葡聚糖。除了在包含蔗糖的食品或化妆品组合物中培养菌株以获得含有活性酶的组合物外，还可以在含有蔗糖的培养基中培养该菌株，以获得含有活性葡聚糖蔗糖酶的培养产物，其可以从培养产品并加入到食品或化妆品中。

76. 发明授权

US6146667A Method for preparing dairy starter cultures 有权
标题翻译：制备乳制品发酵剂培养物的方法
公开(公告)号：US6146667A
公开(公告)日：2000-11-14
申请号：US470440
申请日：1999-12-22
申请人： Wesley D. Sing , Nicole M. Schleef , Steven J. Hess
发明人： Wesley D. Sing , Nicole M. Schleef , Steven J. Hess
IPC分类号： A23C9/123 , A23C19/032 , C12N1/20 , A23C9/127
CPC分类号： C12N1/20 , A23C19/0323 , A23C9/1236
摘要： A method of making a starter culture for inoculating milk to make a cultured dairy product by: (a) introducing an inoculum having at least about 10.sup.9 CFU/g to a growth medium having between about 3% and about 5% solids to produce an inoculated medium having at least about about 10.sup.7 CFU/g; (b) growing the inoculated medium to produce a starter culture having at least about 10.sup.9 CFU/g; and (c) adding the starter culture to milk to produce a cultured dairy product.
摘要翻译：一种制备用于接种牛奶以制备培养的乳制品的起始培养物的方法，其通过以下步骤：（a）将具有至少约109CFU / g的接种物引入具有约3％至约5％固体的生长培养基以产生接种介质具有至少约107CFU / g; （b）培养接种培养基以产生具有至少约109CFU / g的起始培养物; 和（c）将起始培养物加入到牛奶中以产生培养的乳制品。

77. 发明授权

US5676985A Antifreeze polypeptide-expressing microorganisms useful in fermentation and freezing of foods 失效
标题翻译：用于发酵和冷冻食物的抗冻多肽表达微生物
公开(公告)号：US5676985A
公开(公告)日：1997-10-14
申请号：US321991
申请日：1994-10-12
申请人： Garth L. Fletcher , Choy L. Hew , Shashikant B. Joshi , Yaling Wu
发明人： Garth L. Fletcher , Choy L. Hew , Shashikant B. Joshi , Yaling Wu
IPC分类号： A23C9/12 , A23C9/123 , A23C17/02 , A23C19/032 , A23G9/32 , A23G9/38 , A23L3/3571 , A23L3/37 , A23L11/00 , A23L19/20 , A23L29/00 , C12N1/19 , C12N1/21 , C12N15/09 , C12R1/225 , C12R1/46 , A23C9/13 , A23L1/305 , C07K1/00
CPC分类号： A23G9/38 , A23C19/0323 , A23C9/1234 , A23C9/1236 , A23C9/1238 , A23L11/09 , A23L19/20 , A23L29/065 , A23L3/3571 , A23L3/37 , A23C2210/30 , A23C2220/202
摘要： Methods and compositions for preparation of frozen fermented food products using antifreeze polypeptide-expressing microorganisms are provided. In particular the invention provides for use of fish antifreeze polypeptide-expressing microorganisms in fermentation of milk to produce and store frozen yogurt.
摘要翻译：提供了使用防冻多肽表达微生物制备冷冻发酵食品的方法和组合物。特别地，本发明提供了在牛奶发酵中使用表达鱼类抗冻多肽的微生物来生产和储存冷冻酸奶。

78. 发明授权

US5538864A Bacteriophage resistant recombinant bacteria 失效
标题翻译：耐噬菌细菌重组菌
公开(公告)号：US5538864A
公开(公告)日：1996-07-23
申请号：US373877
申请日：1995-01-17
申请人： Colin J. Hill , Todd R. Klaenhammer
发明人： Colin J. Hill , Todd R. Klaenhammer
IPC分类号： A23C9/123 , C12N1/04 , C12N1/21 , C12N15/11 , C12N15/34 , C12N15/65 , C12N15/74 , C12N1/20 , A23C9/00 , C12P7/56
CPC分类号： C12N15/65 , A23C9/1236 , C12N1/04 , C12N15/11 , C12N15/746
摘要： Recombinant bacteria containing phage-encoded resistance ("Per") and methods of making and using the same are disclosed. Such bacteria are made by (a) conducting a fermentation of a substrate in a medium containing a defined bacterial culture until bacteriophage are detected in the medium, the bacteriophage being specific to at least one bacteria in the medium; (b) isolating the bacteriophage; (c) digesting DNA of the bacteriophage to produce a library of DNA fragments; (d) transforming the bacteria susceptible to said bacteriophage with the library of DNA fragments to provide transformed bacteria; (e) selecting from among the transformed bacteria, a bacteriophage-resistant transformed bacteria; (f) adding bacteriophage resistant transformed bacteria to the medium; and (g) recommencing step (a). Also disclosed are bacterial cells which contain a first bacteriophage defense mechanism (Per), wherein Per comprises a bacteriophage origin of replication (ori) operatively associated with a DNA sequence incapable of producing live bacteriophage. The bacterial cell is capable of being infected by a bacteriophage, the DNA of which, once injected into the bacterial cell, competes with Per for binding to DNA polymerase.
摘要翻译：公开了含有噬菌体编码抗性（“Per”）的重组细菌及其制备和使用方法。这样的细菌通过以下方法制备：（a）在含有限定的细菌培养基的培养基中进行底物的发酵，直到在培养基中检测到噬菌体，噬菌体对培养基中的至少一种细菌是特异性的; （b）分离噬菌体; （c）消化噬菌体的DNA以产生DNA片段文库; （d）用DNA片段的文库转化对所述噬菌体易感的细菌，以提供转化的细菌; （e）从转化细菌中选择抗噬菌体转化细菌; （f）向培养基中加入抗噬菌体转化细菌; 和（g）重新开始步骤（a）。还公开了含有第一噬菌体防御机制（Per）的细菌细胞，其中Per包含与不能产生活噬菌体的DNA序列可操作地相关的噬菌体复制起点（ori）。细菌细胞能够被噬菌体感染，其噬菌体一旦被注入到细菌细胞中就与Per结合就与DNA聚合酶结合。

79. 发明授权

US5445835A Method of producing a yogurt product containing bacteriocin PA-1 失效
标题翻译：生产含有细菌素PA-1的酸奶制品的方法
公开(公告)号：US5445835A
公开(公告)日：1995-08-29
申请号：US192960
申请日：1994-02-07
申请人： Ebenezer R. Vedamuthu
发明人： Ebenezer R. Vedamuthu
IPC分类号： A23C9/123 , A23C9/158 , A23C9/12
CPC分类号： A23C9/1236 , A23C9/1585
摘要： A method for producing a yogurt product containing a bacteriocin is described. In the preferred method, a milk based medium is cultured with Pediococcus acidilactici to produce the bacteriocin, the Pediococcus acidilactici is then heat inactivated and finally a yogurt culture is added to the medium with the bacteriocin and cultured to produce the yogurt product. The yogurt product can be dried, either by lyophilization or spray-drying or other means, preferably to a powder, for use in various foods.
摘要翻译：描述了含有细菌素的酸奶制品的制造方法。在优选的方法中，用乳酸球菌培养乳基培养基以产生细菌素，然后将酸性乳球菌热灭活，最后将酸奶培养物加入到具有细菌素的培养基中并培养以产生酸奶产品。可以通过冷冻干燥或喷雾干燥或其它方法，优选用于各种食品的粉末来干燥酸奶产品。

80. 发明授权

US4938973A Process for producing fermented milk products 失效
标题翻译：生产发酵乳制品的方法
公开(公告)号：US4938973A
公开(公告)日：1990-07-03
申请号：US276814
申请日：1988-11-28
申请人： Franciscus A. M. Klaver , Fedde Kingma
发明人： Franciscus A. M. Klaver , Fedde Kingma
IPC分类号： A23C9/12 , A23C9/123 , C12M1/12
CPC分类号： C12M23/58 , A23C9/122 , A23C9/123 , A23C9/1236 , C12M29/04 , C12M41/26 , C12M47/10 , A23C2210/204
摘要： Fermented milk products, such as yoghurt and buttermilk, are produced by fermentation of a suitable raw material, such as milk, with different microorganism species, in such a way that microorganisms that are beneficial in the production stage but unfavourably affect the product quality during storage, are kept apart from the fermentation mixture by means of a semipermeable membrane. The process can be carried out in a fed batch system or continuously, preferably with continous pH control. The products so obtained have improved taste and storage properties.

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