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71. 发明授权

US06314257B1 Simultaneous developing/cleaning device 失效
标题翻译：同时显影/清洗装置
公开(公告)号：US06314257B1
公开(公告)日：2001-11-06
申请号：US09515669
申请日：2000-02-29
申请人： Yasuyuki Ishii , Shinji Uehara , Tomomi Kakeshita
发明人： Yasuyuki Ishii , Shinji Uehara , Tomomi Kakeshita
IPC分类号： G03G1524
CPC分类号： G03G15/081
摘要： A simultaneous developing/cleaning device includes a developer carrying member for carrying a layer of developer, the developer carrying member forming a developing zone where the layer of the developer is contacted to the developer carrying member and to an image bearing member carrying a latent image; and a charge application member for applying electric charge to the developer carried on the developer carrying member by electric discharge, the charge application member being provided upstream of the developing zone with respect to a moving direction of the developer carrying member.
摘要翻译：同时显影/清洁装置包括用于承载显影剂层的显影剂承载构件，显影剂承载构件形成显影区，显影剂层与显影剂承载构件接触，并且承载潜象的图像承载构件; 以及电荷施加构件，用于通过放电对携带在显影剂承载构件上的显影剂施加电荷，电荷施加构件相对于显影剂承载构件的移动方向设置在显影区的上游。

72. 发明授权

US5591294A Recording sheet manufacturing and storing method, recording sheet obtained by the method, and ink jet recording method using the recording sheet 失效
标题翻译：记录纸制造和存储方法，通过该方法获得的记录片材和使用该记录片材的喷墨记录方法
公开(公告)号：US5591294A
公开(公告)日：1997-01-07
申请号：US274028
申请日：1994-07-12
申请人： Mamoru Sakaki , Miyuki Fujita , Yasuyuki Ishii
发明人： Mamoru Sakaki , Miyuki Fujita , Yasuyuki Ishii
IPC分类号： B41M5/00 , B41M5/50 , B41M5/52 , B65H35/04 , B32B31/18 , B32B31/22
CPC分类号： B41M5/52 , B41M5/508 , B41M5/5218 , B41M5/5236 , B41M5/5254 , Y10T156/1052
摘要： In a method of manufacturing and storing a recording sheet, a coating solution is coated on at least one surface of a base member and dried and a resulting recording sheet is cut and enclosed in a packaging material. The process from drying to enclosing is carried out in an atmosphere having a humidity not exceeding 50% RH.
摘要翻译：在制造和存储记录片材的方法中，将涂布溶液涂覆在基底构件的至少一个表面上并干燥，并将所得的记录片材切割并封闭在包装材料中。从干燥到包封的过程在湿度不超过50％RH的气氛中进行。

73. 发明授权

US08920774B2 Drug having regulatory cell ligand contained in liposome 有权
标题翻译：含有脂质体中调节细胞配体的药物
公开(公告)号：US08920774B2
公开(公告)日：2014-12-30
申请号：US12687728
申请日：2010-01-14
申请人： Yasuyuki Ishii , Risa Nozawa , Masaru Taniguchi
发明人： Yasuyuki Ishii , Risa Nozawa , Masaru Taniguchi
IPC分类号： A61K39/00 , A61K45/00 , A61K51/00 , A61K31/4745 , A61K9/127 , A61K31/7028 , A61K31/7088
CPC分类号： A61K9/127 , A61K31/4745 , A61K31/7028 , A61K31/7032 , A61K31/7088 , A61K31/728
摘要： A liposome containing a regulatory cell ligand such as α-galactosyl ceramide or β-galactosyl ceramide is employed as the active ingredient of a drug for preventing or treating immune diseases etc.
摘要翻译：使用含有调节性细胞配体如α-半乳糖基神经酰胺或β-半乳糖神经酰胺的脂质体作为预防或治疗免疫疾病等的药物的活性成分。

74. 发明申请

US20130236470A1 THERAPEUTIC AGENT FOR MALIGNANT TUMORS EXPRESSING MHC CLASS II 有权
标题翻译：用于表达MHC II类的恶性肿瘤的治疗剂
公开(公告)号：US20130236470A1
公开(公告)日：2013-09-12
申请号：US13877844
申请日：2011-10-04
申请人： Shuji Matsuoka , Yasuyuki Ishii
发明人： Shuji Matsuoka , Yasuyuki Ishii
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/2803 , C07K16/30 , C07K2317/34 , G01N2333/70539
摘要： Provided is a novel therapeutic agent specific for a malignant tumor expressing MHC class II. The present invention provides an antibody recognizing a protein constituting MHC class II expressed on a malignant tumor, the antibody comprising at least one selected from heavy chain CDR1 (amino acid sequence represented by positions 49 to 54 of SEQ ID NO: 54), heavy chain CDR2 (amino acid sequence represented by positions 69 to 84 of SEQ ID NO: 54), heavy chain CDR3 (amino acid sequence represented by positions 117 to 128 of SEQ ID NO: 54), light chain CDR1 (amino acid sequence represented by positions 46 to 55 of SEQ ID NO: 56), light chain CDR2 (amino acid sequence represented by positions 71 to 77 of SEQ ID NO: 56), and light chain CDR3 (amino acid sequence represented by positions 100 to 108 of SEQ ID NO: 56).
摘要翻译：提供一种特异于表达II类MHC的恶性肿瘤的新型治疗剂。本发明提供一种抗体，其识别构成在恶性肿瘤上表达的II类MHC的蛋白质，所述抗体包含选自重链CDR1（SEQ ID NO：54的49至54位的氨基酸序列）中的至少一种，重链 CDR2（SEQ ID NO：54的位置69〜84所示的氨基酸序列），重链CDR3（SEQ ID NO：54的117〜128位的氨基酸序列），轻链CDR1（氨基酸序列 SEQ ID NO：56的46〜55），轻链CDR2（由SEQ ID NO：56的71〜77位表示的氨基酸序列）和轻链CDR3（SEQ ID NO：：56）。

75. 发明申请

US20130216276A1 DEVELOPMENT DEVICE, AND IMAGE FORMING APPARATUS AND PROCESS CARTRIDGE INCORPORATING SAME 有权
标题翻译：开发装置和图像形成装置及其加工方法
公开(公告)号：US20130216276A1
公开(公告)日：2013-08-22
申请号：US13730199
申请日：2012-12-28
申请人： Yoshiko OGAWA , Yasuyuki Ishii , Osamu Endou , Yuuji Ishikura
发明人： Yoshiko OGAWA , Yasuyuki Ishii , Osamu Endou , Yuuji Ishikura
IPC分类号： G03G15/08 , G03G21/18
CPC分类号： G03G15/0812 , G03G15/0818 , G03G21/18
摘要： A development device includes a developer bearer to carry by rotation developer to a development range facing a latent image bearer and a developer regulator to adjust an amount of developer transported to the development range by the developer bearer. The developer bearer includes a developer carrying range having surface unevenness; and a surface of the developer bearer is coated with a coating material including a resin material and particles to roughen the surface.
摘要翻译：开发设备包括由旋转开发者承载到面向潜像承载体的开发范围的开发者承载体和开发者调节器，以通过开发者承载者调整运送到开发范围的显影剂的量。显影剂载体包括具有表面不均匀性的显影剂携带范围; 并且显影剂承载体的表面涂覆有包括树脂材料和颗粒的涂层材料以使表面变粗糙。

76. 发明申请

US20090233281A1 DIAGNOSTIC MARKER FOR ALLERGY 审中-公开
标题翻译：用于过敏的诊断标记
公开(公告)号：US20090233281A1
公开(公告)日：2009-09-17
申请号：US12097002
申请日：2006-11-15
申请人： Kenichi Masuda , Yasuyuki Ishii , Masahiro Sakaguchi
发明人： Kenichi Masuda , Yasuyuki Ishii , Masahiro Sakaguchi
IPC分类号： C12Q1/68 , C07K16/00 , C07H21/00 , C12Q1/02 , G01N33/68 , C12N5/06
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/56972 , G01N2800/24
摘要： The present invention provides a test system that specifically detects allergy, a test system that highly sensitively reflects aggravation of allergy and the like.More particularly, the present invention provides a diagnostic reagent, particularly a diagnostic reagent for allergy, or a reagent for detecting a mast cell and/or a blastogenic T cell, comprising one or more means for measuring CHD2, which is/are selected from the group consisting of a primer, a nucleic acid probe and an antibody; a test method for allergy, comprising measuring CHD2 expression in a biological sample obtained from an animal and evaluating allergy in the animal; a method for detecting a mast cell and/or a blastogenic T cell; and the like.
摘要翻译：本发明提供一种特异性检测过敏的检测系统，能够高敏感地反映过敏反应加重等的检测体系。更具体地，本发明提供诊断试剂，特别是用于过敏的诊断试剂或用于检测肥大细胞和/或爆破性T细胞的试剂，其包含一种或多种测量CHD2的装置，所述装置选自由引物，核酸探针和抗体组成的组; 包括测量从动物得到的生物样品中的CHD2表达并评估动物的变态反应的过敏测试方法; 用于检测肥大细胞和/或爆破性T细胞的方法; 等等。

77. 发明申请

US20070280745A1 DEVELOPING APPARATUS 有权
标题翻译：开发设备
公开(公告)号：US20070280745A1
公开(公告)日：2007-12-06
申请号：US11751211
申请日：2007-05-21
申请人： Koichiro Takashima , Yasuyuki Ishii , Yuichiro Hirata , Tomonori Matsunaga
发明人： Koichiro Takashima , Yasuyuki Ishii , Yuichiro Hirata , Tomonori Matsunaga
IPC分类号： G03G15/08
CPC分类号： G03G15/0808
摘要： A developing apparatus including: a developer carrying member carrying a developer with which an electrostatic image on an image bearing member is developed; a developer supplying/removing member having a conductive member and an insulating member on the surface thereof, and provided apart from the developer carrying member to supply and remove the developer to and from the developer carrying member, and moving directions of the developer carrying member and the developer supplying/removing member being opposed in a developer supplying position; and an electric field producing device producing between the developer carrying member and the developer supplying/removing member an oscillating electric field, in which direct potentials of the conductive member and the developer carrying member are the same, or the direct potential of the conductive member, with respect to the direct potential of the developer carrying member, is on the opposite side to a normal charging polarity of the developer.
摘要翻译：一种显影装置，包括：承载显影剂的显影剂承载构件，其上显影图像承载构件上的静电图像; 在其表面上具有导电构件和绝缘构件的显影剂供应/去除构件，并且与显影剂承载构件分开设置，以将显影剂供应到显影剂承载构件和从显影剂承载构件移除，以及显影剂承载构件的移动方向和显影剂供应/去除构件在显影剂供应位置相对; 以及在显影剂承载构件和显影剂供给/去除构件之间产生其中导电构件和显影剂承载构件的直接电位相同的振荡电场或导电构件的直接电位的电场产生装置，相对于显影剂承载构件的直接电位，与显影剂的正常充电极性相反。

78. 发明授权

US07304072B2 Spiro compounds 失效
标题翻译：螺环化合物
公开(公告)号：US07304072B2
公开(公告)日：2007-12-04
申请号：US10922869
申请日：2004-08-23
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh , Masato Chiba
IPC分类号： A61K31/4355 , C07D491/048
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： Compounds represented by the general formula (I) wherein Ar1 represents an aryl or heteroaryl which may be substituted; n represents 0 or 1; T, U, V and W each independently represent a nitrogen atom or a methine group which may have a substituent selected from the group consisting of halogen, lower alkyl, hydroxy and lower alkoxy, wherein at least two of which represent said methine group; X represents methine, hydroxy substituted methine or nitrogen atom; Y represents an imino which may be substituted with lower alkyl, or oxygen; and a salt, ester or N-oxide derivative thereof. The compounds exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders, central nervous system disorders, metabolic diseases, sexual and reproductive dysfunctions, gastro-intestinal disorders, respiratory disorders, inflammation or glaucoma, and the like.
摘要翻译：由通式（I）表示的化合物

79. 发明授权

US06961527B2 Method of detecting life of image bearing member, image forming apparatus and cartridge 有权
标题翻译：检测图像承载部件，成像设备和墨盒的寿命的方法
公开(公告)号：US06961527B2
公开(公告)日：2005-11-01
申请号：US10682078
申请日：2003-10-10
申请人： Minoru Matsuguma , Yasuyuki Ishii
发明人： Minoru Matsuguma , Yasuyuki Ishii
IPC分类号： G03G21/00 , G03G15/00 , G03G21/16 , G03G21/18
CPC分类号： G03G21/1889 , G03G15/75 , G03G2221/1663 , G03G2221/1823
摘要： A method of detecting the end of the life of an image bearing member has: a contact time detecting step of detecting the contact time when a developer carrying member that can be in contact with or have a clearance with an image bearing member contacts the image bearing member, the developer carrying member developing an electrostatic image formed in the image bearing member by a developer; and a determining step of determining the end of the life of the image bearing member in accordance with a parameter calculated by using the contact time detected in the contact time detecting step.
摘要翻译：一种检测图像承载部件的寿命终止的方法具有：接触时间检测步骤，用于检测当与图像承载部件接触或具有间隙的显影剂承载部件与图像承载件接触时的接触时间构件，显影剂承载构件通过显影剂显影形成在图像承载构件中的静电图像; 以及确定步骤，根据通过使用在接触时间检测步骤中检测到的接触时间计算出的参数来确定图像承载部件的寿命的结束。

80. 发明授权

US06803372B2 Spiro compounds 有权
标题翻译：螺环化合物
公开(公告)号：US06803372B2
公开(公告)日：2004-10-12
申请号：US10092549
申请日：2002-03-08
申请人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh
发明人： Takehiro Fukami , Akio Kanatani , Akane Ishihara , Yasuyuki Ishii , Toshiyuki Takahashi , Yuji Haga , Toshihiro Sakamoto , Takahiro Itoh
IPC分类号： A61K31506
CPC分类号： C07D213/61 , C07D307/94 , C07D405/12 , C07D471/10 , C07D491/10
摘要： Compounds of the general formula (I): wherein Ar1 represents optionally substituted aryl or heteroaryl; n represents 0 or 1; T, U, V, and W each independently represent nitrogen atom or optionally substituted methine group, where at least two of them represent the said methine group; X represents methine or hydroxy substituted methine; Y represents an optionally substituted imino or oxygen atom are described and claimed. These novel spiro compounds are useful as neuropeptide Y receptor antagonists and as agents for the treatment of various kinds of cardiovascular disorders, central nervous system disorders, metabolic diseases and the like.
摘要翻译：通式（I）的化合物：其中Ar 1表示任选取代的芳基或杂芳基; n表示0或1; T，U，V和W各自独立地表示氮原子或任选取代的次甲基，其中至少两个代表所述次甲基; X表示次甲基或羟基取代的次甲基; Y表示任选取代的亚氨基或氧原子。这些新颖的螺环化合物可用作神经肽Y受体拮抗剂和用作治疗各种心血管疾病，中枢神经系统疾病，代谢疾病等的药剂。

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