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71. 发明专利

AT311453T 未知
公开(公告)号：AT311453T
公开(公告)日：2005-12-15
申请号：AT99941349
申请日：1999-09-07
申请人： THERATECHNOLOGIES INC
发明人： GRAVEL DENIS , HABI ABDELKRIM , BRAZEAU PAUL
IPC分类号： A61K38/27 , A61K38/00 , A61K49/00 , A61P3/00 , A61P3/04 , A61P5/02 , A61P17/02 , A61P19/00 , A61P19/10 , C07K14/60 , C12N15/16 , A61K38/25 , G01N33/68
摘要： The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

72. 发明专利

DE69727595T2 未知
公开(公告)号：DE69727595T2
公开(公告)日：2004-12-16
申请号：DE69727595
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC
发明人： BRAZEAU PAUL , ABRIBAT THIERRY , IBEA MICHEL , BOUSHIRA MICHELE
IPC分类号： A61K35/14 , A61K35/19

73. 发明专利

DK1007061T3 未知
公开(公告)号：DK1007061T3
公开(公告)日：2004-06-14
申请号：DK97908091
申请日：1997-03-19
申请人： THERATECHNOLOGIES INC
发明人： BRAZEAU PAUL , ABRIBAT THIERRY , IBEA MICHEL , BOUSHIRA MICHELE
IPC分类号： A61K35/14 , A61K35/19

74. 发明专利

AU2003271452A1 MODIFIED GLP-1 PEPTIDES WITH INCREASED BIOLOGICAL POTENCY 未知
公开(公告)号：AU2003271452A1
公开(公告)日：2004-04-19
申请号：AU2003271452
申请日：2003-09-25
申请人： THERATECHNOLOGIES INC
发明人： HABI ABDELKRIM , GRAVEL DENIS , PERI KRISHNA , ABRIBAT THIERRY
IPC分类号： A61K38/00 , A61K38/26 , C07K14/605 , C07K14/00
摘要： The present invention relates to a GLP-1 peptide having the following formula, or a pharmaceutically acceptable salt thereof: X-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-lle-Ala-Trp-Leu-val-Lys-Gly-Arg-Y (SEQ ID NO. 1) wherein X is a rigidifying hydrophobic moiety and wherein Y is selected from the group consisting of OH, NH 2 and Gly-OH. Moreover, the present invention relates to pharmaceutical compositions comprising a therapeutically effective amount of a peptide of the present invention, or a pharmaceutically acceptable salt thereof, in association with at least one constituent selected from a pharmaceutically acceptable carrier, diluent, and excipient.

75. 发明专利

BR0113178A 未知
公开(公告)号：BR0113178A
公开(公告)日：2004-04-06
申请号：BR0113178
申请日：2001-08-02
申请人： THERATECHNOLOGIES INC
发明人： GRAVEL DENIS , HABI ABDELKRIM , ABRIBAT THIERRY
IPC分类号： A61K38/00 , A61K38/04 , A61K38/22 , A61P3/10 , C07K7/08 , C07K7/23 , C07K14/00 , C07K14/47 , C07K14/55 , C07K14/575 , C07K14/58 , C07K14/585 , C07K14/595 , C07K14/60 , C07K14/605 , C07K14/635 , C07K14/65 , C07K14/655 , C07K14/665 , C07K14/675 , C07K14/68 , C07K14/695 , C07K14/78
摘要： The present invention is concerned with modified biological peptides providing increased potency, prolonged activity and/or increased half-life thereof. The modification is made via coupling through an amide bond with at least one conformationally rigid substituent, either at the N-terminal of the peptide, the C-terminal of the peptide, on a free amino or carboxyl group along the peptide chain, or at a plurality of these sites. Those peptides exhibit clinical usefulness for example in treating states of insulin resistance associated with pathologies such as type II diabetes.

76. 发明专利

CA2487061A1 PEPTIDES AND PEPTIDOMIMETICS USEFUL FOR INHIBITING THE ACTIVITY OF PROSTAGLANDIN F2.ALPHA. RECEPTOR 未知
公开(公告)号：CA2487061A1
公开(公告)日：2003-12-18
申请号：CA2487061
申请日：2003-06-11
申请人： UNIV MONTREAL , THERATECHNOLOGIES INC
发明人： LUBELL WILLIAM D , THOUIN ERYK , PERI KRISHNA G , POLYAK FELIX , CHEMTOB SYLVAIN
IPC分类号： A61K38/00 , C07K7/06 , C07K7/00 , A61K38/08
摘要： The invention relates to compositions which are useful for inhibiting prostaglandin F2.alpha. receptor. The compositions include, but are not limited to, linear peptides, peptide analogs, and peptidomimetics. Methods o f using the compositions of the invention to treat preterm labor and dysmenorrhea are disclosed.

77. 发明专利

AU2003233297A1 ANTAGONISTIC PEPTIDES OF PROSTAGLANDIN E2 RECEPTOR SUBTYPE EP4 未知
公开(公告)号：AU2003233297A1
公开(公告)日：2003-12-12
申请号：AU2003233297
申请日：2003-05-23
申请人： THERATECHNOLOGIES INC
发明人： PERI KRISHNA G , MOFFETT SERGE , ABRAN DANIEL , BERGERON ANNIE
IPC分类号： A61K38/00 , C07K7/06 , A61K38/08 , G01N33/53 , G01N33/68
摘要： Antagonistic peptides of prostaglandin E2 receptor subtype EP4 and their use in the treatment or prevention of medical conditions associated with oligouric nephropathy, bone resorption, abnormal intestinal crypt cell proliferation or patency of the ductus arteriosus and the like are provided herein. The antagonistic peptides of the present invention possess the following general formula: wherein X is selected from the group consisting of a hydrogen atom, a sequence of 1 to 3 amino acids, and protecting groups such as a carbamate group and an acyl group; and wherein Y is selected from the group consisting of a hydrogen atom, 1 to 5 L-lysine residues, phosphate, sulfate and 1 to 5 ethylene glycol residues.

78. 发明专利

MXPA01002468A ANALOGOS DE GRF CON POTENCIA BIOLOGICA INCREMENTADA. 未知
公开(公告)号：MXPA01002468A
公开(公告)日：2002-04-24
申请号：MXPA01002468
申请日：1999-09-07
申请人： THERATECHNOLOGIES INC
发明人： GRAVEL DENIS
IPC分类号： A61K38/00 , A61K49/00 , A61P3/00 , A61P3/04 , A61K38/27 , A61P5/02 , A61P17/02 , A61P19/00 , A61P19/10 , C07K14/60 , C12N15/16 , A61K38/25 , G01N33/68
摘要： La presente invencion se refiere a analogos de GRF de cuerpo graso quimericos con potencia biologica incrementada, su aplicacion como agentes anabolicos y en el diagnostico y tratamiento de deficiencias de la hormona de crecimiento. Los analogos de GRF de cuerpo graso quimericos incluyen un elemento hidrofobico (cola) y pueden prepararse ya sea mediante el anclaje de al menos una cola hidrofobica al GRF, en la sistesis quimica del GRF. Los analogos de GRF de la presente invencion son biodegradables, no inmunogenicos y exhiben una potencia anabolica mejorada con una dosis reducida y actividad prolongada.

79. 发明专利

BR9913515A 未知
公开(公告)号：BR9913515A
公开(公告)日：2001-06-05
申请号：BR9913515
申请日：1999-09-07
申请人： THERATECHNOLOGIES INC
发明人： GRAVEL DENIS , HABI ABDELKRIM , BRAZEAU PAUL
IPC分类号： A61K38/27 , A61K38/00 , A61K49/00 , A61P3/00 , A61P3/04 , A61P5/02 , A61P17/02 , A61P19/00 , A61P19/10 , C07K14/60 , C12N15/16 , A61K38/25 , G01N33/68
摘要： The present invention relates to chimeric fatty body-GRF analogs with increased biological potency, their application as anabolic agents and in the diagnosis and treatment of growth hormone deficiencies. The chimeric fatty body-GRF analogs include an hydrophobic moiety (tail), and can be prepared, either by anchoring at least one hydrophobic tail to the GRF, in the chemical synthesis of GRF. The GRF analogs of the present invention are biodegradable, non-immunogenic and exhibit an improved anabolic potency with a reduced dosage and prolonged activity.

80. 发明专利

GR3034375T3 HEADSET FOR ELECTRONIC STETHOSCOPE 未知
公开(公告)号：GR3034375T3
公开(公告)日：2000-12-29
申请号：GR20000402062
申请日：2000-09-08
申请人： THERATECHNOLOGIES INC
发明人： SAVAGE GARY , SWIFT MICHEL
IPC分类号： A61B7/02 , A61B7/04 , H04R1/10
摘要： The headset comprises left and right elongate ear pieces having respective first ends to receive ear tips and respective, interconnected second ends. Each ear piece includes a one-piece elongate body made of flexible and resilient material and curved outwardly to skirt round the user's head when the ear tips are applied to a user's ears. The elongate body is formed with a first length of smaller cross section and therefore of greater flexibility proximate the second end of the corresponding ear piece and with a second length of lower flexibility situated between that first length and the corresponding ear tip. Bending of the elongate bodies when the ear pieces are spread apart is therefore concentrated in the first lengths and pressure applied to the user's ears by the ear tips is mainly produced by the bent first lengths and transmitted to the ear tips through the second lengths of lower flexibility. The elongate ear pieces have respective second end sections assembled laterally adjacent to each other, and a threaded sleeve is mounted on these laterally adjacent second end sections and is rotated and displaced longitudinally to adjust the level of pressure applied to the user's ears by the ear tips.

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