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71. 发明申请

US20090093857A1 SYSTEM AND METHOD TO EVALUATE ELECTRODE POSITION AND SPACING 有权
标题翻译：用于评估电极位置和间隔的系统和方法
公开(公告)号：US20090093857A1
公开(公告)日：2009-04-09
申请号：US12183796
申请日：2008-07-31
申请人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
发明人： H. Toby Markowitz , Phillip Falkner , Douglas A. Hettrick , Sameh Sowelam
IPC分类号： A61N1/368
CPC分类号： A61N1/05 , A61N1/3706
摘要： An IMD can be implanted into a patient to address various conditions. The IMD case and leads can have various electrodes and other portions to measure various physiological conditions. For example, a selected current can be generated between two electrodes, either external or internal in the patient, and a voltage can be measured by one or more electrodes of the IMD. A voltage can be measured at two or more locations to determine a relative motion of different electrodes. If the electrodes are in different portions of the heart, a determination can be made of a relative motion or position of the heart or portions of the heart.
摘要翻译：可以将IMD植入患者中以解决各种情况。 IMD外壳和引线可以具有各种电极和其他部分来测量各种生理条件。例如，可以在患者的外部或内部的两个电极之间产生所选择的电流，并且可以通过IMD的一个或多个电极来测量电压。可以在两个或更多个位置处测量电压以确定不同电极的相对运动。如果电极位于心脏的不同部分，则可以确定心脏或心脏部分的相对运动或位置。

72. 发明授权

US07130687B2 Implantable medical device and method for delivering therapy for sleep-disordered breathing 有权
标题翻译：植入式医疗装置和方法，用于为睡眠呼吸障碍提供治疗
公开(公告)号：US07130687B2
公开(公告)日：2006-10-31
申请号：US10693375
申请日：2003-10-24
申请人： Yong K. Cho , H. Toby Markowitz
发明人： Yong K. Cho , H. Toby Markowitz
IPC分类号： A61N1/362
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.
摘要翻译：可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。

73. 发明授权

US5861007A Adaptive search AV and auto PVARP adaptation to same with additional benefit 失效
标题翻译：自适应搜索AV和自动PVARP适应相同，具有额外的好处
公开(公告)号：US5861007A
公开(公告)日：1999-01-19
申请号：US806302
申请日：1997-02-26
申请人： Michael F. Hess , H. Toby Markowitz , James W. Busacker
发明人： Michael F. Hess , H. Toby Markowitz , James W. Busacker
IPC分类号： A61N1/368 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682
摘要： An AV search method and apparatus is taught with some variation described. It allows a pacemaker to find the appropriate AV interval so as to avoid pacing in the ventricle when it is not necessary, even if there is intermittent AV conduction in the patient. Also, an adaptive PVARP method and apparatus is disclosed that allows the PVARP and AV interval to be adjusted together automatically.
摘要翻译：教导具有一些变化的AV搜索方法和装置。它允许起搏器找到适当的AV间隔，以避免在不必要的情况下在心室起搏，即使在患者中存在间歇性AV传导。此外，公开了一种自适应PVARP方法和装置，其允许PVARP和AV间隔自动调整。

74. 发明授权

US5522859A Sinus preference method and apparatus for cardiac pacemakers 失效
标题翻译：心脏起搏器的窦偏好方法和装置
公开(公告)号：US5522859A
公开(公告)日：1996-06-04
申请号：US343166
申请日：1994-11-22
申请人： John C. Stroebel , H. Toby Markowitz
发明人： John C. Stroebel , H. Toby Markowitz
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/368 , A61N1/36585
摘要： A dual chamber, rate-responsive pacemaker for pacing a patient's heart novelly allows tracking of the patient's sinus rate when the sinus rate is slightly less than the sensor rate; i.e., within a predetermined "Sinus Preference Window Maximum Rate Drop." Pacing at the sensor rate occurs when the sensor rate exceeds the sinus rate by more than the Sinus Preference Window Maximum Rate Drop. In the preferred embodiment a Sinus Preference Window, which occurs at the end of the ventricle-to-atrium interval, is decremented with successive heart beats by a programmable delta to increase the pacing rate until the Sinus Preference Window reaches zero, in which case the pacemaker paces at the sensor rate. The Sinus Preference Window is reset to its maximum value upon either the detection of an atrial sensed event, or upon the expiration of a programmable Sinus Check Interval. The pacemaker paces at the sinus rate or the maximum rate drop rate, whichever is faster, for a number of recovery beats, and then increments the pacing rate up to the sensor rate.
摘要翻译：双室，速率响应的心脏起搏器用于起搏患者的心脏新颖地允许跟踪患者的窦速率，当窦速率略低于传感器速率时; 即在预定的“窦性偏好窗口最大速率下降”内。当传感器速率超过窦性速率超过窦性偏好窗口最大速率下降时，会以传感器速率进行起搏。在优选实施例中，在心室至心房间隔的末端发生的窦偏好窗口以连续的心跳递减可编程的增量以增加起搏速率直到窦偏好窗口达到零，在这种情况下起搏器以传感器速率步进。当检测到心房感应事件时，或者在可编程窦性检查间隔期满时，窦偏好窗口被重置为最大值。起搏器以窦速率或最大速率下降速率（以更快者为准）起搏，以进行多次恢复搏动，然后将起搏速率递增至传感器速率。

75. 发明授权

US5501701A Pacemaker with vasovagal syncope detection and therapy 失效
标题翻译：起搏器与血管迷走性晕厥检测和治疗
公开(公告)号：US5501701A
公开(公告)日：1996-03-26
申请号：US309285
申请日：1994-09-20
申请人： H. Toby Markowitz , Michael F. Hess
发明人： H. Toby Markowitz , Michael F. Hess
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/365 , A61N1/36514
摘要： A method and apparatus for cardiac pacing, in which pacing pulses are provided at an increased rate in response to a detected rapid drop in heart rate. A rapid drop is detected in response to heart rate falling from a persistent rate above a first threshold rate to a stable rate below a second threshold rate. If spontaneous depolarizations are detected while pacing at the increased rate, pacing at the increased rate is terminated.
摘要翻译：用于心脏起搏的方法和装置，其中响应于检测到的心率快速下降以增加的速率提供起搏脉冲。响应于心率从高于第一阈值速率的持续速率下降到低于第二阈值速率的稳定速率，检测到快速下降。如果在以增加的速率起搏时检测到自发去极化，则以增加的速率起搏起止。

76. 发明授权

US5273035A Dual chamber pacemaker with safe airial pacing 失效
标题翻译：双室心脏起搏器，安全气道起搏
公开(公告)号：US5273035A
公开(公告)日：1993-12-28
申请号：US829811
申请日：1992-02-03
申请人： H. Toby Markowitz , John C. Stroebel , Robert A. Betzold
发明人： H. Toby Markowitz , John C. Stroebel , Robert A. Betzold
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： A dual chamber pacemaker is provided, preferably either DDDR or DDIR, having logic hardware and/or software for normally carrying out the DDIR or DDDR mode of operation, and further having means for carrying out a safe atrial pace method of operation in circumstances where normal atrial pacing could otherwise be competitive or result in loss of atrial capture. The pacemaker has means for detecting an atrial sense during PVARP, timing out a delay from the time of the early atrial sense, delivering a safe atrial pulse at the end of the delay, and controlling generation of a ventricular pace pulse in synchronous relation to the safe atrial pulse and with at least a minimum AV interval.
摘要翻译：提供双室起搏器，优选DDDR或DDIR，具有用于正常执行DDIR或DDDR操作模式的逻辑硬件和/或软件，并且还具有用于在正常情况下执行安全心房步速的操作方法的装置心房起搏可能会有竞争力或导致心房骤停。起搏器具有在PVARP期间检测心房感觉的手段，从早期心房感觉时刻延迟，在延迟结束时传送安全的心房脉搏，并且控制与心室起搏脉冲的产生同步关系安全的心房脉搏和至少最小的AV间隔。

77. 发明授权

US5103820A VDD pacemaker with selectable post-ventricular atrial refractory periods 失效
$VDD pacemaker with selectable post-ventricular atrial refractory periods$
标题翻译： VDD起搏器具有可选的心室后不应期
公开(公告)号：US5103820A
公开(公告)日：1992-04-14
申请号：US567431
申请日：1990-08-14
申请人： H. Toby Markowitz
发明人： H. Toby Markowitz
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： An improved atrial synchronous, dual-chamber pacemaker provided with a variable refractory period during which the pacemaker is not responsive to sensed atrial contractions. The atrial refractory period is selected based upon whether the ventricular pacing pulse preceding the refractory period occurred as a result of time out of the interval corresponding to the basic ventricular pacing rate or due to the time out of the A-V delay interval initiated in response to sensing of a natural atrial contraction.
摘要翻译：改进的心房同步双室起搏器，其具有可变不应期，起搏器在此期间对感觉到的心房收缩无反应。心房不应期是基于是否出现不应期的心室起搏脉冲作为对应于基本心室起搏速率的间隔之外的时间的结果或由于响应于感测而启动的AV延迟间隔的时间而出现的的自然心房收缩。

78. 发明申请

US20150366485A1 DEVICES AND METHODS FOR SIZING VALVE APERTURES AND LUMINAL ORGANS 审中-公开
标题翻译：尺寸阀门和灯具的装置和方法
公开(公告)号：US20150366485A1
公开(公告)日：2015-12-24
申请号：US14742025
申请日：2015-06-17
申请人： H. Toby Markowitz , 3DT Holdings, LLC
发明人： Ghassan S. Kassab , H. Toby Markowitz
IPC分类号： A61B5/107 , A61B5/00 , A61B5/053
摘要： Devices and methods for sizing valve apertures and luminal organs. In at least one embodiment of a device for obtaining measurements within a luminal organ of the present disclosure, the device comprises an elongated body, and at least one sizing finger positioned at a distal end of the elongated body, the at least one sizing finger configured to move from a first position to a second position by way of adjustment of at least one movable device coupled thereto, wherein a dimensional measurement within the luminal organ can be determined based upon the first position and the second position.
摘要翻译：用于调整阀孔和腔内器官的尺寸的装置和方法。在用于在本发明的管腔器官内获得测量的装置的至少一个实施例中，该装置包括细长主体和位于细长主体的远端处的至少一个施胶手指，所述至少一个施胶手指配置通过至少一个与其连接的可移动装置的调节从第一位置移动到第二位置，其中可以基于第一位置和第二位置来确定腔内器官内的尺寸测量。

79. 发明授权

US08983619B2 Testing communication during implantation 有权
标题翻译：测量植入过程中的沟通
公开(公告)号：US08983619B2
公开(公告)日：2015-03-17
申请号：US12732403
申请日：2010-03-26
申请人： Can Cinbis , H. Toby Markowitz
发明人： Can Cinbis , H. Toby Markowitz
IPC分类号： A61N1/08 , A61B5/00 , A61N1/372 , A61B19/00 , A61N1/375
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for testing communication through a patient during implantation using telemetry coupling electrodes on a delivery catheter. In one example, at least two telemetry coupling electrodes may be placed on or within a delivery catheter to test conductive communication with external body electrodes during implantation. In some instances, the telemetry coupling electrodes of the delivery catheter may approximate the spacing of telemetry electrodes on an IMD. In this manner, testing conductively coupled communication with telemetry coupling electrodes of the catheter may be used to mimic the telemetry electrodes on the IMD and determine a target position and/or orientation of an electrode or electrodes of the IMD for successful conductive communication through the body.
摘要翻译：描述了一种系统和方法，用于在植入期间通过患者使用传送导管上的遥测耦合电极来测试通信。在一个示例中，至少两个遥测耦合电极可以放置在输送导管上或内部，以在植入期间测试与外部身体电极的导电连通。在一些情况下，输送导管的遥测耦合电极可以接近IMD上遥测电极的间距。以这种方式，测试与导管的遥测耦合电极的导电耦合通信可以用于模拟IMD上的遥测电极，并且确定IMD的电极或电极的目标位置和/或取向以便通过身体成功地导电连通。

80. 发明授权

US08942818B2 Communication with an implantable medical device during implantation 有权
标题翻译：植入期间与可植入医疗器械的通讯
公开(公告)号：US08942818B2
公开(公告)日：2015-01-27
申请号：US12732433
申请日：2010-03-26
申请人： H. Toby Markowitz , Can Cinbis
发明人： H. Toby Markowitz , Can Cinbis
IPC分类号： A61N1/08 , A61B5/00 , A61N1/372 , A61B19/00 , A61N1/375
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for delivering an implantable medical device in a patient and through a catheter. The delivery catheter comprises telemetry means for communicatively coupling the implantable medical device with an external instrumentation during implantation.
摘要翻译：描述了用于将可植入医疗装置递送到患者体内并通过导管的系统和方法。递送导管包括用于在植入期间将可植入医疗装置与外部装置通信地连接的遥测装置。

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