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71. 发明申请

US20100151495A9 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20100151495A9
公开(公告)日：2010-06-17
申请号：US12074228
申请日：2008-02-29
申请人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Klarisa Rikova , Kimberly Lee , Erik Spek , Yu Li , Charles Farnsworth
发明人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Klarisa Rikova , Kimberly Lee , Erik Spek , Yu Li , Charles Farnsworth
IPC分类号： G01N33/53 , C07K16/18 , C07K14/00 , C12N5/18
CPC分类号： C07K16/44 , G01N33/57426
摘要： The invention discloses nearly 443 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein kinases (including Serine/Threonine dual specificity, and Tyrosine kinases), Adaptor/Scaffold proteins, Transcription factors, Phospoatases, Tumor supressors, Ubiquitin conjugating system proteins, Translation initiation complex proteins, RNA binding proteins, Apoptosis proteins, Adhesion proteins, G protein regulators/GTPase activating protein/Guanine nucleotide exchange factor proteins, and DNA binding/replication/repair proteins, as well as other protein types.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的近443个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：蛋白激酶（包括丝氨酸/苏氨酸双特异性和酪氨酸激酶），适配器/支架蛋白，转录因子，磷酸酶，肿瘤抑制因子，泛素缀合系统蛋白，翻译起始复合体蛋白质，RNA结合蛋白，细胞凋亡蛋白，粘附蛋白，G蛋白调节剂/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，以及DNA结合/复制/修复蛋白，以及其他蛋白质类型。

72. 发明申请

US20100015724A1 LYSINE ACETYLATION SITES 审中-公开
标题翻译： LYSINE乙酰化网站
公开(公告)号：US20100015724A1
公开(公告)日：2010-01-21
申请号：US12310279
申请日：2007-08-17
申请人： Peter Hornbeck , Ting-Lie Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
发明人： Peter Hornbeck , Ting-Lie Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C07K16/44 , A61K38/00 , G01N33/574 , G01N2500/04
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在各种癌症中鉴定的332个新的乙酰化位点，包含本发明的乙酰化位点的肽（包括AQUA肽），特异性结合本发明的新型乙酰化位点的抗体，以及上述的诊断和治疗用途。

73. 发明申请

US20090258442A1 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20090258442A1
公开(公告)日：2009-10-15
申请号：US12074199
申请日：2008-02-29
申请人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Klarisa Rikova , Kimberly Lee , Erik Spek , Yu Li , Charles Farnsworth
发明人： Roberto Polakiewicz , Ailan Guo , Albrecht Moritz , Klarisa Rikova , Kimberly Lee , Erik Spek , Yu Li , Charles Farnsworth
IPC分类号： G01N33/536 , C07K16/18
CPC分类号： C07K16/30 , C07K16/44 , G01N33/57426 , G01N33/57496
摘要： The invention discloses nearly 474 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Kinase, Adaptor/Scaffold proteins, Phosphatase, G protein Regulator/Guanine Nucleotide Exchange Factors/GTPase Activating Proteins, Cytoskeleton Proteins, DNA Binding Proteins, Phospholipase, Receptor Proteins, Enzymes, DNA Repair/Replication Proteins, Adhesion Proteins, and Proteases, as well as other protein types.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的近474个新的磷酸化位点和人癌基因的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，如以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：激酶，适配器/支架蛋白，磷酸酶，G蛋白调节剂/鸟嘌呤核苷酸交换因子/ GTP酶活化蛋白，细胞骨架蛋白，DNA结合蛋白，磷脂酶，受体蛋白，酶， DNA修复/复制蛋白，粘附蛋白和蛋白酶，以及其他蛋白质类型。

74. 发明申请

US20090193424A1 METHOD OF PROCESSING INSTRUCTIONS IN PIPELINE-BASED PROCESSOR AND CORRESPONDING PROCESSOR 有权
标题翻译：基于管道处理器和相应处理器的处理指令的方法
公开(公告)号：US20090193424A1
公开(公告)日：2009-07-30
申请号：US12357910
申请日：2009-01-22
申请人： Wen Bo Shen , Peng Shao , Yu Li , Xiao Tao Chang , Yi Ge , Huayong Wang , Huan Hao Zou
发明人： Wen Bo Shen , Peng Shao , Yu Li , Xiao Tao Chang , Yi Ge , Huayong Wang , Huan Hao Zou
IPC分类号： G06F9/46
CPC分类号： G06F1/3287 , G06F9/3867 , G06F9/3885 , G06F9/4818 , G06F11/30 , G06F13/18 , Y02D10/14
摘要： The present invention discloses a method of processing instructions in a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, the base pipeline stages being activated all the while, and the enhanced pipeline stages being activated or shutdown according to requirements for performance of a workload. The present invention further discloses a method of processing instructions in a pipeline-based central processing unit, wherein the pipeline is partitioned into base pipeline stages and enhanced pipeline stages according to functions, each pipeline stage being partitioned into a base module and at least one enhanced module, the base module being activated all the while, and the enhanced module being activated or shutdown according to requirements for performance of a workload.
摘要翻译：本发明公开了一种在基于流水线的中央处理单元中处理指令的方法，其中根据功能将流水线划分为基本流水线阶段和增强流水线阶段，基本流水线阶段同时被激活，增强的流水线阶段根据工作负载的性能要求被激活或关闭。本发明还公开了一种在基于流水线的中央处理单元中处理指令的方法，其中根据功能将流水线划分成基本流水线级和增强的流水线级，每个流水线级分为基模块和至少一增强型模块，基本模块一直被激活，并且增强模块根据工作负载的性能要求被激活或关闭。

75. 发明申请

US20090098581A1 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090098581A1
公开(公告)日：2009-04-16
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： G01N33/574 , C07K16/30 , G01N33/566
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

76. 发明申请

US20080153347A1 Battery Connector 审中-公开
标题翻译：电池连接器
公开(公告)号：US20080153347A1
公开(公告)日：2008-06-26
申请号：US11613271
申请日：2006-12-20
申请人： Ming-Chun Lai , Yu Li
发明人： Ming-Chun Lai , Yu Li
IPC分类号： H01R3/00
CPC分类号： H01R13/2442
摘要： A battery connector includes a housing having a terminal recess and a plurality of electric terminals. The terminal recess has an inlay recess in the bottom of the terminal recess and a receiving cavity extending from the top of the terminal recess to the inlay recess, and an opening is dug at the end of the inlay recess. The electric terminal comprises a base portion, a contacting portion and a soldering portion. The base portion is received in the inlay recess. The contacting portion extends out of the receiving cavity for connecting the battery. The soldering portion was exposed by the opening of the housing. The repairman can replenish solder to the soldering portion by the opening of the housing if the machine omits soldering the soldering portion of the battery connector during excessive production.
摘要翻译：电池连接器包括具有端子凹部和多个电端子的壳体。端子凹部在端子凹槽的底部具有凹槽，并且从端子凹部的顶部延伸到嵌入凹槽，并且在嵌入凹槽的端部挖出开口。电气端子包括基部，接触部和焊接部。基部被容纳在嵌体凹部中。接触部分延伸出接收腔，用于连接电池。焊接部分被壳体的开口暴露。如果在过度生产过程中机器省略焊接电池连接器的焊接部分，修理工可以通过外壳的打开将焊料补充到焊接部分。

77. 发明申请

US20080116919A1 FPGA AND METHOD AND SYSTEM FOR CONFIGURING AND DEBUGGING A FPGA 有权
标题翻译：用于配置和调试FPGA的FPGA和方法和系统
公开(公告)号：US20080116919A1
公开(公告)日：2008-05-22
申请号：US11944408
申请日：2007-11-21
申请人： Yu Li , Guo Hui Lin , Qiang Liu , Yu Dong Yang
发明人： Yu Li , Guo Hui Lin , Qiang Liu , Yu Dong Yang
IPC分类号： G01R31/02
CPC分类号： G01R31/31705 , G01R31/318519
摘要： The present invention provides a Field Programmable Gate Array (FPGA), a system for debugging a Field Programmable Gate Array, a method for debugging a Field Programmable Gate Array, a FPGA configuration data product and a method and system for configuring a FPGA. According to one aspect of the invention, there is provided a Field Programmable Gate Array (FPGA) having a logic unit under test and comprising: a probe signal selecting unit configured to select at least one probe point from a plurality of probe points in said logic unit under test, and obtain a probe signal at said probe point; and a high speed serial transceiver configured to convert said probe signal into a high speed serial signal and transmit it to outside.
摘要翻译：本发明提供了现场可编程门阵列（FPGA），用于调试现场可编程门阵列的系统，用于调试现场可编程门阵列的方法，FPGA配置数据产品以及用于配置FPGA的方法和系统。根据本发明的一个方面，提供了一种具有被测逻辑单元的现场可编程门阵列（FPGA），包括：探测信号选择单元，被配置为从所述逻辑中的多个探测点中选择至少一个探测点并在所述探测点获取探测信号; 以及配置成将所述探测信号转换为高速串行信号并将其传输到外部的高速串行收发器。

78. 发明申请

US20080108795A1 Reagents for the detection of protein phosphorylation in EGFR-signaling pathways 有权
标题翻译：用于检测EGFR-信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20080108795A1
公开(公告)日：2008-05-08
申请号：US11821130
申请日：2007-06-21
申请人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
发明人： Ailan Guo , Kimberly Lee , Klarisa Rikova , Charles Farnsworth , Albrecht Moritz , Yu Li , Robert Polakiewicz
IPC分类号： C07K16/18
CPC分类号： C07K16/2863 , C07B59/008 , C07K2317/34
摘要： The invention discloses 168 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of, and including, EGFR kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Calcium-Binding Proteins, Cell Cycle Regulation proteins, Cytoskeletal proteins, DNA Binding and Replication Proteins, GTPase Activating proteins, Guanine Nucleotide Exchange Factor proteins, Lipid Kinases, Receptor Tyrosine Kinases, Receptor Tyrosine Kinase ligands, Protein Kinases, Receptor and Protein Phosphatases, Transcription Factor proteins, Tumor Suppressor proteins, and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中识别的168个新的磷酸化位点和EGFR激酶下游和包括EGFR激酶的途径，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点 /蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型发生的位点：肌动蛋白结合蛋白，衔接/支架蛋白，钙结合蛋白，细胞周期调节蛋白，细胞骨架蛋白，DNA结合和复制蛋白，GTP酶激活蛋白，鸟嘌呤核苷酸交换因子蛋白质，脂质激酶，受体酪氨酸激酶，受体酪氨酸激酶配体，蛋白激酶，受体和蛋白磷酸酶，转录因子蛋白，肿瘤抑制蛋白和囊泡蛋白。

79. 外观设计

USD559180S1 Battery connector 有权
公开(公告)号：USD559180S1
公开(公告)日：2008-01-08
申请号：US29270291
申请日：2006-12-20
申请人： Ming Chun Lai , Yu Li
设计人： Ming Chun Lai , Yu Li

80. 发明授权

US07253622B2 High field head coil for dual-mode operation in magnetic resonance imaging 失效
标题翻译：用于磁共振成像中双模操作的高场磁头线圈
公开(公告)号：US07253622B2
公开(公告)日：2007-08-07
申请号：US11334241
申请日：2006-01-17
申请人： Charles A. Saylor , Yu Li
发明人： Charles A. Saylor , Yu Li
IPC分类号： G01V3/00
CPC分类号： G01R33/3415 , G01R33/34046 , G01R33/3642 , G01R33/365
摘要： Embodiments of the subject invention can utilize a single coil structure for dual-mode operation. In a specific embodiment, a single coil structure can be used as a volume coil in the transmitting phase and as a phase array in the receiving phase. In an embodiment, a transmit coil array in accordance with the subject invention can be utilized for one or more of the following: 1) parallel RF excitation on an MRI scanner equipped with a multiple-channel transmitter; 2) serial RF excitation with the use of a switch system with a single channel transmitter; and 3) generation of a homogeneous B1 field for regular MRI with the use of a power splitter on a standard scanner. In a specific embodiment, the use of a concentric double loop coil with different tunings of inner and outer loops can be implemented. In an embodiment, the coil elements can be decoupled using the CRC mode of a concentric double loop coil. In an embodiment, a surface coil transmit array can provide better compatibility with a receive array. In a specific embodiment, an over-coupled technique can be used to improve the phase control of the transmitting pulse.
摘要翻译：本发明的实施例可以利用单线圈结构进行双模操作。在具体实施例中，单个线圈结构可以用作发射相位中的体积线圈，并且在接收阶段中用作相位阵列。在一个实施例中，根据本发明的发射线圈阵列可用于以下一个或多个：1）配备有多通道发射器的MRI扫描器上的并行RF激励; 2）使用具有单通道发射器的开关系统进行串行RF激励; 以及3）在标准扫描仪上使用功率分配器产生用于常规MRI的均匀B 1'场。在具体实施例中，可以实现具有内圈和外圈的不同调谐的同心双环线圈的使用。在一个实施例中，线圈元件可以使用同心双环线圈的CRC模式去耦合。在一个实施例中，表面线圈发射阵列可以提供与接收阵列更好的兼容性。在具体实施例中，可以使用过耦合技术来改善发射脉冲的相位控制。

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