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71. 发明申请

WO0018796A3 SECRETORY PROTEIN- ZSIG48 审中-公开
标题翻译：秘密蛋白 - ZSIG48
公开(公告)号：WO0018796A3
公开(公告)日：2000-09-28
申请号：PCT/US9922970
申请日：1999-10-01
申请人： ZYMOGENETICS INC
发明人： LOK SI , SHEPPARD PAUL O
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P7/00 , A61P35/00 , A61P37/04 , C07K14/47 , C07K14/52 , C07K16/24 , C12N5/06 , C12N5/10 , C12N15/12 , A61K38/17 , C07K16/18
CPC分类号： C07K14/4702 , A61K38/00 , A61K48/00
摘要： Secretory Protein - 48 (Zsig48), polypeptides, polynucleotides encoding said polypeptides, antibodies which specifically bind to Zsig48 and anti-idiotypic antibodies. Zsig48 polypeptides cause leukocytes to proliferate and thus can be used to elevate leukocytes in cancer treatments and in immunosuppressed patients.
摘要翻译：分泌蛋白-48（Zsig48），多肽，编码所述多肽的多核苷酸，特异性结合Zsig48和抗独特型抗体的抗体。 Zsig48多肽导致白细胞增殖，因此可用于在癌症治疗和免疫抑制患者中提高白细胞。

72. 发明申请

WO0042183A2 TUMOR MARKER ZSIG62 审中-公开
标题翻译：肿瘤标记ZSIG62
公开(公告)号：WO0042183A2
公开(公告)日：2000-07-20
申请号：PCT/US0001902
申请日：2000-01-18
申请人： ZYMOGENETICS INC
发明人： SHEPPARD PAUL O , NOVAK JULIA E , RAYMOND FENELLA C
IPC分类号： C07K14/47 , C12N15/12 , C07K14/82 , C07K16/32 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4703
摘要： Studies indicate that mutations in tumor suppressor genes occur early in the process of carcinogenesis, and that these mutations are correlated with a subsequent development of cancer. The detection of such alterations would provide useful molecular markers for diagnosis, surveillance, early tumor identification and intervention, and prognosis. A novel human gene, designated as "Zsig62", resides within a region of chromosome 16q that is associated with prostate and breast cancer, and that appears to contain tumor suppressor genes. Like a tumor suppressor gene, the Zsig62 gene is expressed in particular normal tissues, but not in tumors derived from those tissues.
摘要翻译：研究表明，肿瘤抑制基因突变在致癌过程的早期发生，这些突变与随后的癌症发展相关。这种改变的检测将为诊断，监测，早期肿瘤鉴定和干预以及预后提供有用的分子标记。称为“Zsig62”的新型人类基因位于与前列腺和乳腺癌相关的染色体16q的区域中，并且似乎含有肿瘤抑制基因。像肿瘤抑制基因一样，Zsig62基因在特定的正常组织中表达，但不是来源于那些组织的肿瘤。

73. 发明申请

WO0034474A2 GROWTH FACTOR HOMOLOG ZVEGF3 审中-公开
标题翻译：生长因子HOMOLOG ZVEGF3
公开(公告)号：WO0034474A2
公开(公告)日：2000-06-15
申请号：PCT/US9928968
申请日：1999-12-07
申请人： ZYMOGENETICS INC
发明人： GAO ZEREN , HART CHARLES E , PIDDINGTON CHRISTOPHER S , SHEPPARD PAUL O , SHOEMAKER KIMBERLY E , GILBERTSON DEBRA G , WEST JAMES W
IPC分类号： G01N33/53 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P9/10 , A61P9/14 , A61P19/02 , A61P27/06 , A61P29/00 , A61P35/00 , C07K14/475 , C07K14/52 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/566 , A61K38/18 , C12N15/11 , C12N15/62 , G01N33/68
CPC分类号： C07K14/475 , A61K38/00 , C07K14/52
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprises an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译：公开了多肽生长因子，其制备方法，编码它们的多核苷酸，针对它们的抗体以及使用它们的方法。多肽包含与SEQ ID NO：2的残基46-163或SEQ ID NO：2的残基235-345至少90％相同的氨基酸区段。还公开了多肽的多聚体。多肽，多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节，作为细胞培养基的组分和诊断剂。

74. 发明申请

WO9640944A2 FUSED SOLUBLE MHC HETERODIMER:PEPTIDE COMPLEXES AND THEIR USES 审中-公开
标题翻译： FUSED SOLUBLE MHC HETERBRER：肽复合物及其用途
公开(公告)号：WO9640944A2
公开(公告)日：1996-12-19
申请号：PCT/US9610102
申请日：1996-06-07
申请人： ZYMOGENETICS INC , ANERGEN INC
发明人： KINDSVOGEL WAYNE , REICH EVA PIA , GROSS JANE A , DESHPANDE SHRINKANT , SHEPPARD PAUL O
IPC分类号： C12N15/09 , A61K39/00 , A61P37/00 , C07K7/08 , C07K14/47 , C07K14/74 , C07K19/00 , C12N5/00 , C12N5/10 , C12N9/88 , C12R1/91 , C12N15/62 , A61K38/17 , C07K16/18 , C07K16/28 , C07K16/40 , C12N5/08 , C12N15/85
CPC分类号： C12N9/88 , A61K39/00 , A61K2039/5158 , C07K14/4711 , C07K14/70539 , C07K2319/00
摘要： Immune modulators, such as soluble, fused MHC heterodimers and soluble, fused MHC heterodimer:peptide complexes, are described. Related methods and peptides are also disclosed. In a preferred aspect, these mediators and methods are related to autoimmunity.
摘要翻译：描述了免疫调节剂，例如可溶性融合的MHC异源二聚体和可溶性融合的MHC异二聚体：肽复合物。还公开了相关方法和肽。在优选的方面，这些介质和方法与自身免疫有关。

75. 发明专利

ES2432053T3 Homólogo del factor del crecimiento ZVEGF3 未知
公开(公告)号：ES2432053T3
公开(公告)日：2013-11-29
申请号：ES08075507
申请日：1999-12-07
申请人： ZYMOGENETICS INC
发明人： GAO ZEREN , HART CHARLES E , PIDDINGTON CHRISTOPHER S , SHEPPARD PAUL O , SHOEMAKER KIMBERLY E , GILBERTSON DEBRA G , WEST JAMES W
IPC分类号： C07K16/22 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P9/10 , A61P9/14 , A61P19/02 , A61P27/06 , A61P29/00 , A61P35/00 , C07K14/475 , C07K14/52 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/566
摘要： Un antagonista de zvegf3 para su uso en la reducción de fibrosis en un sujeto, en donde el antagonista de zvegf3 es un anticuerpo que se une específicamente a un epítopo de un polipéptido como se muestra en los restos 235-345 o 226-345 de SEC ID Nº: 2.

76. 发明专利

HK1150618A1 HOMOGENEOUS PREPARATIONS OF IL-29 IL-29 未知
公开(公告)号：HK1150618A1
公开(公告)日：2012-01-06
申请号：HK11104722
申请日：2011-05-13
申请人： ZYMOGENETICS INC , SQUIBB BRISTOL MYERS CO
发明人： BRADY LOWELL J , KLUCHER KEVIN M , CHAN CHUNG , DONG DENNIS L , LIU HONG Y , SHEPPARD PAUL O , BUKOWSKI THOMAS R
IPC分类号： A61K20060101 , A61K38/00 , A61K38/20 , A61K38/21 , A61K39/29 , A61K39/395 , A61K39/42 , C07K20060101 , C07K14/54 , C07K14/555 , C12N20060101

77. 发明专利

CA2413258C INTERFERON-LIKE PROTEIN ZCYTO21 未知
公开(公告)号：CA2413258C
公开(公告)日：2012-01-03
申请号：CA2413258
申请日：2001-06-29
申请人： ZYMOGENETICS INC
发明人： SHEPPARD PAUL O , PRESNELL SCOTT R , FOX BRIAN A , GILBERT TERESA , HALDEMAN BETTY A , GRANT FRANCIS J
IPC分类号： C12N15/19 , G01N33/53 , C07H21/02 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/555 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/99 , C12N15/09 , C12N15/21 , C12N15/74 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
摘要： The present invention relates to polynucleotide and polypeptide molecules for Zcyto21, an interferon-like protein, which is most closely related to interferon-.alpha. at the amino acid sequence level. The present invention also includes antibodies to the Zcyto21 polypeptides, and methods of using the polynucleotides and polypeptides.

78. 发明专利

CA2354325C GROWTH FACTOR HOMOLOG ZVEGF3 未知
公开(公告)号：CA2354325C
公开(公告)日：2011-08-16
申请号：CA2354325
申请日：1999-12-07
申请人： ZYMOGENETICS INC
发明人： GAO ZEREN , HART CHARLES E , PIDDINGTON CHRISTOPHER S , SHEPPARD PAUL O , SHOEMAKER KIMBERLY E , GILBERTSON DEBRA G , WEST JAMES W
IPC分类号： C12N15/12 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P9/10 , A61P9/14 , A61P19/02 , A61P27/06 , A61P29/00 , A61P35/00 , C07K14/475 , C07K14/52 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/68
摘要： Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprises an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.

79. 发明专利

DE69740074D1 Fibroblasten-Wachstumsfaktoren-Homologe 未知
公开(公告)号：DE69740074D1
公开(公告)日：2011-01-20
申请号：DE69740074
申请日：1997-10-16
申请人： ZYMOGENETICS INC
发明人： DEISHER THERESA A , CONKLIN DARRELL C , RAYMOND FENELLA C , BUKOWSKI THOMAS R , JULIEN SUSAN D , HANSEN BRIGIT , SHEPPARD PAUL O
IPC分类号： C12N15/09 , C12N15/18 , A61K38/00 , A61K38/18 , A61P9/10 , A61P19/08 , A61P21/00 , C07K14/50 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/077 , C12N5/10 , C12P21/02 , C12P21/08

80. 发明专利

ES2312223T3 ZVEGF3 HOMOLOGO DE FACTOR DE CRECIMIENTO. 未知
公开(公告)号：ES2312223T3
公开(公告)日：2009-02-16
申请号：ES99966032
申请日：1999-12-07
申请人： ZYMOGENETICS INC
发明人： GAO ZEREN , HART CHARLES E , PIDDINGTON CHRISTOPHER S , SHEPPARD PAUL O , SHOEMAKER KIMBERLY E , GILBERTSON DEBRA G
IPC分类号： C12N15/12 , G01N33/53 , A61K31/7088 , A61K38/00 , A61K38/18 , A61K39/395 , A61K45/00 , A61K48/00 , A61P3/10 , A61P9/10 , A61P9/14 , A61P19/02 , A61P27/06 , A61P29/00 , A61P35/00 , C07K14/475 , C07K14/52 , C07K16/22 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/62 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/566 , G01N33/68
摘要： Proteína aislada que comprende un primer disulfuro de polipéptido unido a un segundo polipéptido, en la que cada uno de dichos primer y segundo polipéptidos es de 111 a 136 aminoácidos de longitud y comprende: a) los restos 235 a 345 de la SEC. ID. nº: 2; o b) una secuencia de restos de aminoácidos que es por lo menos 90% idéntica a los restos 235 a 345 de la SEC. ID. nº: 2 en la que la proteína modula la proliferación, la diferenciación, el metabolismo o la migración celulares.

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