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71. 发明专利

AU2010215061A1 Assay for determining epigenetic profiles of markers of Fragile X alleles 未知
公开(公告)号：AU2010215061A1
公开(公告)日：2011-09-08
申请号：AU2010215061
申请日：2010-02-17
申请人： MURDOCH CHILDRENS RES INST
发明人： EUGENY GODLER DAVID
IPC分类号： C12Q1/68
摘要： The present invention relates generally to an assay for the determination of epigenetic profiles, particularly epigenetic profiles associated with a pathological condition. Even more particularly, the present invention provides an assay to detect epigenetic profiles within the Fragile X Mental Retardation (FMR) genetic locus indicative of a pathoneurological condition such as pathoneurodevelopmental and pathoneurodegenerative conditions. The epigenetic profiles can also identify potential non-neurological conditions. Kits and assays for medicaments also form part of the present invention as do computer programs to monitor changes in epigenetic patterns and methods for screening for agents which modulate epigenetic modification.

72. 发明专利

CA2752702A1 ASSAY FOR DETERMINING EPIGENETIC PROFILES OF MARKERS OF FRAGILE X ALLELES 未知
公开(公告)号：CA2752702A1
公开(公告)日：2010-08-26
申请号：CA2752702
申请日：2010-02-17
申请人： MURDOCH CHILDRENS RES INST
发明人： GODLER DAVID EUGENY
IPC分类号： C12Q1/68
摘要： The present invention relates generally to an assay for the determination of epigenetic profiles, particularly epigenetic profiles associated with a pathological condition. Even more particularly, the present invention provides an assay to detect epigenetic profiles within the Fragile X Mental Retardation (FMR) genetic locus indicative of a pathoneurological condition such as pathoneurodevelopmental and pathoneurodegenerative conditions. The epigenetic profiles can also identify potential non-neurological conditions. Kits and assays for medicaments also form part of the present invention as do computer programs to monitor changes in epigenetic patterns and methods for screening for agents which modulate epigenetic modification.

73. 发明专利

AT470861T 未知
公开(公告)号：AT470861T
公开(公告)日：2010-06-15
申请号：AT04721774
申请日：2004-03-19
申请人： MURDOCH CHILDRENS RES INST , MELBOURNE HEALTH
发明人： VISVANATHAN KUMAR , RIORDAN STEPHEN , LOCARNINI STEPHEN
IPC分类号： G01N33/68 , C12Q1/68
摘要： The present invention provides compounds useful in the treatment and prophylaxis of infection in mammals and avian species by pathogenic agents such as, but not limited to, viruses. The present invention further provides compounds useful in the treatment of other disease conditions such as cirrhosis and hepatocellular carcinoma. The present invention further provides methods for diagnosing infection by pathogenic organisms and viruses or other disease conditions and agents useful in diagnostic protocols. The present invention further contemplates methods for monitoring disease states and providing an indication of the susceptibility of a subject for infection by a pathogenic organism or virus or development of other diseased states. In particular, the present invention enables a determination of whether, including a prediction of the level of likelihood that, a subject will respond to therapeutic or prophylactic intervention of an infection or disease condition.

74. 发明专利

AU2005243607B2 Therapeutic, prophylactic and diagnostic agents for hepatitis B 未知
公开(公告)号：AU2005243607B2
公开(公告)日：2010-02-18
申请号：AU2005243607
申请日：2005-05-19
申请人： MELBOURNE HEALTH , MURDOCH CHILDRENS RES INST
发明人： VISVANATHAN KUMAR , LOCARNINI STEPHEN
IPC分类号： C12N7/00 , A61K38/00 , A61K38/16 , A61K39/00 , C07K14/02 , C12N15/12 , C12N15/51 , C12Q1/68 , C12Q1/70

75. 发明专利

DE60121219T2 未知
公开(公告)号：DE60121219T2
公开(公告)日：2007-06-06
申请号：DE60121219
申请日：2001-12-20
申请人： MURDOCH CHILDRENS RES INST
发明人： SIEMERING KIRBY
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/44 , C12Q1/683 , G01N33/58 , G01N37/00

76. 发明专利

NZ526484A Neocentromere-based mini-chromosomes or artificial chromosomes 未知
公开(公告)号：NZ526484A
公开(公告)日：2005-04-29
申请号：NZ52648401
申请日：2001-12-20
申请人： MURDOCH CHILDRENS RES INST
发明人： CHOO KONG-HONG ANDY , WONG LEE HWA , SAFFERY RICHARD ERIC
IPC分类号： G01N33/53 , A61K31/7088 , A61K48/00 , C12N5/10 , C12N15/09 , C12N15/68 , C12N15/85 , C12Q1/68 , G01N33/566
摘要： Described is an isolated nucleic acid molecule encompassing a neocentromere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic mini-chromosomes and artificial chromosomes including mammalian (non-human) and non-mammalian mini-chromosomes and artificial chromosomes. Further provided is a telomere-associated chromosome truncation (TACT) approach to develop mini-chromosomes, but is not limited to this approach. It is directed to any truncation approach that produces a neocentromere-containing mini-chromosome, or any transfection approach using cloned or pre-fabricated DNA that provides neocentromere function in the construction of artificial chromosome. Such mini-chromosomes and artificial chromosomes are useful in a range of genetic therapies. Figure 1B is a schematic formation of mardel(10) and NC-MiCs. Open arrows indicate the breakpoints on the normal chromosome 10 in the generation of mardel(10). The long and short arms of mardel(l0) are denoted as q' and p', respectively. The truncation events resulting in the formation of NC-MiCs 1-5 are represented by Tcl and Tc2. Location of the zeocin resistance gene inserted into mardel(l0) is indicated by an asterisk. The position of BAC B1OK1 used in a screening assay for loss of p' arm is shown. Bold lines above chromosome 10 denote the locations and designations of subchromosomal DNA paints used to characterise the NC-MiCs

77. 发明专利

CA2519864A1 THERAPEUTIC, PROPHYLACTIC AND DIAGNOSTIC AGENTS 未知
公开(公告)号：CA2519864A1
公开(公告)日：2004-09-30
申请号：CA2519864
申请日：2004-03-19
申请人： MURDOCH CHILDRENS RES INST , SOUTH EASTERN SYDNEY AREA HEAL , MELBOURNE HEALTH
发明人： VISVANATHAN KUMAR , RIORDAN STEPHEN , LOCARNINI STEPHEN
IPC分类号： C12Q1/68 , G01N33/68
摘要： The present invention provides compounds useful in the treatment and prophylaxis of infection in mammals and avian species by pathogenic agents such as, but not limited to, viruses. The present invention further provides compounds useful in the treatment of other disease conditions such as cirrhosis and hepatocellular carcinoma. The present invention further provid es methods for diagnosing infection by pathogenic organisms and viruses or othe r disease conditions and agents useful in diagnostic protocols. The present invention further contemplates methods for monitoring disease states and providing an indication of the susceptibility of a subject for infection by a pathogenic organism or virus or development of other diseased states. In particular, the present invention enables a determination of whether, including a prediction of the level of likelihood that, a subject will respo nd to therapeutic or prophylactic intervention of an infection or disease condition.

78. 发明专利

AU2004221795A1 Therapeutic, prophylactic and diagnostic agents 未知
公开(公告)号：AU2004221795A1
公开(公告)日：2004-09-30
申请号：AU2004221795
申请日：2004-03-19
申请人： MURDOCH CHILDRENS RES INST , MELBOURNE HEALTH , SOUTH EASTERN SYDNEY AREA HEAL
发明人： RIORDAN STEPHEN , VISVANATHAN KUMAR , LOCARNINI STEPHEN
IPC分类号： C12Q1/68 , G01N33/68
摘要： The present invention provides compounds useful in the treatment and prophylaxis of infection in mammals and avian species by pathogenic agents such as, but not limited to, viruses. The present invention further provides compounds useful in the treatment of other disease conditions such as cirrhosis and hepatocellular carcinoma. The present invention further provides methods for diagnosing infection by pathogenic organisms and viruses or other disease conditions and agents useful in diagnostic protocols. The present invention further contemplates methods for monitoring disease states and providing an indication of the susceptibility of a subject for infection by a pathogenic organism or virus or development of other diseased states. In particular, the present invention enables a determination of whether, including a prediction of the level of likelihood that, a subject will respond to therapeutic or prophylactic intervention of an infection or disease condition.

79. 发明专利

CA2551172A1 GENETIC THERAPY AND GENETIC MODIFICATION USING NEOCENTROMERIC MINICHROMOSOMES 未知
公开(公告)号：CA2551172A1
公开(公告)日：2004-07-08
申请号：CA2551172
申请日：2003-12-23
申请人： MURDOCH CHILDRENS RES INST
发明人： WONG LEE HWA , SAFFERY RICHARD ERIC , CHOO ANDY
IPC分类号： C12N15/90 , A61K48/00 , C12N15/12 , C12N15/79 , C12N15/82 , C12N15/85
摘要： The present invention provides a target region within a mammalian, avian, plant or other eukaryotic chromosome or an artificial or engineered chromosomal construct which is capable of carrying and expressing a heterologous gene or other genetic molecule of interest. The gene or genetic molecule of interest is expressed in a region of the chromosome which corresponds to or which immediately adjoins or is proximal to a centromeric or neocentromeric region or a functional derivative thereof or a latent, synthetic or hybrid form thereof. A method for facilitating genetic therapy or genetic modification or other applications are also provided including prote in production for proteomic therapy in a mammal, avian species or plant or othe r higher eukaryotes.

80. 发明专利

NZ515964A A method for the prophylaxis and/or treatment of medical disorders 未知
公开(公告)号：NZ515964A
公开(公告)日：2004-03-26
申请号：NZ51596400
申请日：2000-06-21
申请人： MURDOCH CHILDRENS RES INST
发明人： WRAIGHT CHRISTOPHER JOHN , WERTHER GEORGE ARTHUR , DMONDSON STEPHANIE RUTH
IPC分类号： C12N15/09 , A61K31/7088 , A61K31/711 , A61K38/00 , A61K48/00 , A61P1/00 , A61P9/00 , A61P9/10 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P17/12 , A61P29/00 , A61P35/00 , A61P43/00 , C12N15/113 , A61K38/30 , A61K17/02 , A61K17/06
摘要： Use of a nucleic acid molecule selected from the group consisting of 5'-UCCGGAGCCAGACUU-3' (SEQ ID NO:12); 5'- CACAGUUGCUGCAAG-3' (SEQ ID NO:13); 5'-UCUCCGCUUCCUUUC-3' (SEQ ID NO:14); 5'-AGCCCCCACAGCGAG-3' (SEQ ID NO:15); 5'- GCCUUGGAGAUGAGC-3' (SEQ ID NO:16); 5'-UAACAGAGGUCAGCA-3' (SEQ ID NO:17); 5'-GGAUCAGGGACCAGU-3' (SEQ ID NO:18); 5'- CGGCAAGCUACACAG-3' (SEQ ID NO:19); 5'-GGCAGGCAGGCACAC-3' (SEQ ID NO:20) or chemical analogue of any one of said nucleic acid molecules as hereinbefore defined in the manufacture of a medicament for the treatment of a proliferative or inflammatory skin disorder or in a composition capable of inhibiting or otherwise reducing IGF- I mediated cell proliferation.

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