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71. 发明申请

US20060069322A1 Cardiac activation sequence monitoring and tracking 有权
公开(公告)号：US20060069322A1
公开(公告)日：2006-03-30
申请号：US10955397
申请日：2004-09-30
申请人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey Stahmann , Yinghong Yu , Carlos Ricci
发明人： Yi Zhang , Scott Meyer , Aaron McCabe , Jeffrey Stahmann , Yinghong Yu , Carlos Ricci
IPC分类号： A61B5/0402
CPC分类号： A61B5/04011 , A61B5/7203
摘要： Cardiac monitoring and/or stimulation methods and systems provide monitoring, diagnosis, and defibrillation and/or pacing therapies. A signal processor receives a plurality of composite signals associated with a plurality of sources, performs a source separation, and produces one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences based on the source separation. A method of signal separation involves detecting a change in a characteristic of the cardiac signal vector relative to a baseline. One or more vectors and/or activation sequences may be selected, and information associated with the vectors and/or activation sequences may be stored and tracked.

72. 发明申请

US20060041279A1 Detection and treatment of prolonged inter-atrial delay in cardiac resynchronization patients 审中-公开
标题翻译：心脏再同步化患者延长心房延迟的检测与治疗
公开(公告)号：US20060041279A1
公开(公告)日：2006-02-23
申请号：US11113809
申请日：2005-04-25
申请人： Yinghong Yu , Jiang Ding , Milton Morris
发明人： Yinghong Yu , Jiang Ding , Milton Morris
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method and system for identifying and assessing inter-atrial conduction delays in patients is disclosed. Patients who are so identified and are also in need of ventricular resynchronization therapy may then be treated with left atrial pacing and ventricular resynchronization pacing. Certain patients may alternatively be treated with ventricular resynchronization therapy delivered with a conservatively selected atrio-ventricular delay interval and without left atrial pacing.
摘要翻译：公开了一种用于识别和评估患者心房间传导延迟的方法和系统。那些如此确定并且也需要心室再同步治疗的患者然后可以用左心房起搏和心室再同步起搏治疗。某些患者可以替代地以具有保守选择的心房延迟间隔并且没有左心房起搏的心室再同步治疗进行治疗。

73. 发明授权

US06937901B2 Capture verification for cardiac resynchronization pacing optimization 有权
公开(公告)号：US06937901B2
公开(公告)日：2005-08-30
申请号：US09999255
申请日：2001-10-31
申请人： Qingsheng Zhu , Julio C. Spinelli , Jiang Ding , Yinghong Yu
发明人： Qingsheng Zhu , Julio C. Spinelli , Jiang Ding , Yinghong Yu
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37 , A61N1/18
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3688 , A61N1/371
摘要： A system and method for automatically selecting among a plurality of pacing modes based upon capture detection. Patients suffering from heart failure may be optimally treated with different resynchronization pacing modes or configurations. By detecting whether capture is being achieved by a particular configuration or mode, a device is able to automatically switch to one that is both optimal in treating the patient and is successful in capturing the heart with pacing pulses.

74. 发明授权

US06923772B2 Apparatus and method for determining responders to cardiac resynchronization therapy using implantable accelerometers 有权
标题翻译：用于使用可植入加速度计确定心脏再同步治疗的响应者的装置和方法
公开(公告)号：US06923772B2
公开(公告)日：2005-08-02
申请号：US10236714
申请日：2002-09-06
申请人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
发明人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
IPC分类号： A61B5/11 , A61B5/02
CPC分类号： A61B5/1107 , A61B5/6869 , A61B5/7242 , A61B2562/0219
摘要： A device for measuring a synchronicity of contraction of a heart to determine if an individual would be a responder to cardiac resynchronization therapy. The device may include a first electrode positioned at a first ventricular wall location to measure movement of the first ventricular wall location and generate a first signal, as well as a second electrode positioned at a second ventricular wall location to measure movement of the second ventricular wall location and generate a second signal. A processing module may process the first and second signals, for example, integrate the signals multiple times, and generate an output based on the processed signals. Based on this output, an individual can be labeled a responder or non-responder to cardiac resynchronization therapy. The electrodes may each include an accelerometer to measure acceleration of the heart wall.
摘要翻译：用于测量心脏收缩的同步性的装置，以确定个体是否是心脏再同步治疗的应答者。该装置可以包括位于第一心室壁位置处的第一电极，以测量第一心室壁位置的运动并产生第一信号，以及定位在第二心室壁位置处的第二电极，以测量第二心室壁的运动位置并产生第二个信号。处理模块可以处理第一和第二信号，例如，多次对信号进行积分，并且基于处理的信号生成输出。基于该输出，个体可以被标记为心脏再同步治疗的应答者或非应答者。电极可以各自包括用于测量心脏壁的加速度的加速度计。

75. 发明授权

US06360127B1 Cardiac pacing using adjustable atrio-ventricular delays 有权
公开(公告)号：US06360127B1
公开(公告)日：2002-03-19
申请号：US09492911
申请日：2000-01-20
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

76. 发明授权

US06351673B1 Cardiac pacing using adjustable atrio-ventricular delays 有权
公开(公告)号：US06351673B1
公开(公告)日：2002-02-26
申请号：US09661608
申请日：2000-09-14
申请人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
发明人： Jiang Ding , Yinghong Yu , Andrew P. Kramer , Julio Spinelli
IPC分类号： A61N1365
CPC分类号： E21B17/01 , A61N1/3627 , A61N1/3682 , E21B43/36
摘要： A pacing system for providing optimal hemodynamic cardiac function for parameters such as contractility (peak left ventricle pressure change during systole or LV+dp/dt), or stroke volume (aortic pulse pressure) using system for calculating atrio-ventricular delays for optimal timing of a ventricular pacing pulse. The system providing an option for near optimal pacing of multiple hemodynamic parameters. The system deriving the proper timing using electrical or mechanical events having a predictable relationship with an optimal ventricular pacing timing signal.

77. 发明授权

US08792980B2 Cardiac resynchronization system employing mechanical measurement of cardiac walls 有权
标题翻译：心脏再同步系统采用心脏壁的机械测量
公开(公告)号：US08792980B2
公开(公告)日：2014-07-29
申请号：US12980417
申请日：2010-12-29
申请人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
发明人： Yinghong Yu , Jiang Ding , Qingsheng Zhu
IPC分类号： A61N1/368 , A61N1/365
CPC分类号： A61N1/36578 , A61N1/3627 , A61N1/36542 , A61N1/3684
摘要： Methods and devices are disclosed for employing mechanical measurements to synchronize contractions of ventricular wall locations. Accelerometers that may be placed within electrode leads are positioned at ventricular wall locations, such as the left ventricle free wall, right ventricle free wall, and the anterior wall/septum wall. The accelerometers produce signals in response to the motion of the ventricular wall locations. A processor may then compare the signals to determine a difference in the synchronization of the ventricular wall location contractions. The difference in synchronization can be determined in various ways such as computing a phase difference and/or amplitude difference between the accelerometer signals. One or more stimulation pulses may be provided per cardiac cycle to resynchronize the contractions as measured by the accelerometers to thereby constantly and automatically optimize the cardiac resynchronization therapy.
摘要翻译：公开了用于采用机械测量来同步心室壁位置收缩的方法和装置。可以放置在电极引线内的加速度计定位在心室壁位置，例如左心室游离壁，右心室游离壁和前壁/隔膜壁。加速度计响应于心室壁位置的运动产生信号。然后，处理器可以比较信号以确定心室壁位置收缩的同步的差异。可以以各种方式确定同步差异，例如计算加速度计信号之间的相位差和/或振幅差。可以在每个心动周期提供一个或多个刺激脉冲，以重新同步由加速度计测量的收缩，从而不断地和自动地优化心脏再同步治疗。

78. 发明授权

US08725255B2 Cardiac resynchronization therapy optimization using cardiac activation sequence information 有权
标题翻译：心脏再同步治疗优化使用心脏激活序列信息
公开(公告)号：US08725255B2
公开(公告)日：2014-05-13
申请号：US11601216
申请日：2006-11-17
申请人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
发明人： Shantha Arcot-Krishnamurthy , Yi Zhang , Jiang Ding , Yinghong Yu , Yanting Dong
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61B5/04011 , A61B5/0452 , A61N1/365 , A61N1/36535 , A61N1/36542
摘要： Systems and methods provide for pacing a heart to improve pumping efficiency of the heart, such as by producing a cardiac fusion response for patient's subject to cardiac resynchronization therapy. A pacing parameter, such as an A-V delay, V-V delay, lead/electrode configuration or vector, is adjusted and a cardiac signal vector representative of all or a portion of one or more cardiac activation sequences is monitored during pacing parameter adjustment. A change in a characteristic of the cardiac signal vector is detected in response to an adjusted pacing parameter, the change indicative of a cardiac fusion response. A pacing therapy may be delivered to produce the cardiac fusion response using the adjusted pacing parameter.
摘要翻译：系统和方法提供心脏起搏以改善心脏的泵送效率，例如通过为患者进行心脏再同步治疗产生心脏融合反应。调整起搏参数，例如A-V延迟，V-V延迟，引线/电极配置或载体，并且在起搏参数调整期间监测表示一个或多个心脏激活序列的全部或一部分的心脏信号载体。响应于调整的起搏参数，指示心脏融合反应的变化来检测心脏信号载体的特性变化。可以使用调整的起搏参数来递送起搏治疗以产生心脏融合反应。

79. 发明授权

US08588910B2 Non-linear dynamic AV delay 有权
标题翻译：非线性动态AV延迟
公开(公告)号：US08588910B2
公开(公告)日：2013-11-19
申请号：US13154661
申请日：2011-06-07
申请人： David J. Ternes , Donald L. Hopper , Yinghong Yu
发明人： David J. Ternes , Donald L. Hopper , Yinghong Yu
IPC分类号： A61N1/00
CPC分类号： A61N1/3682 , A61N1/3627 , A61N1/365 , A61N1/3684
摘要： A non-linear dynamic specified AV delay can be used, such as to help maintain cardiac resynchronization therapy, such as in patients with one or more symptoms of congestive heart failure.
摘要翻译：可以使用非线性动态指定的AV延迟，例如帮助维持心脏再同步治疗，例如患有一种或多种充血性心力衰竭症状的患者。

80. 发明授权

US08489204B2 Method and apparatus for identification of ischemic/infarcted regions and therapy optimization 有权
标题翻译：用于鉴别缺血/梗死区域的方法和装置以及治疗优化
公开(公告)号：US08489204B2
公开(公告)日：2013-07-16
申请号：US13544007
申请日：2012-07-09
申请人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
发明人： Shantha Arcot-Krishnamurthy , Allan C. Shuros , Jiang Ding , Yinghong Yu , Michael J. Stucky , Christopher Hartemink
IPC分类号： A61N1/00 , A61B5/02
CPC分类号： A61N1/36585 , A61B5/02028 , A61N1/3627 , A61N1/3682 , A61N1/3684 , A61N1/3702 , G06F19/00
摘要： A method and apparatus is described for detecting and localizing areas of myocardial infarction or ischemia. By pacing sites in proximity to the infarcted or ischemic region with appropriately timed pacing pulses, the region is pre-excited in a manner that lessens the mechanical stress to which it is subjected, thus reducing the metabolic demand of the region and the stimulus for remodeling.
摘要翻译：描述了用于检测和定位心肌梗死或缺血区域的方法和装置。通过以适当的定时起搏脉冲对位于梗塞或缺血区域附近的部位进行起搏，该区域以减轻其受到的机械应力的方式预激发，从而降低该区域的代谢需求和重塑刺激。

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