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71. 发明申请

WO2009135013A3 THERMOELECTRIC SKUTTERUDITE COMPOSITIONS AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：热电钻石组合物及其制造方法
公开(公告)号：WO2009135013A3
公开(公告)日：2010-02-18
申请号：PCT/US2009042327
申请日：2009-04-30
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN GANG , HE QINYU , YAN XIAO , HAO QING , REN ZHIFENG , YANG JIAN , TRUSTEES BOSTON COLLEGE
发明人： CHEN GANG , HE QINYU , YAN XIAO , HAO QING , REN ZHIFENG , YANG JIAN
IPC分类号： C01G30/00 , B82B3/00 , H01L35/18
CPC分类号： H01L35/18 , B22F2998/10 , B22F2999/00 , B82Y30/00 , C01G49/009 , C01G51/006 , C01G53/006 , C01P2002/52 , C01P2002/54 , C01P2002/72 , C01P2002/77 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/64 , C01P2006/10 , C01P2006/40 , C22C1/0433 , C22C1/0466 , H01L35/26 , Y02P20/129 , Y10S977/773 , B22F9/04 , B22F9/14 , B22F1/0018 , B22F2009/043 , B22F2203/11
摘要： Compositions related to skutterudite-based thermoelectric materials are disclosed. Such compositions can result in materials that have enhanced ZT values relative to one or more bulk materials from which the compositions are derived. Thermoelectric materials such as n-type and p-type skutterudites with high thermoelectric figures-of- merit can include materials with filler atoms and/or materials formed by compacting particles (e.g., nanoparticles) into a material with a plurality of grains each having a portion having a skutterudite-based structure. Methods of forming thermoelectric skutterudites, which can include the use of hot press processes to consolidate particles, are also disclosed. The particles to be consolidated can be derived from (e.g., grinded from), skutterudite-based bulk materials, elemental materials, other non- Skutterudite- based materials, or combinations of such materials.
摘要翻译：公开了与基于方钴矿的热电材料相关的组合物。这样的组合物可以产生相对于衍生组合物的一种或多种散装材料具有增强的ZT值的材料。具有高热电性能的n型和p型方钴矿的热电材料可以包括具有填料原子和/或通过将颗粒（例如纳米颗粒）压实成多个颗粒而形成的材料的材料，每个颗粒具有部分具有基于方钴矿的结构。还公开了形成热电方钴矿的方法，其可以包括使用热压工艺来固结颗粒。要固结的颗粒可以衍生自（例如研磨），基于方钴矿的散装材料，元素材料，其他基于非方钴矿的材料或这些材料的组合。

72. 发明申请

WO2008140596A2 METHODS FOR HIGH FIGURE-OF-MERIT IN NANOSTRUCTURED THERMOELECTRIC MATERIALS 审中-公开
标题翻译：在纳米结构的热电材料中的高图形方法
公开(公告)号：WO2008140596A2
公开(公告)日：2008-11-20
申请号：PCT/US2007086291
申请日：2007-12-03
申请人： MASSACHUSETTS INST TECHNOLOGY , REN ZHIFENG , POUDEL BED , CHEN GANG , LAN YUCHENG , WANG DEZHI , HAO QING , DRESSELHAUS MILDRED , MA YI , YAN XIAO , CHEN XIAOYUAN , WANG XIAOWEI , JOSHI GIRI RAJ , YU BO
发明人： REN ZHIFENG , POUDEL BED , CHEN GANG , LAN YUCHENG , WANG DEZHI , HAO QING , DRESSELHAUS MILDRED , MA YI , YAN XIAO , CHEN XIAOYUAN , WANG XIAOWEI , JOSHI GIRI RAJ , YU BO
IPC分类号： H01L35/16 , H01L35/34
CPC分类号： H01L35/16 , H01L35/26 , H01L35/34
摘要： Thermoelectric materials with high figures of merit, ZT values, are disclosed In many instances, such materials include nano-sized domains (e g, nanocrystalhne), which are hypothesized to help increase the ZT value of the material (e g, by increasing phonon scattering due to interfaces at grain boundaries or grain/inclusion boundaries) The ZT value of such materials can be greater than about 1, 1.2, 1.4, 1.5, 1.8, 2 and even higher Such materials can be manufactured from a thermoelectric starting material by generating nanoparticles therefrom, or mechanically alloyed nanoparticles from elements which can be subsequently consolidated (e g, via direct current induced hot press) into a new bulk material Non-limiting examples of starting materials include bismuth, lead, and/or silicon-based materials, which can be alloyed, elemental, and/or doped Various compositions and methods relating to aspects of nanostructured theromoelectpc materials (e g, modulation doping) are further disclosed
摘要翻译：公开了具有高品质因数（ZT值）的热电材料在许多情况下，这些材料包括纳米尺寸域（例如，纳米晶体），其被假设为有助于增加材料的ZT值（例如，通过增加声子散射在晶界或晶粒/夹杂物界面处的界面）这些材料的ZT值可以大于约1,1.2,1.4,1.5,1.8,2甚至更高。这样的材料可以通过从热电原料生成纳米颗粒来制造或来自可以随后固化（例如通过直流感应热压机）的元件的机械合金化纳米颗粒转化为新的体材料起始材料的非限制性实例包括铋，铅和/或硅基材料，其可以是合金化，元素化和/或掺杂进一步公开了与纳米结构的高选择性材料的方面有关的各种组成和方法（例如，调制掺杂）

73. 发明申请

WO2006049764A3 METHODS OF MAKING 2,6-DIARYL PIPERIDINE DERIVATIVES 审中-公开
标题翻译：制备2,6-二芳基哌啶衍生物的方法
公开(公告)号：WO2006049764A3
公开(公告)日：2006-12-14
申请号：PCT/US2005034950
申请日：2005-09-28
申请人： ANORMED INC , CHEN GANG , CRAWFORD JASON , SKERLJ RENATO
发明人： CHEN GANG , CRAWFORD JASON , SKERLJ RENATO
IPC分类号： C07D251/00 , A61K31/444 , C07D257/00 , C07D401/14 , C07D473/00
CPC分类号： C07D401/14 , C07D211/74 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Methods for preparing 2,6-diaryl piperidine derivatives are described. More particularly, 2,6-diaryl piperidines having formula 1-4 are prepared by cyclocondensation of an aryl or heteroaryl aldehyde with 1,3-acetonedicarboxylic acid.
摘要翻译：描述了制备2,6-二芳基哌啶衍生物的方法。更特别地，具有式I-4的2,6-二芳基哌啶通过芳基或杂芳基醛与1,3-丙酮二羧酸的环化缩合来制备。

74. 发明申请

WO2006124234A2 SENSE OPTIMIZED MRI RF COIL DESIGNED WITH A TARGET FIELD METHOD 审中-公开
标题翻译：感应优化的MRI射频线圈设计与目标场方法
公开(公告)号：WO2006124234A2
公开(公告)日：2006-11-23
申请号：PCT/US2006016167
申请日：2006-04-26
申请人： UNIV CALIFORNIA , MUFTULER LUTFI , CHEN GANG , NALCIOGLU ORHAN
发明人： MUFTULER LUTFI , CHEN GANG , NALCIOGLU ORHAN
IPC分类号： G01V3/00 , H01Q17/00
CPC分类号： G01R33/3415 , G01R33/34007 , Y10T29/49 , Y10T29/49018 , Y10T29/4902 , Y10T29/49071
摘要： An MRI RF coil that is optimized for SENSE imaging is used in a method where the surface current density distribution on a coil former was calculated to maximize the SNR sense within a volume of interest. An analytic relationship was formulated between the SNR sense and surface current density on the coil former. The SNR at pixel p in a SENSE-MR image, SNR sense , p , is inversely proportional to the g- factor. The g-factor was formulated in terms of the B1 distribution of the coils. By specifying the geometry of the desired coil former and using a finite element mesh, the surface current distribution was calculated to maximize the SNR sense , by minimizing (1 /SNR sense ) in the volume of interest using a least squares procedure. A simple two-coil array was tested and phantom images were collected. The results show that the new coil design method yielded better uniformity and SNR compared to standard coils.
摘要翻译：针对SENSE成像优化的MRI RF线圈用于其中计算线圈架上的表面电流密度分布以使感兴趣的体积内的SNR <>的最大值的方法。在线圈形成器之间的SNR＆lt; S＆gt;和表面电流密度之间就形成了分析关系。 SENSE-MR图像中的像素p处的SNR与SNR因子成反比。 g因子是根据线圈的B1分布来制定的。通过指定所需的线圈形成器的几何形状并使用有限元网格，通过最小化（1 / SNR ）来计算表面电流分布以使SNR最大化，使用最小二乘法处理感兴趣的体积。测试简单的双线圈阵列并收集幻影图像。结果表明，与标准线圈相比，新的线圈设计方法产生更好的均匀性和SNR。

75. 发明申请

WO2004046118A3 2-4-(DI-PHENYL-AMINO)-PYRIMIDINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS 审中-公开
标题翻译：用于治疗高血压疾病的2-4-（对 - 苯胺基） - 吡啶衍生物
公开(公告)号：WO2004046118A3
公开(公告)日：2004-08-12
申请号：PCT/US0314294
申请日：2003-05-06
申请人： BAYER PHARMACEUTICALS CORP , WOOD JILL E , BIERER DONALD , BEAR BRIAN , BRENNAN CATHERINE , CHANDLER BRENT , CHEN GANG , CHEN YUANWEI , DIXON JULIE , FU WENLANG , GUERNON LEATTE , LIU DONGLEI , MCCLURE ANDREA , MIRANDA KARL , NAGARATHNAM DHANAPALAN , SIBLEY ROBERT , TURNER MICHAEL , VERMA SHARAD , WANG CHUNGUANG , YI LIN , ZHAO JIN , ZHU QINGMING
发明人： WOOD JILL E , BIERER DONALD , BEAR BRIAN , BRENNAN CATHERINE , CHANDLER BRENT , CHEN GANG , CHEN YUANWEI , DIXON JULIE , FU WENLANG , GUERNON LEATTE , LIU DONGLEI , MCCLURE ANDREA , MIRANDA KARL , NAGARATHNAM DHANAPALAN , SIBLEY ROBERT , TURNER MICHAEL , VERMA SHARAD , WANG CHUNGUANG , YI LIN , ZHAO JIN , ZHU QINGMING
IPC分类号： A61P35/00 , C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04 , C07D239/48 , A61K31/505
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a 2-4-(diphenyl-amino)-pyrimidinyl compound of Formula I useful for treating hyper-proliferative disorders.
摘要翻译：本发明涉及可用于治疗高增殖性疾病的式I的2-4-（二苯基 - 氨基） - 嘧啶基化合物。

76. 发明申请

WO0234886A3 ISOLATION OF BINDING PROTEINS WITH HIGH AFFINITY TO LIGANDS 审中-公开
标题翻译：分离具有高亲和力的结合蛋白
公开(公告)号：WO0234886A3
公开(公告)日：2003-07-31
申请号：PCT/US0146795
申请日：2001-10-26
申请人： UNIV TEXAS , CHEN GANG , HAYHURST ANDREW , THOMAS JEFFREY G , IVERSON BRENT L , GEORGIOU GEORGE
发明人： CHEN GANG , HAYHURST ANDREW , THOMAS JEFFREY G , IVERSON BRENT L , GEORGIOU GEORGE
IPC分类号： C12N15/09 , C12N15/10 , C12N5/00
CPC分类号： C12N15/1034
摘要： The invention overcomes the deficiencies of the prior art by providing a rapid approach for isolating binding proteins capable of binding small molecules and peptides via "display-less" library screening. In the technique, libraries of candidate binding proteins, such as antibody sequences, are expressed in soluble form in the periplasmic space of gram negative bacteria, such as Escherichia coli, and are mixed with a labeled ligand. In clones expressing recombinant polypeptides with affinity for the ligand, the concentration of the labeled ligand bound to the binding protein is increased and allows the cells to be isolated from the rest of the library. Where fluorescent labeling of the target ligand is used, cells may be isolated by fluorescence activated cell sorting (FACS). The approach is more rapid than prior art methods and avoids problems associated with the surface-expression of ligand fusion proteins employed with phage display.
摘要翻译：本发明通过提供通过“无显示”文库筛选分离能够结合小分子和肽的结合蛋白的快速方法来克服现有技术的缺陷。在该技术中，候选结合蛋白（例如抗体序列）的文库以可溶形式表达在革兰氏阴性细菌如大肠杆菌的周质空间中，并与标记的配体混合。在表达对配体具有亲和性的重组多肽的克隆中，与结合蛋白结合的标记配体的浓度增加，并允许细胞与文库的其余部分分离。当使用靶配体的荧光标记时，可以通过荧光激活细胞分选（FACS）分离细胞。该方法比现有技术方法更快速，并避免与噬菌体展示所用配体融合蛋白的表面表达相关的问题。

77. 发明申请

WO9849286A9 DIRECTED EVOLUTION OF ENZYMES AND ANTIBODIES 审中-公开
标题翻译：有针对性地进化酶和抗体
公开(公告)号：WO9849286A9
公开(公告)日：1999-04-29
申请号：PCT/US9808714
申请日：1998-04-30
申请人： UNIV TEXAS , IVERSON BRENT , GEORGIOU GEORGE , CHEN GANG , OLSEN MARK J , DAUGHERTY PATRICK S
发明人： IVERSON BRENT , GEORGIOU GEORGE , CHEN GANG , OLSEN MARK J , DAUGHERTY PATRICK S
IPC分类号： C12N15/10 , C40B40/02 , A61K39/40 , C07K16/16 , C07K16/42 , C12N9/00 , C12N15/62 , G01N33/554
CPC分类号： C40B40/02 , C07K2319/035 , C12N15/1037
摘要： The invention relates to methods of selecting proteins, out of large libraries, having desirable characteristics. Exemplified are methods of expressing enzymes and antibodies on the surface of host cells and selecting for desired activities. These methods have the advantage of speed and ease of operation when compared with current methods. They also provide, without additional cloning, a source of significant quantities of the protein of interest.
摘要翻译：本发明涉及从大型文库中选择具有期望特征的蛋白质的方法。举例说明在宿主细胞表面表达酶和抗体并选择所需活性的方法。与目前的方法相比，这些方法具有速度快并且易于操作的优点。它们还提供了无需额外克隆的大量目的蛋白质的来源。

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