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71. 发明专利

CA2947339A1 IMPLANTABLE DRUG DELIVERY DEVICES AND METHODS OF MAKING THE SAME 未知
公开(公告)号：CA2947339A1
公开(公告)日：2010-12-29
申请号：CA2947339
申请日：2010-06-28
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , LARRIVEE-ELKINS CHERYL
IPC分类号： A61M31/00 , A61K9/00 , A61K9/20
摘要： A drug delivery device is provided that includes a device body, a number of solid, compressed drug tablets, and a retention frame. The device body includes a drug reservoir lumen and a retention frame lumen. The number of solid, compressed drug tablets are positioned in the drug reservoir lumen, and the retention frame is positioned in the retention frame lumen. The drug tablets may be mini-tablets aligned in the drug reservoir lumen, with an interstice formed between any two adjacent drug tablets facilitating deformation of the device body. Systems and method are also provided for loading a drug delivery device. In one embodiment, the method includes positioning one or more solid drug units upstream of the drug delivery device; and driving the drug units into the drug delivery device with a flow of pressurized gas.

72. 发明专利

IL295592A Method of treating lower tract urothelial cancer 未知
公开(公告)号：IL295592A
公开(公告)日：2022-10-01
申请号：IL29559222
申请日：2022-08-14
申请人： TARIS BIOMEDICAL LLC
IPC分类号： A61K31/7068 , A61K45/06 , A61M31/00 , A61P13/02 , A61P13/10 , A61P35/00 , A61P35/04
摘要： The present invention provides methods, devices, and kits related to treatment of urothelial carcinomas of the lower tract with antimetabolite (such as gemcitabine). In some aspects the methods, devices and kits relate to treatment of urothelial carcinomas of the lower tract with an antimetabolite (such as gemcitabine) and an immunomodulating agent.

73. 发明专利

HRP20211921T1 SUSTAVI ISPORUKE LIJEKA I POSTUPCI ZA LIJEČENJE RAKA MOKRAĆNOG MJEHURA S OKSALIPLATINOM 未知
公开(公告)号：HRP20211921T1
公开(公告)日：2022-03-04
申请号：HRP20211921
申请日：2013-09-03
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/555 , A61K9/00 , A61M31/00 , A61P13/10 , A61P35/00

74. 发明专利

SI2890384T1 Sistemi za dostavo zdravila in postopki za zdravljenje raka sečnega mehurja, ki obsegajo oksaliplatin 未知
公开(公告)号：SI2890384T1
公开(公告)日：2022-02-28
申请号：SI201331961
申请日：2013-09-03
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS
IPC分类号： A61K31/00 , A61K9/00 , A61M31/00 , A61P13/00 , A61P35/00

75. 发明专利

PT2890384T SISTEMAS E MÉTODOS PARA ADMINISTRAÇÃO DE FÁRMACOS PARA TRATAMENTO DE CANCRO DE BEXIGA CONTENDO OXALIPLATINA 未知
公开(公告)号：PT2890384T
公开(公告)日：2022-01-21
申请号：PT13765839
申请日：2013-09-03
申请人： TARIS BIOMEDICAL LLC
IPC分类号： A61K31/555 , A61K9/00 , A61K31/7048 , A61K45/06 , A61L29/14 , A61L29/16 , A61L31/16 , A61M31/00 , A61P13/10

76. 发明专利

RU2764747C2 СПОСОБ ЛЕЧЕНИЯ РАКА УРОТЕЛИЯ НИЖНИХ ПУТЕЙ 未知
公开(公告)号：RU2764747C2
公开(公告)日：2022-01-20
申请号：RU2018142908
申请日：2017-05-05
申请人： TARIS BIOMEDICAL LLC
发明人： GIESING DENNIS , CUTIE CHRISTOPHER , SARMA PURNANAND , LARRIVEE-ELKINS CHERYL , SEARCY CHRISTOPHER , AGARWAL VIKAS
IPC分类号： A61K9/00 , A61K31/7068 , A61K45/06 , A61M31/00 , A61P13/02 , A61P13/10 , A61P35/00 , A61P35/04
摘要： Изобретениеотноситсяк медицине, аименнок способулечениякарциномыуротелиянижнихпутейу индивидуума. Способлечениякарциномыуротелиянижнихпутейу индивидуумавключаетвведениеиндивидуумуэффективногоколичествагемцитабина, гдегемцитабиндоставляютлокальнов мочевойпузырь, гдекарциномауротелиянижнихпутейпредставляетсобоймышечно-инвазивныйракмочевогопузыря, гдегемцитабиндоставляетсянепрерывнов мочевойпузырьиндивидуумав течениепериодаот 24 часовдошестинедель. Вышеописанныйспособпозволяетэффективнолечитьпациентовс мышечно-инвазивнымракоммочевогопузыря. 46 з.п. ф-лы, 10 ил., 2 табл., 5 пр.

77. 发明专利

BR112014028916B1 Dispositivo médico 未知
公开(公告)号：BR112014028916B1
公开(公告)日：2022-01-11
申请号：BR112014028916
申请日：2013-05-20
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , HONG LINH HO DUC
IPC分类号： A61K9/00 , A61M25/00 , A61M27/00
摘要： dispositivo urológico implantável com recurso de recuperação. é apresentado um dispositivo médico urológico que tem uma corda de recuperação. a corda de recuperação tem uma extremidade proximal conectada ao dispositivo e uma extremidade distal oposta. em uma primeira modalidade, a corda de recuperação é configurada em uma forma confinada inicial que, após um período de implantação do dispositivo médico em uma bexiga urinária de um paciente, muda para uma forma não confinada em que a extremidade distal de pelo menos uma corda de recuperação é extensível na uretra da bexiga para permitir a extração do dispositivo médico da bexiga, puxando pelo menos uma corda de recuperação. o dispositivo pode incluir um componente bioerodível que permite que a corda de recuperação assuma uma forma não confinada seguindo a degradação do componente bioerodível in vivo. em outra modalidade, a corda de recuperação inclui um material ferromagnético, que pode ser capturado magneticamente para facilitar a remoção do dispositivo da bexiga. a corda de recuperação ferromagnética pode flutuar na urina.

78. 发明专利

PL2512581T3 WSZCZEPIANE URZĄDZENIE Z TOLERANCJĄ WEWNĄTRZPĘCHERZOWĄ 未知
公开(公告)号：PL2512581T3
公开(公告)日：2021-11-02
申请号：PL10801519
申请日：2010-12-17
申请人： TARIS BIOMEDICAL LLC
发明人： CIMA MICHAEL J , LEE HEEJIN
IPC分类号： A61M31/00 , A61K9/00 , A61K31/00 , A61K31/167

79. 发明专利

AU2019203394B2 MULTI-UNIT DRUG DELIVERY DEVICES AND METHODS 未知
公开(公告)号：AU2019203394B2
公开(公告)日：2021-09-09
申请号：AU2019203394
申请日：2019-05-14
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN , DANIEL KAREN , SANSONE MATTHEW
IPC分类号： A61M31/00 , A61K9/00
摘要： Implantable drug delivery devices include a housing defining a reservoir, a first unit within the reservoir, and a second unit within the reservoir. The first unit contains a drug and the second unit contains a functional agent that facilitates release of the drug. Intravesical drug delivery devices include a housing portion containing a drug formulation and a housing portion containing an excipient, and are configured to release the drug according to a first release profile and the excipient according to a second release profile. Methods include inserting any of these devices into a patient and releasing drug from the device. WO 2015/026813 PCT/US2014/051672 A-100 104 102 102 102 102 102 102 102 102 102 102 102 102 102 102 102 -200 210 210 210 210 202 202 202 tIJW 2404 A ::r206 208 210 210 210 210 210 202 202 202 306 g- 300 310 310 302 302 302 310 310 308 310 310 310 302 302 310 310 310 r- 400 410 410 410 410 S¶/4 410 410410410 410 402

80. 发明专利

CA2902556C DRUG DELIVERY DEVICES AND METHODS FOR DRUG DELIVERY 未知
公开(公告)号：CA2902556C
公开(公告)日：2021-06-22
申请号：CA2902556
申请日：2014-03-14
申请人： TARIS BIOMEDICAL LLC
发明人： LEE HEEJIN
IPC分类号： A61K9/00 , A61K31/167
摘要： An orifice-free drug delivery device is provided. In an embodiment, the device includes a body having at least one water-permeable wall bounding a reservoir defined within the body. A drug formulation is disposed within the reservoir. The body has an elastic portion and at least one restraining plug closing off an opening of the body. The opening is in fluid communication with the reservoir, and the restraining plug contacts the elastic portion of the body and controls release of the drug from the device by the transient formation of one or more microchannels between the elastic portion of the body and the at least one restraining plug. The elastic portion may define an opening having an inner diameter, which is exceeded by the outer diameter of the restraining plug by at least 3 %.

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